R S Chung

Summary

Affiliation: University of Tasmania
Country: Australia

Publications

  1. ncbi request reprint Metallothionein-IIA promotes initial neurite elongation and postinjury reactive neurite growth and facilitates healing after focal cortical brain injury
    Roger S Chung
    NeuroRepair Group, School of Medicine, University of Tasmania, Hobart, Tasmania 7001, Australia
    J Neurosci 23:3336-42. 2003
  2. pmc Tg2576 cortical neurons that express human Ab are susceptible to extracellular Aβ-induced, K+ efflux dependent neurodegeneration
    Shannon Ray
    NeuroRepair Group, Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    PLoS ONE 6:e19026. 2011
  3. pmc Prolonged Abeta treatment leads to impairment in the ability of primary cortical neurons to maintain K+ and Ca2+ homeostasis
    Lana Shabala
    NeuroRepair Group, Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania, 7001, Australia
    Mol Neurodegener 5:30. 2010
  4. pmc Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT)-I/II null mutant mice
    Michael W Pankhurst
    Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia
    J Neuroinflammation 8:172. 2011
  5. doi request reprint Metallothionein treatment attenuates microglial activation and expression of neurotoxic quinolinic acid following traumatic brain injury
    R S Chung
    NeuroRepair Group, Menzies Research Institute, University of Tasmania, Private Bag 58, Hobart, TAS, 7001, Australia
    Neurotox Res 15:381-9. 2009
  6. ncbi request reprint Mild axonal stretch injury in vitro induces a progressive series of neurofilament alterations ultimately leading to delayed axotomy
    Roger S Chung
    NeuroRepair Group, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia
    J Neurotrauma 22:1081-91. 2005
  7. ncbi request reprint Glutamate induces rapid loss of axonal neurofilament proteins from cortical neurons in vitro
    Roger S Chung
    NeuroRepair Group, School of Medicine, University of Tasmania, Private Bag 58, Hobart, Tasmania 7001, Australia
    Exp Neurol 193:481-8. 2005
  8. ncbi request reprint New insight into the molecular pathways of metallothionein-mediated neuroprotection and regeneration
    R S Chung
    NeuroRepair Group, Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    J Neurochem 104:14-20. 2008
  9. ncbi request reprint Metallothionein expression by NG2 glial cells following CNS injury
    R S Chung
    NeuroRepair Group, Menzies Research Institute, University of Tasmania, Private Bag 58, Hobart, Tasmania, 7001, Australia
    Cell Mol Life Sci 64:2716-22. 2007
  10. ncbi request reprint Olfactory ensheathing cells promote neurite sprouting of injured axons in vitro by direct cellular contact and secretion of soluble factors
    R S Chung
    NeuroRepair Group, School of Medicine, University of Tasmania, Private Bag 58, Hobart, Tasmania 7001, Australia
    Cell Mol Life Sci 61:1238-45. 2004

