A L Cunningham

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. pmc Determination of suitable housekeeping genes for normalisation of quantitative real time PCR analysis of cells infected with human immunodeficiency virus and herpes viruses
    Sarah Watson
    Centre for Virus Research, Westmead Millennium Institute, Sydney, Australia
    Virol J 4:130. 2007
  2. pmc Phenotype and envelope gene diversity of nef-deleted HIV-1 isolated from long-term survivors infected from a single source
    Lachlan Gray
    Macfarlane Burnet Institute for Medical Research and Public Health, Victoria, Australia
    Virol J 4:75. 2007
  3. pmc Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS
    Jasminka Sterjovski
    Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    Retrovirology 4:89. 2007
  4. pmc Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo
    Paul R Gorry
    Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    Retrovirology 4:66. 2007
  5. pmc Antibody microarray analysis of cell surface antigens on CD4+ and CD8+ T cells from HIV+ individuals correlates with disease stages
    Jing Qin Wu
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Darcy Road, Westmead, NSW 2145, Sydney, Australia
    Retrovirology 4:83. 2007
  6. pmc Home sweet home: How do virus specific T cells navigate to the skin?
    Anthony L Cunningham
    Centre for Virus Research, Westmead Millennium Institute, Westmead, New South Wales, Australia
    J Clin Invest 110:441-2. 2002
  7. ncbi request reprint The Holy Grail: immune control of human herpes simplex virus infection and disease
    A L Cunningham
    Centre for Virus Research, Westmead Millennium Institute, and University of Sydney, Sydney, Australia
    Herpes 8:6A-10A. 2001
  8. ncbi request reprint The cycle of human herpes simplex virus infection: virus transport and immune control
    Anthony L Cunningham
    Centre for Virus Research, Westmead Millennium Institute, University of Sydney and Westmead Hospital, Sydney, 2145, Australia
    J Infect Dis 194:S11-8. 2006
  9. ncbi request reprint The level of HIV infection of macrophages is determined by interaction of viral and host cell genotypes
    A L Cunningham
    Centre for Virus Research, The Westmead Millennium Institute, University of Sydney, Australia
    J Leukoc Biol 68:311-7. 2000
  10. ncbi request reprint The prevention and management of herpes zoster
    Anthony L Cunningham
    University of Sydney, Sydney, NSW, Australia
    Med J Aust 188:171-6. 2008

Detail Information

Publications99

  1. pmc Determination of suitable housekeeping genes for normalisation of quantitative real time PCR analysis of cells infected with human immunodeficiency virus and herpes viruses
    Sarah Watson
    Centre for Virus Research, Westmead Millennium Institute, Sydney, Australia
    Virol J 4:130. 2007
    ..This provides researchers of these viruses with a shortlist of potential housekeeping genes to use as normalisers for QPCR experiments...
  2. pmc Phenotype and envelope gene diversity of nef-deleted HIV-1 isolated from long-term survivors infected from a single source
    Lachlan Gray
    Macfarlane Burnet Institute for Medical Research and Public Health, Victoria, Australia
    Virol J 4:75. 2007
    ..To better understand mechanisms underlying the pathogenicity of nef-deleted HIV-1, we examined the phenotype and env sequence diversity of sequentially isolated viruses (n = 2) from 3 SBBC members...
  3. pmc Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS
    Jasminka Sterjovski
    Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    Retrovirology 4:89. 2007
    ....
  4. pmc Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo
    Paul R Gorry
    Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    Retrovirology 4:66. 2007
    ....
  5. pmc Antibody microarray analysis of cell surface antigens on CD4+ and CD8+ T cells from HIV+ individuals correlates with disease stages
    Jing Qin Wu
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Darcy Road, Westmead, NSW 2145, Sydney, Australia
    Retrovirology 4:83. 2007
    ....
  6. pmc Home sweet home: How do virus specific T cells navigate to the skin?
    Anthony L Cunningham
    Centre for Virus Research, Westmead Millennium Institute, Westmead, New South Wales, Australia
    J Clin Invest 110:441-2. 2002
  7. ncbi request reprint The Holy Grail: immune control of human herpes simplex virus infection and disease
    A L Cunningham
    Centre for Virus Research, Westmead Millennium Institute, and University of Sydney, Sydney, Australia
    Herpes 8:6A-10A. 2001
    ..These in vitro results are consistent with the findings of the most recent HSV vaccine trials...
  8. ncbi request reprint The cycle of human herpes simplex virus infection: virus transport and immune control
    Anthony L Cunningham
    Centre for Virus Research, Westmead Millennium Institute, University of Sydney and Westmead Hospital, Sydney, 2145, Australia
    J Infect Dis 194:S11-8. 2006
    ....
  9. ncbi request reprint The level of HIV infection of macrophages is determined by interaction of viral and host cell genotypes
    A L Cunningham
    Centre for Virus Research, The Westmead Millennium Institute, University of Sydney, Australia
    J Leukoc Biol 68:311-7. 2000
    ..Such host-cell genetic factors may affect viral load in vivo where macrophages are the predominant target cells...
  10. ncbi request reprint The prevention and management of herpes zoster
    Anthony L Cunningham
    University of Sydney, Sydney, NSW, Australia
    Med J Aust 188:171-6. 2008
    ..Clinicians should refer to the Australian immunisation handbook for advice on the use of the live vaccine in immunosuppressed individuals...
