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Genomes and Genes | A L CunninghamSummaryAffiliation: University of Sydney Country: Australia Publications
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Publications
Determination of suitable housekeeping genes for normalisation of quantitative real time PCR analysis of cells infected with human immunodeficiency virus and herpes virusesSarah Watson
Centre for Virus Research, Westmead Millennium Institute, Sydney, Australia
Virol J 4:130. 2007..This provides researchers of these viruses with a shortlist of potential housekeeping genes to use as normalisers for QPCR experiments...
Phenotype and envelope gene diversity of nef-deleted HIV-1 isolated from long-term survivors infected from a single sourceLachlan Gray
Macfarlane Burnet Institute for Medical Research and Public Health, Victoria, Australia
Virol J 4:75. 2007..To better understand mechanisms underlying the pathogenicity of nef-deleted HIV-1, we examined the phenotype and env sequence diversity of sequentially isolated viruses (n = 2) from 3 SBBC members...- Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDSJasminka Sterjovski
Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
Retrovirology 4:89. 2007.... - Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivoPaul R Gorry
Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
Retrovirology 4:66. 2007.... - Antibody microarray analysis of cell surface antigens on CD4+ and CD8+ T cells from HIV+ individuals correlates with disease stagesJing Qin Wu
Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Darcy Road, Westmead, NSW 2145, Sydney, Australia
Retrovirology 4:83. 2007.... - Home sweet home: How do virus specific T cells navigate to the skin?Anthony L Cunningham
Centre for Virus Research, Westmead Millennium Institute, Westmead, New South Wales, Australia
J Clin Invest 110:441-2. 2002 
The Holy Grail: immune control of human herpes simplex virus infection and diseaseA L Cunningham
Centre for Virus Research, Westmead Millennium Institute, and University of Sydney, Sydney, Australia
Herpes 8:6A-10A. 2001..These in vitro results are consistent with the findings of the most recent HSV vaccine trials...- The cycle of human herpes simplex virus infection: virus transport and immune controlAnthony L Cunningham
Centre for Virus Research, Westmead Millennium Institute, University of Sydney and Westmead Hospital, Sydney, 2145, Australia
J Infect Dis 194:S11-8. 2006.... - The level of HIV infection of macrophages is determined by interaction of viral and host cell genotypesA L Cunningham
Centre for Virus Research, The Westmead Millennium Institute, University of Sydney, Australia
J Leukoc Biol 68:311-7. 2000..Such host-cell genetic factors may affect viral load in vivo where macrophages are the predominant target cells... - The prevention and management of herpes zosterAnthony L Cunningham
University of Sydney, Sydney, NSW, Australia
Med J Aust 188:171-6. 2008..Clinicians should refer to the Australian immunisation handbook for advice on the use of the live vaccine in immunosuppressed individuals... 
Langerhans cells and viral immunityAnthony L Cunningham
Centre for Virus Research, Westmead Millennium Institute and University of Sydney, Westmead, Sydney, Australia
Eur J Immunol 38:2377-85. 2008..Although all three viruses interact with LC during initial infection, the effects can be quite different, reflecting differences in biology and pathogenesis...- Manipulation of dendritic cell function by virusesAnthony L Cunningham
Centre for Virus Research, Westmead Millennium Institute, University of Sydney, Westmead, NSW 2145, Australia
Curr Opin Microbiol 13:524-9. 2010.... - Viruses and Langerhans cellsAnthony L Cunningham
Centre for Virus Research, Westmead Millennium Institute, New South Wales, Australia
Immunol Cell Biol 88:416-23. 2010..The full spectrum of biological responses of LCs even to these viruses has yet to be understood and will require complementary studies in human LCs in vitro and in murine models in vivo... - In vivo production of cytokines and beta (C-C) chemokines in human recurrent herpes simplex lesions--do herpes simplex virus-infected keratinocytes contribute to their production?Z Mikloska
Centre for Virus Research, Westmead Institutes of Health Research, NSW, Australia
J Infect Dis 177:827-38. 1998.... - Bitter-sweet symphony: defining the role of dendritic cell gp120 receptors in HIV infectionS G Turville
Center for Virus Research, Westmead Millennium Institute, PO Box 412 Darcy Road, Westmead, Sydney, NSW 2145, Australia
J Clin Virol 22:229-39. 2001..Mucosal transmission of HIV in vivo targets immature sessile DCs, including Langerhans cells which lack DC-SIGN. The role of CLRs and DC-SIGN in such transmission remains to be defined... - Direct evidence for native CD4 oligomers in lymphoid and monocytoid cellsG W Lynch
Centre for Virus Research, Westmead Institutes of Health Research, Westmead Hospital and University of Sydney, Sydney, Australia
