Andrew D Cook

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. pmc Differing roles for urokinase and tissue-type plasminogen activator in collagen-induced arthritis
    Andrew D Cook
    Arthritis and Inflammation Research Center, University of Melbourne, Department of Medicine, Victoria, Australia
    Am J Pathol 160:917-26. 2002
  2. ncbi request reprint The effect of tissue type-plasminogen activator deletion and associated fibrin(ogen) deposition on macrophage localization in peritoneal inflammation
    Andrew D Cook
    Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Royal Parade, Parkville, 3010, Victoria, Australia
    Thromb Haemost 95:659-67. 2006
  3. pmc Urokinase-type plasminogen activator and arthritis progression: role in systemic disease with immune complex involvement
    Andrew D Cook
    Arthritis and Inflammation Research Centre, Department of Medicine, The University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia
    Arthritis Res Ther 12:R37. 2010
  4. doi request reprint Granulocyte-macrophage colony-stimulating factor is a key mediator in inflammatory and arthritic pain
    Andrew D Cook
    Correspondence to Dr Andrew D Cook, Department of Medicine, University of Melbourne, The Royal Melbourne Hospital, Parkville, VC 3010, Australia
    Ann Rheum Dis 72:265-70. 2013
  5. doi request reprint Regulation of systemic and local myeloid cell subpopulations by bone marrow cell-derived granulocyte-macrophage colony-stimulating factor in experimental inflammatory arthritis
    Andrew D Cook
    Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
    Arthritis Rheum 63:2340-51. 2011
  6. pmc Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): requirement for GM-CSF in the effector phase of disease
    A D Cook
    Arthritis and Inflammation Research Centre, Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
    Arthritis Res 3:293-8. 2001
  7. ncbi request reprint Molecular targets in immune-mediated diseases: focus on rheumatoid arthritis
    Andrew D Cook
    Cooperative Research Centre for Chronic Inflammatory Diseases, Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Victoria, 3010, Australia
    Expert Opin Ther Targets 8:375-90. 2004
  8. ncbi request reprint Stimulus-dependent requirement for granulocyte-macrophage colony-stimulating factor in inflammation
    Andrew D Cook
    Arthritis and Inflammation Research Centre, Department of Medicine, Royal Melbourne Hospital, and Cooperative Research Centre for Chronic Inflammatory Diseases, University of Melbourne, Victoria, Australia
    J Immunol 173:4643-51. 2004
  9. pmc Antibodies against the CB10 fragment of type II collagen in rheumatoid arthritis
    Andrew D Cook
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Arthritis Res Ther 6:R477-83. 2004
  10. ncbi request reprint The phenotype of inflammatory macrophages is stimulus dependent: implications for the nature of the inflammatory response
    Andrew D Cook
    Arthritis and Inflammation Research Center, Department of Medicine, and Cooperative Research Center for Chronic Inflammatory Diseases, University of Melbourne, Parkville, Victoria, Australia
    J Immunol 171:4816-23. 2003

