R J Daly

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. ncbi request reprint Cloning and characterization of GRB14, a novel member of the GRB7 gene family
    R J Daly
    Cancer Biology Division, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    J Biol Chem 271:12502-10. 1996
  2. ncbi request reprint The Grb7 family of signalling proteins
    R J Daly
    Cancer Research Program, The Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, NSW, Australia
    Cell Signal 10:613-8. 1998
  3. ncbi request reprint Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14
    R J Lyons
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
    J Biol Chem 276:17172-80. 2001
  4. doi request reprint Functional characterization of cancer-associated Gab1 mutations
    C Ortiz-Padilla
    Cancer Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    Oncogene 32:2696-702. 2013
  5. ncbi request reprint Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3
    R J Fiddes
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
    J Biol Chem 273:7717-24. 1998
  6. ncbi request reprint Signaling pathways and structural domains required for phosphorylation of EMS1/cortactin
    D H Campbell
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    Cancer Res 59:5376-85. 1999
  7. ncbi request reprint Functional analysis of the regulatory requirements of B-Raf and the B-Raf(V600E) oncoprotein
    T Brummer
    Cancer Research Program, The Garvan Institute of Medical Research, Sydney, NSW, Australia
    Oncogene 25:6262-76. 2006
  8. ncbi request reprint Structural determinants of the interaction between the erbB2 receptor and the Src homology 2 domain of Grb7
    P W Janes
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
    J Biol Chem 272:8490-7. 1997
  9. doi request reprint Annexin A6 is a scaffold for PKCα to promote EGFR inactivation
    M Koese
    Faculty of Pharmacy, University of Sydney, Sydney, New South Wales, Australia
    Oncogene 32:2858-72. 2013
  10. ncbi request reprint Gab2 and Src co-operate in human mammary epithelial cells to promote growth factor independence and disruption of acinar morphogenesis
    H L Bennett
    Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
    Oncogene 27:2693-704. 2008

Collaborators

  • T Brummer
  • R L Sutherland
  • C J Ormandy
  • A S Yap
  • H Sasaki
  • W B Church
  • C Wallasch
  • P Martin
  • E A Musgrove
  • W Li
  • Tony Pawson
  • C Ortiz-Padilla
  • M Koese
  • R J Lyons
  • C E Caldon
  • H N Hilton
  • H L Bennett
  • D H Campbell
  • D Gallego-Ortega
  • A Swarbrick
  • C Rentero
  • F Tebar
  • D R Croucher
  • F Hochgräfe
  • D Rickwood
  • C Enrich
  • R Cairns
  • P Wood
  • M Hoque
  • M Reverter
  • T Grewal
  • A Alvarez-Guaita
  • W E Hughes
  • B P Kota
  • B C Browne
  • K Monastyrskaya
  • S Vilà de Muga
  • P W Janes
  • K Blazek
  • J D Graham
  • M J Cowley
  • M Kalyuga
  • M C Alles
  • M J Naylor
  • C L Clarke
  • W Kaplan
  • H J Lee
  • A Jeanes
  • G M Sanderson
  • G R Sutherland
  • R J Fiddes
  • E Baker
  • R Deane
  • Z S Ye
  • H J Eyre
  • D K Lynch
  • S P Sivertsen
  • M Lackmann
  • E J Lowenstein
  • M J Stern
  • J Schlessinger
  • L E Marengere
  • P Olivier
  • A Batzer
  • M Kokel
  • R Lammers
  • E Y Skolnik
  • A Ullrich
  • A G Batzer
  • D Bar-Sagi
  • B Margolis