Eur J Immunol 29:2590-602. 1999..These findings demonstrate that different quaternary forms of CD4 such as monomers, homodimers and tetramers are expressed by T lymphocytes and monocytes/macrophages... - Neutralizing antibodies inhibit axonal spread of herpes simplex virus type 1 to epidermal cells in vitroZ Mikloska
Centre for Virus Research, Westmead Institutes of Health Research, Westmead Hospital and University of Sydney, Sydney, New South Wales 2145, Australia
J Virol 73:5934-44. 1999..Therefore, selected human monoclonal antibodies to protective epitopes might even be effective in preventing epidermis-to-neuron transmission during primary HSV infection, especially neonatal infection... - Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transportMark W Douglas
Centre for Virus Research, Westmead Millennium Institute, University of Sydney and Westmead Hospital, Westmead 2145, New South Wales, Australia
J Biol Chem 279:28522-30. 2004..We propose that VP26 mediates binding of incoming herpes simplex virus capsids to cytoplasmic dynein during cellular infection, through interactions with dynein light chains... - Transport and egress of herpes simplex virus in neuronsRussell J Diefenbach
Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital and The University of Sydney, Westmead, NSW 2145, Australia
Rev Med Virol 18:35-51. 2008..Current hypotheses suggest that unenveloped HSV capsids complete assembly in the axonal growth cones and varicosities, whereas with PrV unenveloped capsids are only found travelling in a retrograde direction... - Definition of the stage of host cell genetic restriction of replication of human immunodeficiency virus type 1 in monocytes and monocyte-derived macrophages by using twinsH M Naif
Centre for Virus Research, Westmead Institutes of Health Research, Australian National Centre for HIV Virology Research, Westmead Hospital, Westmead, New South Wales 2145, Australia
J Virol 73:4866-81. 1999..Although CCR5 was necessary for infection, other unidentified host genes are likely to limit productive infection... - Analysis of recombinant and native CD4 by one- and two-dimensional gel electrophoresisG W Lynch
Department of Virology, ICPMR, University of Sydney, Westmead Hospital, Westmead and National Centre for HIV Virology Research, Australia
Electrophoresis 17:227-34. 1996..These studies describe the biotinylation, 1-DE and 2-DE of CD4 preparations, and indicate the capacity of CD4 of lymphocytes to form complexes which may influence CD4 conformation and epitope availability... - Varicella-zoster virus infection of human dendritic cells and transmission to T cells: implications for virus dissemination in the hostA Abendroth
Centre for Virus Research, Westmead Millennium Institute and University of Sydney, Westmead, New South Wales 2145, Australia
J Virol 75:6183-92. 2001..These findings have implications for our understanding of how virus may be disseminated during primary VZV infection... - Viral gene expression during the establishment of human cytomegalovirus latent infection in myeloid progenitor cellsAllen K L Cheung
Centre for Virus Research, Westmead Millennium Institute, PO Box 412, Westmead, NSW 2145, Australia
Blood 108:3691-9. 2006..Viral genes expressed during the establishment phase may serve as targets for therapies to interrupt this process... - Immature monocyte-derived dendritic cells are productively infected with herpes simplex virus type 1Z Mikloska
Centre for Virus Research, Westmead Millennium Institute and University of Sydney, Westmead, NSW 2145, Australia
J Virol 75:5958-64. 2001..Thus, we propose that productive infection of epidermal Langerhans cells in vivo may lead to delayed activation of T cells, allowing more time for replication of HSV type 1 in epidermal cells... - The axonal transmission of herpes simplex virus to epidermal cells: a novel use of the freeze substitution technique applied to explant cultures retained on cover slipsD J Holland
Centre for Virus Research, Westmead Institutes of Health Research, Westmead Hospital, Sydney, NSW, Australia
J Microsc 192:69-72. 1998..It should be adaptable to a number of cell-culture applications and has a number of advantages over other techniques... - Herpes simplex virus tegument protein US11 interacts with conventional kinesin heavy chainRussell J Diefenbach
Centre for Virus Research and Electron Microscopy Unit, The Westmead Millennium Institute, Westmead Hospital and University of Sydney, Westmead, New South Wales, Australia
J Virol 76:3282-91. 2002..These observations suggest a major role for the uKHC-US11 interaction in anterograde transport of unenveloped HSV nucleocapsids in axons... - Diversity of receptors binding HIV on dendritic cell subsetsStuart G Turville
Center for Virus Research, Westmead Millennium Institute, Westmead Hospital and University of Sydney, Sydney, NSW 2145, Australia