Collaborators

Detail Information

Publications24

  1. pmc Differing roles for urokinase and tissue-type plasminogen activator in collagen-induced arthritis
    Andrew D Cook
    Arthritis and Inflammation Research Center, University of Melbourne, Department of Medicine, Victoria, Australia
    Am J Pathol 160:917-26. 2002
    ..Our data highlight the complexities of PA function, and suggest that approaches either to target u-PA or to enhance local t-PA activity in joints may be of therapeutic benefit in rheumatoid arthritis...
  2. ncbi request reprint The effect of tissue type-plasminogen activator deletion and associated fibrin(ogen) deposition on macrophage localization in peritoneal inflammation
    Andrew D Cook
    Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Royal Parade, Parkville, 3010, Victoria, Australia
    Thromb Haemost 95:659-67. 2006
    ..Peritoneal inflammation in t-PA-/- mice represents a useful model to study the progression of intra-abdominal adhesions during surgery and clinical peritonitis...
  3. pmc Urokinase-type plasminogen activator and arthritis progression: role in systemic disease with immune complex involvement
    Andrew D Cook
    Arthritis and Inflammation Research Centre, Department of Medicine, The University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia
    Arthritis Res Ther 12:R37. 2010
    ..The aim of the current study is to determine how u-PA might be acting in systemic arthritis models...
  4. doi request reprint Granulocyte-macrophage colony-stimulating factor is a key mediator in inflammatory and arthritic pain
    Andrew D Cook
    Correspondence to Dr Andrew D Cook, Department of Medicine, University of Melbourne, The Royal Melbourne Hospital, Parkville, VC 3010, Australia
    Ann Rheum Dis 72:265-70. 2013
    ..However, its contribution to inflammatory and arthritic pain is unknown. The aims of this study were to determine whether GM-CSF controls inflammatory and/or arthritic pain...
  5. doi request reprint Regulation of systemic and local myeloid cell subpopulations by bone marrow cell-derived granulocyte-macrophage colony-stimulating factor in experimental inflammatory arthritis
    Andrew D Cook
    Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
    Arthritis Rheum 63:2340-51. 2011
    ....
  6. pmc Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): requirement for GM-CSF in the effector phase of disease
    A D Cook
    Arthritis and Inflammation Research Centre, Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
    Arthritis Res 3:293-8. 2001
    ..The results also highlight the essential role of GM-CSF in the ongoing development of inflammation and arthritis in CIA, with possible therapeutic implications for rheumatoid arthritis...
  7. ncbi request reprint Molecular targets in immune-mediated diseases: focus on rheumatoid arthritis
    Andrew D Cook
    Cooperative Research Centre for Chronic Inflammatory Diseases, Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Victoria, 3010, Australia
    Expert Opin Ther Targets 8:375-90. 2004
    ....
  8. ncbi request reprint Stimulus-dependent requirement for granulocyte-macrophage colony-stimulating factor in inflammation
    Andrew D Cook
    Arthritis and Inflammation Research Centre, Department of Medicine, Royal Melbourne Hospital, and Cooperative Research Centre for Chronic Inflammatory Diseases, University of Melbourne, Victoria, Australia
    J Immunol 173:4643-51. 2004
    ..Of general significance, the findings also indicate that the nature of the stimulus is quite critical in determining whether a particular inflammatory mediator, such as GM-CSF, plays a role in an ensuing inflammatory reaction...
  9. pmc Antibodies against the CB10 fragment of type II collagen in rheumatoid arthritis
    Andrew D Cook
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Arthritis Res Ther 6:R477-83. 2004
    ..Moreover, our findings should encourage renewed interest in the role of collagen autoimmunity in the pathogenesis of RA...
  10. ncbi request reprint The phenotype of inflammatory macrophages is stimulus dependent: implications for the nature of the inflammatory response
    Andrew D Cook
    Arthritis and Inflammation Research Center, Department of Medicine, and Cooperative Research Center for Chronic Inflammatory Diseases, University of Melbourne, Parkville, Victoria, Australia
    J Immunol 171:4816-23. 2003
    ..The inflammatory response elicited using the Ag mBSA may be more relevant for studying the inflammatory responses in many diseases, such as those of autoimmune origin and those involving an acquired immune response...
  11. ncbi request reprint GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on type I interferon signaling
    Andrew J Fleetwood
    Department of Medicine, University of Melbourne, The Royal Melbourne Hospital, Parkville, Victoria, Australia
    J Leukoc Biol 86:411-21. 2009
    ..Collectively, these findings demonstrate that constitutive and LPS-induced type I IFN play significant roles in regulating the differences in phenotype and function between BMM and GM-BMM...
  12. doi request reprint Defining GM-CSF- and macrophage-CSF-dependent macrophage responses by in vitro models
    Derek C Lacey
