Christine F Carson

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. ncbi request reprint Safety, efficacy and provenance of tea tree (Melaleuca alternifolia) oil
    C F Carson
    Department of Microbiology, The University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands WA 6009, Australia
    Contact Dermatitis 45:65-7. 2001
  2. ncbi request reprint Use of deception to achieve double-blinding in a clinical trial of Melaleuca alternifolia (tea tree) oil for the treatment of recurrent herpes labialis
    Christine F Carson
    Microbiology and Immunology Discipline, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, Australia
    Contemp Clin Trials 29:9-12. 2008
  3. pmc Mechanism of action of Melaleuca alternifolia (tea tree) oil on Staphylococcus aureus determined by time-kill, lysis, leakage, and salt tolerance assays and electron microscopy
    Christine F Carson
    Department of Microbiology, The University of Western Australia, Crawley
    Antimicrob Agents Chemother 46:1914-20. 2002
  4. pmc Effects of Melaleuca alternifolia (tea tree) essential oil and the major monoterpene component terpinen-4-ol on the development of single- and multistep antibiotic resistance and antimicrobial susceptibility
    Katherine A Hammer
    Discipline of Microbiology and Immunology, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Crawley, Western Australia 6009, Australia
    Antimicrob Agents Chemother 56:909-15. 2012
  5. doi request reprint Frequencies of resistance to Melaleuca alternifolia (tea tree) oil and rifampicin in Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis
    Katherine A Hammer
    Discipline of Microbiology and Immunology, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, WA, Australia
    Int J Antimicrob Agents 32:170-3. 2008
  6. pmc Role of the MexAB-OprM efflux pump of Pseudomonas aeruginosa in tolerance to tea tree (Melaleuca alternifolia) oil and its monoterpene components terpinen-4-ol, 1,8-cineole, and alpha-terpineol
    Chelsea J Papadopoulos
    Discipline of Microbiology and Immunology M502, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley, Western Australia 6009, Australia
    Appl Environ Microbiol 74:1932-5. 2008
  7. ncbi request reprint Susceptibility of pseudomonads to Melaleuca alternifolia (tea tree) oil and components
    Chelsea J Papadopoulos
    Microbiology and Immunology Discipline, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    J Antimicrob Chemother 58:449-51. 2006
  8. ncbi request reprint Tolerance of Pseudomonas aeruginosa to Melaleuca alternifolia (tea tree) oil is associated with the outer membrane and energy-dependent cellular processes
    Chelsea J Longbottom
    Microbiology Discipline M502, School of Biomedical and Chemical Sciences, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009
    J Antimicrob Chemother 54:386-92. 2004
  9. doi request reprint Antimicrobial and anti-inflammatory activity of five Taxandria fragrans oils in vitro
    Katherine A Hammer
    Discipline of Microbiology and Immunology, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Crawley, WA, Australia
    Microbiol Immunol 52:522-30. 2008
  10. doi request reprint Induction of necrosis and cell cycle arrest in murine cancer cell lines by Melaleuca alternifolia (tea tree) oil and terpinen-4-ol
    S J Greay
    Discipline of Microbiology and Immunology M502, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    Cancer Chemother Pharmacol 65:877-88. 2010

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Safety, efficacy and provenance of tea tree (Melaleuca alternifolia) oil
    C F Carson
    Department of Microbiology, The University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands WA 6009, Australia
    Contact Dermatitis 45:65-7. 2001
    ..The identity, sources and composition of tea tree (Melaleuca alternifolia) oil are discussed, and earlier errors in the literature indicated. Reports of both therapeutic and allergenic effects are reviewed...
  2. ncbi request reprint Use of deception to achieve double-blinding in a clinical trial of Melaleuca alternifolia (tea tree) oil for the treatment of recurrent herpes labialis
    Christine F Carson
    Microbiology and Immunology Discipline, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, Australia
    Contemp Clin Trials 29:9-12. 2008
    ..Among the volunteers that were not treated, the P-value was 0.083. This study showed that the ethical use of deception may provide effective blinding in challenging circumstances...
  3. pmc Mechanism of action of Melaleuca alternifolia (tea tree) oil on Staphylococcus aureus determined by time-kill, lysis, leakage, and salt tolerance assays and electron microscopy
    Christine F Carson
    Department of Microbiology, The University of Western Australia, Crawley
    Antimicrob Agents Chemother 46:1914-20. 2002
    ....
  4. pmc Effects of Melaleuca alternifolia (tea tree) essential oil and the major monoterpene component terpinen-4-ol on the development of single- and multistep antibiotic resistance and antimicrobial susceptibility
    Katherine A Hammer
    Discipline of Microbiology and Immunology, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Crawley, Western Australia 6009, Australia
    Antimicrob Agents Chemother 56:909-15. 2012
    ..Overall, these data indicate that tea tree oil and terpinen-4-ol have little impact on the development of antimicrobial resistance and susceptibility...
