Neville J Butcher

Summary

Affiliation: University of Queensland
Country: Australia

Publications

  1. Witham K, Minchin R, Butcher N. Role for human arylamine N-acetyltransferase 1 in the methionine salvage pathway. Biochem Pharmacol. 2017;125:93-100 pubmed publisher
    ..The present study has identified a novel endogenous role for human NAT1 that might explain some of its effects in cancer cell growth and survival. ..
  2. request reprint
    Butcher N, Arulpragasam A, Minchin R. Proteasomal degradation of N-acetyltransferase 1 is prevented by acetylation of the active site cysteine: a mechanism for the slow acetylator phenotype and substrate-dependent down-regulation. J Biol Chem. 2004;279:22131-7 pubmed
    ..From this study, we conclude that NAT1 exists in the cell in either a stable acetylated state or an unstable non-acetylated state and that mutations in the NAT1 gene that prevent protein acetylation produce a slow acetylator phenotype. ..
  3. Butcher N, Minchin R. Arylamine N-acetyltransferase 1 gene regulation by androgens requires a conserved heat shock element for heat shock factor-1. Carcinogenesis. 2010;31:820-6 pubmed publisher
    ..Our results show that HSF1 is an important transcription factor for induction of NAT1 in human cells and is required for androgen activation of the NAT1 promoter. ..

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Detail Information

Publications3

  1. Witham K, Minchin R, Butcher N. Role for human arylamine N-acetyltransferase 1 in the methionine salvage pathway. Biochem Pharmacol. 2017;125:93-100 pubmed publisher
    ..The present study has identified a novel endogenous role for human NAT1 that might explain some of its effects in cancer cell growth and survival. ..
  2. request reprint
    Butcher N, Arulpragasam A, Minchin R. Proteasomal degradation of N-acetyltransferase 1 is prevented by acetylation of the active site cysteine: a mechanism for the slow acetylator phenotype and substrate-dependent down-regulation. J Biol Chem. 2004;279:22131-7 pubmed
    ..From this study, we conclude that NAT1 exists in the cell in either a stable acetylated state or an unstable non-acetylated state and that mutations in the NAT1 gene that prevent protein acetylation produce a slow acetylator phenotype. ..
  3. Butcher N, Minchin R. Arylamine N-acetyltransferase 1 gene regulation by androgens requires a conserved heat shock element for heat shock factor-1. Carcinogenesis. 2010;31:820-6 pubmed publisher
    ..Our results show that HSF1 is an important transcription factor for induction of NAT1 in human cells and is required for androgen activation of the NAT1 promoter. ..