Murray J Cairns
Affiliation: University of Newcastle
Reay W, Atkins J, Quidé Y, Carr V, Green M, Cairns M. Polygenic disruption of retinoid signalling in schizophrenia and a severe cognitive deficit subtype. Mol Psychiatry. 2018;: pubmed publisher
..Our results suggest that genomic variation may disrupt retinoid signalling in schizophrenia, with particular significance for cases with severe cognitive impairment. ..
Wang X, Gardiner E, Cairns M. Optimal consistency in microRNA expression analysis using reference-gene-based normalization. Mol Biosyst. 2015;11:1235-40 pubmed publisher
Wang X, Cairns M. Understanding complex transcriptome dynamics in schizophrenia and other neurological diseases using RNA sequencing. Int Rev Neurobiol. 2014;116:127-52 pubmed publisher
Geaghan M, Cairns M. MicroRNA and Posttranscriptional Dysregulation in Psychiatry. Biol Psychiatry. 2015;78:231-9 pubmed publisher
..We further assess the functional roles of some outstanding miRNAs associated with these conditions and how they may be influencing the development of psychiatric symptoms. ..
Cairns M, Thomas T, Beltran C, Tillett D. Primer fabrication using polymerase mediated oligonucleotide synthesis. BMC Genomics. 2009;10:344 pubmed publisher
..On the basis of these experiments, we believe this novel system would be broadly applicable and could in many circumstances replace the need for conventional oligonucleotide synthesis. ..
Liu B, Li J, Cairns M. Identifying miRNAs, targets and functions. Brief Bioinform. 2014;15:1-19 pubmed publisher
..We also briefly introduce the research in miRNA discovery and miRNA-target identification with an emphasis on the challenges to computational biology. ..
Hollins S, Goldie B, Carroll A, Mason E, Walker F, Eyles D, et al
. Ontogeny of small RNA in the regulation of mammalian brain development. BMC Genomics. 2014;15:777 pubmed publisher
..Our findings suggest that miRNA have significant implications for the development of neural structure and support important mechanisms that if disrupted, may contribute to or drive neurodevelopmental disorders. ..
Wu J, Green M, Gardiner E, Tooney P, Scott R, Carr V, et al
. Altered neural signaling and immune pathways in peripheral blood mononuclear cells of schizophrenia patients with cognitive impairment: A transcriptome analysis. Brain Behav Immun. 2016;53:194-206 pubmed publisher
Hollins S, Zavitsanou K, Walker F, Cairns M. Alteration of transcriptional networks in the entorhinal cortex after maternal immune activation and adolescent cannabinoid exposure. Brain Behav Immun. 2016;56:187-96 pubmed publisher