  11. doi request reprint Langerhans cells and viral immunity
    Anthony L Cunningham
    Centre for Virus Research, Westmead Millennium Institute and University of Sydney, Westmead, Sydney, Australia
    Eur J Immunol 38:2377-85. 2008
    ..Although all three viruses interact with LC during initial infection, the effects can be quite different, reflecting differences in biology and pathogenesis...
  12. ncbi request reprint Manipulation of dendritic cell function by viruses
    Anthony L Cunningham
    Centre for Virus Research, Westmead Millennium Institute, University of Sydney, Westmead, NSW 2145, Australia
    Curr Opin Microbiol 13:524-9. 2010
    ....
  13. doi request reprint Viruses and Langerhans cells
    Anthony L Cunningham
    Centre for Virus Research, Westmead Millennium Institute, New South Wales, Australia
    Immunol Cell Biol 88:416-23. 2010
    ..The full spectrum of biological responses of LCs even to these viruses has yet to be understood and will require complementary studies in human LCs in vitro and in murine models in vivo...
  14. ncbi request reprint In vivo production of cytokines and beta (C-C) chemokines in human recurrent herpes simplex lesions--do herpes simplex virus-infected keratinocytes contribute to their production?
    Z Mikloska
    Centre for Virus Research, Westmead Institutes of Health Research, NSW, Australia
    J Infect Dis 177:827-38. 1998
    ....
  15. ncbi request reprint Bitter-sweet symphony: defining the role of dendritic cell gp120 receptors in HIV infection
    S G Turville
    Center for Virus Research, Westmead Millennium Institute, PO Box 412 Darcy Road, Westmead, Sydney, NSW 2145, Australia
    J Clin Virol 22:229-39. 2001
    ..Mucosal transmission of HIV in vivo targets immature sessile DCs, including Langerhans cells which lack DC-SIGN. The role of CLRs and DC-SIGN in such transmission remains to be defined...
  16. ncbi request reprint Direct evidence for native CD4 oligomers in lymphoid and monocytoid cells
    G W Lynch
    Centre for Virus Research, Westmead Institutes of Health Research, Westmead Hospital and University of Sydney, Sydney, Australia
    Eur J Immunol 29:2590-602. 1999
    ..These findings demonstrate that different quaternary forms of CD4 such as monomers, homodimers and tetramers are expressed by T lymphocytes and monocytes/macrophages...
  17. pmc Neutralizing antibodies inhibit axonal spread of herpes simplex virus type 1 to epidermal cells in vitro
    Z Mikloska
    Centre for Virus Research, Westmead Institutes of Health Research, Westmead Hospital and University of Sydney, Sydney, New South Wales 2145, Australia
    J Virol 73:5934-44. 1999
    ..Therefore, selected human monoclonal antibodies to protective epitopes might even be effective in preventing epidermis-to-neuron transmission during primary HSV infection, especially neonatal infection...
  18. ncbi request reprint Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport
    Mark W Douglas
    Centre for Virus Research, Westmead Millennium Institute, University of Sydney and Westmead Hospital, Westmead 2145, New South Wales, Australia
    J Biol Chem 279:28522-30. 2004
    ..We propose that VP26 mediates binding of incoming herpes simplex virus capsids to cytoplasmic dynein during cellular infection, through interactions with dynein light chains...
  19. ncbi request reprint Transport and egress of herpes simplex virus in neurons
    Russell J Diefenbach
    Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital and The University of Sydney, Westmead, NSW 2145, Australia
    Rev Med Virol 18:35-51. 2008
    ..Current hypotheses suggest that unenveloped HSV capsids complete assembly in the axonal growth cones and varicosities, whereas with PrV unenveloped capsids are only found travelling in a retrograde direction...
  20. pmc Definition of the stage of host cell genetic restriction of replication of human immunodeficiency virus type 1 in monocytes and monocyte-derived macrophages by using twins
    H M Naif
    Centre for Virus Research, Westmead Institutes of Health Research, Australian National Centre for HIV Virology Research, Westmead Hospital, Westmead, New South Wales 2145, Australia
    J Virol 73:4866-81. 1999
    ..Although CCR5 was necessary for infection, other unidentified host genes are likely to limit productive infection...
  21. ncbi request reprint Analysis of recombinant and native CD4 by one- and two-dimensional gel electrophoresis
    G W Lynch
    Department of Virology, ICPMR, University of Sydney, Westmead Hospital, Westmead and National Centre for HIV Virology Research, Australia
    Electrophoresis 17:227-34. 1996
    ..These studies describe the biotinylation, 1-DE and 2-DE of CD4 preparations, and indicate the capacity of CD4 of lymphocytes to form complexes which may influence CD4 conformation and epitope availability...
  22. pmc Varicella-zoster virus infection of human dendritic cells and transmission to T cells: implications for virus dissemination in the host
    A Abendroth
    Centre for Virus Research, Westmead Millennium Institute and University of Sydney, Westmead, New South Wales 2145, Australia
    J Virol 75:6183-92. 2001
    ..These findings have implications for our understanding of how virus may be disseminated during primary VZV infection...
  23. ncbi request reprint Viral gene expression during the establishment of human cytomegalovirus latent infection in myeloid progenitor cells
    Allen K L Cheung
    Centre for Virus Research, Westmead Millennium Institute, PO Box 412, Westmead, NSW 2145, Australia
    Blood 108:3691-9. 2006
    ..Viral genes expressed during the establishment phase may serve as targets for therapies to interrupt this process...