  5. doi request reprint Frequencies of resistance to Melaleuca alternifolia (tea tree) oil and rifampicin in Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis
    Katherine A Hammer
    Discipline of Microbiology and Immunology, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, WA, Australia
    Int J Antimicrob Agents 32:170-3. 2008
    ..aureus mutator strains, which had slightly higher frequencies. These data suggest that Gram-positive organisms such as Staphylococcus and Enterococcus spp. have very low frequencies of resistance to tea tree oil...
  6. pmc Role of the MexAB-OprM efflux pump of Pseudomonas aeruginosa in tolerance to tea tree (Melaleuca alternifolia) oil and its monoterpene components terpinen-4-ol, 1,8-cineole, and alpha-terpineol
    Chelsea J Papadopoulos
    Discipline of Microbiology and Immunology M502, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley, Western Australia 6009, Australia
    Appl Environ Microbiol 74:1932-5. 2008
    ..These data show that a multidrug efflux system of P. aeruginosa can extrude monoterpenes and related alcohols...
  7. ncbi request reprint Susceptibility of pseudomonads to Melaleuca alternifolia (tea tree) oil and components
    Chelsea J Papadopoulos
    Microbiology and Immunology Discipline, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    J Antimicrob Chemother 58:449-51. 2006
    ....
  8. ncbi request reprint Tolerance of Pseudomonas aeruginosa to Melaleuca alternifolia (tea tree) oil is associated with the outer membrane and energy-dependent cellular processes
    Chelsea J Longbottom
    Microbiology Discipline M502, School of Biomedical and Chemical Sciences, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009
    J Antimicrob Chemother 54:386-92. 2004
    ..The mechanism(s) by which Pseudomonas aeruginosa NCTC 10662 maintains a decreased susceptibility to tea tree oil and components was investigated...
  9. doi request reprint Antimicrobial and anti-inflammatory activity of five Taxandria fragrans oils in vitro
    Katherine A Hammer
    Discipline of Microbiology and Immunology, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Crawley, WA, Australia
    Microbiol Immunol 52:522-30. 2008
    ..In conclusion, T. fragrans oil showed both antimicrobial and anti-inflammatory activity in vitro, however, the clinical relevance of this remains to be determined...
  10. doi request reprint Induction of necrosis and cell cycle arrest in murine cancer cell lines by Melaleuca alternifolia (tea tree) oil and terpinen-4-ol
    S J Greay
    Discipline of Microbiology and Immunology M502, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    Cancer Chemother Pharmacol 65:877-88. 2010
    ..To examine the in vitro anticancer activity of Melaleuca alternifolia (tea tree) oil (TTO), and its major active terpene component, terpinen-4-ol, against two aggressive murine tumour cell lines, AE17 mesothelioma and B16 melanoma...
  11. pmc Melaleuca alternifolia (Tea Tree) oil: a review of antimicrobial and other medicinal properties
    C F Carson
    Microbiology and Immunology M502, School of Biomedical and Chemical Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley, Western Australia 6009, Australia
    Clin Microbiol Rev 19:50-62. 2006
    ..Specific mechanisms of antimicrobial and anti-inflammatory action are reviewed, and the toxicity of the oil is briefly discussed...
  12. ncbi request reprint A review of the toxicity of Melaleuca alternifolia (tea tree) oil
    K A Hammer
    Microbiology and Immunology M502, School of Biomedical and Chemical Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley, WA 6009, Australia
    Food Chem Toxicol 44:616-25. 2006
    ..The limited ecotoxicity data available indicate that TTO is toxic to some insect species but more studies are required...
  13. ncbi request reprint Effectiveness of hand-cleansing formulations containing tea tree oil assessed ex vivo on human skin and in vivo with volunteers using European standard EN 1499
    S Messager
    Discipline of Microbiology, School of Biomedical and Chemical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley WA 6009, Australia
    J Hosp Infect 59:220-8. 2005
    ..TTO in Tween 80 and in formulations met the European in-vivo method requirements...
  14. ncbi request reprint In vitro susceptibility of Malassezia furfur to the essential oil of Melaleuca alternifolia
    K A Hammer
    Department of Microbiology, University of Western Australia, Nedlands
    J Med Vet Mycol 35:375-7. 1997
    ..The minimum inhibitory concentration for 90% of isolates was 0.25% by agar dilution and 0.12% by broth dilution. These data indicate that tea tree oil may be useful in the treatment of skin conditions involving M. furfur...
  15. ncbi request reprint Melaleuca alternifolia (tea tree) oil inhibits germ tube formation by Candida albicans
    K A Hammer
    Department of Microbiology, The University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands
    Med Mycol 38:355-62. 2000
    ..25% differed significantly from control cells at later time points (P < 0.01). GTF by C. albicans is affected by the presence of, or pre-exposure to, sub-inhibitory concentrations of TTO. This may have therapeutic implications...