    Department of Medicine, Arthritis and Inflammation Research Centre, University of Melbourne, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    J Immunol 188:5752-65. 2012
    ..Care needs to be exercised when drawing definitive conclusions from a particular in vitro system about the roles of GM-CSF and M-CSF in macrophage lineage biology...
  13. doi request reprint Control of macrophage lineage populations by CSF-1 receptor and GM-CSF in homeostasis and inflammation
    Jason C Lenzo
    Arthritis and Inflammation Research Centre, Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
    Immunol Cell Biol 90:429-40. 2012
    ..A correlation has been observed between macrophage numbers and the severity of certain inflammatory conditions, and it could be that CSF-1 and GM-CSF contribute to the control of these numbers in the ways proposed...
  14. ncbi request reprint Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation
    Andrew J Fleetwood
    Department of Medicine and Cooperative Research Centre for Chronic Inflammatory Diseases, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia
    J Immunol 178:5245-52. 2007
    ....
  15. doi request reprint The generation and properties of human macrophage populations from hemopoietic stem cells
    Kerrie J Way
    Department of Medicine and CRC for Chronic Inflammatory Diseases, The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia
    J Leukoc Biol 85:766-78. 2009
    ..In addition to the large numbers of macrophage lineage cells able to be produced, this replicating system may be suitable for the molecular analysis of macrophage lineage commitment and progression and for gene targeting and delivery...
  16. ncbi request reprint Macrophage lineage phenotypes and osteoclastogenesis--complexity in the control by GM-CSF and TGF-beta
    Roya Lari
    Department of Medicine and CRC for Chronic Inflammatory Diseases, University of Melbourne, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Bone 40:323-36. 2007
    ..It is proposed that the findings have particular relevance for the control of bone resorption in pathology, for example, in inflammatory lesions...
  17. pmc Urokinase-type plasminogen activator and arthritis progression: contrasting roles in systemic and monoarticular arthritis models
    Christine M De Nardo
    Department of Medicine, Arthritis and Inflammation Research Centre, The University of Melbourne, Royal Parade, Parkville, Melbourne, Victoria 3010, Australia
    Arthritis Res Ther 12:R199. 2010
    ....
  18. ncbi request reprint Functions of granulocyte-macrophage colony-stimulating factor
    Andrew J Fleetwood
    Arthritis and Inflammation Research Centre, Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville 3010, Victoria, Australia
    Crit Rev Immunol 25:405-28. 2005
    ..This review summarizes the evidence supporting a major role for GM-CSF in inflammation and autoimmunity and its functions as major regulator governing granulocyte and macrophage lineage populations at all stages of maturation...
  19. ncbi request reprint Innate immune responses to LPS in mouse lung are suppressed and reversed by neutralization of GM-CSF via repression of TLR-4
    Steven Bozinovski
    Lung Disease Research Group, Dept of Pharmacology, Cooperative Research Center for Chronic Inflammatory Diseases, Univ of Melbourne, Parkville 3010, Victoria, Australia
    Am J Physiol Lung Cell Mol Physiol 286:L877-85. 2004
    ..These data expand the understanding of the contribution of GM-CSF to innate immune responses in lung and suggest that blocking GM-CSF might benefit some lung diseases where LPS has been implicated in etiology...
  20. doi request reprint CSF-1 receptor signalling from endosomes mediates the sustained activation of Erk1/2 and Akt in macrophages
    Jennifer Huynh
    Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Cell Signal 24:1753-61. 2012
    ..Together, our data argue that key signalling responses to CSF-1 depend on the ability of the CSF-1R to signal from endosomes following its internalisation, thus adding an important spatiotemporal aspect to CSF-1R signalling...
  21. doi request reprint GM-CSF is not essential for optimal fertility or for weight control
    John A Hamilton
    Arthritis and Inflammation Research Centre, Department of Medicine, The University of Melbourne, Parkville, Victoria 3050, Australia
    Cytokine 57:30-1. 2012
    ..It is concluded that GM-CSF is not necessary for an optimal fertility outcome or for normal weight maintenance during development...
  22. pmc Granulocyte-macrophage colony-stimulating factor is neuroprotective in experimental traumatic brain injury
    Sandy R Shultz
    1 Department of Medicine The Royal Melbourne Hospital, Melbourne Brain Centre, The University of Melbourne, Parkville, Victoria, Australia
    J Neurotrauma 31:976-83. 2014
    ....
  23. ncbi request reprint Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1
    R Tedjo Sasmono
    CRC for Chronic Inflammatory Diseases and ARC Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia
    J Leukoc Biol 82:111-23. 2007
    ..In keeping with this hypothesis, we showed that purified Ly-6G-positive granulocytes express CSF-1R after overnight culture and can subsequently differentiate to form F4/80-positive macrophages in response to CSF-1...