  24. pmc Immature monocyte-derived dendritic cells are productively infected with herpes simplex virus type 1
    Z Mikloska
    Centre for Virus Research, Westmead Millennium Institute and University of Sydney, Westmead, NSW 2145, Australia
    J Virol 75:5958-64. 2001
    ..Thus, we propose that productive infection of epidermal Langerhans cells in vivo may lead to delayed activation of T cells, allowing more time for replication of HSV type 1 in epidermal cells...
  25. ncbi request reprint The axonal transmission of herpes simplex virus to epidermal cells: a novel use of the freeze substitution technique applied to explant cultures retained on cover slips
    D J Holland
    Centre for Virus Research, Westmead Institutes of Health Research, Westmead Hospital, Sydney, NSW, Australia
    J Microsc 192:69-72. 1998
    ..It should be adaptable to a number of cell-culture applications and has a number of advantages over other techniques...
  26. pmc Herpes simplex virus tegument protein US11 interacts with conventional kinesin heavy chain
    Russell J Diefenbach
    Centre for Virus Research and Electron Microscopy Unit, The Westmead Millennium Institute, Westmead Hospital and University of Sydney, Westmead, New South Wales, Australia
    J Virol 76:3282-91. 2002
    ..These observations suggest a major role for the uKHC-US11 interaction in anterograde transport of unenveloped HSV nucleocapsids in axons...
  27. ncbi request reprint Diversity of receptors binding HIV on dendritic cell subsets
    Stuart G Turville
    Center for Virus Research, Westmead Millennium Institute, Westmead Hospital and University of Sydney, Sydney, NSW 2145, Australia
    Nat Immunol 3:975-83. 2002
    ..The diversity of CLRs able to bind HIV-1 in skin DCs may reflect their ability to bind a range of microbial glycoproteins...
  28. pmc HIV-1-infected dendritic cells show 2 phases of gene expression changes, with lysosomal enzyme activity decreased during the second phase
    Andrew N Harman
    Centre for Virus Research, Westmead Millennium Institute, Sydney, Australia
    Blood 114:85-94. 2009
    ..The net effect was markedly diminished cathepsin activity likely to result in enhanced HIV-1 survival and transfer to contacting T lymphocytes but decreased HIV-1 antigen processing and presentation to these T cells...
  29. ncbi request reprint Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells
    Stuart G Turville
    Centre for Virus Research, Westmead Millennium Institute, Sydney, Australia
    Blood 103:2170-9. 2004
    ..Thus, the controversy of DCs being infected or not infected for the mechanics of viral transfer to CD4+ lymphocytes can be addressed as a function of time...
  30. pmc Alpha and gamma interferons inhibit herpes simplex virus type 1 infection and spread in epidermal cells after axonal transmission
    Z Mikloska
    Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital and University of Sydney, Westmead, New South Wales 2145, Australia
    J Virol 75:11821-6. 2001
    ..Therefore, both IFN-alpha and -gamma could contribute to the control of HSV-1 spread and shedding in a similar fashion in recurrent herpetic lesions...
  31. pmc Immunodominant epitopes in herpes simplex virus type 2 glycoprotein D are recognized by CD4 lymphocytes from both HSV-1 and HSV-2 seropositive subjects
    Min Kim
    Centre for Virus Research, Westmead Millennium Institute, Westmead, New South Wales and University of Sydney, New South Wales, Australia
    J Immunol 181:6604-15. 2008
    ..This work provides a basis for CD4 lymphocyte cross-recognition of gD2 and possibly cross-protection observed in previous clinical studies and in vaccine trials...
  32. ncbi request reprint Dendritic cell biology in herpesvirus infections
    Lidija Bosnjak
    Centre for Virus Research, Westmead Millennium Institute, Darcy Road, Westmead, NSW 2145, Australia
    Viral Immunol 18:419-33. 2005
  33. ncbi request reprint Development of prophylactic vaccines for genital and neonatal herpes
    Cheryl A Jones
    Herpesvirus Research Unit, and Department of Immunology and Infectious Diseases, The Children s Hospital at Westmead, Westmead, Australia
    Expert Rev Vaccines 2:541-9. 2003
    ....
  34. doi request reprint Identification of binding domains in the herpes simplex virus type 1 small capsid protein pUL35 (VP26)
    Arin Apcarian
    Centre for Virus Research, Westmead Millennium Institute, The University of Sydney and Westmead Hospital, Westmead, NSW 2145, Australia
    J Gen Virol 91:2659-63. 2010
    ..In contrast, only the C-terminal half of pUL35 was found to mediate the binding of pUL19 and pUL37 through distinct regions. The relevance of this information to the role of pUL35 in viral transport and assembly is discussed...
  35. ncbi request reprint The murine cytomegalovirus (MCMV) homolog of the HCMV phosphotransferase (UL97(pk)) gene
    W D Rawlinson
    Department of Microbiology, Prince of Wales Hospital, Randwick, New South Wales, Australia
    Virology 233:358-63. 1997
    ..MCMV provides a useful model for studying the in vivo function of the phosphotransferase genes of the betatherpesviruses and has potential for use in studies of antiviral resistance...
  36. ncbi request reprint CD4 is expressed by epidermal Langerhans' cells predominantly as covalent dimers
    G W Lynch
    Centre for Virus Research, Westmead Millennium Institute, University of Sydney, Westmead Hospital, Sydney, Australia
    Exp Dermatol 12:700-11. 2003
    ..It remains to be determined, however, why tissue embedded LC express mainly CD4 dimers, but single-celled blood lymphocytes and monocytes mainly monomers...