Nat Immunol 3:975-83. 2002..The diversity of CLRs able to bind HIV-1 in skin DCs may reflect their ability to bind a range of microbial glycoproteins... - HIV-1-infected dendritic cells show 2 phases of gene expression changes, with lysosomal enzyme activity decreased during the second phaseAndrew N Harman
Centre for Virus Research, Westmead Millennium Institute, Sydney, Australia
Blood 114:85-94. 2009..The net effect was markedly diminished cathepsin activity likely to result in enhanced HIV-1 survival and transfer to contacting T lymphocytes but decreased HIV-1 antigen processing and presentation to these T cells... - Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cellsStuart G Turville
Centre for Virus Research, Westmead Millennium Institute, Sydney, Australia
Blood 103:2170-9. 2004..Thus, the controversy of DCs being infected or not infected for the mechanics of viral transfer to CD4+ lymphocytes can be addressed as a function of time... - Alpha and gamma interferons inhibit herpes simplex virus type 1 infection and spread in epidermal cells after axonal transmissionZ Mikloska
Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital and University of Sydney, Westmead, New South Wales 2145, Australia
J Virol 75:11821-6. 2001..Therefore, both IFN-alpha and -gamma could contribute to the control of HSV-1 spread and shedding in a similar fashion in recurrent herpetic lesions... - Immunodominant epitopes in herpes simplex virus type 2 glycoprotein D are recognized by CD4 lymphocytes from both HSV-1 and HSV-2 seropositive subjectsMin Kim
Centre for Virus Research, Westmead Millennium Institute, Westmead, New South Wales and University of Sydney, New South Wales, Australia
J Immunol 181:6604-15. 2008..This work provides a basis for CD4 lymphocyte cross-recognition of gD2 and possibly cross-protection observed in previous clinical studies and in vaccine trials... - Dendritic cell biology in herpesvirus infectionsLidija Bosnjak
Centre for Virus Research, Westmead Millennium Institute, Darcy Road, Westmead, NSW 2145, Australia
Viral Immunol 18:419-33. 2005 - Development of prophylactic vaccines for genital and neonatal herpesCheryl A Jones
Herpesvirus Research Unit, and Department of Immunology and Infectious Diseases, The Children's Hospital at Westmead, Westmead, Australia
Expert Rev Vaccines 2:541-9. 2003.... - Identification of binding domains in the herpes simplex virus type 1 small capsid protein pUL35 (VP26)Arin Apcarian
Centre for Virus Research, Westmead Millennium Institute, The University of Sydney and Westmead Hospital, Westmead, NSW 2145, Australia
J Gen Virol 91:2659-63. 2010..In contrast, only the C-terminal half of pUL35 was found to mediate the binding of pUL19 and pUL37 through distinct regions. The relevance of this information to the role of pUL35 in viral transport and assembly is discussed... - The murine cytomegalovirus (MCMV) homolog of the HCMV phosphotransferase (UL97(pk)) geneW D Rawlinson
Department of Microbiology, Prince of Wales Hospital, Randwick, New South Wales, Australia
Virology 233:358-63. 1997..MCMV provides a useful model for studying the in vivo function of the phosphotransferase genes of the betatherpesviruses and has potential for use in studies of antiviral resistance... - CD4 is expressed by epidermal Langerhans' cells predominantly as covalent dimersG W Lynch
Centre for Virus Research, Westmead Millennium Institute, University of Sydney, Westmead Hospital, Sydney, Australia
Exp Dermatol 12:700-11. 2003..It remains to be determined, however, why tissue embedded LC express mainly CD4 dimers, but single-celled blood lymphocytes and monocytes mainly monomers... - The use of flow cytometry to detect antiviral resistance in human cytomegalovirusA M Kesson
Faculty of Medicine and Health Sciences, University of Newcastle, NSW, Australia
J Virol Methods 71:177-86. 1998..The FACS assay is a rapid and reproducible method for detecting antiviral resistance of HCMV... - Monophosphoryl lipid A and QS21 increase CD8 T lymphocyte cytotoxicity to herpes simplex virus-2 infected cell proteins 4 and 27 through IFN-gamma and IL-12 productionZ Mikloska
Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital and University of Sydney, Westmead, Australia
J Immunol 164:5167-76. 2000..Therefore, the mechanism for the enhancement of CD8 T cell cytotoxicity by adjuvants in this system appears to be via increased levels of IL-12 and IFN-gamma... - An examination of signs of disease progression in survivors of the Sydney Blood Bank Cohort (SBBC)M R Birch
HIV Epidemiology Research Unit HERU, Australian Red Cross Blood Service NSW ARCBS NSW, Level 3 131 Clarence Street, Sydney, NSW 2000, Australia
J Clin Virol 22:263-70. 2001..In contrast, in the SA cohort, comparison study group for the SBBC, five of 24 remain therapy naïve after 15 years infection with HIV-1 and all have detectable VL... - CCR5 expression correlates with susceptibility of maturing monocytes to human immunodeficiency virus type 1 infectionH M Naif
