I G Campbell

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi request reprint LCC15-MB cells are MDA-MB-435: a review of misidentified breast and prostate cell lines
    Erik W Thompson
    Invasion and Metastasis Unit, University of Melbourne, Department of Surgery, St Vincent s Hospital, 29 Regent St, Fitzroy, 3065, Australia
    Clin Exp Metastasis 21:535-41. 2004
  2. ncbi request reprint Prohibitin 3' untranslated region polymorphism and breast cancer risk
    Ian G Campbell
    VBCRC Cancer Genetics Laboratory, Centre for Cancer Genomics and Predictive Medicine, Peter MacCallum Cancer Centre, St Andrew s Place, East Melbourne, Victoria, Australia
    Cancer Epidemiol Biomarkers Prev 12:1273-4. 2003
  3. pmc Methylenetetrahydrofolate reductase polymorphism and susceptibility to breast cancer
    Ian G Campbell
    VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne, Victoria, 3002, Australia
    Breast Cancer Res 4:R14. 2002
  4. ncbi request reprint Endometriosis: candidate genes
    I G Campbell
    VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Institute, Victoria, Australia
    Hum Reprod Update 7:15-20. 2001
  5. ncbi request reprint GSTM1 null polymorphism and susceptibility to endometriosis and ovarian cancer
    S W Baxter
    VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Institute, Locked Bag No 1 A Beckett St, Victoria 8006, Australia
    Carcinogenesis 22:63-5. 2001
  6. ncbi request reprint Microsomal epoxide hydrolase polymorphism and susceptibility to ovarian cancer
    S W Baxter
    VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Institute, Locked Bag No 1 A Beckett Street, Melbourne, Victoria, 8006, Australia
    Cancer Lett 177:75-81. 2002
  7. ncbi request reprint Polymorphic variation in CYP19 and the risk of breast cancer
    S W Baxter
    VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Institute, Locked Bag No 1 A Beckett St, Victoria 8006, Australia
    Carcinogenesis 22:347-9. 2001
  8. ncbi request reprint Mutation of the ST7 tumor suppressor gene on 7q31.1 is rare in breast, ovarian and colorectal cancers
    N A Thomas
    Cancer Genetics Laboratory, Victorian Breast Cancer Research Consortium, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne, Victoria 3002, Australia
    Nat Genet 29:379-80. 2001
  9. ncbi request reprint The phosphatidylinositol 3'-kinase p85alpha gene is an oncogene in human ovarian and colon tumors
    A J Philp
    Surgical Oncology Research Laboratory, Peter MacCallum Cancer Institute, Melbourne, Victoria 3002, Australia
    Cancer Res 61:7426-9. 2001
  10. ncbi request reprint Changes in gene expressions elicited by physiological concentrations of genistein on human endometrial cancer cells
    N Konstantakopoulos
    Gynaecological Cancer Research Centre, Royal Women s Hospital, Carlton, Victoria, Australia
    Mol Carcinog 45:752-63. 2006

Collaborators

Detail Information

Publications39

  1. ncbi request reprint LCC15-MB cells are MDA-MB-435: a review of misidentified breast and prostate cell lines
    Erik W Thompson
    Invasion and Metastasis Unit, University of Melbourne, Department of Surgery, St Vincent s Hospital, 29 Regent St, Fitzroy, 3065, Australia
    Clin Exp Metastasis 21:535-41. 2004
    ..We also review the known misclassification of breast and prostate cancer cell lines to date and have initiated a register maintained at http://www.svi.edu.au/cell_lines_registry.doc...
  2. ncbi request reprint Prohibitin 3' untranslated region polymorphism and breast cancer risk
    Ian G Campbell
    VBCRC Cancer Genetics Laboratory, Centre for Cancer Genomics and Predictive Medicine, Peter MacCallum Cancer Centre, St Andrew s Place, East Melbourne, Victoria, Australia
    Cancer Epidemiol Biomarkers Prev 12:1273-4. 2003
  3. pmc Methylenetetrahydrofolate reductase polymorphism and susceptibility to breast cancer
    Ian G Campbell
    VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne, Victoria, 3002, Australia
    Breast Cancer Res 4:R14. 2002
    ....
  4. ncbi request reprint Endometriosis: candidate genes
    I G Campbell
    VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Institute, Victoria, Australia
    Hum Reprod Update 7:15-20. 2001
    ..Studies aimed at identifying the predisposing genes are still in their infancy but should eventually provide invaluable insights into the pathology and aetiology of endometriosis...
  5. ncbi request reprint GSTM1 null polymorphism and susceptibility to endometriosis and ovarian cancer
    S W Baxter
    VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Institute, Locked Bag No 1 A Beckett St, Victoria 8006, Australia
    Carcinogenesis 22:63-5. 2001
    ..0%, P = 0.004). We conclude that the GSTM1 null allele is not an endometriosis susceptibility allele, however, it may predispose endometriotic lesions to malignant transformation to endometrioid and clear cell ovarian cancer...