  37. ncbi request reprint The use of flow cytometry to detect antiviral resistance in human cytomegalovirus
    A M Kesson
    Faculty of Medicine and Health Sciences, University of Newcastle, NSW, Australia
    J Virol Methods 71:177-86. 1998
    ..The FACS assay is a rapid and reproducible method for detecting antiviral resistance of HCMV...
  38. ncbi request reprint Monophosphoryl lipid A and QS21 increase CD8 T lymphocyte cytotoxicity to herpes simplex virus-2 infected cell proteins 4 and 27 through IFN-gamma and IL-12 production
    Z Mikloska
    Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital and University of Sydney, Westmead, Australia
    J Immunol 164:5167-76. 2000
    ..Therefore, the mechanism for the enhancement of CD8 T cell cytotoxicity by adjuvants in this system appears to be via increased levels of IL-12 and IFN-gamma...
  39. ncbi request reprint An examination of signs of disease progression in survivors of the Sydney Blood Bank Cohort (SBBC)
    M R Birch
    HIV Epidemiology Research Unit HERU, Australian Red Cross Blood Service NSW ARCBS NSW, Level 3 131 Clarence Street, Sydney, NSW 2000, Australia
    J Clin Virol 22:263-70. 2001
    ..In contrast, in the SA cohort, comparison study group for the SBBC, five of 24 remain therapy naïve after 15 years infection with HIV-1 and all have detectable VL...
  40. pmc CCR5 expression correlates with susceptibility of maturing monocytes to human immunodeficiency virus type 1 infection
    H M Naif
    Molecular Pathogenesis Laboratory, Westmead Institutes of Health Research, The University of Sydney, and National Centre for HIV Virology Research, Australia
    J Virol 72:830-6. 1998
    ..The concordance of levels of HIV DNA and p24 antigen suggested that the changes in susceptibility with monocyte maturation were at or immediately after entry and correlated well with CCR5 expression and inversely with CXCR4 expression...
  41. pmc Rapid and sensitive detection of severe acute respiratory syndrome coronavirus by rolling circle amplification
    Bin Wang
    Retroviral Genetics Laboratory, Centre for Virus Research, Westmead Millennium Institute, The University of Sydney, Darcy Rd, Westmead, Sydney, NSW 2145, Australia
    J Clin Microbiol 43:2339-44. 2005
    ..Furthermore, the RCA technology provides a faster, more sensitive, and economical option to currently available PCR-based methods...
  42. pmc A human immunodeficiency virus type 1 isolate from an infected person homozygous for CCR5Delta32 exhibits dual tropism by infecting macrophages and MT2 cells via CXCR4
    Hassan M Naif
    Centre for Virus Research Institute of Immunology and Allergy Research, The Westmead Millennium Institute, The University of Sydney, Sydney, New South Wales, Australia
    J Virol 76:3114-24. 2002
    ..Our study demonstrates the ability of certain strains of HIV to readily use CXCR4 for infection or entry into macrophages, which is highly relevant to the pathogenesis of late-stage disease and presumably also HIV transmission...
  43. ncbi request reprint 10: Herpes simplex and varicella-zoster virus infections
    Dominic E Dwyer
    Centre for Infectious Diseases and Microbiology Laboratory Service, ICPMR, Westmead Hospital, PO Box 533, Wentworthville, NSW 2145
    Med J Aust 177:267-73. 2002
    ..The availability of effective antiviral therapy makes early diagnosis vital..
  44. ncbi request reprint HIV induces maturation of monocyte-derived dendritic cells and Langerhans cells
    Andrew N Harman
    Centre for Virus Research, Westmead Millennium Institute, Sydney, Australia
    J Immunol 177:7103-13. 2006
    ..Increased maturation marker surface expression was also demonstrated in native DCs, ex vivo Langerhans cells derived from human skin. Thus, HIV initiates maturation of DCs which could facilitate subsequent enhanced transfer to T cells...
  45. pmc Herpes simplex virus type 1 accumulation, envelopment, and exit in growth cones and varicosities in mid-distal regions of axons
    Monica Miranda Saksena
    Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital, P O Box 412, Westmead, NSW 2145, Australia
    J Virol 80:3592-606. 2006
    ..Envelopment probably occurs by budding of capsids into vesicles with associated tegument and envelope proteins. Virions appear to exit from these sites by exocytosis...
  46. ncbi request reprint Herpes simplex virus type 2 (HSV-2) infection in women attending an antenatal clinic in the South Pacific island nation of Vanuatu
    Lewis J Haddow
    Sexually Transmitted Infections Research Centre, Westmead, New South Wales, Australia
    Sex Transm Dis 34:258-61. 2007
    ..The objective of this study was to estimate the prevalence and correlates of herpes simplex virus type 2 infection in women in an antenatal clinic in the South Pacific island nation of Vanuatu...
  47. ncbi request reprint The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23
    Russell J Diefenbach
    Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital and The University of Sydney, NSW 2145, Australia
    Biochemistry 41:14906-15. 2002
    ..In support of separate binding sites on heavy chain for light chain and SNAPs, a complex of heavy and light chains was observed to interact with SNAP25 and SNAP23...
  48. pmc Herpes simplex virus utilizes the large secretory vesicle pathway for anterograde transport of tegument and envelope proteins and for viral exocytosis from growth cones of human fetal axons
    Monica Miranda-Saksena
    Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital, Westmead, NSW 2145, Australia
    J Virol 83:3187-99. 2009
    ..We postulate that HSV-1 capsids invaginate tegument- and envelope-bearing TGN-derived vesicles and utilize the large secretory vesicle pathway of exocytosis for exit from axons...
