Research Topics


Ashley I Bush


Affiliation: University of Melbourne
Country: Australia


  1. Hare D, Faux N, Roberts B, Volitakis I, Martins R, Bush A. Lead and manganese levels in serum and erythrocytes in Alzheimer's disease and mild cognitive impairment: results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing. Metallomics. 2016;8:628-32 pubmed publisher
    ..However, prospective studies might reveal whether the burden of either metal modifies disease outcomes. ..
  2. Bousman C, Luza S, Mancuso S, Kang D, Opazo C, Mostaid M, et al. Elevated ubiquitinated proteins in brain and blood of individuals with schizophrenia. Sci Rep. 2019;9:2307 pubmed publisher
    ..A derangement in protein ubiquitination may be linked to pathogenesis or neurotoxicity in schizophrenia, and its manifestation in the blood may have prognostic utility. ..
  3. Ayton S, Wang Y, Diouf I, Schneider J, Brockman J, Morris M, et al. Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology. Mol Psychiatry. 2019;: pubmed publisher
    ..Thus, cortical iron might act to propel cognitive deterioration upon the underlying proteinopathy of AD, possibly by inducing oxidative stress or ferroptotic cell death, or may be related to an inflammatory response. ..
  4. Bray L, Volitakis I, Ayton S, Bush A, Adlard P. Zn-DTSM, A Zinc Ionophore with Therapeutic Potential for Acrodermatitis Enteropathica?. Nutrients. 2019;11: pubmed publisher
    ..These data suggest that Zn-DTSM, or similar compounds, should be further explored as potential therapeutic options for the long-term treatment of AE. ..
  5. Masaldan S, Bush A, Devos D, Rolland A, Moreau C. Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration. Free Radic Biol Med. 2019;133:221-233 pubmed publisher
    ..These emerging findings are of relevance to neurodegeneration where ferroptotic signalling may offer new targets to mitigate cell death and dysfunction. ..
  6. Belaidi A, Gunn A, Wong B, Ayton S, Appukuttan A, Roberts B, et al. Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice. Neurotherapeutics. 2018;15:1055-1062 pubmed publisher
    ..Our results support a crucial role of APP in regulating brain and peripheral iron, and show that APP may act to oppose brain iron elevation during aging. ..
  7. Hung Y, Faux N, Killilea D, Yanjanin N, Firnkes S, Volitakis I, et al. Altered transition metal homeostasis in Niemann-Pick disease, type C1. Metallomics. 2014;6:542-53 pubmed publisher
    ..These findings highlight the importance of NPC1 function in metal homeostasis, and indicate that metal-targeting therapy may be of value as a treatment for NP-C. ..
  8. Lei P, Ayton S, Appukuttan A, Volitakis I, Adlard P, Finkelstein D, et al. Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse. Neurobiol Dis. 2015;81:168-75 pubmed publisher
    ..These data raise the possibility that lowering brain iron levels in symptomatic patients could reverse neuronal atrophy and improve brain function, possibly by elevating neurotrophins. ..
  9. Kim M, Oh S, Kim J, Kim K, Ryu H, Kim M, et al. Association of metals with the risk and clinical characteristics of Parkinson's disease. Parkinsonism Relat Disord. 2018;55:117-121 pubmed publisher
    ..This clinical study suggests significant associations between serum metal levels and PD risk or essential clinical features, demonstrating the possible roles of metals in PD pathogenesis or symptom development. ..

More Information


  1. Li X, Lei P, Tuo Q, Ayton S, Li Q, Moon S, et al. Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau. Neurotherapeutics. 2015;12:862-73 pubmed publisher
    ..While the results from our study support the amyloid cascade hypothesis, they also suggest that downstream effectors of Aβ, which propagate toxicity after Aβ has been cleared, may be tractable therapeutic targets. ..
  2. Lei P, Ayton S, Moon S, Zhang Q, Volitakis I, Finkelstein D, et al. Motor and cognitive deficits in aged tau knockout mice in two background strains. Mol Neurodegener. 2014;9:29 pubmed publisher
    ..Therefore excessive lowering of tau should be avoided in therapeutic strategies for AD. ..
  3. Ayton S, Lei P, Hare D, Duce J, George J, Adlard P, et al. Parkinson's disease iron deposition caused by nitric oxide-induced loss of β-amyloid precursor protein. J Neurosci. 2015;35:3591-7 pubmed publisher
    ..Conversely, APP-overexpressing mice are protected in the MPTP PD model. NO suppresses APP translation in mouse MPTP models, explaining how elevated NO causes iron-dependent neurodegeneration in PD. ..
  4. Belaidi A, Bush A. Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics. J Neurochem. 2016;139 Suppl 1:179-197 pubmed publisher
    ..Here, we discuss the current knowledge on brain iron homeostasis and its involvement in major aging-related neurodegenerative diseases. This article is part of a special issue on Parkinson disease. ..
  5. Hung Y, Walterfang M, Churilov L, Bray L, Jacobson L, Barnham K, et al. Neurological Dysfunction in Early Maturity of a Model for Niemann-Pick C1 Carrier Status. Neurotherapeutics. 2016;13:614-22 pubmed publisher
    ..Our findings indicate that pathogenic NPC1 allele carriers, who represent about 0.66 % of humans, could be vulnerable to motor and anxiety disorders. ..
  6. Ayton S, James S, Bush A. Nanoscale Imaging Reveals Big Role for Iron in Alzheimer's Disease. Cell Chem Biol. 2017;24:1192-1194 pubmed publisher
    ..The characterization of abnormal iron chemistry in the disease model highlights the potential for iron to combine with the ?-amyloid peptide and accelerate the disease process...