Peter J Crouch

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi request reprint Mechanisms of A beta mediated neurodegeneration in Alzheimer's disease
    Peter J Crouch
    Department of Pathology, The University of Melbourne, Victoria 3010, Australia
    Int J Biochem Cell Biol 40:181-98. 2008
  2. doi request reprint Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation
    Peter J Crouch
    Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia
    J Neurochem 108:1198-207. 2009
  3. doi request reprint The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity
    Peter J Crouch
    Department of Pathology, The University of Melbourne, Victoria, Australia
    J Neurochem 119:220-30. 2011
  4. doi request reprint Sustained activation of glial cell epidermal growth factor receptor by bis(thiosemicarbazonato) metal complexes is associated with inhibition of protein tyrosine phosphatase activity
    Katherine Ann Price
    Department of Pathology, The University of Melbourne, Victoria 3010, Australia
    J Med Chem 52:6606-20. 2009
  5. ncbi request reprint Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide
    Katherine A Price
    Department of Pathology, The University of Melbourne, Victoria 3010, Australia
    Int J Biochem Cell Biol 40:1901-17. 2008
  6. pmc Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model
    Cynthia P W Soon
    Department of Pathology, Mental Health Research Institute, School of Chemistry, The University of Melbourne, Parkville, Victoria, Australia
    J Biol Chem 286:44035-44. 2011
  7. pmc Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes
    Sarah J Parker
    Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia
    PLoS ONE 7:e42277. 2012
  8. doi request reprint Metallo-complex activation of neuroprotective signalling pathways as a therapeutic treatment for Alzheimer's disease
    Laura Bica
    Department of Pathology, The University of Melbourne, 3010, Victoria, Australia
    Mol Biosyst 5:134-42. 2009
  9. pmc Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation
    Peter J Crouch
    Department of Pathology, Centre for Neuroscience, School of Chemistry, and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victorial, 3010, Australia
    Proc Natl Acad Sci U S A 106:381-6. 2009
  10. doi request reprint The role of metals in modulating metalloprotease activity in the AD brain
    Gulay Filiz
    Department of Pathology and the Centre for Neuroscience, The University of Melbourne, Melbourne, VIC 3010, Australia
    Eur Biophys J 37:315-21. 2008

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Mechanisms of A beta mediated neurodegeneration in Alzheimer's disease
    Peter J Crouch
    Department of Pathology, The University of Melbourne, Victoria 3010, Australia
    Int J Biochem Cell Biol 40:181-98. 2008
    ..Further study of the mechanisms of A beta mediated neurodegeneration will considerably improve our understanding of AD, and may provide fundamental insights needed for the development of more effective therapeutic strategies...
  2. doi request reprint Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation
    Peter J Crouch
    Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia
    J Neurochem 108:1198-207. 2009
    ..This provides new data indicating that therapeutic compounds designed to modulate Abeta-metal interactions can inhibit Abeta accumulation by restoring the catalytic potential of Abeta-degrading proteases...
  3. doi request reprint The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity
    Peter J Crouch
    Department of Pathology, The University of Melbourne, Victoria, Australia
    J Neurochem 119:220-30. 2011
    ..Intracellular translocation of Zn and Cu via the metal chaperone activity of PBT2 may be an important mechanism by which PBT2 improves cognitive function in people with AD...
  4. doi request reprint Sustained activation of glial cell epidermal growth factor receptor by bis(thiosemicarbazonato) metal complexes is associated with inhibition of protein tyrosine phosphatase activity
    Katherine Ann Price
    Department of Pathology, The University of Melbourne, Victoria 3010, Australia
    J Med Chem 52:6606-20. 2009
    ..These studies provide an important insight into the mechanism of action of a neuroprotective M(II)(btsc) and provide a basis for future studies into this novel approach to AD therapy...
  5. ncbi request reprint Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide
    Katherine A Price
    Department of Pathology, The University of Melbourne, Victoria 3010, Australia
    Int J Biochem Cell Biol 40:1901-17. 2008
    ..These findings provide the first evidence that metal-ligand complexes can activate the epidermal growth factor receptor with potentially neuroprotective effects...