  49. pmc Oligomerization of the macrophage mannose receptor enhances gp120-mediated binding of HIV-1
    Joey Lai
    Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital, Westmead, Sydney, New South Wales 2145, Australia
    J Biol Chem 284:11027-38. 2009
    ....
  50. ncbi request reprint Detection of the rapid emergence of the H275Y mutation associated with oseltamivir resistance in severe pandemic influenza virus A/H1N1 09 infections
    Bin Wang
    Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead, NSW 2145, Australia
    Antiviral Res 87:16-21. 2010
    ..In the light of emerging resistance, close monitoring and understanding of the nature and dynamics of resistance mutations in newly emerging strains should be a priority...
  51. pmc Impact of varicella-zoster virus on dendritic cell subsets in human skin during natural infection
    Jennifer H Huch
    University of Sydney, Discipline of Infectious Diseases and Immunology, Blackburn Building, Room 601, New South Wales 2006, Australia
    J Virol 84:4060-72. 2010
    ..This study defines changes in the response of DC which occur during cutaneous VZV infection and implicates infection of DC subtypes in VZV pathogenesis...
  52. ncbi request reprint The role of the human cytomegalovirus UL111A gene in down-regulating CD4+ T-cell recognition of latently infected cells: implications for virus elimination during latency
    Allen K L Cheung
    Centre for Virus Research, Westmead Millennium Institute and University of Sydney, Westmead, NSW 2145, Australia
    Blood 114:4128-37. 2009
    ..The detection of a viral gene that suppresses CD4(+) T-cell recognition of latently infected cells identifies an immune evasion strategy that probably enhances the capacity of HCMV to persist in a latent state within the human host...
  53. pmc Impact of human cytomegalovirus latent infection on myeloid progenitor cell gene expression
    Barry Slobedman
    Centre for Virus Research, Westmead Millennium Institute and University of Sydney, Westmead, New South Wales 2145, Australia
    J Virol 78:4054-62. 2004
    ..The host genes whose expression we found altered are likely to contribute to an environment that sustains latent infection...
  54. ncbi request reprint Herpes simplex virus infection of human dendritic cells induces apoptosis and allows cross-presentation via uninfected dendritic cells
    Lidija Bosnjak
    Center for Virus Research, Westmead Millennium Institutem, Westmead Millennium Institute and Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, Australia
    J Immunol 174:2220-7. 2005
    ..In this study we provide an explanation for this phenomenon, demonstrating that HSV-infected apoptotic DCs are readily phagocytosed by uninfected bystander DCs, which, in turn, stimulate virus-specific CD8+ T cell clones...
  55. ncbi request reprint Sensitive detection of the K103N non-nucleoside reverse transcriptase inhibitor resistance mutation in treatment-naïve HIV-1 infected individuals by rolling circle amplification
    Bin Wang
    Center for Virus Research, Westmead Millennium Institute, University of Sydney, Sydney, NSW 2145, Australia
    J Virol Methods 161:128-35. 2009
    ..Importantly, the new RCA technology allows large-scale, sensitive detection of drug resistance mutations, including detection of minority populations with minimal equipment requirement...
  56. pmc Varicella-zoster virus productively infects mature dendritic cells and alters their immune function
    Gavin Morrow
    Centre for Virus Research, Westmead Millennium Institute and University of Sydney, Westmead, New South Wales 2145, Australia
    J Virol 77:4950-9. 2003
    ..Thus, VZV has evolved yet another immune evasion strategy that would likely impair immunosurveillance and enhance the chances for lifelong persistence in the human population...
  57. ncbi request reprint The ribosome receptor, p180, interacts with kinesin heavy chain, KIF5B
    Russell J Diefenbach
    Centre for Virus Research, Westmead Millennium Institute, The University of Sydney and Westmead Hospital, Westmead, NSW 2145, Australia
    Biochem Biophys Res Commun 319:987-92. 2004
    ..A role for the kinesin/p180 interaction may include mRNA localization and/or transport of endoplasmic reticulum-derived vesicles...
  58. ncbi request reprint Gene expression in HIV-1/Mycobacterium tuberculosis co-infected macrophages is dominated by M. tuberculosis
    Susan Maddocks
    HIV Molecular Pathogenesis Group, Centre for Virus Research, Westmead Millennium Institute, University of Sydney, Westmead NSW 2145, Australia
    Tuberculosis (Edinb) 89:285-93. 2009
    ..Thus, the effects of M. tuberculosis infection on global gene expression dominated the effects of HIV-1 in co-infected primary human macrophages...
  59. pmc Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human macrophages
    Gary D Ewart
    Biotron Limited, LPO Box A315, Eggleston Rd, Australian National University, Canberra, ACT 2601, Australia
    Antimicrob Agents Chemother 48:2325-30. 2004
    ..These compounds also inhibit the in vitro activities of the HIV-1 Vpu protein and might represent lead compounds for a new class of anti-HIV-1 drugs...
  60. ncbi request reprint HIV gp120 receptors on human dendritic cells
    S G Turville
    Center for Virus Research, Westmead Millennium Institute, Sydney, Australia
    Blood 98:2482-8. 2001
    ..In view of these marked differences between MDDCs and blood DCs, HIV capture by DCs and transfer mechanisms to T cells as well as potential antigenic processing pathways will need to be determined for each DC phenotype...
