Louise M Burrell

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi Combined inhibition of neutral endopeptidase with angiotensin converting enzyme or endothelin converting enzyme in experimental diabetes
    Ilkka Tikkanen
    Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
    J Hypertens 20:707-14. 2002
  2. ncbi Diabetic pyomyositis: an uncommon cause of a painful leg
    Michele Y Y Seah
    Department of Medicine, University of Melbourne, Heidelberg Repatriation Hospital, Victoria, Australia
    Diabetes Care 27:1743-4. 2004
  3. ncbi Age-dependent regulation of renal vasopressin V(1A) and V₂ receptors in rats with genetic hypertension: implications for the treatment of hypertension
    Louise M Burrell
    Department of Medicine, The University of Melbourne, Austin Health, Heidelberg, Australia
    J Am Soc Hypertens 7:3-13. 2013
  4. ncbi The ACE2 gene: its potential as a functional candidate for cardiovascular disease
    Louise M Burrell
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
    Clin Sci (Lond) 124:65-76. 2013
  5. ncbi Chronic kidney disease: cardiac and renal angiotensin-converting enzyme (ACE) 2 expression in rats after subtotal nephrectomy and the effect of ACE inhibition
    L M Burrell
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
    Exp Physiol 97:477-85. 2012
  6. ncbi Association between intrarenal arterial resistance and diastolic dysfunction in type 2 diabetes
    Richard J MacIsaac
    Endocrine Centre, Austin Health and University of Melbourne, Melbourne, Australia
    Cardiovasc Diabetol 7:15. 2008
  7. ncbi ACE2, a new regulator of the renin-angiotensin system
    Louise M Burrell
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg Heights 3081, Australia
    Trends Endocrinol Metab 15:166-9. 2004
  8. ncbi Myocardial infarction increases ACE2 expression in rat and humans
    Louise M Burrell
    Department of Medicine, University of Melbourne, Austin Health, Repatriation Heidelberg Hospital, Heidelberg 3081, Victoria, Australia
    Eur Heart J 26:369-75; discussion 322-4. 2005
  9. ncbi Portal pressure responses and angiotensin peptide production in rat liver are determined by relative activity of ACE and ACE2
    Chandana B Herath
    Department of Medicine, The University of Melbourne, Austin Repatriation Hospital, Heidelberg Heights, Victoria, Australia
    Am J Physiol Gastrointest Liver Physiol 297:G98-G106. 2009
  10. ncbi The CTGF gene -945 G/C polymorphism is not associated with cardiac or kidney complications in subjects with type 2 diabetes
    Sheila K Patel
    Department of Medicine, Austin Health, University of Melbourne, Level 7, Lance Townsend Building, 145 Studley Road, Melbourne, VIC 3084, Australia
    Cardiovasc Diabetol 11:42. 2012