  6. pmc Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model
    Cynthia P W Soon
    Department of Pathology, Mental Health Research Institute, School of Chemistry, The University of Melbourne, Parkville, Victoria, Australia
    J Biol Chem 286:44035-44. 2011
    ..CuII(atsm) therefore represents a potential new class of neuroprotective agents targeting multiple major disease pathways of motor neurons with therapeutic potential for ALS...
  7. pmc Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes
    Sarah J Parker
    Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia
    PLoS ONE 7:e42277. 2012
    ..These results demonstrate that Cu(II)(btsc) complexes could potentially be developed as a neuroprotective agent to modulate neuronal kinase function and inhibit TDP-43 aggregation. Further studies in TDP-43 animal models are warranted...
  8. doi request reprint Metallo-complex activation of neuroprotective signalling pathways as a therapeutic treatment for Alzheimer's disease
    Laura Bica
    Department of Pathology, The University of Melbourne, 3010, Victoria, Australia
    Mol Biosyst 5:134-42. 2009
    ..Further in vivo investigation is required to elucidate the mechanism of action of these metallo-complexes in vivo and determine their efficacy and safety as potential treatments of neurodegenerative diseases...
  9. pmc Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation
    Peter J Crouch
    Department of Pathology, Centre for Neuroscience, School of Chemistry, and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victorial, 3010, Australia
    Proc Natl Acad Sci U S A 106:381-6. 2009
    ..This study demonstrates that increasing intracellular copper bioavailability can restore cognitive function by inhibiting the accumulation of neurotoxic Abeta trimers and phosphorylated tau...
  10. doi request reprint The role of metals in modulating metalloprotease activity in the AD brain
    Gulay Filiz
    Department of Pathology and the Centre for Neuroscience, The University of Melbourne, Melbourne, VIC 3010, Australia
    Eur Biophys J 37:315-21. 2008
    ..Elucidation of this pathway may have important implications for the development of metal ligand based therapeutics for treatment of AD and other neurodegenerative disorders...
  11. pmc Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis
    Katja M Kanninen
    Department of Pathology, The University of Melbourne, Victoria, Australia
    PLoS ONE 8:e58644. 2013
    ..These results demonstrate that altered metal concentrations, synaptic protein changes, and aberrant modulation of cellular signaling pathways are characteristic features in the CLN6 ovine form of NCL...
  12. doi request reprint Cell cycle arrest in cultured neuroblastoma cells exposed to a bis(thiosemicarbazonato) metal complex
    Laura Bica
    Department of Pathology, The University of Melbourne, Melbourne, VIC 3010, Australia
    Biometals 24:117-33. 2011
    ..Further studies are needed to examine the therapeutic potential of Cu(II)(gtsm) and other bis(thiosemicarbazonato) metal complexes as metallo-drugs for treatment of systemic or brain tumors...
  13. pmc Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease
    Paul A Adlard
    Oxidation Biology Laboratory, The Mental Health Research Institute, Parkville, Victoria, Australia
    PLoS ONE 6:e17669. 2011
    ..In Alzheimer's disease therefore, PBT2 may restore the uptake of physiological metal ions trapped within extracellular β-amyloid aggregates that then induce biochemical and anatomical changes to improve cognitive function...
  14. doi request reprint Subcellular localization of a fluorescent derivative of CuII(atsm) offers insight into the neuroprotective action of CuII(atsm)
    Katherine Ann Price
    Department of Pathology, The University of Melbourne, Victoria, Australia
    Metallomics 3:1280-90. 2011
    ....
  15. doi request reprint A potential copper-regulatory role for cytosolic expression of the DNA repair protein XRCC5
    Tai Du
    Department of Pathology, The University of Melbourne, Melbourne, VIC 3010, Australia
    Free Radic Biol Med 51:2060-72. 2011
    ..Our findings have important implications for the development of therapeutic treatments targeting Cu in neurodegeneration and/or cancer...