Molecular Pathogenesis Laboratory, Westmead Institutes of Health Research, The University of Sydney, and National Centre for HIV Virology Research, Australia
J Virol 72:830-6. 1998..The concordance of levels of HIV DNA and p24 antigen suggested that the changes in susceptibility with monocyte maturation were at or immediately after entry and correlated well with CCR5 expression and inversely with CXCR4 expression... - Rapid and sensitive detection of severe acute respiratory syndrome coronavirus by rolling circle amplificationBin Wang
Retroviral Genetics Laboratory, Centre for Virus Research, Westmead Millennium Institute, The University of Sydney, Darcy Rd, Westmead, Sydney, NSW 2145, Australia
J Clin Microbiol 43:2339-44. 2005..Furthermore, the RCA technology provides a faster, more sensitive, and economical option to currently available PCR-based methods... - A human immunodeficiency virus type 1 isolate from an infected person homozygous for CCR5Delta32 exhibits dual tropism by infecting macrophages and MT2 cells via CXCR4Hassan M Naif
Centre for Virus Research Institute of Immunology and Allergy Research, The Westmead Millennium Institute, The University of Sydney, Sydney, New South Wales, Australia
J Virol 76:3114-24. 2002..Our study demonstrates the ability of certain strains of HIV to readily use CXCR4 for infection or entry into macrophages, which is highly relevant to the pathogenesis of late-stage disease and presumably also HIV transmission... - 10: Herpes simplex and varicella-zoster virus infectionsDominic E Dwyer
Centre for Infectious Diseases and Microbiology Laboratory Service, ICPMR, Westmead Hospital, PO Box 533, Wentworthville, NSW 2145
Med J Aust 177:267-73. 2002..The availability of effective antiviral therapy makes early diagnosis vital.. - HIV induces maturation of monocyte-derived dendritic cells and Langerhans cellsAndrew N Harman
Centre for Virus Research, Westmead Millennium Institute, Sydney, Australia
J Immunol 177:7103-13. 2006..Increased maturation marker surface expression was also demonstrated in native DCs, ex vivo Langerhans cells derived from human skin. Thus, HIV initiates maturation of DCs which could facilitate subsequent enhanced transfer to T cells... - Herpes simplex virus type 1 accumulation, envelopment, and exit in growth cones and varicosities in mid-distal regions of axonsMonica Miranda Saksena
Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital, P.O. Box 412, Westmead, NSW 2145, Australia
J Virol 80:3592-606. 2006..Envelopment probably occurs by budding of capsids into vesicles with associated tegument and envelope proteins. Virions appear to exit from these sites by exocytosis... - Herpes simplex virus type 2 (HSV-2) infection in women attending an antenatal clinic in the South Pacific island nation of VanuatuLewis J Haddow
Sexually Transmitted Infections Research Centre, Westmead, New South Wales, Australia
Sex Transm Dis 34:258-61. 2007..The objective of this study was to estimate the prevalence and correlates of herpes simplex virus type 2 infection in women in an antenatal clinic in the South Pacific island nation of Vanuatu... - The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23Russell J Diefenbach
Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital and The University of Sydney, NSW 2145, Australia
Biochemistry 41:14906-15. 2002..In support of separate binding sites on heavy chain for light chain and SNAPs, a complex of heavy and light chains was observed to interact with SNAP25 and SNAP23... - Herpes simplex virus utilizes the large secretory vesicle pathway for anterograde transport of tegument and envelope proteins and for viral exocytosis from growth cones of human fetal axonsMonica Miranda-Saksena
Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital, Westmead, NSW 2145, Australia
J Virol 83:3187-99. 2009..We postulate that HSV-1 capsids invaginate tegument- and envelope-bearing TGN-derived vesicles and utilize the large secretory vesicle pathway of exocytosis for exit from axons... - Oligomerization of the macrophage mannose receptor enhances gp120-mediated binding of HIV-1Joey Lai
Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital, Westmead, Sydney, New South Wales 2145, Australia
J Biol Chem 284:11027-38. 2009.... - Detection of the rapid emergence of the H275Y mutation associated with oseltamivir resistance in severe pandemic influenza virus A/H1N1 09 infectionsBin Wang
Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead, NSW 2145, Australia
Antiviral Res 87:16-21. 2010..In the light of emerging resistance, close monitoring and understanding of the nature and dynamics of resistance mutations in newly emerging strains should be a priority... - Impact of varicella-zoster virus on dendritic cell subsets in human skin during natural infectionJennifer H Huch
University of Sydney, Discipline of Infectious Diseases and Immunology, Blackburn Building, Room 601, New South Wales 2006, Australia