  61. ncbi request reprint Gastrointestinal viral infections in homosexual men who were symptomatic and seropositive for human immunodeficiency virus
    A L Cunningham
    Department of Virology, Westmead Hospital, Sydney, New South Wales, Australia
    J Infect Dis 158:386-91. 1988
    ..These viruses apparently cause acute episodes or relapses of diarrhea in some patients but may be co-pathogens or noncontributory to chronic diarrhea in others...
  62. pmc Prevalence of infection with herpes simplex virus types 1 and 2 in Australia: a nationwide population based survey
    A L Cunningham
    Sexually Transmitted Infections Research Centre and University of Sydney, Marian Villa, Westmead Hospital, Westmead, NSW 2145, Australia
    Sex Transm Infect 82:164-8. 2006
    ..The only nationwide seroprevalence studies have been conducted in the United States...
  63. ncbi request reprint Kinesin-1 plays a role in transport of SNAP-25 to the plasma membrane
    April M Morton
    Centre for Virus Research, Westmead Millennium Institute, The University of Sydney and Westmead Hospital, Westmead, NSW 2145, Australia
    Biochem Biophys Res Commun 391:388-93. 2010
    ..This indicates that kinesin-1 facilitates the transport of SNAP-25 containing vesicles as a prerequisite to SNAP-25 driven membrane fusion events...
  64. ncbi request reprint Potential drug resistance polymorphisms in the integrase gene of HIV type 1 subtype A
    Belinda L Herring
    Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, Westmead, NSW 2145, Australia
    AIDS Res Hum Retroviruses 20:1010-4. 2004
    ..IN can vary significantly within a subtype as well as between subtypes, and mutations associated with resistance to anti-integrase compounds can be present in drug naive individuals...
  65. ncbi request reprint Identification of structural protein-protein interactions of herpes simplex virus type 1
    Jin H Lee
    Centre for Virus Research, The Westmead Millennium Institute, The University of Sydney and Westmead Hospital, PO Box 412 Westmead, NSW 2145, Australia
    Virology 378:347-54. 2008
    ..This information will provide further insights into the pathways of HSV-1 assembly and the identified interactions are potential targets for new antiviral drugs...
  66. ncbi request reprint Proteomic analysis of DC-SIGN on dendritic cells detects tetramers required for ligand binding but no association with CD4
    Oliver K Bernhard
    Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital, Westmead NSW 2145, Sydney, Australia and The University of Sydney, NSW 2006, Australia
    J Biol Chem 279:51828-35. 2004
    ....
  67. ncbi request reprint Marked structural and functional heterogeneity in CXCR4: separation of HIV-1 and SDF-1alpha responses
    Andrew J Sloane
    HIV Protein Interactions Laboratory, Centre for Virus Research, Westmead, NSW, Australia
    Immunol Cell Biol 83:129-43. 2005
    ..This separation of structure and function has implications for understanding HIV-1 entry and SDF-1alpha responses and may indicate therapeutic possibilities...
  68. ncbi request reprint Mucosal transmission of HIV-1: first stop dendritic cells
    John Wilkinson
    Centre for Virus Research, Westmead Millennium Institute, Westmead, NSW 2145, Australia
    Curr Drug Targets 7:1563-9. 2006
    ..Such measures will lead to the development of effective microbicides and vaccines that will diminish the global spread of HIV...
  69. pmc Determination of interactions between tegument proteins of herpes simplex virus type 1
    Valerio Vittone
    Centre for Virus Research, The Westmead Millennium Institute, Australia
    J Virol 79:9566-71. 2005
    ..Knowledge of HSV-1 tegument protein-protein interactions will provide insights into the pathways of tegument assembly, and the identified interactions are potential targets for new antiviral drugs...
  70. pmc In rat dorsal root ganglion neurons, herpes simplex virus type 1 tegument forms in the cytoplasm of the cell body
    Monica Miranda-Saksena
    Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital and University of Sydney, Westmead, New South Wales 2145, Australia
    J Virol 76:9934-51. 2002
    ..Finally, the addition of tegument proteins to unenveloped nucleocapsids in the cell body allows access to these unenveloped nucleocapsids to one of two pathways: egress through the cell body or transport into the axon...
  71. ncbi request reprint Residues F593 and E596 of HSV-1 tegument protein pUL36 (VP1/2) mediate binding of tegument protein pUL37
    Branka Mijatov
    Centre for Virus Research, The Westmead Millennium Institute, The University of Sydney and Westmead Hospital, PO Box 412, Westmead, NSW 2145, Australia
    Virology 368:26-31. 2007
    ..This information will provide the basis for generation of viral mutants to further define the importance of the pUL36/pUL37 interaction in assembly of HSV-1...
  72. pmc Role for plasmacytoid dendritic cells in the immune control of recurrent human herpes simplex virus infection
    Heather Donaghy
    Centre for Virus Research, Westmead Millennium Institute, Sydney, Australia
    J Virol 83:1952-61. 2009
    ..Furthermore, these HSV-exposed pDC were able to stimulate virus-specific autologous T-lymphocyte proliferation. We conclude from this work that pDC may contribute to the immune control of recurrent herpes virus infection in vivo...
  73. ncbi request reprint The role of dendritic cell C-type lectin receptors in HIV pathogenesis
    Stuart Turville
    Centre for Virus Research, Westmead Millennium Institute, Westmead, NSW 2145, Australia
    J Leukoc Biol 74:710-8. 2003
    ..The exact details of these processes are currently the subject of intense study...