  16. doi request reprint Mechanisms controlling the cellular accumulation of copper bis(thiosemicarbazonato) complexes
    Katherine Ann Price
    Department of Pathology, The University of Melbourne, Victoria 3010, Australia
    Inorg Chem 50:9594-605. 2011
    ..The study delineates strategies to investigate the uptake and efflux mechanisms of metal complexes in cells, while highlighting specific difficulties and challenges that need to be considered before drawing definitive conclusions...
  17. pmc An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII
    Paul S Donnelly
    School of Chemistry, University of Melbourne, Victoria 3010, Australia
    Proc Natl Acad Sci U S A 109:47-52. 2012
    ....
  18. doi request reprint Zinc induces depletion and aggregation of endogenous TDP-43
    Aphrodite Caragounis
    Department of Pathology, The University of Melbourne, Melbourne, VIC 3010, Australia
    Free Radic Biol Med 48:1152-61. 2010
    ..These studies describe for the first time specific induction of endogenous TDP-43 aggregation in neuronal-like cells and suggest that specific Zn-associated processes could affect TDP-43 metabolism in neurodegenerative diseases...
  19. doi request reprint Copper and zinc bis(thiosemicarbazonato) complexes with a fluorescent tag: synthesis, radiolabelling with copper-64, cell uptake and fluorescence studies
    SinChun Lim
    School of Chemistry, University of Melbourne, Parkville, Vic, 3010, Australia
    J Biol Inorg Chem 15:225-35. 2010
    ..In both cases, there was no evidence of uptake of the copper(II) bis(thiosemicarbazonato) complexes in the area of the cell nucleus...
  20. ncbi request reprint Therapeutic treatments for Alzheimer's disease based on metal bioavailability
    Peter J Crouch
    Department of Pathology, University of Melbourne, Victoria 3010, Australia
    Drug News Perspect 19:469-74. 2006
    ..The metal ligand clioquinol has been used successfully in vitro, as well as in animal models and small clinical trials, and a new generation of metal ligand-based therapeutics is under development...
  21. pmc Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation
    Laura Bica
    Department of Pathology, The University of Melbourne, Melbourne, Victoria, Australia
    PLoS ONE 9:e90070. 2014
    ....
  22. pmc Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder
    Alexandra Grubman
    Department of Pathology, The University of Melbourne, Parkville, VIC 3010, Australia
    Acta Neuropathol Commun 2:25. 2014
    ..This study extended the concept that alteration of biometal functions is involved in pathology in these disorders, and investigated molecular mechanisms underlying impaired biometal trafficking in CLN6 disease...
  23. doi request reprint Copper modulates the large dense core vesicle secretory pathway in PC12 cells
    Clare Duncan
    Department of Pathology, The University of Melbourne, Victoria 3010, Australia
    Metallomics 5:700-14. 2013
    ..Our findings demonstrate that elevated Cu can modulate LDCV metabolism potentially resulting in sequestration of Cu in this vesicle pool...
  24. pmc Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands
    Aphrodite Caragounis
    Department of Pathology, The University of Melbourne, Victoria 3010, Australia
    Biochem J 407:435-50. 2007
    ..Given that a structurally diverse array of ligands was assessed, the results are consistent with the effects being due to metal transport rather than the chelating ligand interacting directly with a receptor...
  25. pmc Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis
    Katja M Kanninen
    Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia Present address AI Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio 70211, Finland
    Biol Open 2:635-46. 2013
    ..These data are consistent with a link between CLN6 expression and biometal homeostasis in CLN6 disease, and provide further support for altered cation transporter regulation as a key factor in neurodegeneration. ..
  26. ncbi request reprint Copper-dependent inhibition of cytochrome c oxidase by Abeta(1-42) requires reduced methionine at residue 35 of the Abeta peptide
    Peter J Crouch
    Centre for Neuroscience, The University of Melbourne, Victoria, Australia
    J Neurochem 99:226-36. 2006
    ..We propose that amyloid-beta-mediated inhibition of cytochrome oxidase is dependent on the peptide's capacity to bind, then reduce Cu2+, and that it may involve the formation of a redox active amyloid-beta-methionine radical...
