Research Topics
Genomes and GenesSpecies | Leonard Da SilvaSummaryAffiliation: University of Queensland Country: Australia Publications
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Publications
Molecular and morphological analysis of adenoid cystic carcinoma of the breast with synchronous tubular adenosisLeonard Da Silva
University of Queensland Centre for Clinical Research, The Royal Brisbane and Women s Hospital, Level 6, Building 71 918, Herston, Brisbane, 4029, Australia
Virchows Arch 454:107-14. 2009..These molecular data highlight the genomic instability of TA, a benign florid proliferation intermingled with ACC, and do not provide evidence of molecular evolution from TA to ACC...
Rare variants in the ATM gene and risk of breast cancerDavid E Goldgar
Department of Dermatology, University of Utah School of Medicine, 30 N 1900 E, Salt Lake City, UT 84132 2101, USA
Breast Cancer Res 13:R73. 2011..However, the magnitude of risk and the subset of variants that are pathogenic for breast cancer remain unresolved...- Dissecting the transcriptional networks underlying breast cancer: NR4A1 reduces the migration of normal and breast cancer cell linesAnnika N Alexopoulou
University of Oxford Branch, Ludwig Institute for Cancer Research, Old Road Campus, off Roosevelt Drive, Oxford OX3 7DQ, UK
Breast Cancer Res 12:R51. 2010..The purpose of the study was to identify the role of NR4A1 in normal mammary epithelial and breast cancer cell biology... - Gene expression profiling of formalin-fixed, paraffin-embedded familial breast tumours using the whole genome-DASL assayNic Waddell
The Queensland Institute of Medical Research, Brisbane, Australia
J Pathol 221:452-61. 2010.... - Gene expression profiling of tumour epithelial and stromal compartments during breast cancer progressionAna Cristina Vargas
UQ Centre for Clinical Research, The University of Queensland, Herston, Brisbane, QLD, Australia
Breast Cancer Res Treat 135:153-65. 2012..We propose that these expression changes could be involved in facilitating the transition from in situ disease to invasive cancer and may thus mark a critical point in disease development... - Subtypes of familial breast tumours revealed by expression and copy number profilingNic Waddell
Queensland Institute of Medical Research, Brisbane, Australia
Breast Cancer Res Treat 123:661-77. 2010..This study highlights the heterogeneity of familial tumours and the clinical consequences for treatment and prognosis... - HER3 and downstream pathways are involved in colonization of brain metastases from breast cancerLeonard Da Silva
Molecular and Cellular Pathology, The University of Queensland Centre for Clinical Research, and School of Medicine, Building 918 B71, RBWH complex, Brisbane, 4029, Australia
Breast Cancer Res 12:R46. 2010..Metastases to the brain from breast cancer have a high mortality, and basal-like breast cancers have a propensity for brain metastases. However, the mechanisms that allow cells to colonize the brain are unclear... - Tumor heterogeneity in a follicular carcinoma of thyroid: a study by comparative genomic hybridizationLeonard Da Silva
The University of Queensland, UQ Centre for Clinical Research, Herston, Building 918 B71, Royal Brisbane and Women s Hospital, Herston, QLD, 4029, Australia
Endocr Pathol 22:103-7. 2011.... - Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor-negative breast cancerAmelia A Peters
The University of Queensland, School of Pharmacy, Brisbane, Queensland, Australia, 4072
Mol Cancer Ther 11:2158-68. 2012..Our findings suggest that inhibitors of TRPV6 may offer a novel therapeutic strategy for the treatment of ER-negative breast cancers... - Aberrant expression of E-cadherin in lobular carcinomas of the breastLeonard Da Silva
Molecular and Cellular Pathology, Mayne Medical School, University of Queensland, Brisbane, Australia
Am J Surg Pathol 32:773-83. 2008..Misclassification of tumors may lead to mismanagement of patients in clinical practice, particularly in the context of in situ disease at margins... - The contribution of breast cancer pathology to statistical models to predict mutation risk in BRCA carriersAna Cristina Vargas
Molecular and Cellular Pathology, The University of Queensland Centre for Clinical Research, The Royal Brisbane and Women s Hospital, Building 71 918, Brisbane, QLD 4029, Australia
Fam Cancer 9:545-53. 2010..Here we review the pathology of familial breast cancer and assess the evidence to justify the use of pathology in refining risk assessment models... - Pathology of hereditary breast cancerLeonard Da Silva
Molecular and Cellular Pathology, The University of Queensland Centre for Clinical Research, The Royal Brisbane and Women s Hospital, Brisbane, QLD, Australia
Mod Pathol 23:S46-51. 2010..A number of low-to-moderate-penetrant genes/loci have also been identified, but their role and contribution in breast cancer development is still under investigation... - Expression and function of the protein tyrosine phosphatase receptor J (PTPRJ) in normal mammary epithelial cells and breast tumorsChanel E Smart
School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia
PLoS ONE 7:e40742. 2012..These data indicate that PTPRJ may regulate differentiation of normal mammary epithelia and that dysregulation of protein localisation may be associated with tumorigenesis... - Molecular aspects of breast cancer metastasis to the brainJodi M Saunus
UQ Centre for Clinical Research, The University of Queensland, Herston, QLD 4029, Australia
Genet Res Int 2011:219189. 2011.... - Fibroadenoma and intraduct papilloma--a common pathogenesis?Margaret C Cummings
Molecular and Cellular Pathology, Centre for Clinical Research, University of Queensland, Brisbane, Queensland, Australia
Virchows Arch 455:271-5. 2009..That fibroadenoma and intraduct papilloma may have a common pathogenesis is discussed... - What's in a cancer syndrome? Genes, phenotype and pathologyNicola Wayte
The Queensland Institute of Medical Research, Brisbane, Australia
Pathology 40:247-59. 2008....