Leila Cuttle

Summary

Affiliation: University of Queensland
Country: Australia

Publications

  1. ncbi request reprint A porcine deep dermal partial thickness burn model with hypertrophic scarring
    Leila Cuttle
    Royal Children s Hospital Burns Research Group, University of Queensland, Department of Paediatrics and Child Health, Royal Children s Hospital, Herston, Queensland 4029, Australia
    Burns 32:806-20. 2006
  2. doi request reprint A review of first aid treatments for burn injuries
    Leila Cuttle
    Royal Children s Hospital Burns Research Group, University of Queensland, Department of Paediatrics and Child Health, Royal Children s Hospital, Herston Rd, Herston, Queensland 4029, Australia
    Burns 35:768-75. 2009
  3. doi request reprint The optimal duration and delay of first aid treatment for deep partial thickness burn injuries
    Leila Cuttle
    Royal Children s Hospital Burns and Trauma Research Group, University of Queensland, Department of Paediatrics and Child Health, Royal Children s Hospital, Herston, Queensland, Australia
    Burns 36:673-9. 2010
  4. doi request reprint The optimal temperature of first aid treatment for partial thickness burn injuries
    Leila Cuttle
    Royal Children s Hospital Burns Research Group, Department of Paediatrics and Child Health, Royal Children s Hospital, University of Queensland, Herston, QLD 4029, Australia
    Wound Repair Regen 16:626-34. 2008
  5. ncbi request reprint Collagen in the scarless fetal skin wound: detection with picrosirius-polarization
    Leila Cuttle
    Department of Paediatrics and Child Health, University of Queensland, Royal Children s Hospital, Queensland, Australia
    Wound Repair Regen 13:198-204. 2005
  6. doi request reprint The efficacy of Aloe vera, tea tree oil and saliva as first aid treatment for partial thickness burn injuries
    Leila Cuttle
    Royal Children s Hospital Burns Research Group, University of Queensland, Department of Paediatrics and Child Health, Royal Children s Hospital, Herston Road, Herston, Queensland 4029, Australia
    Burns 34:1176-82. 2008
  7. doi request reprint Silver absorption on burns after the application of Acticoat: data from pediatric patients and a porcine burn model
    Xue Qing Wang
    Royal Children s Hospital Burns Research Group, University of Queensland, Brisbane, Queensland, Australia
    J Burn Care Res 30:341-8. 2009
  8. doi request reprint Silver deposits in cutaneous burn scar tissue is a common phenomenon following application of a silver dressing
    Xue Qing Wang
    Department of Paediatrics, Child Health Royal Children s Hospital Burns Research Group, University of Queensland, Brisbane, Queensland, Australia
    J Cutan Pathol 36:788-92. 2009
  9. doi request reprint Burn healing is dependent on burn site: a quantitative analysis from a porcine burn model
    Xue Qing Wang
    Department of Paediatrics and Child Health, University of Queensland, Royal Children s Hospital, Brisbane 4029, Australia
    Burns 35:264-9. 2009
  10. doi request reprint A randomised controlled trial of amniotic membrane in the treatment of a standardised burn injury in the merino lamb
    John F Fraser
    Department of Paediatrics and Child Health, Royal Children s Hospital Burns Research Group, Royal Children s Hospital, University of Queensland, Australia
    Burns 35:998-1003. 2009