Collaborators

Detail Information

Publications50

  1. ncbi Combined inhibition of neutral endopeptidase with angiotensin converting enzyme or endothelin converting enzyme in experimental diabetes
    Ilkka Tikkanen
    Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
    J Hypertens 20:707-14. 2002
    ..CONCLUSIONS: Combined inhibition of NEP/ACE or NEP/ECE confers beneficial effects on blood pressure, albuminuria and heart to body weight ratio in experimental diabetes...
  2. ncbi Diabetic pyomyositis: an uncommon cause of a painful leg
    Michele Y Y Seah
    Department of Medicine, University of Melbourne, Heidelberg Repatriation Hospital, Victoria, Australia
    Diabetes Care 27:1743-4. 2004
  3. ncbi Age-dependent regulation of renal vasopressin V(1A) and V₂ receptors in rats with genetic hypertension: implications for the treatment of hypertension
    Louise M Burrell
    Department of Medicine, The University of Melbourne, Austin Health, Heidelberg, Australia
    J Am Soc Hypertens 7:3-13. 2013
    ..The use of V(1A) receptor antagonists in prehypertension may provide a unique opportunity for the prevention of hypertension in high-risk individuals...
  4. ncbi The ACE2 gene: its potential as a functional candidate for cardiovascular disease
    Louise M Burrell
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
    Clin Sci (Lond) 124:65-76. 2013
    ..Large-scale carefully conducted clinical studies are urgently needed to clarify more precisely the potential role of ACE2 in the CVD continuum...
  5. ncbi Chronic kidney disease: cardiac and renal angiotensin-converting enzyme (ACE) 2 expression in rats after subtotal nephrectomy and the effect of ACE inhibition
    L M Burrell
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
    Exp Physiol 97:477-85. 2012
    ..As long-term ACE inhibition only partly ameliorated the adverse cardio-renal effects of CKD, adjunctive therapies that lead to further increases in ACE2 activity may be needed to combat the cardio-renal complications of CKD...
  6. ncbi Association between intrarenal arterial resistance and diastolic dysfunction in type 2 diabetes
    Richard J MacIsaac
    Endocrine Centre, Austin Health and University of Melbourne, Melbourne, Australia
    Cardiovasc Diabetol 7:15. 2008
    ....
  7. ncbi ACE2, a new regulator of the renin-angiotensin system
    Louise M Burrell
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg Heights 3081, Australia
    Trends Endocrinol Metab 15:166-9. 2004
    ..ACE2 might act in a counter-regulatory manner to ACE, modulating the balance between vasoconstrictors and vasodilators within the heart and kidney, and playing a significant role in regulating cardiovascular and renal function...
  8. ncbi Myocardial infarction increases ACE2 expression in rat and humans
    Louise M Burrell
    Department of Medicine, University of Melbourne, Austin Health, Repatriation Heidelberg Hospital, Heidelberg 3081, Victoria, Australia
    Eur Heart J 26:369-75; discussion 322-4. 2005
    ..We studied the expression of ACE2 after myocardial infarction (MI) in the rat as well as in human failing hearts...
  9. ncbi Portal pressure responses and angiotensin peptide production in rat liver are determined by relative activity of ACE and ACE2
    Chandana B Herath
    Department of Medicine, The University of Melbourne, Austin Repatriation Hospital, Heidelberg Heights, Victoria, Australia
    Am J Physiol Gastrointest Liver Physiol 297:G98-G106. 2009
    ..NEP has the ability to generate large amounts of Ang-(1-7) in the BDL liver from Ang I only when ACE2 activity is greatly decreased or inhibited...
  10. ncbi The CTGF gene -945 G/C polymorphism is not associated with cardiac or kidney complications in subjects with type 2 diabetes
    Sheila K Patel
    Department of Medicine, Austin Health, University of Melbourne, Level 7, Lance Townsend Building, 145 Studley Road, Melbourne, VIC 3084, Australia
    Cardiovasc Diabetol 11:42. 2012
    ..This study investigated the association of the CTGF -945 G/C promoter variant with cardiac complications (left ventricular (LV) hypertrophy (LVH), diastolic and systolic dysfunction) and chronic kidney disease (CKD) in type 2 diabetes...
  11. ncbi Angiotensin-(1-7), an alternative metabolite of the renin-angiotensin system, is up-regulated in human liver disease and has antifibrotic activity in the bile-duct-ligated rat
    John S Lubel
    Department of Medicine, The University of Melbourne, Austin Health and Northern Health, Vic, Australia
    Clin Sci (Lond) 117:375-86. 2009
    ..In conclusion, Ang-(1-7) is up-regulated in human liver disease and has antifibrotic actions in a rat model of cirrhosis. The ACE2/Ang-(1-7)/mas receptor axis represents a potential target for antifibrotic therapy in humans...
  12. ncbi Combination renin-angiotensin system blockade and angiotensin-converting enzyme 2 in experimental myocardial infarction: implications for future therapeutic directions
    Luke J Burchill
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
    Clin Sci (Lond) 123:649-58. 2012
    ..Strategies that do augment ACE2 after MI may be a useful addition to standard RAS blockade after MI...
  13. ncbi Liver disease and the renin-angiotensin system: recent discoveries and clinical implications
    John S Lubel
    Department of Medicine, The University of Melbourne, Austin and Northern Health, Melbourne, Victoria, Australia
    J Gastroenterol Hepatol 23:1327-38. 2008
    ..The present review focuses on the novel components and pathways of the RAS with particular reference to their potential contribution towards the pathophysiology of liver disease...