Detail Information

Publications33

  1. ncbi request reprint Metallothionein-IIA promotes initial neurite elongation and postinjury reactive neurite growth and facilitates healing after focal cortical brain injury
    Roger S Chung
    NeuroRepair Group, School of Medicine, University of Tasmania, Hobart, Tasmania 7001, Australia
    J Neurosci 23:3336-42. 2003
    ..These results are discussed in relation to a possible physiological role of metallothioneins in the brain, as well as in a therapeutic context...
  2. pmc Tg2576 cortical neurons that express human Ab are susceptible to extracellular Aβ-induced, K+ efflux dependent neurodegeneration
    Shannon Ray
    NeuroRepair Group, Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    PLoS ONE 6:e19026. 2011
    ..Due to the slowly progressive nature of the disease, it is likely that neurons are exposed to sublethal concentrations of both intracellular and extracellular Aβ for extended periods of time...
  3. pmc Prolonged Abeta treatment leads to impairment in the ability of primary cortical neurons to maintain K+ and Ca2+ homeostasis
    Lana Shabala
    NeuroRepair Group, Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania, 7001, Australia
    Mol Neurodegener 5:30. 2010
    ..We also investigated whether chronic Abeta exposure affects neuronal susceptibility to the subsequent acute excitotoxicity induced by 10 muM glutamate and assessed how Ca2+ and K+ homeostasis were affected by either treatment...
  4. pmc Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT)-I/II null mutant mice
    Michael W Pankhurst
    Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia
    J Neuroinflammation 8:172. 2011
    ..The present study tests the hypothesis that MT-I/II may have an indirect neuroprotective action via modulation of the immune system...
  5. doi request reprint Metallothionein treatment attenuates microglial activation and expression of neurotoxic quinolinic acid following traumatic brain injury
    R S Chung
    NeuroRepair Group, Menzies Research Institute, University of Tasmania, Private Bag 58, Hobart, TAS, 7001, Australia
    Neurotox Res 15:381-9. 2009
    ..These results demonstrate the neuroimmunomodulatory properties of MT, which may have therapeutic applications for the treatment of traumatic brain injury...
  6. ncbi request reprint Mild axonal stretch injury in vitro induces a progressive series of neurofilament alterations ultimately leading to delayed axotomy
    Roger S Chung
    NeuroRepair Group, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia
    J Neurotrauma 22:1081-91. 2005
    ..Hence, it is possible that the cytoskeletal characteristics that we have used in this study may be useful parameters for discriminating between mildly and severely injured axons following TBI...
  7. ncbi request reprint Glutamate induces rapid loss of axonal neurofilament proteins from cortical neurons in vitro
    Roger S Chung
    NeuroRepair Group, School of Medicine, University of Tasmania, Private Bag 58, Hobart, Tasmania 7001, Australia
    Exp Neurol 193:481-8. 2005
    ..This work suggests that excitotoxicity triggers a progressive pathway of cytoskeletal degeneration within axons, initially characterised by the loss of neurofilament proteins...
  8. ncbi request reprint New insight into the molecular pathways of metallothionein-mediated neuroprotection and regeneration
    R S Chung
    NeuroRepair Group, Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    J Neurochem 104:14-20. 2008
    ..in the context of our current understanding of the role of MT in astrocyte-neuron interactions in the injured brain, and also discuss the significant therapeutic potential of their work...
  9. ncbi request reprint Metallothionein expression by NG2 glial cells following CNS injury
    R S Chung
    NeuroRepair Group, Menzies Research Institute, University of Tasmania, Private Bag 58, Hobart, Tasmania, 7001, Australia
    Cell Mol Life Sci 64:2716-22. 2007
    ..Our data suggest that expression of MT by NG2 glial cells may contribute to the overall permissiveness of these cells to axon regeneration...
  10. ncbi request reprint Olfactory ensheathing cells promote neurite sprouting of injured axons in vitro by direct cellular contact and secretion of soluble factors
    R S Chung
    NeuroRepair Group, School of Medicine, University of Tasmania, Private Bag 58, Hobart, Tasmania 7001, Australia
    Cell Mol Life Sci 61:1238-45. 2004
    ..Our findings provide new insight into the ability of OECs to promote axonal regeneration, and also indicate potential targets for manipulation of these cells to enhance their restorative ability...