  74. pmc Segregation of human immunodeficiency virus type 1 subtypes by risk factor in Australia
    Belinda L Herring
    Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, Westmead, NSW 2145, Australia
    J Clin Microbiol 41:4600-4. 2003
    ..Subtype B strains of group M viruses predominate in Australia in HIV-1 transmitted by homosexual or bisexual contact and IDU. However, non-B subtypes have been introduced, mostly acquired via heterosexual contact...
  75. ncbi request reprint HIV interactions with dendritic cells: has our focus been too narrow?
    Heather Donaghy
    Centre for Virus Research, Westmead Millennium Institute, Westmead Hosptial, Darcy Rd, Sydney, NSW 2145, Australia
    J Leukoc Biol 80:1001-12. 2006
    ..It is clear that the small number of studies on tissue-derived DCs limits current research into the pathogenesis of HIV...
  76. ncbi request reprint Vaccination strategies to prevent genital herpes and neonatal herpes simplex virus (HSV) disease
    Cheryl A Jones
    Herpesvirus Research Unit and Department of Immunology and Infectious Diseases, The Children s Hospital at Westmead, and the University of Sydney, NSW, Australia
    Herpes 11:12-7. 2004
    ....
  77. ncbi request reprint Pathogenesis of macrophage tropic HIV-1
    Paul R Gorry
    Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    Curr HIV Res 3:53-60. 2005
    ..These variants are likely to impact HIV-1 disease progression, particularly in patients who persistently harbor only R5 viral strains...
  78. ncbi request reprint Impaired complement-mediated phagocytosis by HIV type-1-infected human monocyte-derived macrophages involves a cAMP-dependent mechanism
    Rula Azzam
    AIDS Pathogenesis and Clinical Research Program, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia
    AIDS Res Hum Retroviruses 22:619-29. 2006
    ....
  79. ncbi request reprint The influence of cytokines, chemokines and their receptors on HIV-1 replication in monocytes and macrophages
    Katherine Kedzierska
    AIDS Pathogenesis Research Unit, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia
    Rev Med Virol 13:39-56. 2003
    ..The effects of cytokines/chemokines on viral entry and productive HIV-1 infection are also reviewed...
  80. ncbi request reprint Uncoupling coreceptor usage of human immunodeficiency virus type 1 (HIV-1) from macrophage tropism reveals biological properties of CCR5-restricted HIV-1 isolates from patients with acquired immunodeficiency syndrome
    Lachlan Gray
    Macfarlane Burnet Institute for Medical Research and Public Health, GPO Box 2284, Melbourne, 3001 Victoria, Australia Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
    Virology 337:384-98. 2005
    ..Thus, reduced CD4/CCR5 dependence is a phenotype of R5 HIV-1 associated with M-tropism and late stage infection, which may affect the efficacy of HIV-1 entry inhibitors...
  81. ncbi request reprint Glycoprotein-D-adjuvant vaccine to prevent genital herpes
    Lawrence R Stanberry
    Department of Pediatrics and Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston 77555 0351, USA
    N Engl J Med 347:1652-61. 2002
    ..An effective prophylactic vaccine would help control the spread of genital herpes...
  82. pmc Varicella-zoster virus-infected human sensory neurons are resistant to apoptosis, yet human foreskin fibroblasts are susceptible: evidence for a cell-type-specific apoptotic response
    C Hood
    Centre for Virus Research, Westmead Millennium Institute and University of Sydney, Westmead Millennium Institute and Institute of Clinical Pathology and Medical Research, Westmead Hospital, New South Wales 2145, Australia
    J Virol 77:12852-64. 2003
    ..Inhibition of apoptosis during infection of neurons may play a significant role in the establishment, maintenance, and reactivation of latent infection by promoting survival of these postmitotic cells...
  83. ncbi request reprint The C-terminal region of the stalk domain of ubiquitous human kinesin heavy chain contains the binding site for kinesin light chain
    R J Diefenbach
    Centre for Virus Research, Westmead Institutes of Health Research, Westmead Hospital, NSW, Australia
    Biochemistry 37:16663-70. 1998
    ..5 m)...
  84. ncbi request reprint Herpes simplex virus infects skin gamma delta T cells before Langerhans cells and impedes migration of infected Langerhans cells by inducing apoptosis and blocking E-cadherin downregulation
    Franz K Puttur
    Sydney Medical School, University of Sydney, Sydney, Australia
    J Immunol 185:477-87. 2010
    ..Thus, HSV infection of LCs is preceded by infection of gammadelta T cells and delays migration...
  85. pmc Productive varicella-zoster virus infection of cultured intact human ganglia
    Kavitha Gowrishankar
    Center for Virus Research, Westmead Millenium Institute, and Department of Infectious Diseases and Immunology, University of Sydney, Blackburn Building, 2006 NSW, Australia
    J Virol 81:6752-6. 2007
    ..This model enables VZV infection of ganglionic cells to be studied in the context of intact DRG...
  86. ncbi request reprint The pathogenesis underlying the interaction of HIV and herpes simplex virus after co-infection
    Anthony L Cunningham
    Centre for Virus Research, Westmead Millennium Institute and Westmead Hospital, University of Sydney, Westmead, New South Wales, Australia
    J HIV Ther 9:9-13. 2004
    ..This could be especially important in countries where the HSV seroprevalence is very high, for example in Central Africa, where HSV-2 may stimulate HIV transmission in more than 40% of cases...