  6. ncbi request reprint Microsomal epoxide hydrolase polymorphism and susceptibility to ovarian cancer
    S W Baxter
    VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Institute, Locked Bag No 1 A Beckett Street, Melbourne, Victoria, 8006, Australia
    Cancer Lett 177:75-81. 2002
    ..Furthermore previous disease association studies of exon 3 alleles which utilized the PCR-RFLP assay may be compromised by the existence of a codon 119 G>A polymorphism which may be common in Caucasian populations...
  7. ncbi request reprint Polymorphic variation in CYP19 and the risk of breast cancer
    S W Baxter
    VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Institute, Locked Bag No 1 A Beckett St, Victoria 8006, Australia
    Carcinogenesis 22:347-9. 2001
    ..00). The CYP19 intron 4 [TTTA]n repeat is unlikely to have a functional effect on aromatase activity and it is more likely that the [TTTA](8) and [TTTA](10) variants are in linkage disequilibrium with other functional CYP19 variants...
  8. ncbi request reprint Mutation of the ST7 tumor suppressor gene on 7q31.1 is rare in breast, ovarian and colorectal cancers
    N A Thomas
    Cancer Genetics Laboratory, Victorian Breast Cancer Research Consortium, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne, Victoria 3002, Australia
    Nat Genet 29:379-80. 2001
    ..These data suggest that epigenetic downregulation or haploinsufficiency, rather than somatic genetic alterations, may be the primary mechanism of abrogation of ST7 function in these tumor types...
  9. ncbi request reprint The phosphatidylinositol 3'-kinase p85alpha gene is an oncogene in human ovarian and colon tumors
    A J Philp
    Surgical Oncology Research Laboratory, Peter MacCallum Cancer Institute, Melbourne, Victoria 3002, Australia
    Cancer Res 61:7426-9. 2001
    ..Expression of a mutant protein with a 23 amino acid deletion leads to constitutive activation of PI3k providing the first direct evidence that p85alpha is a new oncogene involved in human tumorigenesis...
  10. ncbi request reprint Changes in gene expressions elicited by physiological concentrations of genistein on human endometrial cancer cells
    N Konstantakopoulos
    Gynaecological Cancer Research Centre, Royal Women s Hospital, Carlton, Victoria, Australia
    Mol Carcinog 45:752-63. 2006
    ..Supraphysiological concentrations of genistein, such as those used in many previous studies, elicit changes in gene expression that are unlikely to occur in vivo...
  11. ncbi request reprint ST7-mediated suppression of tumorigenicity of prostate cancer cells is characterized by remodeling of the extracellular matrix
    Cs F Hooi
    VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Oncogene 25:3924-33. 2006
    ..These data indicate that ST7 may mediate tumor suppression through modification of the tumor microenvironment...
  12. pmc A novel duplication polymorphism in the FANCA promoter and its association with breast and ovarian cancer
    Ella Thompson
    Department of Pathology, Peter MacCallum Cancer Centre, Locked Bag 1 A Beckett St, Melbourne, Victoria 8006, Australia
    BMC Cancer 5:43. 2005
    ..FANCA is also a potential breast and ovarian cancer susceptibility gene. A novel allele was identified which has a tandem duplication of a 13 base pair sequence in the promoter region...
  13. pmc The AIB1 glutamine repeat polymorphism is not associated with risk of breast cancer before age 40 years in Australian women
    Karen G Montgomery
    Cancer Genetics Laboratory, Victorian Breast Cancer Research Consortium, Peter MacCallum Cancer Centre, St, Andrews Place, East Melbourne, Victoria, Australia
    Breast Cancer Res 7:R353-6. 2005
    ..It contains a glutamine repeat (CAG/CAA) polymorphism at its carboxyl-terminal region that may alter the transcriptional activation of the receptor and affect susceptibility to breast cancer through altered sensitivity to hormones...
  14. ncbi request reprint Differential hypermethylation of SOCS genes in ovarian and breast carcinomas
    Kate D Sutherland
    The Walter and Eliza Hall Institute of Medical Research and Bone Marrow Research Laboratories, Royal Melbourne Hospital, Parkville, VIC 3050, Australia
    Oncogene 23:7726-33. 2004
    ..Hypermethylation and silencing of specific SOCS genes in the ovary, and to a lesser extent in breast, may augment cytokine responsiveness in these tissues, thereby contributing to oncogenesis...