J Virol 84:4060-72. 2010..This study defines changes in the response of DC which occur during cutaneous VZV infection and implicates infection of DC subtypes in VZV pathogenesis... - The role of the human cytomegalovirus UL111A gene in down-regulating CD4+ T-cell recognition of latently infected cells: implications for virus elimination during latencyAllen K L Cheung
Centre for Virus Research, Westmead Millennium Institute and University of Sydney, Westmead, NSW 2145, Australia
Blood 114:4128-37. 2009..The detection of a viral gene that suppresses CD4(+) T-cell recognition of latently infected cells identifies an immune evasion strategy that probably enhances the capacity of HCMV to persist in a latent state within the human host... - Impact of human cytomegalovirus latent infection on myeloid progenitor cell gene expressionBarry Slobedman
Centre for Virus Research, Westmead Millennium Institute and University of Sydney, Westmead, New South Wales 2145, Australia
J Virol 78:4054-62. 2004..The host genes whose expression we found altered are likely to contribute to an environment that sustains latent infection... - Herpes simplex virus infection of human dendritic cells induces apoptosis and allows cross-presentation via uninfected dendritic cellsLidija Bosnjak
Center for Virus Research, Westmead Millennium Institutem, Westmead Millennium Institute and Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, Australia
J Immunol 174:2220-7. 2005..In this study we provide an explanation for this phenomenon, demonstrating that HSV-infected apoptotic DCs are readily phagocytosed by uninfected bystander DCs, which, in turn, stimulate virus-specific CD8+ T cell clones... - Sensitive detection of the K103N non-nucleoside reverse transcriptase inhibitor resistance mutation in treatment-naïve HIV-1 infected individuals by rolling circle amplificationBin Wang
Center for Virus Research, Westmead Millennium Institute, University of Sydney, Sydney, NSW 2145, Australia
J Virol Methods 161:128-35. 2009..Importantly, the new RCA technology allows large-scale, sensitive detection of drug resistance mutations, including detection of minority populations with minimal equipment requirement... - Varicella-zoster virus productively infects mature dendritic cells and alters their immune functionGavin Morrow
Centre for Virus Research, Westmead Millennium Institute and University of Sydney, Westmead, New South Wales 2145, Australia
J Virol 77:4950-9. 2003..Thus, VZV has evolved yet another immune evasion strategy that would likely impair immunosurveillance and enhance the chances for lifelong persistence in the human population... - The ribosome receptor, p180, interacts with kinesin heavy chain, KIF5BRussell J Diefenbach
Centre for Virus Research, Westmead Millennium Institute, The University of Sydney and Westmead Hospital, Westmead, NSW 2145, Australia
Biochem Biophys Res Commun 319:987-92. 2004..A role for the kinesin/p180 interaction may include mRNA localization and/or transport of endoplasmic reticulum-derived vesicles... - Gene expression in HIV-1/Mycobacterium tuberculosis co-infected macrophages is dominated by M. tuberculosisSusan Maddocks
HIV Molecular Pathogenesis Group, Centre for Virus Research, Westmead Millennium Institute, University of Sydney, Westmead NSW 2145, Australia
Tuberculosis (Edinb) 89:285-93. 2009..Thus, the effects of M. tuberculosis infection on global gene expression dominated the effects of HIV-1 in co-infected primary human macrophages... - Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human macrophagesGary D Ewart
Biotron Limited, LPO Box A315, Eggleston Rd, Australian National University, Canberra, ACT 2601, Australia
Antimicrob Agents Chemother 48:2325-30. 2004..These compounds also inhibit the in vitro activities of the HIV-1 Vpu protein and might represent lead compounds for a new class of anti-HIV-1 drugs... - HIV gp120 receptors on human dendritic cellsS G Turville
Center for Virus Research, Westmead Millennium Institute, Sydney, Australia
Blood 98:2482-8. 2001..In view of these marked differences between MDDCs and blood DCs, HIV capture by DCs and transfer mechanisms to T cells as well as potential antigenic processing pathways will need to be determined for each DC phenotype... - Gastrointestinal viral infections in homosexual men who were symptomatic and seropositive for human immunodeficiency virusA L Cunningham
Department of Virology, Westmead Hospital, Sydney, New South Wales, Australia
J Infect Dis 158:386-91. 1988..These viruses apparently cause acute episodes or relapses of diarrhea in some patients but may be co-pathogens or noncontributory to chronic diarrhea in others... - Prevalence of infection with herpes simplex virus types 1 and 2 in Australia: a nationwide population based surveyA L Cunningham
Sexually Transmitted Infections Research Centre and University of Sydney, Marian Villa, Westmead Hospital, Westmead, NSW 2145, Australia
