Siew Yeen Chai

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. pmc Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase
    Siew Yeen Chai
    Howard Florey Institute, The University of Melbourne, Parkville, Victoria 3010, Australia
    BMC Neurosci 9:S14. 2008
  2. ncbi request reprint Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP)
    Rebecca A Lew
    Baker Heart Research Institute, Melbourne Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia
    J Neurochem 86:344-50. 2003
  3. doi request reprint Identification of modulating residues defining the catalytic cleft of insulin-regulated aminopeptidase
    Siying Ye
    Howard Florey Institute, Florey Neurosciences Institutes, University of Melbourne, Parkville, Victoria, Australia
    Biochem Cell Biol 86:251-61. 2008
  4. doi request reprint Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase
    Anthony L Albiston
    Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, Australia
    Mol Pharmacol 78:600-7. 2010
  5. doi request reprint Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase
    Anthony L Albiston
    Howard Florey Institute, University of Melbourne, Parkville, VIC 3010, Australia
    FASEB J 22:4209-17. 2008
  6. pmc Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers
    Anthony L Albiston
    Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia
    Br J Pharmacol 164:37-47. 2011
  7. ncbi request reprint Structure-activity study of LVV-hemorphin-7: angiotensin AT4 receptor ligand and inhibitor of insulin-regulated aminopeptidase
    Joohyung Lee
    Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia
    J Pharmacol Exp Ther 305:205-11. 2003
  8. doi request reprint Gene knockout of insulin-regulated aminopeptidase: loss of the specific binding site for angiotensin IV and age-related deficit in spatial memory
    Anthony L Albiston
    Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, Australia
    Neurobiol Learn Mem 93:19-30. 2010
  9. doi request reprint Reproduction and maternal behavior in insulin-regulated aminopeptidase (IRAP) knockout mice
    Vi Pham
    Florey Neuroscience Institutes, University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia
    Peptides 30:1861-5. 2009
  10. ncbi request reprint Therapeutic targeting of insulin-regulated aminopeptidase: heads and tails?
    Anthony L Albiston
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria 3010, Australia
    Pharmacol Ther 116:417-27. 2007

