Leonard Da Silva

Summary

Affiliation: University of Queensland
Country: Australia

Publications

  1. pmc HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer
    Leonard Da Silva
    Molecular and Cellular Pathology, The University of Queensland Centre for Clinical Research, and School of Medicine, Building 918 B71, RBWH complex, Brisbane, 4029, Australia
    Breast Cancer Res 12:R46. 2010
  2. doi request reprint Molecular and morphological analysis of adenoid cystic carcinoma of the breast with synchronous tubular adenosis
    Leonard Da Silva
    University of Queensland Centre for Clinical Research, The Royal Brisbane and Women s Hospital, Level 6, Building 71 918, Herston, Brisbane, 4029, Australia
    Virchows Arch 454:107-14. 2009
  3. pmc Rare variants in the ATM gene and risk of breast cancer
    David E Goldgar
    Department of Dermatology, University of Utah School of Medicine, 30 N 1900 E, Salt Lake City, UT 84132 2101, USA
    Breast Cancer Res 13:R73. 2011
  4. pmc Dissecting the transcriptional networks underlying breast cancer: NR4A1 reduces the migration of normal and breast cancer cell lines
    Annika N Alexopoulou
    University of Oxford Branch, Ludwig Institute for Cancer Research, Old Road Campus, off Roosevelt Drive, Oxford OX3 7DQ, UK
    Breast Cancer Res 12:R51. 2010
  5. doi request reprint Gene expression profiling of formalin-fixed, paraffin-embedded familial breast tumours using the whole genome-DASL assay
    Nic Waddell
    The Queensland Institute of Medical Research, Brisbane, Australia
    J Pathol 221:452-61. 2010
  6. doi request reprint Gene expression profiling of tumour epithelial and stromal compartments during breast cancer progression
    Ana Cristina Vargas
    UQ Centre for Clinical Research, The University of Queensland, Herston, Brisbane, QLD, Australia
    Breast Cancer Res Treat 135:153-65. 2012
  7. doi request reprint Subtypes of familial breast tumours revealed by expression and copy number profiling
    Nic Waddell
    Queensland Institute of Medical Research, Brisbane, Australia
    Breast Cancer Res Treat 123:661-77. 2010
  8. doi request reprint Aberrant expression of E-cadherin in lobular carcinomas of the breast
    Leonard Da Silva
    Molecular and Cellular Pathology, Mayne Medical School, University of Queensland, Brisbane, Australia
    Am J Surg Pathol 32:773-83. 2008
  9. doi request reprint Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor-negative breast cancer
    Amelia A Peters
    The University of Queensland, School of Pharmacy, Brisbane, Queensland, Australia, 4072
    Mol Cancer Ther 11:2158-68. 2012
  10. doi request reprint Tumor heterogeneity in a follicular carcinoma of thyroid: a study by comparative genomic hybridization
    Leonard Da Silva
    The University of Queensland, UQ Centre for Clinical Research, Herston, Building 918 B71, Royal Brisbane and Women s Hospital, Herston, QLD, 4029, Australia
    Endocr Pathol 22:103-7. 2011