  15. pmc The DNMT3B C-->T promoter polymorphism and risk of breast cancer in a British population: a case-control study
    Karen G Montgomery
    Victorian Breast Cancer Research Consortium, Cancer Genetics Laboratory, Peter MacCallum Cancer Center, East Melbourne, Victoria, Australia
    Breast Cancer Res 6:R390-4. 2004
    ....
  16. ncbi request reprint Common origins of MDA-MB-435 cells from various sources with those shown to have melanoma properties
    James M Rae
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Clin Exp Metastasis 21:543-52. 2004
    ..Collectively, our results show that the MDA-MB-435 cells used widely have identical origins to those that exhibit a melanoma-like gene expression signature, but exhibit a small degree of genotypic and phenotypic drift...
  17. ncbi request reprint The HER2 I655V polymorphism and risk of breast cancer in women < age 40 years
    Karen G Montgomery
    Cancer Genetics Laboratory, Victorian Breast Cancer Research Consortium, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne, Victoria 3002, Australia
    Cancer Epidemiol Biomarkers Prev 12:1109-11. 2003
    ..3-6.2; P = 0.005), gave the best fit under parsimony. Although the biological role of the I655V polymorphism is not known, large independent studies of early onset breast cancer are warranted to attempt to replicate this finding...
  18. ncbi request reprint Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas
    Kate D Sutherland
    The Walter and Eliza Hall Institute of Medical Research and Bone Marrow Research Laboratories, Parkville, Australia
    Int J Cancer 107:155-8. 2003
    ..Thus, the primary mechanism by which LMO4 is deregulated in breast cancers appears to reflect overexpression of the gene rather than the acquisition of activating genetic mutations...
  19. ncbi request reprint BARD1 variants are not associated with breast cancer risk in Australian familial breast cancer
    Kylie L Gorringe
    Peter MacCallum Cancer Centre, East Melbourne, Vic, 8006, Australia
    Breast Cancer Res Treat 111:505-9. 2008
    ....
  20. ncbi request reprint Genome-wide, high-resolution detection of copy number, loss of heterozygosity, and genotypes from formalin-fixed, paraffin-embedded tumor tissue using microarrays
    Sharoni Jacobs
    Affymetrix, Inc, Santa Clara, California 95051, USA
    Cancer Res 67:2544-51. 2007
    ....
  21. ncbi request reprint Genetic and epigenetic analysis of the putative tumor suppressor km23 in primary ovarian, breast, and colorectal cancers
    Ian G Campbell
    Victorian Breast Cancer Research Consortium Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, 8006, Australia
    Clin Cancer Res 12:3713-5. 2006
    ..If verified, this would elevate mutation of km23 as the single most frequent somatic event in ovarian cancer...
  22. pmc No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas
    Wen Qiu
    VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    Nat Genet 40:650-5. 2008
    ..Our data show conclusively that LOH and copy number alterations are extremely rare in CAFs and cannot be the basis of the carcinoma-promoting phenotypes of breast and ovarian CAFs...
  23. doi request reprint Breast-cancer stromal cells with TP53 mutations
    Ian G Campbell
    N Engl J Med 358:1634-5; author reply 1636. 2008
  24. ncbi request reprint Genetic and epigenetic analysis of CHEK2 in sporadic breast, colon, and ovarian cancers
    Louise H Williams
    Victorian Breast Cancer Research Consortium Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Clin Cancer Res 12:6967-72. 2006
    ..The aim of this study was to determine if somatic mutation and/or epigenetic modification play a role in development of sporadic breast, colon, or ovarian cancers...
  25. ncbi request reprint Genetic and epigenetic analysis of the TIMP-3 gene in ovarian cancer
    Mira C P Liu
    Cancer Genetics Laboratory, Victorian Breast Cancer Research Consortium, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Vic, Australia
    Cancer Lett 247:91-7. 2007
    ..Our data indicate that inactivation of TIMP-3 by somatic mutation or promoter hypermethylation is rare in ovarian cancer...
  26. ncbi request reprint Loss of heterozygosity analysis in ductal lavage samples from BRCA1 and BRCA2 carriers: a cautionary tale
    Yoland C Antill
    Victorian Breast Cancer Research Consortium Cancer Genetics Laboratory, Melbourne, Australia
    Cancer Epidemiol Biomarkers Prev 15:1396-8. 2006
    ..Interpretation of LOH is reliant on sufficient quality and quantity of DNA. We investigated LOH of the BRCA1/2 loci in DL samples from BRCA1/2 mutation carriers, while also assessing the effect of DNA quantity...
  27. ncbi request reprint No association of the MDM2 SNP309 polymorphism with risk of breast or ovarian cancer
    Ian G Campbell
    VBCRC Cancer Genetics Laboratory, Centre for Cancer Genomics and Predictive Medicine, Peter MacCallum Cancer Centre, St Andrew s Place, East Melbourne, Victoria 3002, Australia
    Cancer Lett 240:195-7. 2006
    ..04, 95% CI 0.67-1.60) or ovarian cancer (OR 0.86, 95% CI 0.53-1.37). This study has found no evidence that the GG genotype of the MDM2 SNP309 polymorphism is associated with early onset or familial breast cancer or with ovarian cancer...