  16. ncbi request reprint Antifungal effects of Melaleuca alternifolia (tea tree) oil and its components on Candida albicans, Candida glabrata and Saccharomyces cerevisiae
    K A Hammer
    Microbiology Discipline, School of Biomedical and Chemical Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley
    J Antimicrob Chemother 53:1081-5. 2004
    ..The aim of this study was to investigate the mechanism of action of tea tree oil and its components against Candida albicans, Candida glabrata and Saccharomyces cerevisiae...
  17. ncbi request reprint Susceptibility of oral bacteria to Melaleuca alternifolia (tea tree) oil in vitro
    K A Hammer
    Discipline of Microbiology, School of Biomedical and Chemical Sciences, The University of Western Australia, Crawley, Western Australia, Australia
    Oral Microbiol Immunol 18:389-92. 2003
    ..These studies indicate that a range of oral bacteria are susceptible to tea tree oil, suggesting that tea tree oil may be of use in oral healthcare products and in the maintenance of oral hygiene...
  18. ncbi request reprint Antifungal activity of the components of Melaleuca alternifolia (tea tree) oil
    K A Hammer
    Discipline of Microbiology, School of Biomedical and Chemical Sciences, The University of Western Australia, Crawley, WA, Australia
    J Appl Microbiol 95:853-60. 2003
    ..To investigate the in vitro antifungal activity of the components of Melaleuca alternifolia (tea tree) oil...
  19. ncbi request reprint Influence of organic matter, cations and surfactants on the antimicrobial activity of Melaleuca alternifolia (tea tree) oil in vitro
    K A Hammer
    Department of Microbiology, University of Western Australia, Nedlands, Western Australia
    J Appl Microbiol 86:446-52. 1999
    ..In conclusion, organic matter and surfactants compromise the antimicrobial activity of tea tree oil, although these effects vary between organisms...
  20. ncbi request reprint In vitro activity of Melaleuca alternifolia (tea tree) oil against dermatophytes and other filamentous fungi
    K A Hammer
    Department of Microbiology, The University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, Western Australia 6009, Australia
    J Antimicrob Chemother 50:195-9. 2002
    ..These data demonstrate that tea tree oil has both inhibitory and fungicidal activity...
  21. ncbi request reprint Antimicrobial activity of essential oils and other plant extracts
    K A Hammer
    Department of Microbiology, The University of Western Australia, Nedlands, Western Australia
    J Appl Microbiol 86:985-90. 1999
    ..03% (v/v) thyme oil against C. albicans and E. coli and 0.008% (v/v) vetiver oil against Staph. aureus. These results support the notion that plant essential oils and extracts may have a role as pharmaceuticals and preservatives...
  22. ncbi request reprint Prevalence of delayed hypersensitivity to the European standard series in a self-selected population
    J E Greig
    Department of Microbiology, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, Australia
    Australas J Dermatol 41:86-9. 2000
    ....
  23. pmc In vitro activities of ketoconazole, econazole, miconazole, and Melaleuca alternifolia (tea tree) oil against Malassezia species
    K A Hammer
    Department of Microbiology, The University of Western Australia, Nedlands, Australia
    Antimicrob Agents Chemother 44:467-9. 2000
    ..M. furfur was the least susceptible species. M. sympodialis, M. slooffiae, M. globosa, and M. obtusa showed similar susceptibilities to the four agents...
  24. doi request reprint Candida albicans adhesion to human epithelial cells and polystyrene and formation of biofilm is reduced by sub-inhibitory Melaleuca alternifolia (tea tree) essential oil
    Aurelia N Sudjana
    Discipline of Microbiology and Immunology M502, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Crawley, Western Australia, Australia
    Med Mycol 50:863-70. 2012
    ..These data demonstrate that sub-inhibitory TTO reduces the adhesion of C. albicans to both human cells and polystyrene, inhibits biofilm formation and decreases cell surface hydrophobicity...
  25. doi request reprint Inhibition of established subcutaneous murine tumour growth with topical Melaleuca alternifolia (tea tree) oil
    Sara J Greay
    Discipline of Microbiology and Immunology M502, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    Cancer Chemother Pharmacol 66:1095-102. 2010
    ..Here, we show for the first time that topical Melaleuca alternifolia (tea tree) oil (TTO), abundant in terpenes, has in vivo antitumour activity...
  26. ncbi request reprint Assessment of the antibacterial activity of tea tree oil using the European EN 1276 and EN 12054 standard suspension tests
    S Messager
    Discipline of Microbiology, School of Biomedical and Chemical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley WA 6009, Australia
    J Hosp Infect 59:113-25. 2005
    ..The formulations used in this study are now being tested using a novel ex vivo method as well as the in vivo European standard handwashing method EN 1499...
  27. ncbi request reprint Non-antibiotic therapies for infectious diseases
    Christine F Carson
    Department of Microbiology, The University of Western Australia, Crawley, Western Australia
    Commun Dis Intell 27:S143-6. 2003
    ..Many infections may prove amenable to safe and effective treatment with non-antibiotics...