Sex Transm Infect 82:164-8. 2006..In addition, the high HSV-1 seroprevalence will be important for future deployment of genital herpes vaccines... - Kinesin-1 plays a role in transport of SNAP-25 to the plasma membraneApril M Morton
Centre for Virus Research, Westmead Millennium Institute, The University of Sydney and Westmead Hospital, Westmead, NSW 2145, Australia
Biochem Biophys Res Commun 391:388-93. 2010..This indicates that kinesin-1 facilitates the transport of SNAP-25 containing vesicles as a prerequisite to SNAP-25 driven membrane fusion events... - Potential drug resistance polymorphisms in the integrase gene of HIV type 1 subtype ABelinda L Herring
Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, Westmead, NSW 2145, Australia
AIDS Res Hum Retroviruses 20:1010-4. 2004..IN can vary significantly within a subtype as well as between subtypes, and mutations associated with resistance to anti-integrase compounds can be present in drug naive individuals... - Identification of structural protein-protein interactions of herpes simplex virus type 1Jin H Lee
Centre for Virus Research, The Westmead Millennium Institute, The University of Sydney and Westmead Hospital, PO Box 412 Westmead, NSW 2145, Australia
Virology 378:347-54. 2008..This information will provide further insights into the pathways of HSV-1 assembly and the identified interactions are potential targets for new antiviral drugs... - Proteomic analysis of DC-SIGN on dendritic cells detects tetramers required for ligand binding but no association with CD4Oliver K Bernhard
Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital, Westmead NSW 2145, Sydney, Australia and The University of Sydney, NSW 2006, Australia
J Biol Chem 279:51828-35. 2004.... - Marked structural and functional heterogeneity in CXCR4: separation of HIV-1 and SDF-1alpha responsesAndrew J Sloane
HIV Protein Interactions Laboratory, Centre for Virus Research, Westmead, NSW, Australia
Immunol Cell Biol 83:129-43. 2005..This separation of structure and function has implications for understanding HIV-1 entry and SDF-1alpha responses and may indicate therapeutic possibilities... - Mucosal transmission of HIV-1: first stop dendritic cellsJohn Wilkinson
Centre for Virus Research, Westmead Millennium Institute, Westmead, NSW 2145, Australia
Curr Drug Targets 7:1563-9. 2006..Such measures will lead to the development of effective microbicides and vaccines that will diminish the global spread of HIV... - Determination of interactions between tegument proteins of herpes simplex virus type 1Valerio Vittone
Centre for Virus Research, The Westmead Millennium Institute, Australia
J Virol 79:9566-71. 2005..Knowledge of HSV-1 tegument protein-protein interactions will provide insights into the pathways of tegument assembly, and the identified interactions are potential targets for new antiviral drugs... - In rat dorsal root ganglion neurons, herpes simplex virus type 1 tegument forms in the cytoplasm of the cell bodyMonica Miranda-Saksena
Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital and University of Sydney, Westmead, New South Wales 2145, Australia
J Virol 76:9934-51. 2002..Finally, the addition of tegument proteins to unenveloped nucleocapsids in the cell body allows access to these unenveloped nucleocapsids to one of two pathways: egress through the cell body or transport into the axon... - Residues F593 and E596 of HSV-1 tegument protein pUL36 (VP1/2) mediate binding of tegument protein pUL37Branka Mijatov
Centre for Virus Research, The Westmead Millennium Institute, The University of Sydney and Westmead Hospital, PO Box 412, Westmead, NSW 2145, Australia
Virology 368:26-31. 2007..This information will provide the basis for generation of viral mutants to further define the importance of the pUL36/pUL37 interaction in assembly of HSV-1... - Role for plasmacytoid dendritic cells in the immune control of recurrent human herpes simplex virus infectionHeather Donaghy
Centre for Virus Research, Westmead Millennium Institute, Sydney, Australia
J Virol 83:1952-61. 2009..Furthermore, these HSV-exposed pDC were able to stimulate virus-specific autologous T-lymphocyte proliferation. We conclude from this work that pDC may contribute to the immune control of recurrent herpes virus infection in vivo... - The role of dendritic cell C-type lectin receptors in HIV pathogenesisStuart Turville
Centre for Virus Research, Westmead Millennium Institute, Westmead, NSW 2145, Australia
J Leukoc Biol 74:710-8. 2003..The exact details of these processes are currently the subject of intense study... - Segregation of human immunodeficiency virus type 1 subtypes by risk factor in AustraliaBelinda L Herring
Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, Westmead, NSW 2145, Australia
J Clin Microbiol 41:4600-4. 2003..Subtype B strains of group M viruses predominate in Australia in HIV-1 transmitted by homosexual or bisexual contact and IDU. However, non-B subtypes have been introduced, mostly acquired via heterosexual contact... - HIV interactions with dendritic cells: has our focus been too narrow?Heather Donaghy