Collaborators

Detail Information

Publications16

  1. pmc HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer
    Leonard Da Silva
    Molecular and Cellular Pathology, The University of Queensland Centre for Clinical Research, and School of Medicine, Building 918 B71, RBWH complex, Brisbane, 4029, Australia
    Breast Cancer Res 12:R46. 2010
    ..Metastases to the brain from breast cancer have a high mortality, and basal-like breast cancers have a propensity for brain metastases. However, the mechanisms that allow cells to colonize the brain are unclear...
  2. doi request reprint Molecular and morphological analysis of adenoid cystic carcinoma of the breast with synchronous tubular adenosis
    Leonard Da Silva
    University of Queensland Centre for Clinical Research, The Royal Brisbane and Women s Hospital, Level 6, Building 71 918, Herston, Brisbane, 4029, Australia
    Virchows Arch 454:107-14. 2009
    ..These molecular data highlight the genomic instability of TA, a benign florid proliferation intermingled with ACC, and do not provide evidence of molecular evolution from TA to ACC...
  3. pmc Rare variants in the ATM gene and risk of breast cancer
    David E Goldgar
    Department of Dermatology, University of Utah School of Medicine, 30 N 1900 E, Salt Lake City, UT 84132 2101, USA
    Breast Cancer Res 13:R73. 2011
    ..However, the magnitude of risk and the subset of variants that are pathogenic for breast cancer remain unresolved...
  4. pmc Dissecting the transcriptional networks underlying breast cancer: NR4A1 reduces the migration of normal and breast cancer cell lines
    Annika N Alexopoulou
    University of Oxford Branch, Ludwig Institute for Cancer Research, Old Road Campus, off Roosevelt Drive, Oxford OX3 7DQ, UK
    Breast Cancer Res 12:R51. 2010
    ..The purpose of the study was to identify the role of NR4A1 in normal mammary epithelial and breast cancer cell biology...
  5. doi request reprint Gene expression profiling of formalin-fixed, paraffin-embedded familial breast tumours using the whole genome-DASL assay
    Nic Waddell
    The Queensland Institute of Medical Research, Brisbane, Australia
    J Pathol 221:452-61. 2010
    ....
  6. doi request reprint Gene expression profiling of tumour epithelial and stromal compartments during breast cancer progression
    Ana Cristina Vargas
    UQ Centre for Clinical Research, The University of Queensland, Herston, Brisbane, QLD, Australia
    Breast Cancer Res Treat 135:153-65. 2012
    ..We propose that these expression changes could be involved in facilitating the transition from in situ disease to invasive cancer and may thus mark a critical point in disease development...
  7. doi request reprint Subtypes of familial breast tumours revealed by expression and copy number profiling
    Nic Waddell
    Queensland Institute of Medical Research, Brisbane, Australia
    Breast Cancer Res Treat 123:661-77. 2010
    ..This study highlights the heterogeneity of familial tumours and the clinical consequences for treatment and prognosis...
  8. doi request reprint Aberrant expression of E-cadherin in lobular carcinomas of the breast
    Leonard Da Silva
    Molecular and Cellular Pathology, Mayne Medical School, University of Queensland, Brisbane, Australia
    Am J Surg Pathol 32:773-83. 2008
    ..Misclassification of tumors may lead to mismanagement of patients in clinical practice, particularly in the context of in situ disease at margins...
  9. doi request reprint Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor-negative breast cancer
    Amelia A Peters
    The University of Queensland, School of Pharmacy, Brisbane, Queensland, Australia, 4072
    Mol Cancer Ther 11:2158-68. 2012
    ..Our findings suggest that inhibitors of TRPV6 may offer a novel therapeutic strategy for the treatment of ER-negative breast cancers...
  10. doi request reprint Tumor heterogeneity in a follicular carcinoma of thyroid: a study by comparative genomic hybridization
    Leonard Da Silva
    The University of Queensland, UQ Centre for Clinical Research, Herston, Building 918 B71, Royal Brisbane and Women s Hospital, Herston, QLD, 4029, Australia
    Endocr Pathol 22:103-7. 2011
    ....
  11. pmc Expression and function of the protein tyrosine phosphatase receptor J (PTPRJ) in normal mammary epithelial cells and breast tumors
    Chanel E Smart
    School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia
    PLoS ONE 7:e40742. 2012
    ..These data indicate that PTPRJ may regulate differentiation of normal mammary epithelia and that dysregulation of protein localisation may be associated with tumorigenesis...
  12. doi request reprint The contribution of breast cancer pathology to statistical models to predict mutation risk in BRCA carriers
    Ana Cristina Vargas
    Molecular and Cellular Pathology, The University of Queensland Centre for Clinical Research, The Royal Brisbane and Women s Hospital, Building 71 918, Brisbane, QLD 4029, Australia
    Fam Cancer 9:545-53. 2010
    ..Here we review the pathology of familial breast cancer and assess the evidence to justify the use of pathology in refining risk assessment models...
  13. doi request reprint Pathology of hereditary breast cancer
    Leonard Da Silva
    Molecular and Cellular Pathology, The University of Queensland Centre for Clinical Research, The Royal Brisbane and Women s Hospital, Brisbane, QLD, Australia
    Mod Pathol 23:S46-51. 2010
    ..A number of low-to-moderate-penetrant genes/loci have also been identified, but their role and contribution in breast cancer development is still under investigation...
  14. doi request reprint Fibroadenoma and intraduct papilloma--a common pathogenesis?
    Margaret C Cummings
    Molecular and Cellular Pathology, Centre for Clinical Research, University of Queensland, Brisbane, Queensland, Australia
    Virchows Arch 455:271-5. 2009
    ..That fibroadenoma and intraduct papilloma may have a common pathogenesis is discussed...
  15. pmc Molecular aspects of breast cancer metastasis to the brain
    Jodi M Saunus
    UQ Centre for Clinical Research, The University of Queensland, Herston, QLD 4029, Australia
    Genet Res Int 2011:219189. 2011
    ....
  16. doi request reprint What's in a cancer syndrome? Genes, phenotype and pathology
    Nicola Wayte
    The Queensland Institute of Medical Research, Brisbane, Australia
    Pathology 40:247-59. 2008
    ....