Murray J Cairns


Affiliation: University of Newcastle
Country: Australia


  1. Mahmoudi E, Fitzsimmons C, Geaghan M, Shannon Weickert C, Atkins J, Wang X, et al. Circular RNA biogenesis is decreased in postmortem cortical gray matter in schizophrenia and may alter the bioavailability of associated miRNA. Neuropsychopharmacology. 2019;: pubmed publisher
    ..Given their capacity for modulating miRNA function, circRNA may play a significant role in the pathophysiology of disease and even be targeted for therapeutic manipulation. ..
  2. Mahmoudi E, Cairns M. Circular RNAs are temporospatially regulated throughout development and ageing in the rat. Sci Rep. 2019;9:2564 pubmed publisher
    ..These observations suggest that circRNAs are dynamically expressed in a spatial-, temporal- and gender-specific manner in mammals, and may have important biological function in differentiation, development and aging. ..
  3. Geaghan M, Atkins J, Brichta A, Tooney P, Scott R, Carr V, et al. Alteration of miRNA-mRNA interactions in lymphocytes of individuals with schizophrenia. J Psychiatr Res. 2019;112:89-98 pubmed publisher
    ..Interestingly, while we explored expression in lymphocytes, the systems biology of miRNA-mRNA interactions was suggestive of significant pleiotropy with enrichment of networks related to neuronal activity. ..
  4. Reay W, Atkins J, Quidé Y, Carr V, Green M, Cairns M. Polygenic disruption of retinoid signalling in schizophrenia and a severe cognitive deficit subtype. Mol Psychiatry. 2018;: pubmed publisher
    ..Our results suggest that genomic variation may disrupt retinoid signalling in schizophrenia, with particular significance for cases with severe cognitive impairment. ..
  5. Wang X, Gardiner E, Cairns M. Optimal consistency in microRNA expression analysis using reference-gene-based normalization. Mol Biosyst. 2015;11:1235-40 pubmed publisher
  6. Wang X, Cairns M. Understanding complex transcriptome dynamics in schizophrenia and other neurological diseases using RNA sequencing. Int Rev Neurobiol. 2014;116:127-52 pubmed publisher
  7. Geaghan M, Cairns M. MicroRNA and Posttranscriptional Dysregulation in Psychiatry. Biol Psychiatry. 2015;78:231-9 pubmed publisher
    ..We further assess the functional roles of some outstanding miRNAs associated with these conditions and how they may be influencing the development of psychiatric symptoms. ..
  8. Cairns M, Thomas T, Beltran C, Tillett D. Primer fabrication using polymerase mediated oligonucleotide synthesis. BMC Genomics. 2009;10:344 pubmed publisher
    ..On the basis of these experiments, we believe this novel system would be broadly applicable and could in many circumstances replace the need for conventional oligonucleotide synthesis. ..
  9. Liu B, Li J, Cairns M. Identifying miRNAs, targets and functions. Brief Bioinform. 2014;15:1-19 pubmed publisher
    ..We also briefly introduce the research in miRNA discovery and miRNA-target identification with an emphasis on the challenges to computational biology. ..

More Information


  1. Hollins S, Goldie B, Carroll A, Mason E, Walker F, Eyles D, et al. Ontogeny of small RNA in the regulation of mammalian brain development. BMC Genomics. 2014;15:777 pubmed publisher
    ..Our findings suggest that miRNA have significant implications for the development of neural structure and support important mechanisms that if disrupted, may contribute to or drive neurodevelopmental disorders. ..
  2. Wu J, Green M, Gardiner E, Tooney P, Scott R, Carr V, et al. Altered neural signaling and immune pathways in peripheral blood mononuclear cells of schizophrenia patients with cognitive impairment: A transcriptome analysis. Brain Behav Immun. 2016;53:194-206 pubmed publisher
  3. Hollins S, Zavitsanou K, Walker F, Cairns M. Alteration of transcriptional networks in the entorhinal cortex after maternal immune activation and adolescent cannabinoid exposure. Brain Behav Immun. 2016;56:187-96 pubmed publisher
  4. Hollins S, Cairns M. MicroRNA: Small RNA mediators of the brains genomic response to environmental stress. Prog Neurobiol. 2016;143:61-81 pubmed publisher
    ..A greater understanding of the dynamics that mediate an individual's predisposition to stress-induced neuropathology has major human health benefits and is an important area of research. ..
  5. Zhou L, Pupo G, Gupta P, Liu B, Tran S, Rahme R, et al. A parallel genome-wide mRNA and microRNA profiling of the frontal cortex of HIV patients with and without HIV-associated dementia shows the role of axon guidance and downstream pathways in HIV-mediated neurodegeneration. BMC Genomics. 2012;13:677 pubmed publisher
    ..These data provide an excellent avenue for the development of new generation of diagnostic/prognostic biomarkers and therapeutic intervention strategies for HIV-associated neurodegeneration. ..
  6. Beveridge N, Santarelli D, Wang X, Tooney P, Webster M, Weickert C, et al. Maturation of the human dorsolateral prefrontal cortex coincides with a dynamic shift in microRNA expression. Schizophr Bull. 2014;40:399-409 pubmed publisher