Research Topics
Genomes and Genes | Andrew D CookSummaryAffiliation: University of Melbourne Country: Australia Publications
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Publications
Differing roles for urokinase and tissue-type plasminogen activator in collagen-induced arthritisAndrew D Cook
Arthritis and Inflammation Research Center, University of Melbourne, Department of Medicine, Victoria, Australia
Am J Pathol 160:917-26. 2002..Our data highlight the complexities of PA function, and suggest that approaches either to target u-PA or to enhance local t-PA activity in joints may be of therapeutic benefit in rheumatoid arthritis...
The effect of tissue type-plasminogen activator deletion and associated fibrin(ogen) deposition on macrophage localization in peritoneal inflammationAndrew D Cook
Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Royal Parade, Parkville, 3010, Victoria, Australia
Thromb Haemost 95:659-67. 2006..Peritoneal inflammation in t-PA-/- mice represents a useful model to study the progression of intra-abdominal adhesions during surgery and clinical peritonitis...
Granulocyte-macrophage colony-stimulating factor is a key mediator in inflammatory and arthritic painAndrew D Cook
Correspondence to Dr Andrew D Cook, Department of Medicine, University of Melbourne, The Royal Melbourne Hospital, Parkville, VC 3010, Australia
Ann Rheum Dis 72:265-70. 2013..However, its contribution to inflammatory and arthritic pain is unknown. The aims of this study were to determine whether GM-CSF controls inflammatory and/or arthritic pain...- Regulation of systemic and local myeloid cell subpopulations by bone marrow cell-derived granulocyte-macrophage colony-stimulating factor in experimental inflammatory arthritisAndrew D Cook
Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
Arthritis Rheum 63:2340-51. 2011.... - Urokinase-type plasminogen activator and arthritis progression: role in systemic disease with immune complex involvementAndrew D Cook
Arthritis and Inflammation Research Centre, Department of Medicine, The University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia
Arthritis Res Ther 12:R37. 2010..The aim of the current study is to determine how u-PA might be acting in systemic arthritis models... - Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): requirement for GM-CSF in the effector phase of diseaseA D Cook
Arthritis and Inflammation Research Centre, Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
Arthritis Res 3:293-8. 2001..The results also highlight the essential role of GM-CSF in the ongoing development of inflammation and arthritis in CIA, with possible therapeutic implications for rheumatoid arthritis... - Molecular targets in immune-mediated diseases: focus on rheumatoid arthritisAndrew D Cook
Cooperative Research Centre for Chronic Inflammatory Diseases, Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Victoria, 3010, Australia
Expert Opin Ther Targets 8:375-90. 2004.... - Stimulus-dependent requirement for granulocyte-macrophage colony-stimulating factor in inflammationAndrew D Cook
Arthritis and Inflammation Research Centre, Department of Medicine, Royal Melbourne Hospital, and Cooperative Research Centre for Chronic Inflammatory Diseases, University of Melbourne, Victoria, Australia
J Immunol 173:4643-51. 2004..Of general significance, the findings also indicate that the nature of the stimulus is quite critical in determining whether a particular inflammatory mediator, such as GM-CSF, plays a role in an ensuing inflammatory reaction... - The phenotype of inflammatory macrophages is stimulus dependent: implications for the nature of the inflammatory responseAndrew D Cook
Arthritis and Inflammation Research Center, Department of Medicine, and Cooperative Research Center for Chronic Inflammatory Diseases, University of Melbourne, Parkville, Victoria, Australia
J Immunol 171:4816-23. 2003..The inflammatory response elicited using the Ag mBSA may be more relevant for studying the inflammatory responses in many diseases, such as those of autoimmune origin and those involving an acquired immune response... - Antibodies against the CB10 fragment of type II collagen in rheumatoid arthritisAndrew D Cook
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
Arthritis Res Ther 6:R477-83. 2004..Moreover, our findings should encourage renewed interest in the role of collagen autoimmunity in the pathogenesis of RA... - GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on type I interferon signalingAndrew J Fleetwood
Department of Medicine, University of Melbourne, The Royal Melbourne Hospital, Parkville, Victoria, Australia