  11. ncbi request reprint A role for extracellular metallothioneins in CNS injury and repair
    R S Chung
    NeuroRepair Group, School of Medicine, University of Tasmania, Private Bag 58, Tasmania 7001, Hobart, Australia
    Neuroscience 123:595-9. 2004
    ....
  12. ncbi request reprint Neuron-glia communication: metallothionein expression is specifically up-regulated by astrocytes in response to neuronal injury
    Roger S Chung
    NeuroRepair Group, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia
    J Neurochem 88:454-61. 2004
    ..Based upon recent reports indicating that MT-I/-II are major neuroprotective proteins within the brain, our results provide further evidence that MT-I/-II plays an important role in the cellular response to neuronal injury...
  13. pmc Redefining the role of metallothionein within the injured brain: extracellular metallothioneins play an important role in the astrocyte-neuron response to injury
    Roger S Chung
    NeuroRepair Group, Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7001, Australia
    J Biol Chem 283:15349-58. 2008
    ..This unsuspected action of MT represents a novel paradigm of astrocyte-neuronal interaction after injury and may have implications for the development of MT-based therapeutic agents...
  14. doi request reprint Neuron-glia interactions underlie ALS-like axonal cytoskeletal pathology
    A E King
    NeuroRepair Group and Wicking Dementia Research and Education Centre, Menzies Research Institute, Hobart, Tasmania 7000, Australia
    Neurobiol Aging 32:459-69. 2011
    ..These data provide strong evidence for the involvement of non-neuronal cells in axonal dysfunction in ALS. This cell culture model may be of benefit for the development of therapeutic interventions directed at axonal preservation...
  15. ncbi request reprint Excitotoxicity mediated by non-NMDA receptors causes distal axonopathy in long-term cultured spinal motor neurons
    A E King
    NeuroRepair Group, Menzies Research Institute, Hobart, Tasmania 7000, Australia
    Eur J Neurosci 26:2151-9. 2007
    ..These data provide a strong link between excitotoxicity and the selective pattern of axonopathy of lower motor neurons that underlies neuronal dysfunction in ALS...
  16. doi request reprint Metallothionein induces a regenerative reactive astrocyte phenotype via JAK/STAT and RhoA signalling pathways
    Y K J Leung
    Menzies Research Institute, University of Tasmania, Private Bag 58, Tasmania, Australia
    Exp Neurol 221:98-106. 2010
    ..The results suggest that MT has an important role in mediating permissive astrocytic responses to traumatic brain injury...
  17. ncbi request reprint Olfactory ensheathing cells promote collateral axonal branching in the injured adult rat spinal cord
    M I Chuah
    NeuroRepair Group, School of Medicine, University of Tasmania, Hobart, Tasmania 7001, Australia
    Exp Neurol 185:15-25. 2004
    ..003), while a trend for increased collateral branches was observed in rats that received encapsulated ECs (P=0.07)...
  18. ncbi request reprint Metallothionein-III inhibits initial neurite formation in developing neurons as well as postinjury, regenerative neurite sprouting
    R S Chung
    NeuroRepair Group, University of Tasmania, P O Box 252 58, Hobart, Tasmania 7001, Australia
    Exp Neurol 178:1-12. 2002
    ..Based on these results, we propose that MT-III, in the presence of brain extract, is a potent inhibitor of neurite sprouting, and may be involved in abnormal sprouting potentially underlying both AD and epilepsy...
  19. ncbi request reprint Cyclosporin-A treatment attenuates delayed cytoskeletal alterations and secondary axotomy following mild axonal stretch injury
    J A Staal
    NeuroRepair Group, Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    Dev Neurobiol 67:1831-42. 2007
    ..In summary, these results suggest that cyclosporin-A reduces progressive cytoskeletal damage and secondary axotomy following transient axonal stretch injury in vitro...
  20. ncbi request reprint Localization of glutamate receptors in developing cortical neurons in culture and relationship to susceptibility to excitotoxicity
    A E King
    NeuroRepair Group, University of Tasmania, Hobart, Tasmania 7001, Australia
    J Comp Neurol 498:277-94. 2006
    ..These data also suggest that excitotoxicity can be mediated through extrasynaptic receptor subunit complexes along dendrites...
  21. ncbi request reprint Metallothionein biology in the ageing and neurodegenerative brain
    J Dittmann
    NeuroRepair Group, School of Medicine, University of Tasmania, Tasmania 7001 Australia
