Ashley I BushSummaryAffiliation: University of Melbourne Country: Australia Publications
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Publications
- Li X, Lei P, Tuo Q, Ayton S, Li Q, Moon S, et al. Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau. Neurotherapeutics. 2015;12:862-73 pubmed publisher..While the results from our study support the amyloid cascade hypothesis, they also suggest that downstream effectors of Aβ, which propagate toxicity after Aβ has been cleared, may be tractable therapeutic targets. ..
- Lei P, Ayton S, Moon S, Zhang Q, Volitakis I, Finkelstein D, et al. Motor and cognitive deficits in aged tau knockout mice in two background strains. Mol Neurodegener. 2014;9:29 pubmed publisher..Therefore excessive lowering of tau should be avoided in therapeutic strategies for AD. ..
- Ayton S, Lei P, Hare D, Duce J, George J, Adlard P, et al. Parkinson's disease iron deposition caused by nitric oxide-induced loss of β-amyloid precursor protein. J Neurosci. 2015;35:3591-7 pubmed publisher..Conversely, APP-overexpressing mice are protected in the MPTP PD model. NO suppresses APP translation in mouse MPTP models, explaining how elevated NO causes iron-dependent neurodegeneration in PD. ..
- Belaidi A, Bush A. Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics. J Neurochem. 2016;139 Suppl 1:179-197 pubmed publisher..Here, we discuss the current knowledge on brain iron homeostasis and its involvement in major aging-related neurodegenerative diseases. This article is part of a special issue on Parkinson disease. ..
- Hung Y, Walterfang M, Churilov L, Bray L, Jacobson L, Barnham K, et al. Neurological Dysfunction in Early Maturity of a Model for Niemann-Pick C1 Carrier Status. Neurotherapeutics. 2016;13:614-22 pubmed publisher..Our findings indicate that pathogenic NPC1 allele carriers, who represent about 0.66Â % of humans, could be vulnerable to motor and anxiety disorders. ..
- Ayton S, James S, Bush A. Nanoscale Imaging Reveals Big Role for Iron in Alzheimer's Disease. Cell Chem Biol. 2017;24:1192-1194 pubmed publisher..The characterization of abnormal iron chemistry in the disease model highlights the potential for iron to combine with the ?-amyloid peptide and accelerate the disease process...