Collaborators

Detail Information

Publications23

  1. pmc Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase
    Siew Yeen Chai
    Howard Florey Institute, The University of Melbourne, Parkville, Victoria 3010, Australia
    BMC Neurosci 9:S14. 2008
    ..Although the exact mechanism by which the peptides enhance memory is yet to be elucidated, IRAP still represents a promising target for the development of a new class of cognitive enhancing agents...
  2. ncbi request reprint Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP)
    Rebecca A Lew
    Baker Heart Research Institute, Melbourne Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia
    J Neurochem 86:344-50. 2003
    ..We propose that the physiological effects of AT4 ligands result, in part, from inhibition of IRAP cleavage of neuropeptides involved in memory processing...
  3. doi request reprint Identification of modulating residues defining the catalytic cleft of insulin-regulated aminopeptidase
    Siying Ye
    Howard Florey Institute, Florey Neurosciences Institutes, University of Melbourne, Parkville, Victoria, Australia
    Biochem Cell Biol 86:251-61. 2008
    ..In additionm we predict that the peptide inhibitors bind to the catalytic site, with the NH2-terminal P1 residue occupying the catalytic cleft (S1 subsite) in a manner similar to that proposed for peptide substrates...
  4. doi request reprint Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase
    Anthony L Albiston
    Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, Australia
    Mol Pharmacol 78:600-7. 2010
    ..These findings demonstrate a key role of Phe544 in the binding of the benzopyran IRAP inhibitors and for optimal positioning of enzyme substrates during catalysis...
  5. doi request reprint Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase
    Anthony L Albiston
    Howard Florey Institute, University of Melbourne, Parkville, VIC 3010, Australia
    FASEB J 22:4209-17. 2008
    ..Notably, this study also provides unequivocal proof of principal that inhibition of IRAP results in memory enhancement...
  6. pmc Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers
    Anthony L Albiston
    Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia
    Br J Pharmacol 164:37-47. 2011
    ..The proof of principal that inhibition of IRAP activity results in facilitation of memory has been obtained by the demonstration that the small-molecule IRAP inhibitors also exhibit memory-enhancing properties...
  7. ncbi request reprint Structure-activity study of LVV-hemorphin-7: angiotensin AT4 receptor ligand and inhibitor of insulin-regulated aminopeptidase
    Joohyung Lee
    Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia
    J Pharmacol Exp Ther 305:205-11. 2003
    ..The current study highlights the minimal residues necessary for binding and inhibition of IRAP and provides a basis to design peptidomimetic analogs for experimental and potentially clinical use...
  8. doi request reprint Gene knockout of insulin-regulated aminopeptidase: loss of the specific binding site for angiotensin IV and age-related deficit in spatial memory
    Anthony L Albiston
    Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, Australia
    Neurobiol Learn Mem 93:19-30. 2010
    ..Our results highlight the importance of analysing the behavioural phenotype of knockout mice across different ages and in distinct memory paradigms...
  9. doi request reprint Reproduction and maternal behavior in insulin-regulated aminopeptidase (IRAP) knockout mice
    Vi Pham
    Florey Neuroscience Institutes, University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia
    Peptides 30:1861-5. 2009
    ..In conclusion, the physiological significance of circulating IRAP during human pregnancy cannot be addressed by investigations on mice...
  10. ncbi request reprint Therapeutic targeting of insulin-regulated aminopeptidase: heads and tails?
    Anthony L Albiston
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria 3010, Australia
    Pharmacol Ther 116:417-27. 2007
    ..This protein appears to have multiple physiological roles that are tissue- and domain-specific; thus the protein can be specifically targeted for treating different clinical conditions...
  11. ncbi request reprint Sub-cellular localization of insulin-regulated membrane aminopeptidase, IRAP to vesicles in neurons
    Ruani N Fernando
    Howard Florey Institute, The University of Melbourne, Parkville, Victoria, Australia
    J Neurochem 102:967-76. 2007
    ..Therefore, we propose that the function of IRAP in neurons may be similar to that in insulin responsive cells...
  12. ncbi request reprint Insulin-regulated aminopeptidase: analysis of peptide substrate and inhibitor binding to the catalytic domain
    Siying Ye
    Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, Australia
    Biol Chem 388:399-403. 2007
    ....
  13. doi request reprint Distinct distribution of GLUT4 and insulin regulated aminopeptidase in the mouse kidney
    Anthony L Albiston
    Howard Florey Institute, Florey Neurosciences Institutes, Centre for Neuroscience, University of Melbourne, Parkville, Victoria 3010, Australia
    Regul Pept 166:83-9. 2011
    ....
  14. doi request reprint Insulin-regulated aminopeptidase deficiency provides protection against ischemic stroke in mice
    Vi Pham
    Howard Florey Institute, Victoria, Australia
    J Neurotrauma 29:1243-8. 2012
    ..This study indicates that IRAP is potentially a new therapeutic target for the development of treatment for ischemic stroke...
  15. ncbi request reprint Attenuation of scopolamine-induced learning deficits by LVV-hemorphin-7 in rats in the passive avoidance and water maze paradigms
    Anthony L Albiston
    Howard Florey Institute of Experimental Physiology and Medicine, The University of Melbourne, Parkville, VIC 3010, Australia
    Behav Brain Res 154:239-43. 2004
    ..These studies clearly demonstrate that LVV-H7, like Ang IV, is a pharmacologically active AT(4) ligand that attenuates the deleterious effects of scopolamine on learning performance in two different behavioral paradigms...
  16. ncbi request reprint Interaction of the Akt substrate, AS160, with the glucose transporter 4 vesicle marker protein, insulin-regulated aminopeptidase
    Grantley R Peck
    Department of Medicine, Howard Florey Institute, University of Melbourne, Parkville, Victoria 3052, Australia
    Mol Endocrinol 20:2576-83. 2006
    ..We hypothesize that AS160 is localized to GLUT4-containing vesicles via its interaction with IRAP where it inhibits the activity of Rab substrates in its vicinity, effectively tethering the vesicles intracellularly...
  17. ncbi request reprint Oxytocinase/insulin-regulated aminopeptidase is distributed throughout the sheep, female reproductive tract and is regulated by oestrogen in the uterus
    Tomris Mustafa
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria 3010, Australia
    Regul Pept 122:85-9. 2004
    ..05) in the level of IRAP in the outer myometrium. These findings indicate an important role for IRAP in reproductive physiology in regulating the action of peptide hormones...
  18. pmc Different cross-presentation pathways in steady-state and inflammatory dendritic cells
    Elodie Segura
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 106:20377-81. 2009
    ..These results demonstrate that the mechanisms responsible for cross-priming by steady-state and inflammatory DC are different, which has important implications for vaccine design...
  19. ncbi request reprint Distribution and cellular localization of insulin-regulated aminopeptidase in the rat central nervous system
    Ruani N Fernando
    Howard Florey Institute of Experimental Medicine and Physiology, The University of Melbourne, Parkville, Victoria 3010, Australia
    J Comp Neurol 487:372-90. 2005
    ....
  20. ncbi request reprint Effect of fimbria-fornix lesion on 125I-angiotensin IV (Ang IV) binding in the guinea pig hippocampus
    Joohyung Lee
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Victoria 3010, Parkville, Australia
    Brain Res 979:7-14. 2003
    ..003) of the rostral hippocampus. No other changes in 125I-Ang IV binding were observed. These results provide evidence that the majority of AT(4) receptor binding occurs in a post-synaptic locus in the guinea pig hippocampus...
  21. ncbi request reprint AT4 receptor is insulin-regulated membrane aminopeptidase: potential mechanisms of memory enhancement
    Anthony L Albiston
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, VIC 3010, Australia
    Trends Endocrinol Metab 14:72-7. 2003
    ..Here, we explore the potential mechanisms by which Ang IV binding to IRAP leads to the facilitation of learning and memory...
  22. ncbi request reprint Alzheimer's, angiotensin IV and an aminopeptidase
    Anthony Lloyd Albiston
    Howard Florey Institute, The University of Melbourne, Parkville, Victoria, Australia
    Biol Pharm Bull 27:765-7. 2004
    ..Both Ang IV and LVV-H7 are competitive inhibitors of IRAP catalytic activity and are not substrates of the enzyme...
  23. ncbi request reprint GLUT4 associated proteins as therapeutic targets for diabetes
    Broden J Morgan
    Florey Neurosciences Institutes, University of Melbourne, Parkville, Victoria, 3010, Australia
    Recent Pat Endocr Metab Immune Drug Discov 5:25-32. 2011
    ..Inventions in this area include methods and agents to translocate GLUT4 to the plasma membrane independent of insulin and methods to increase the level of GLUT4 in insulin responsive cells...