Centre for Virus Research, Westmead Millennium Institute, Westmead Hosptial, Darcy Rd, Sydney, NSW 2145, Australia
J Leukoc Biol 80:1001-12. 2006..It is clear that the small number of studies on tissue-derived DCs limits current research into the pathogenesis of HIV... - Vaccination strategies to prevent genital herpes and neonatal herpes simplex virus (HSV) diseaseCheryl A Jones
Herpesvirus Research Unit and Department of Immunology and Infectious Diseases, The Children's Hospital at Westmead, and the University of Sydney, NSW, Australia
Herpes 11:12-7. 2004.... - Pathogenesis of macrophage tropic HIV-1Paul R Gorry
Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
Curr HIV Res 3:53-60. 2005..These variants are likely to impact HIV-1 disease progression, particularly in patients who persistently harbor only R5 viral strains... - Impaired complement-mediated phagocytosis by HIV type-1-infected human monocyte-derived macrophages involves a cAMP-dependent mechanismRula Azzam
AIDS Pathogenesis and Clinical Research Program, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia
AIDS Res Hum Retroviruses 22:619-29. 2006.... - The influence of cytokines, chemokines and their receptors on HIV-1 replication in monocytes and macrophagesKatherine Kedzierska
AIDS Pathogenesis Research Unit, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia
Rev Med Virol 13:39-56. 2003..The effects of cytokines/chemokines on viral entry and productive HIV-1 infection are also reviewed... - Uncoupling coreceptor usage of human immunodeficiency virus type 1 (HIV-1) from macrophage tropism reveals biological properties of CCR5-restricted HIV-1 isolates from patients with acquired immunodeficiency syndromeLachlan Gray
Macfarlane Burnet Institute for Medical Research and Public Health, GPO Box 2284, Melbourne, 3001 Victoria, Australia Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
Virology 337:384-98. 2005..Thus, reduced CD4/CCR5 dependence is a phenotype of R5 HIV-1 associated with M-tropism and late stage infection, which may affect the efficacy of HIV-1 entry inhibitors... - Glycoprotein-D-adjuvant vaccine to prevent genital herpesLawrence R Stanberry
Department of Pediatrics and Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston 77555 0351, USA
N Engl J Med 347:1652-61. 2002..An effective prophylactic vaccine would help control the spread of genital herpes... - Varicella-zoster virus-infected human sensory neurons are resistant to apoptosis, yet human foreskin fibroblasts are susceptible: evidence for a cell-type-specific apoptotic responseC Hood
Centre for Virus Research, Westmead Millennium Institute and University of Sydney, Westmead Millennium Institute and Institute of Clinical Pathology and Medical Research, Westmead Hospital, New South Wales 2145, Australia
J Virol 77:12852-64. 2003..Inhibition of apoptosis during infection of neurons may play a significant role in the establishment, maintenance, and reactivation of latent infection by promoting survival of these postmitotic cells... - The C-terminal region of the stalk domain of ubiquitous human kinesin heavy chain contains the binding site for kinesin light chainR J Diefenbach
Centre for Virus Research, Westmead Institutes of Health Research, Westmead Hospital, NSW, Australia
Biochemistry 37:16663-70. 1998..5 m)... - Herpes simplex virus infects skin gamma delta T cells before Langerhans cells and impedes migration of infected Langerhans cells by inducing apoptosis and blocking E-cadherin downregulationFranz K Puttur
Sydney Medical School, University of Sydney, Sydney, Australia
J Immunol 185:477-87. 2010..Thus, HSV infection of LCs is preceded by infection of gammadelta T cells and delays migration... - Productive varicella-zoster virus infection of cultured intact human gangliaKavitha Gowrishankar
Center for Virus Research, Westmead Millenium Institute, and Department of Infectious Diseases and Immunology, University of Sydney, Blackburn Building, 2006 NSW, Australia
J Virol 81:6752-6. 2007..This model enables VZV infection of ganglionic cells to be studied in the context of intact DRG... - The pathogenesis underlying the interaction of HIV and herpes simplex virus after co-infectionAnthony L Cunningham
Centre for Virus Research, Westmead Millennium Institute and Westmead Hospital, University of Sydney, Westmead, New South Wales, Australia
J HIV Ther 9:9-13. 2004..This could be especially important in countries where the HSV seroprevalence is very high, for example in Central Africa, where HSV-2 may stimulate HIV transmission in more than 40% of cases... - Functional roles of the tegument proteins of herpes simplex virus type 1Barbara J Kelly
Centre for Virus Research, The Westmead Millennium Institute, The University of Sydney and Westmead Hospital, Westmead, NSW 2145, Australia
Virus Res 145:173-86. 2009.... - The major determinant for addition of tegument protein pUL48 (VP16) to capsids in herpes simplex virus type 1 is the presence of the major tegument protein pUL36 (VP1/2)Debbie H Ko