  27. ncbi request reprint Neurotoxicity from glutathione depletion is mediated by Cu-dependent p53 activation
    Tai Du
    Department of Pathology, The University of Melbourne, Melbourne, VIC 3010, Australia
    Free Radic Biol Med 44:44-55. 2008
    ..These findings may have important implications for neurodegenerative disorders that involve GSH depletion and aberrant Cu metabolism...
  28. pmc Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress
    Diane Moujalled
    Department of Pathology, The University of Melbourne, Victoria, Australia and Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia
    PLoS ONE 8:e67433. 2013
    ..This knowledge provides a valuable insight into the mechanisms controlling abnormal cytoplasmic TDP-43 accumulation and may herald new opportunities for kinase modulation-based therapeutic intervention in ALS and FTLD...
  29. doi request reprint Lipophilic adamantyl- or deferasirox-based conjugates of desferrioxamine B have enhanced neuroprotective capacity: implications for Parkinson disease
    Jeffrey R Liddell
    Department of Pathology, University of Melbourne, and Mental Health Research Institute, Melbourne Brain Centre, University of Melbourne, Parkville, VIC 3010, Australia
    Free Radic Biol Med 60:147-56. 2013
    ..These novel compounds have potential as therapeutics for the treatment of PD and other conditions of Fe dyshomeostasis...
  30. doi request reprint Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates
    Sarah J Parker
    Department of Pathology, Centre for Neuroscience, The University of Melbourne, Mental Health Research Institute, Melbourne, Victoria 3010, Australia
    Neurochem Int 60:415-24. 2012
    ..This may provide a therapeutic opportunity to inhibit the transition of TDP-43 from SG protein to aggregate...
  31. doi request reprint Copper(II) complexes of hybrid hydroxyquinoline-thiosemicarbazone ligands: GSK3β inhibition due to intracellular delivery of copper
    James L Hickey
    School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia
    Dalton Trans 40:1338-47. 2011
    ..The increased intracellular copper results in a dose-dependent inhibition (phosphorylation) of GSK3β...
  32. doi request reprint A domain level interaction network of amyloid precursor protein and Abeta of Alzheimer's disease
    Victoria M Perreau
    Neuroproteomics and Neurogenomics Platform, National Neurosciences Facility, The University of Melbourne, Parkville, Vic, Australia
    Proteomics 10:2377-95. 2010
    ..Gene ontology and network analysis were used to identify potentially novel functional relationships among interacting proteins...
  33. doi request reprint Membrane-targeted strategies for modulating APP and Abeta-mediated toxicity
    Katherine A Price
    Department of Pathology, The University of Melbourne, Victoria, Australia
    J Cell Mol Med 13:249-61. 2009
    ..The putative role of copper (Cu) in AD is also discussed, and we highlight how targeting the cell membrane with Cu complexes has therapeutic potential in AD...
  34. ncbi request reprint Linker histone H1 binds to disease associated amyloid-like fibrils
    James A Duce
    Centre for Neuroscience, The University of Melbourne, Victoria 3010, Australia
    J Mol Biol 361:493-505. 2006
    ..We conclude that the binding of histone H1 to a general amyloid-like motif indicates that histone H1 may play an important common role in diseases associated with amyloid-like fibrils...
  35. doi request reprint Serum matrix metalloproteinase-9 activity is dysregulated with disease progression in the mutant SOD1 transgenic mice
    Cynthia P W Soon
    Department of Pathology, The University of Melbourne, Parkville, VIC 3010, Australia
    Neuromuscul Disord 20:260-6. 2010
    ..These data indicate that circulating MMP-9 is altered throughout the course of disease progression in mice. Further studies in human ALS may validate the suitability of serum MMP-9 activity as a biomarker for early stage disease...
  36. ncbi request reprint Therapeutic treatment of Alzheimer's disease using metal complexing agents
    Katherine A Price
    Department of Pathology and the Centre for Neuroscience, The University of Melbourne, Victoria, Australia
    Recent Pat CNS Drug Discov 2:180-7. 2007
    ..Further research will be necessary to fully understand the complex pathways associated with efficacious metal-based pharmaceuticals for treatment of AD...