J Leukoc Biol 86:411-21. 2009..Collectively, these findings demonstrate that constitutive and LPS-induced type I IFN play significant roles in regulating the differences in phenotype and function between BMM and GM-BMM... - Defining GM-CSF- and macrophage-CSF-dependent macrophage responses by in vitro modelsDerek C Lacey
Department of Medicine, Arthritis and Inflammation Research Centre, University of Melbourne, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
J Immunol 188:5752-65. 2012..Care needs to be exercised when drawing definitive conclusions from a particular in vitro system about the roles of GM-CSF and M-CSF in macrophage lineage biology... - Control of macrophage lineage populations by CSF-1 receptor and GM-CSF in homeostasis and inflammationJason C Lenzo
Arthritis and Inflammation Research Centre, Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
Immunol Cell Biol 90:429-40. 2012..A correlation has been observed between macrophage numbers and the severity of certain inflammatory conditions, and it could be that CSF-1 and GM-CSF contribute to the control of these numbers in the ways proposed... - Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammationAndrew J Fleetwood
Department of Medicine and Cooperative Research Centre for Chronic Inflammatory Diseases, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia
J Immunol 178:5245-52. 2007.... - Macrophage lineage phenotypes and osteoclastogenesis--complexity in the control by GM-CSF and TGF-betaRoya Lari
Department of Medicine and CRC for Chronic Inflammatory Diseases, University of Melbourne, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
Bone 40:323-36. 2007..It is proposed that the findings have particular relevance for the control of bone resorption in pathology, for example, in inflammatory lesions... - The generation and properties of human macrophage populations from hemopoietic stem cellsKerrie J Way
Department of Medicine and CRC for Chronic Inflammatory Diseases, The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia
J Leukoc Biol 85:766-78. 2009..In addition to the large numbers of macrophage lineage cells able to be produced, this replicating system may be suitable for the molecular analysis of macrophage lineage commitment and progression and for gene targeting and delivery... - Urokinase-type plasminogen activator and arthritis progression: contrasting roles in systemic and monoarticular arthritis modelsChristine M De Nardo
Department of Medicine, Arthritis and Inflammation Research Centre, The University of Melbourne, Royal Parade, Parkville, Melbourne, Victoria 3010, Australia
Arthritis Res Ther 12:R199. 2010.... - Functions of granulocyte-macrophage colony-stimulating factorAndrew J Fleetwood
Arthritis and Inflammation Research Centre, Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville 3010, Victoria, Australia
Crit Rev Immunol 25:405-28. 2005..This review summarizes the evidence supporting a major role for GM-CSF in inflammation and autoimmunity and its functions as major regulator governing granulocyte and macrophage lineage populations at all stages of maturation... - Innate immune responses to LPS in mouse lung are suppressed and reversed by neutralization of GM-CSF via repression of TLR-4Steven Bozinovski
Lung Disease Research Group, Dept of Pharmacology, Cooperative Research Center for Chronic Inflammatory Diseases, Univ of Melbourne, Parkville 3010, Victoria, Australia
Am J Physiol Lung Cell Mol Physiol 286:L877-85. 2004..These data expand the understanding of the contribution of GM-CSF to innate immune responses in lung and suggest that blocking GM-CSF might benefit some lung diseases where LPS has been implicated in etiology... - GM-CSF is not essential for optimal fertility or for weight controlJohn A Hamilton
Arthritis and Inflammation Research Centre, Department of Medicine, The University of Melbourne, Parkville, Victoria 3050, Australia
Cytokine 57:30-1. 2012..It is concluded that GM-CSF is not necessary for an optimal fertility outcome or for normal weight maintenance during development... - CSF-1 receptor signalling from endosomes mediates the sustained activation of Erk1/2 and Akt in macrophagesJennifer Huynh
Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
Cell Signal 24:1753-61. 2012..Together, our data argue that key signalling responses to CSF-1 depend on the ability of the CSF-1R to signal from endosomes following its internalisation, thus adding an important spatiotemporal aspect to CSF-1R signalling... - Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1R Tedjo Sasmono
CRC for Chronic Inflammatory Diseases and ARC Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia
J Leukoc Biol 82:111-23. 2007..In keeping with this hypothesis, we showed that purified Ly-6G-positive granulocytes express CSF-1R after overnight culture and can subsequently differentiate to form F4/80-positive macrophages in response to CSF-1...