Centre for Virus Research, Westmead Millennium Institute, P O Box 412, Westmead, 2145 NSW, Australia
J Virol 84:1397-405. 2010.... - DC-SIGN 'AIDS' HIV immune evasion and infectionAnthony L Cunningham
Nat Immunol 8:556-8. 2007 - Prevalence and risk factors for herpes simplex virus type 2 antibodies among low- and high-risk populations in IndonesiaStephen C Davies
Sexual Health Service, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
Sex Transm Dis 34:132-8. 2007..This study investigated the seroprevalence of, and risk factors for, antibodies to HSV-2 among low- and high-risk, predominantly asymptomatic populations in Indonesia... - Macrophage-derived proinflammatory factors contribute to the development of arthritis and myositis after infection with an arthrogenic alphavirusBrett A Lidbury
Virus and Inflammation Research Group, Faculty of Sciences, University of Canberra, Australia
J Infect Dis 197:1585-93. 2008..To our knowledge, these findings are the first to demonstrate that macrophage-derived products play important roles in the development of arthritis and myositis triggered by alphavirus infection... - High levels of human antigen-specific CD4+ T cells in peripheral blood revealed by stimulated coexpression of CD25 and CD134 (OX40)John J Zaunders
Centre for Immunology, St Vincent s Hospital, Sydney, New South Wales, Australia
J Immunol 183:2827-36. 2009..In addition to revealing the true extent of Ag-specific human CD4(+) memory T lymphocytes, its greatest use will be as a simple in vitro monitor of CD4(+) T cell responses to Ags such as tuberculosis infection or vaccines... - Lateral membrane protein associations of CD4 in lymphoid cells detected by cross-linking and mass spectrometryOliver K Bernhard
Centre for Virus Research, Westmead Millennium Institute, National Centre for HIV Virology Research, Westmead Hospital and The University of Sydney, Darcy Road, Westmead, NSW 2145, Australia
Biochemistry 43:256-64. 2004..As both molecules undergo endocytic recycling, the association and cross-linking result from their clustering in the same pit and/or vesicle. The CD4-CD98 association probably results from nonspecific cross-linking... - Tolerability of treatments for postherpetic neuralgiaMark W Douglas
Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital and University of Sydney, Westmead, Australia
Drug Saf 27:1217-33. 2004..Intrathecal methyl prednisolone may be considered for intractable pain but efficacy and safety have not been confirmed... - Characterization of the host immune response in human Ganglia after herpes zosterKavitha Gowrishankar
Centre for Virus Research, Westmead Millennium Institute, Sydney, NSW, Australia
J Virol 84:8861-70. 2010..This is the first report defining the nature of the immune response in ganglia following herpes zoster and provides evidence for persistence of non-latency-associated viral antigen and inflammation beyond rash resolution... - New insights into viral structure and virus-cell interactions through proteomicsOliver K Bernhard
Joint ProteomicS Laboratory, The Ludwig Institute for Cancer Research and The Walter and Eliza Hall Institute for Medical Research, Royal Melbourne Hospital, Royal Parade, Parkville, VIC 3050, Australia
Expert Rev Proteomics 2:577-88. 2005.... - Mass spectrometry analysis of CD4-associating proteins using affinity chromatography and affinity tag-mediated purification of tryptic peptidesOliver K Bernhard
Centre for Virus Research, Westmead Milennium Institute, National Centre for HIV Virology Research, Westmead Hospital and The University of Sydney, Westmead NSW, Australia
Proteomics 3:139-46. 2003..This represents only one-third of the cysteine-containing peptides, however, suggesting that this approach does not enable detection of all individual proteins... - Analysis of proteins copurifying with the CD4/lck complex using one-dimensional polyacrylamide gel electrophoresis and mass spectrometry: comparison with affinity-tag based protein detection and evaluation of different solubilization methodsOliver K Bernhard
Center for Virus Research, Westmead Millennium Institute, National Center for HIV Virology Research, Westmead Hospital and The University of Sydney, Westmead, New South Wales, Australia
J Am Soc Mass Spectrom 15:558-67. 2004..Non-specific binding was inconsistent and involved various types of proteins underlining the importance of reproducibility and control experiments in proteomic studies... - Varicella-zoster virus ORF63 inhibits apoptosis of primary human neuronsChantelle Hood
Centre for Virus Research, Westmead Millennium Institute, and University of Sydney, P.O. Box 412, Westmead, 2145 NSW, Australia
J Virol 80:1025-31. 2006..As ORF63 is expressed in neurons during both productive and latent infection, it may play a significant role in viral pathogenesis by promoting neuron survival during primary and reactivated infections...