Detail Information

Publications15

  1. ncbi request reprint Cloning and characterization of GRB14, a novel member of the GRB7 gene family
    R J Daly
    Cancer Biology Division, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    J Biol Chem 271:12502-10. 1996
    ..Grb14 is therefore a target for a PDGF-regulated serine kinase, an interaction that does not require PDGFR-Grb14 association...
  2. ncbi request reprint The Grb7 family of signalling proteins
    R J Daly
    Cancer Research Program, The Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, NSW, Australia
    Cell Signal 10:613-8. 1998
    ..Consequently, these proteins not only are likely to perform a fundamental signalling role, but may also modulate RTK signalling in cancer cells...
  3. ncbi request reprint Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14
    R J Lyons
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
    J Biol Chem 276:17172-80. 2001
    ..This study supports a role for the tankyrases in cytoplasmic signal transduction pathways and suggests that vesicle trafficking may be involved in the subcellular localization or signaling function of Grb14...
  4. doi request reprint Functional characterization of cancer-associated Gab1 mutations
    C Ortiz-Padilla
    Cancer Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    Oncogene 32:2696-702. 2013
    ..These data indicate that aberrant Gab1 signaling can directly contribute to breast cancer progression, and that negative feedback sites in docking proteins can be targeted by oncogenic mutations...
  5. ncbi request reprint Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3
    R J Fiddes
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
    J Biol Chem 273:7717-24. 1998
    ..These studies therefore identify Grb7 as an in vivo target of erbB3 and erbB4 and provide an underlying mechanism for the ability of erbB3 to recruit Grb7 and not Grb2, a property unique among erbB receptors...
  6. ncbi request reprint Signaling pathways and structural domains required for phosphorylation of EMS1/cortactin
    D H Campbell
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    Cancer Res 59:5376-85. 1999
    ..These data identify MEK as an important intermediate involved in EMS1 phosphorylation and highlight the helical-proline-rich region as a key regulatory domain...
  7. ncbi request reprint Functional analysis of the regulatory requirements of B-Raf and the B-Raf(V600E) oncoprotein
    T Brummer
    Cancer Research Program, The Garvan Institute of Medical Research, Sydney, NSW, Australia
    Oncogene 25:6262-76. 2006
    ..Our analysis identifies important regulatory differences between B-Raf(wt) and B-Raf(V600E) and suggests that B-Raf(V600E) cannot be inhibited by strategies aimed at blocking S446 phosphorylation or Ras activation...
  8. ncbi request reprint Structural determinants of the interaction between the erbB2 receptor and the Src homology 2 domain of Grb7
    P W Janes
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
    J Biol Chem 272:8490-7. 1997
    ..The reverse switch at the betaD6 position abrogated Grb7 binding to erbB2. This residue therefore represents an important determinant of SH2 domain specificity within the Grb7 family...
  9. doi request reprint Annexin A6 is a scaffold for PKCα to promote EGFR inactivation
    M Koese
    Faculty of Pharmacy, University of Sydney, Sydney, New South Wales, Australia
    Oncogene 32:2858-72. 2013
    ..In summary, AnxA6 is a new PKCα scaffold to promote PKCα-mediated EGFR inactivation through increased membrane targeting of PKCα and EGFR/PKCα complex formation...
  10. ncbi request reprint Gab2 and Src co-operate in human mammary epithelial cells to promote growth factor independence and disruption of acinar morphogenesis
    H L Bennett
    Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
    Oncogene 27:2693-704. 2008
    ..Overall, these findings demonstrate a novel mechanism whereby Gab2 may promote metastatic spread and indicate that Gab2 may play several roles during breast cancer progression...
  11. doi request reprint The antiproliferative effects of progestins in T47D breast cancer cells are tempered by progestin induction of the ETS transcription factor Elf5
    H N Hilton
    Cancer Research Program, Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia
    Mol Endocrinol 24:1380-92. 2010
    ....
  12. ncbi request reprint Assignment of the human GRB14 gene to chromosome 2q22-q24 by fluorescence in situ hybridization
    E Baker
    Centre for Medical Genetics, Women s and Children s Hospital, Adelaide, South Australia, 5006, Australia
    Genomics 36:218-20. 1996
  13. pmc The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5
    M J Stern
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520 8005
    Mol Biol Cell 4:1175-88. 1993
    ..These data indicate that GRB2 and Drk are functional homologues of Sem-5 and demonstrate the high degree of conservation of both structure and function between signaling systems throughout evolution...
  14. ncbi request reprint The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling
    E J Lowenstein
    Department of Pharmacology, New York University Medical Center, New York 10016
    Cell 70:431-42. 1992
    ..These results suggest that GRB2/sem-5 plays a crucial role in a highly conserved mechanism for growth factor control of ras signaling...