Murray J Cairns
Affiliation: University of Newcastle
Mahmoudi E, Fitzsimmons C, Geaghan M, Shannon Weickert C, Atkins J, Wang X, et al
. Circular RNA biogenesis is decreased in postmortem cortical gray matter in schizophrenia and may alter the bioavailability of associated miRNA. Neuropsychopharmacology. 2019;: pubmed publisher
..Given their capacity for modulating miRNA function, circRNA may play a significant role in the pathophysiology of disease and even be targeted for therapeutic manipulation. ..
Mahmoudi E, Cairns M. Circular RNAs are temporospatially regulated throughout development and ageing in the rat. Sci Rep. 2019;9:2564 pubmed publisher
..These observations suggest that circRNAs are dynamically expressed in a spatial-, temporal- and gender-specific manner in mammals, and may have important biological function in differentiation, development and aging. ..
Geaghan M, Atkins J, Brichta A, Tooney P, Scott R, Carr V, et al
. Alteration of miRNA-mRNA interactions in lymphocytes of individuals with schizophrenia. J Psychiatr Res. 2019;112:89-98 pubmed publisher
..Interestingly, while we explored expression in lymphocytes, the systems biology of miRNA-mRNA interactions was suggestive of significant pleiotropy with enrichment of networks related to neuronal activity. ..
Reay W, Atkins J, Quidé Y, Carr V, Green M, Cairns M. Polygenic disruption of retinoid signalling in schizophrenia and a severe cognitive deficit subtype. Mol Psychiatry. 2018;: pubmed publisher
..Our results suggest that genomic variation may disrupt retinoid signalling in schizophrenia, with particular significance for cases with severe cognitive impairment. ..
Wang X, Gardiner E, Cairns M. Optimal consistency in microRNA expression analysis using reference-gene-based normalization. Mol Biosyst. 2015;11:1235-40 pubmed publisher
Wang X, Cairns M. Understanding complex transcriptome dynamics in schizophrenia and other neurological diseases using RNA sequencing. Int Rev Neurobiol. 2014;116:127-52 pubmed publisher
Geaghan M, Cairns M. MicroRNA and Posttranscriptional Dysregulation in Psychiatry. Biol Psychiatry. 2015;78:231-9 pubmed publisher
..We further assess the functional roles of some outstanding miRNAs associated with these conditions and how they may be influencing the development of psychiatric symptoms. ..
Cairns M, Thomas T, Beltran C, Tillett D. Primer fabrication using polymerase mediated oligonucleotide synthesis. BMC Genomics. 2009;10:344 pubmed publisher
..On the basis of these experiments, we believe this novel system would be broadly applicable and could in many circumstances replace the need for conventional oligonucleotide synthesis. ..
Liu B, Li J, Cairns M. Identifying miRNAs, targets and functions. Brief Bioinform. 2014;15:1-19 pubmed publisher
..We also briefly introduce the research in miRNA discovery and miRNA-target identification with an emphasis on the challenges to computational biology. ..