  87. doi request reprint Functional roles of the tegument proteins of herpes simplex virus type 1
    Barbara J Kelly
    Centre for Virus Research, The Westmead Millennium Institute, The University of Sydney and Westmead Hospital, Westmead, NSW 2145, Australia
    Virus Res 145:173-86. 2009
    ....
  88. pmc The major determinant for addition of tegument protein pUL48 (VP16) to capsids in herpes simplex virus type 1 is the presence of the major tegument protein pUL36 (VP1/2)
    Debbie H Ko
    Centre for Virus Research, Westmead Millennium Institute, P O Box 412, Westmead, 2145 NSW, Australia
    J Virol 84:1397-405. 2010
    ....
  89. ncbi request reprint DC-SIGN 'AIDS' HIV immune evasion and infection
    Anthony L Cunningham
    Nat Immunol 8:556-8. 2007
  90. ncbi request reprint Prevalence and risk factors for herpes simplex virus type 2 antibodies among low- and high-risk populations in Indonesia
    Stephen C Davies
    Sexual Health Service, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
    Sex Transm Dis 34:132-8. 2007
    ..This study investigated the seroprevalence of, and risk factors for, antibodies to HSV-2 among low- and high-risk, predominantly asymptomatic populations in Indonesia...
  91. ncbi request reprint Macrophage-derived proinflammatory factors contribute to the development of arthritis and myositis after infection with an arthrogenic alphavirus
    Brett A Lidbury
    Virus and Inflammation Research Group, Faculty of Sciences, University of Canberra, Australia
    J Infect Dis 197:1585-93. 2008
    ..To our knowledge, these findings are the first to demonstrate that macrophage-derived products play important roles in the development of arthritis and myositis triggered by alphavirus infection...
  92. doi request reprint High levels of human antigen-specific CD4+ T cells in peripheral blood revealed by stimulated coexpression of CD25 and CD134 (OX40)
    John J Zaunders
    Centre for Immunology, St Vincent s Hospital, Sydney, New South Wales, Australia
    J Immunol 183:2827-36. 2009
    ..In addition to revealing the true extent of Ag-specific human CD4(+) memory T lymphocytes, its greatest use will be as a simple in vitro monitor of CD4(+) T cell responses to Ags such as tuberculosis infection or vaccines...
  93. ncbi request reprint Lateral membrane protein associations of CD4 in lymphoid cells detected by cross-linking and mass spectrometry
    Oliver K Bernhard
    Centre for Virus Research, Westmead Millennium Institute, National Centre for HIV Virology Research, Westmead Hospital and The University of Sydney, Darcy Road, Westmead, NSW 2145, Australia
    Biochemistry 43:256-64. 2004
    ..As both molecules undergo endocytic recycling, the association and cross-linking result from their clustering in the same pit and/or vesicle. The CD4-CD98 association probably results from nonspecific cross-linking...
  94. ncbi request reprint Tolerability of treatments for postherpetic neuralgia
    Mark W Douglas
    Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital and University of Sydney, Westmead, Australia
    Drug Saf 27:1217-33. 2004
    ..Intrathecal methyl prednisolone may be considered for intractable pain but efficacy and safety have not been confirmed...
  95. pmc Characterization of the host immune response in human Ganglia after herpes zoster
    Kavitha Gowrishankar
    Centre for Virus Research, Westmead Millennium Institute, Sydney, NSW, Australia
    J Virol 84:8861-70. 2010
    ..This is the first report defining the nature of the immune response in ganglia following herpes zoster and provides evidence for persistence of non-latency-associated viral antigen and inflammation beyond rash resolution...
  96. ncbi request reprint New insights into viral structure and virus-cell interactions through proteomics
    Oliver K Bernhard
    Joint ProteomicS Laboratory, The Ludwig Institute for Cancer Research and The Walter and Eliza Hall Institute for Medical Research, Royal Melbourne Hospital, Royal Parade, Parkville, VIC 3050, Australia
    Expert Rev Proteomics 2:577-88. 2005
    ....
  97. ncbi request reprint Mass spectrometry analysis of CD4-associating proteins using affinity chromatography and affinity tag-mediated purification of tryptic peptides
    Oliver K Bernhard
    Centre for Virus Research, Westmead Milennium Institute, National Centre for HIV Virology Research, Westmead Hospital and The University of Sydney, Westmead NSW, Australia
    Proteomics 3:139-46. 2003
    ..This represents only one-third of the cysteine-containing peptides, however, suggesting that this approach does not enable detection of all individual proteins...
  98. ncbi request reprint Analysis of proteins copurifying with the CD4/lck complex using one-dimensional polyacrylamide gel electrophoresis and mass spectrometry: comparison with affinity-tag based protein detection and evaluation of different solubilization methods
    Oliver K Bernhard
    Center for Virus Research, Westmead Millennium Institute, National Center for HIV Virology Research, Westmead Hospital and The University of Sydney, Westmead, New South Wales, Australia
    J Am Soc Mass Spectrom 15:558-67. 2004
    ..Non-specific binding was inconsistent and involved various types of proteins underlining the importance of reproducibility and control experiments in proteomic studies...
  99. pmc Varicella-zoster virus ORF63 inhibits apoptosis of primary human neurons
    Chantelle Hood
    Centre for Virus Research, Westmead Millennium Institute, and University of Sydney, P O Box 412, Westmead, 2145 NSW, Australia
    J Virol 80:1025-31. 2006
    ..As ORF63 is expressed in neurons during both productive and latent infection, it may play a significant role in viral pathogenesis by promoting neuron survival during primary and reactivated infections...