  37. ncbi request reprint Clioquinol inhibits peroxide-mediated toxicity through up-regulation of phosphoinositol-3-kinase and inhibition of p53 activity
    Gulay Filiz
    Centre for Neuroscience and Department of Pathology, The University of Melbourne, Victoria 3010, Australia
    Int J Biochem Cell Biol 40:1030-42. 2008
    ..These findings have important implications for the development of protective metal ligand-based therapies for treatment of disorders involving oxidative stress...
  38. ncbi request reprint The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer's disease
    Peter J Crouch
    Department of Pathology and Centre for Neuroscience, The University of Melbourne, Australia
    FEBS J 274:3775-83. 2007
    ..In this review, we focus on copper dyshomeostasis in Alzheimer's disease, but we also discuss zinc and iron...
  39. doi request reprint Investigating copper-regulated protein expression in Menkes fibroblasts using antibody microarrays
    Tai Du
    Centre for Neuroscience, The University of Melbourne, Victoria, Australia
    Proteomics 8:1819-31. 2008
    ..Further analysis confirmed that expression of the DNA repair protein Ku80 was dependent on cellular Cu homeostasis and that Low-Cu levels in fibroblasts resulted in elevated susceptibility to DNA oxidation...
  40. pmc Increased metal content in the TDP-43(A315T) transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    Theresa N T Dang
    Department of Pathology, The University of Melbourne VIC, Australia
    Front Aging Neurosci 6:15. 2014
    ..Disrupted metal ion homeostasis in the spinal cord but not the brain may explain why the TDP-43 (A315T) mice show symptoms of locomotive decline and not cognitive decline. ..
  41. ncbi request reprint Therapeutic redistribution of metal ions to treat Alzheimer's disease
    Peter J Crouch
    Department of Pathology, University of Melbourne, Victoria, Australia
    Acc Chem Res 45:1604-11. 2012
    ..PBT2 improved cognition in a phase II clinical trial with AD patients, and further clinical testing is currently underway...
  42. pmc C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress
    Jodi Meyerowitz
    Department of Pathology, The University of Melbourne, Victoria, 3010, Australia
    Mol Neurodegener 6:57. 2011
    ..abstract:..
  43. doi request reprint Deregulation of biometal homeostasis: the missing link for neuronal ceroid lipofuscinoses?
    Alexandra Grubman
    Department of Pathology, The University of Melbourne, Victoria, 3010, Australia
    Metallomics 6:932-43. 2014
    ..These results demonstrate that altered biometal homeostasis is a key feature of at least 4 genetically distinct forms of NCL disease. ..
  44. ncbi request reprint Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42
    Peter J Crouch
    Centre for Neuroscience, The University of Melbourne, Victoria 3010, Australia
    J Neurosci 25:672-9. 2005
    ..We conclude that Cu2+-dependent Abeta-mediated inhibition of COX may be an important contributor to the neurodegeneration process in Alzheimer's disease...
  45. doi request reprint Modulation of ceramide-induced cell death and superoxide production by mitochondrial DNA-encoded respiratory chain defects in Rattus xenocybrid mouse cells
    Ian A Trounce
    Department of Ophthalmology, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia
    Biochim Biophys Acta 1827:817-25. 2013
    ..We propose a novel mechanism of altered mitochondrial cell death signaling due to mtDNA mutations whereby ceramide directly induces OXPHOS complex ROS generation to initiate cell death pathways...
  46. ncbi request reprint Clioquinol promotes cancer cell toxicity through tumor necrosis factor alpha release from macrophages
    Tai Du
    Centre for Neuroscience and Department of Pathology, University of Melbourne, Victoria, Australia 3010
    J Pharmacol Exp Ther 324:360-7. 2008
    ..These studies demonstrate that CQ can induce cancer cell toxicity through metal-dependent release of TNFalpha from macrophages. Our results may help to explain the targeted inhibition of tumor growth in vivo by CQ...
  47. pmc ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation
    Adam K Walker
    Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria, Australia Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia
    PLoS ONE 8:e81170. 2013
    ..This study provides evidence for ER stress as a pathogenic pathway in TDP-43-mediated disease. ..