Collaborators

Detail Information

Publications26

  1. ncbi request reprint A porcine deep dermal partial thickness burn model with hypertrophic scarring
    Leila Cuttle
    Royal Children s Hospital Burns Research Group, University of Queensland, Department of Paediatrics and Child Health, Royal Children s Hospital, Herston, Queensland 4029, Australia
    Burns 32:806-20. 2006
    ..Immunohistochemistry and electron microscopy showed that our porcine hypertrophic scar appears similar to human hypertrophic scarring. The development of this model allows us to test and compare different treatments on burn wounds...
  2. doi request reprint A review of first aid treatments for burn injuries
    Leila Cuttle
    Royal Children s Hospital Burns Research Group, University of Queensland, Department of Paediatrics and Child Health, Royal Children s Hospital, Herston Rd, Herston, Queensland 4029, Australia
    Burns 35:768-75. 2009
    ..From the published work to date, the current recommendations for the first aid treatment of burn injuries should be to use cold running tap water (between 2 and 15 degrees C) on the burn, not ice or alternative plant therapies...
  3. doi request reprint The optimal duration and delay of first aid treatment for deep partial thickness burn injuries
    Leila Cuttle
    Royal Children s Hospital Burns and Trauma Research Group, University of Queensland, Department of Paediatrics and Child Health, Royal Children s Hospital, Herston, Queensland, Australia
    Burns 36:673-9. 2010
    ..First aid application of cold water for as little as 10min duration or up to 1h delay still provides benefit...
  4. doi request reprint The optimal temperature of first aid treatment for partial thickness burn injuries
    Leila Cuttle
    Royal Children s Hospital Burns Research Group, Department of Paediatrics and Child Health, Royal Children s Hospital, University of Queensland, Herston, QLD 4029, Australia
    Wound Repair Regen 16:626-34. 2008
    ..Colder water at 2 degrees C is also beneficial. Ice should not be used...
  5. ncbi request reprint Collagen in the scarless fetal skin wound: detection with picrosirius-polarization
    Leila Cuttle
    Department of Paediatrics and Child Health, University of Queensland, Royal Children s Hospital, Queensland, Australia
    Wound Repair Regen 13:198-204. 2005
    ..This study indicates that healing in the scarless fetal wound is representative of the normal fetal growth pattern, rather than a "response" to burn injury...
  6. doi request reprint The efficacy of Aloe vera, tea tree oil and saliva as first aid treatment for partial thickness burn injuries
    Leila Cuttle
    Royal Children s Hospital Burns Research Group, University of Queensland, Department of Paediatrics and Child Health, Royal Children s Hospital, Herston Road, Herston, Queensland 4029, Australia
    Burns 34:1176-82. 2008
    ..However, they did not decrease the microflora or improve re-epithelialisation, scar strength, scar depth or cosmetic appearance of the scar and cannot be recommended for the first aid treatment of partial thickness burns...
  7. doi request reprint Silver absorption on burns after the application of Acticoat: data from pediatric patients and a porcine burn model
    Xue Qing Wang
    Royal Children s Hospital Burns Research Group, University of Queensland, Brisbane, Queensland, Australia
    J Burn Care Res 30:341-8. 2009
    ....
  8. doi request reprint Silver deposits in cutaneous burn scar tissue is a common phenomenon following application of a silver dressing
    Xue Qing Wang
    Department of Paediatrics, Child Health Royal Children s Hospital Burns Research Group, University of Queensland, Brisbane, Queensland, Australia
    J Cutan Pathol 36:788-92. 2009
    ..However, in a few cases, skin discolouration or argyria-like appearances have been reported. This study investigated the level of silver in scar tissue post-burn injury following application of Acticoat, a silver dressing...
  9. doi request reprint Burn healing is dependent on burn site: a quantitative analysis from a porcine burn model
    Xue Qing Wang
    Department of Paediatrics and Child Health, University of Queensland, Royal Children s Hospital, Brisbane 4029, Australia
    Burns 35:264-9. 2009
    ..We recommend that similar symmetrical burns should be used for future comparative assessments of burn healing...
  10. doi request reprint A randomised controlled trial of amniotic membrane in the treatment of a standardised burn injury in the merino lamb
    John F Fraser
    Department of Paediatrics and Child Health, Royal Children s Hospital Burns Research Group, Royal Children s Hospital, University of Queensland, Australia
    Burns 35:998-1003. 2009
    ..AM resulted in reduced scar tissue as assessed histopathologically and reduced alphaSMA content. This study provides the first laboratory evidence that AM may reduce scar formation after burn injury...
  11. ncbi request reprint Deep dermal burn injury results in scarless wound healing in the ovine fetus
    John F Fraser
    Royal Children s Hospital Burns Research Group, Royal Children s Hospital, University of Queensland, Herston, Brisbane, Queensland, Australia
    Wound Repair Regen 13:189-97. 2005
    ..Further elucidation of this specific fetal process of burn injury repair may lead to improved outcome for patients with burn injury...
  12. doi request reprint Conservative surgical debridement as a burn treatment: supporting evidence from a porcine burn model
    Xue Qing Wang
    Department of Paediatrics and Child Health, University of Queensland, Royal Children s Hospital, QLD, Australia
    Wound Repair Regen 16:774-83. 2008
    ..This study provides supporting evidence that immediate debridement with an appropriate dressing and without skin grafting may promote wound healing, suggesting its potential benefit for clinical patients...
  13. doi request reprint Laser Doppler imaging in a paediatric burns population
    Julie Mill
    Royal Children s Hospital Burns Research Group, University of Queensland, Department of Paediatrics and Child Health, Royal Children s Hospital, Herston Rd, Herston, Queensland 4029, Australia
    Burns 35:824-31. 2009