    Neurotox Res 7:87-93. 2005
    ....
  22. doi request reprint Disruption of the ubiquitin proteasome system following axonal stretch injury accelerates progression to secondary axotomy
    Jerome A Staal
    NeuroRepair Group, Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7001, Australia
    J Neurotrauma 26:781-8. 2009
    ..Protein ubiquitination in the axon may therefore have a protective role relative to the diffuse axonal changes that follow traumatic brain injury...
  23. pmc The native copper- and zinc-binding protein metallothionein blocks copper-mediated Abeta aggregation and toxicity in rat cortical neurons
    Roger S Chung
    NeuroRepair Group, Menzies Research Institute, University of Tasmania, Hobart, Australia
    PLoS ONE 5:e12030. 2010
    ..A major pathological hallmark of AD is the deposition of insoluble extracellular beta-amyloid (Abeta) plaques. There are compelling data suggesting that Abeta aggregation is catalysed by reaction with the metals zinc and copper...
  24. ncbi request reprint Protective role of metallothioneins in the injured mammalian brain
    Adrian K West
    NeuroRepair Group, University of Tasmania, Hobart, Australia
    Rev Neurosci 15:157-66. 2004
    ....
  25. ncbi request reprint Acute reactive and regenerative changes in mature cortical axons following injury
    Tracey C Dickson
    NeuroRepair Group, School of Medicine, University of Tasmania, Tasmania, Australia
    Neuroreport 18:283-8. 2007
    ..These results indicate that damaged mature axons have an intrinsic capacity to react adaptively and attempt regeneration...
  26. doi request reprint The two faces of metallothionein in carcinogenesis: photoprotection against UVR-induced cancer and promotion of tumour survival
    Heather M McGee
    Menzies Research Institute, University of Tasmania, Australia
    Photochem Photobiol Sci 9:586-96. 2010
    ..These two discordant sets of attributes are context-dependent, and represent the two faces of metallothionein...
  27. doi request reprint Olfactory ensheathing cells are attracted to, and can endocytose, bacteria
    J Y K Leung
    Menzies Research Institute, University of Tasmania, Private Bag 24, Hobart, Tasmania 7001, Australia
    Cell Mol Life Sci 65:2732-9. 2008
    ..The ability of OECs to endocytose bacteria supports the notion that OECs play an innate immune function by protecting olfactory tissues from bacterial infection...
  28. ncbi request reprint Spinal cord tissue affects ensheathing cell proliferation and apoptosis
    Adele Woodhouse
    NeuroRepair Group, School of Medicine, University of Tasmania, Private Bag 24, Hobart, Tasmania 7001, Australia
    Neuroreport 16:737-40. 2005
    ..These results suggest that delaying transplantation after spinal cord injury may be beneficial to ensheathing cell survival...
  29. ncbi request reprint Identification and characterization of a population of motile neurons in long-term cortical culture
    Matilda A Haas
    NeuroRepair Group, University of Tasmania, Hobart, Tasmania, Australia
    Cell Motil Cytoskeleton 64:274-87. 2007
    ..These studies provide new information on the structurally dynamic features of subsets of neurons...
  30. ncbi request reprint Distribution of exogenous metallothionein following intraperitoneal and intramuscular injection of metallothionein-deficient mice
    Katherine E Lewis
    Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia
    Histol Histopathol 27:1459-70. 2012
    ..Peptide analogues of MT-I/II with similar neuroactive properties (emtins) may be more suited for CNS delivery...
  31. doi request reprint Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain
    Claire Howells
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    FEBS J 277:2931-9. 2010
    ..In this review, we examine the recent developments regarding the function of neuronal growth-inhibitory factor within the brain, particularly in response to brain injury or during neurodegenerative disease progression...
  32. ncbi request reprint Metallothionein-IIA promotes neurite growth via the megalin receptor
    Melinda Fitzgerald
    Experimental and Regenerative Neurosciences, School of Animal Biology, University of Western Australia, Hackett Drive, Crawley 6009, WA, Australia
    Exp Brain Res 183:171-80. 2007
    ....
  33. ncbi request reprint Metallothioneins I and II: neuroprotective significance during CNS pathology
    Roger K Stankovic
    Department of Pathology, University of Sydney, NSW, Australia
    Int J Biochem Cell Biol 39:484-9. 2007
    ..Hence, MT-I, II may provide neurotherapeutic targets offering protection against neuronal injury and degeneration...