Neville J Butcher
Affiliation: University of Queensland
Minchin R, Rosengren K, Burow R, Butcher N. Allosteric regulation of arylamine N-acetyltransferase 1 by adenosine triphosphate. Biochem Pharmacol. 2018;158:153-160 pubmed publisher
..This observation provides important understanding of the molecular regulation of NAT1 activity and may reveal possible insight into the endogenous role of the enzyme. ..
Butcher N, Broadhurst G, Minchin R. Polyamine-dependent regulation of spermidine-spermine N1-acetyltransferase mRNA translation. J Biol Chem. 2007;282:28530-9 pubmed
..These results suggest that polyamines regulate SSAT mRNA translational efficiency by inhibiting a repressor protein from binding to regions of the coding sequence of the SSAT transcript. ..
Butcher N, Tetlow N, Cheung C, Broadhurst G, Minchin R. Induction of human arylamine N-acetyltransferase type I by androgens in human prostate cancer cells. Cancer Res. 2007;67:85-92 pubmed
..These results show that human NAT1 is induced by androgens, which may have implications for cancer risk in individuals. ..
Butcher N, Mitchell D, Burow R, Minchin R. Regulation of mouse brain-selective sulfotransferase sult4a1 by cAMP response element-binding protein and activating transcription factor-2. Mol Pharmacol. 2010;78:503-10 pubmed publisher
..These results suggest that Sult4a1 is a target gene for the mu-opioid receptor signaling pathway and other pathways involving activation of CREB and ATF-2. ..
Witham K, Minchin R, Butcher N. Role for human arylamine N-acetyltransferase 1 in the methionine salvage pathway. Biochem Pharmacol. 2017;125:93-100 pubmed publisher
..The present study has identified a novel endogenous role for human NAT1 that might explain some of its effects in cancer cell growth and survival. ..
Butcher N, Arulpragasam A, Minchin R. Proteasomal degradation of N-acetyltransferase 1 is prevented by acetylation of the active site cysteine: a mechanism for the slow acetylator phenotype and substrate-dependent down-regulation. J Biol Chem. 2004;279:22131-7 pubmed
..From this study, we conclude that NAT1 exists in the cell in either a stable acetylated state or an unstable non-acetylated state and that mutations in the NAT1 gene that prevent protein acetylation produce a slow acetylator phenotype. ..
Butcher N, Minchin R. Arylamine N-acetyltransferase 1 gene regulation by androgens requires a conserved heat shock element for heat shock factor-1. Carcinogenesis. 2010;31:820-6 pubmed publisher
..Our results show that HSF1 is an important transcription factor for induction of NAT1 in human cells and is required for androgen activation of the NAT1 promoter. ..