    ..Laser Doppler imaging (LDI) was compared to wound outcomes in children's burns, to determine if the technology could be used to predict these outcomes...
  14. doi request reprint The evaluation of a clinical scar scale for porcine burn scars
    Xue Qing Wang
    Department of Paediatrics and Child Health, University of Queensland, Royal Children s Hospital, Brisbane 4029, Australia
    Burns 35:538-46. 2009
    ..We believe that the successful use of porcine scar scales is invaluable for assessing potential human burn treatments...
  15. doi request reprint Vitronectin: growth factor complexes hold potential as a wound therapy approach
    Zee Upton
    Tissue Repair and Regeneration Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia
    J Invest Dermatol 128:1535-44. 2008
    ..This suggests that coupling delivery of growth factors to ECM proteins such as VN may ultimately prove to be a more effective strategy for developing a wound healing therapy...
  16. ncbi request reprint A retrospective cohort study of Acticoat versus Silvazine in a paediatric population
    Leila Cuttle
    Royal Children s Hospital Burns Research Group, University of Queensland, Department of Paediatrics and Child Health, Royal Children s Hospital, Herston, Queensland 4029, Australia
    Burns 33:701-7. 2007
    ..We have concluded that Acticoat is a safe, cost-effective, efficacious dressing that reduces the time for re-epithelialisation and the requirement for grafting and long term scar management, compared to Silvazine...
  17. doi request reprint Second harmonic generation and multiphoton microscopic detection of collagen without the need for species specific antibodies
    Alice C H Chen
    The Centre for Children s Burns Research, Queensland Children s Medical Research Institute, Royal Children s Hospital, The University of Queensland, Brisbane, QLD 4029, Australia
    Burns 37:1001-9. 2011
    ..Collectively, our results demonstrate that MPM SHG-detection is a useful tool for high resolution examination of collagen architecture in both normal and wounded human, porcine and ovine dermal tissue...
  18. pmc Efficacy of a children's procedural preparation and distraction device on healing in acute burn wound care procedures: study protocol for a randomized controlled trial
    Nadia J Brown
    Centre for Children s Burns and Trauma Research, Queensland Children s Medical Research Institute, University of Queensland, Royal Children s Hospital, Brisbane, Queensland, Australia
    Trials 13:238. 2012
    ....
  19. doi request reprint Cytotoxicity testing of burn wound dressings, ointments and creams: a method using polycarbonate cell culture inserts on a cell culture system
    Margit Kempf
    Centre for Children s Burns and Trauma Research, The University of Queensland, Department of Paediatrics and Child Health and Queensland Children s Medical Research Institute, Level 4, Foundation Building, Royal Children s Hospital, Brisbane, QLD 4029, Australia
    Burns 37:994-1000. 2011
    ....
  20. doi request reprint The efficacy of an augmented virtual reality system to alleviate pain in children undergoing burns dressing changes: a randomised controlled trial
    Jonathan Mott
    Royal Children s Hospital Burns Research Group, University of Queensland, Department of Paediatrics and Child Health, Royal Children s Hospital, Brisbane, Queensland, Australia
    Burns 34:803-8. 2008
    ..Oxygen saturation did not differ significantly over time or between the two study groups. This trial shows that augmented reality is a useful adjunct to pharmacological analgesia...
  21. doi request reprint An audit of first-aid treatment of pediatric burns patients and their clinical outcome
    Leila Cuttle
    Royal Children s Hospital Burns Research Group, Department of Pediatrics and Child Health, Royal Children s Hospital, University of Queensland, Herston, Australia
    J Burn Care Res 30:1028-34. 2009
    ..There is also a need for more public awareness of recommended first-aid treatment...
  22. ncbi request reprint Cytotoxicity of topical antimicrobial agents used in burn wounds in Australasia
    John F Fraser
    Royal Children s Hospital Burns Research Group, Department of Paediatrics and Child Health, University of Queensland, Royal Children s Hospital, Brisbane, Queensland, Australia
    ANZ J Surg 74:139-42. 2004
    ..This study compared the relative cytotoxicity of Silvazine with 1% silver sulphadiazine (Flamazine (Smith & Nephew Healthcare, Hull, UK)) and a silver-based dressing (Acticoat (Smith & Nephew Healthcare, Hull, UK))...
  23. ncbi request reprint In vivo and in vitro models demonstrate a role for caveolin-1 in the pathogenesis of ischaemic acute renal failure
    Mitra Mahmoudi
    Department of Molecular and Cellular Pathology, School of Medicine, University of Queensland, Herston, Brisbane, Australia 4006
    J Pathol 200:396-405. 2003
    ..Caveolin-1 was also found to localize intensely within apoptotic cells. The results are indicative of a role for caveolin-1 in ARF-induced renal injury. Whether it functions for cell repair or death remains to be elucidated...
  24. ncbi request reprint Fetuin-A: a major fetal serum protein that promotes "wound closure" and scarless healing
    Xue Qing Wang
    J Invest Dermatol 128:753-7. 2008
  25. ncbi request reprint Interleukin-1beta induces human proximal tubule cell injury, alpha-smooth muscle actin expression and fibronectin production
    David A Vesey
    Department of Renal Medicine, Princess Alexandra Hospital, Woolloongabba, Brisbane, Queensland 4102, Australia
    Kidney Int 62:31-40. 2002
    ..The aim of the present study, therefore, was to investigate the potentially fibrogenic mechanisms of interleukin-1beta (IL-1beta), a macrophage-derived pro-inflammatory cytokine, on human proximal tubule cells (PTC)...
  26. ncbi request reprint Interleukin-1beta stimulates human renal fibroblast proliferation and matrix protein production by means of a transforming growth factor-beta-dependent mechanism
    David A Vesey
    Department of Renal Medicine, Princess Alexandra Hospital, Brisbane, QLD, Australia
    J Lab Clin Med 140:342-50. 2002
    ..The fibrogenic and proliferative action of IL-1beta on CF appears not to involve activation of PKC or production of NO but is at least partly TGFbeta-dependent...