  28. ncbi request reprint PIK3CA mutations in ovarian cancer
    Ian G Campbell
    Clin Cancer Res 11:7042; author reply 7042-3. 2005
  29. ncbi request reprint Transforming growth factor beta receptor 1 polyalanine polymorphism and exon 5 mutation analysis in breast and ovarian cancer
    Simon W Baxter
    Cancer Genetics Laboratory, Victorian Breast Cancer Research Consortium, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne, Victoria 3002, Australia
    Cancer Epidemiol Biomarkers Prev 11:211-4. 2002
  30. ncbi request reprint DNA microarrays for assessing ovarian cancer gene expression
    Izhak Haviv
    Signal Transduction Laboratory, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne, VIC 3002, Australia
    Mol Cell Endocrinol 191:121-6. 2002
    ..In this review, we describe the technical aspects of DNA microarray analysis and some of the current and future applications of this technology for analysing gene expression in ovarian cancer...
  31. ncbi request reprint Mutation analysis of EP300 in colon, breast and ovarian carcinomas
    Emma J Bryan
    VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Institute, Locked Bag No 1 A Beckett Street, East Melbourne, Victoria, Australia
    Int J Cancer 102:137-41. 2002
    ..Alternatively, silencing of EP300 may be achieved by epigenetic mechanisms such as promoter methylation...
  32. ncbi request reprint Genetic analysis of benign ovarian tumors
    Nicola A Thomas
    VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Institute, East Melbourne, Australia
    Int J Cancer 105:499-505. 2003
    ..It does however provide a framework for future analysis of the molecular genetic etiology of ovarian tumorigenesis...
  33. ncbi request reprint Mutation analysis of CDP, TP53, and KRAS in uterine leiomyomas
    Maria I Patrikis
    Department of Obstetrics and Gynaecology, Gynaecological Cancer Research Centre, University of Melbourne, Royal Women s Hospital, Carlton, Victoria, Australia
    Mol Carcinog 37:61-4. 2003
    ..It is possible that CDP belongs to a class of tumor suppressor in which loss of only one copy of the gene, either by genetic or epigenetic mechanisms, is sufficient to allow tumor growth...
  34. ncbi request reprint EDD, the human orthologue of the hyperplastic discs tumour suppressor gene, is amplified and overexpressed in cancer
    Jennifer L Clancy
    Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW 2010, Australia
    Oncogene 22:5070-81. 2003
    ..These results demonstrate that AI at the EDD locus is common in a diversity of carcinomas and that the EDD gene is frequently overexpressed in breast and ovarian cancer, implying a potential role in cancer progression...
  35. pmc No germline mutations in the histone acetyltransferase gene EP300 in BRCA1 and BRCA2 negative families with breast cancer and gastric, pancreatic, or colorectal cancer
    Ian G Campbell
    Victorian Breast Cancer Research Consortium Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Victoria, Australia
    Breast Cancer Res 6:R366-71. 2004
    ..We hypothesized that germline mutations in EP300 may account for some breast cancer families that include cases of gastric, pancreatic and/or colorectal cancer...
  36. ncbi request reprint Concentric left ventricular morphology in aerobically trained kayak canoeists
    Phillip E Gates
    Department of Exercise and Sport Science, The Manchester Metropolitan University, Alsager Faculty, Alsager ST7 2HL, UK
    J Sports Sci 22:859-65. 2004
    ..Thus aerobically upper body trained athletes demonstrated a concentric pattern of cardiac enlargement, but resting left ventricle function was not different between athletes, moderately active and sedentary individuals...
  37. ncbi request reprint Mutation of the PIK3CA gene in ovarian and breast cancer
    Ian G Campbell
    VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    Cancer Res 64:7678-81. 2004
    ..5% of all ovarian cancers and 45% of the endometrioid and clear cell subtypes. Our study is the first direct evidence that PIK3CA is an oncogene in ovarian cancer and greatly extends recent findings in breast cancer...
  38. ncbi request reprint Oncolysis of human ovarian cancers by echovirus type 1
    Darren R Shafren
    Picornaviral Research Unit, School of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Newcastle, Newcastle, New South Wales, Australia
    Int J Cancer 115:320-8. 2005
    ..These findings demonstrate an important proof of principle for employing wild-type EV1 as a potential oncolytic agent in the control of human ovarian cancers...
  39. pmc A rational approach to cancer therapy
    Kylie L Gorringe
    VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    Genome Biol 9:306. 2008