  14. ncbi Prevalence and predictors of cardiac hypertrophy and dysfunction in patients with Type 2 diabetes
    Piyush M Srivastava
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria 3081, Australia
    Clin Sci (Lond) 114:313-20. 2008
    ....
  15. ncbi Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy
    Christos Tikellis
    Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Melbourne, Australia
    Hypertension 41:392-7. 2003
    ....
  16. ncbi Association of ACE2 genetic variants with blood pressure, left ventricular mass, and cardiac function in Caucasians with type 2 diabetes
    Sheila K Patel
    Department of Medicine, University of Melbourne, Austin Health, Victoria, Australia
    Am J Hypertens 25:216-22. 2012
    ..Angiotensin-converting enzyme (ACE)2 is a recently described member of the RAS, and this study investigated whether ACE2 polymorphisms are associated with hypertension, left ventricular (LV) mass, and cardiac function in type 2 diabetes...
  17. ncbi Reduction in renal ACE2 expression in subtotal nephrectomy in rats is ameliorated with ACE inhibition
    Elena Velkoska
    Department of Medicine, The University of Melbourne, Austin Health, Heidelberg 3081, Victoria, Australia
    Clin Sci (Lond) 118:269-79. 2010
    ..As ACE2 both degrades AngII and generates the vasodilator Ang-(1-7), a decrease in renal ACE2 activity, as observed in the present study, has the potential to contribute to the progression of kidney disease...
  18. ncbi N-terminal pro-brain natriuretic peptide and angiotensin-converting enzyme-2 levels and their association with postoperative cardiac complications after emergency orthopedic surgery
    Carol P Chong
    Department of Aged Care, The Northern Hospital, Epping, Victoria, Australia
    Am J Cardiol 109:1365-73. 2012
    ..In conclusion, elevated perioperative NT-proBNP predicted in-hospital and 1-year cardiac events in an emergency orthopedic population but the ACE-2 levels did not, which requires additional study for validation...
  19. ncbi Reduction of the accumulation of advanced glycation end products by ACE inhibition in experimental diabetic nephropathy
    Josephine M Forbes
    Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, West Heidelberg, Australia
    Diabetes 51:3274-82. 2002
    ..The present study has identified a relationship between the renin-angiotensin system and the accumulation of AGEs in experimental diabetic nephropathy that may be linked through oxidative stress..
  20. ncbi Cardiorenal protective effects of vasopeptidase inhibition with omapatrilat in hypertensive transgenic (mREN-2)27 rats
    Sally A Mifsud
    Department of Physiology, The University of Melbourne, Parkville, Victoria, Australia
    Clin Exp Hypertens 26:69-80. 2004
    ....
  21. ncbi Connective tissue growth factor and cardiac fibrosis after myocardial infarction
    Rachael G Dean
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
    J Histochem Cytochem 53:1245-56. 2005
    ..TGF-beta(1) is involved in the initial, acute phase of inflammation and repair after MI, whereas CTGF is involved in the ongoing fibrosis of the heart. The antifibrotic benefits of captopril are not mediated through a reduction in CTGF...
  22. ncbi Troponin I and NT-proBNP (N-terminal pro-brain natriuretic peptide) do not predict 6-month mortality in frail older patients undergoing orthopedic surgery
    Carol P Chong
    Department of Aged Care, The Northern Hospital, Epping, Victoria, Australia
    J Am Med Dir Assoc 11:415-20. 2010
    ..To determine if troponin I and NT-proBNP were predictors of 6-month mortality after emergency orthopedic-geriatric surgery in a frail population...
  23. ncbi Differential tissue and enzyme inhibitory effects of the vasopeptidase inhibitor omapatrilat in the rat
    Eiji Kubota
    Department of Medicine, University of Melbourne, Austin, Victoria 3084, Australia
    Clin Sci (Lond) 105:339-45. 2003
    ..The degree and site of tissue enzyme inhibition by vasopeptidase inhibitors may be relevant to end-organ protection as well as to the side-effect profiles of these agents...
  24. ncbi Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental biliary fibrosis
    Chandana B Herath
    Department of Medicine, The University of Melbourne, Austin Health, Heidelberg, Vic, Australia
    J Hepatol 47:387-95. 2007
    ..We examined the expression of these novel components of the renin angiotensin system (RAS) and the production and vasoactive effects of angiotensin-(1-7) in the bile duct ligated (BDL) rat...
  25. ncbi Angiotensin-(1-7) infusion is associated with increased blood pressure and adverse cardiac remodelling in rats with subtotal nephrectomy
    Elena Velkoska
    Department of Medicine, The University of Melbourne, Austin Health, Heidelberg, Victoria 3081, Australia
    Clin Sci (Lond) 120:335-45. 2011
    ..Our results add to the increasing evidence that Ang-(1-7) may have deleterious cardiovascular effects in kidney failure and highlight the need for further in vivo studies of the ACE2/Ang-(1-7)/mas receptor axis in kidney disease...
  26. ncbi Angiotensin-(1-7) reduces the perfusion pressure response to angiotensin II and methoxamine via an endothelial nitric oxide-mediated pathway in cirrhotic rat liver
    Chandana B Herath
    Department of Medicine, The University of Melbourne, Austin Health, Heidelberg, Victoria 3084, Victoria, Australia
    Am J Physiol Gastrointest Liver Physiol 304:G99-108. 2013
    ....
  27. ncbi Beta blocker use in subjects with type 2 diabetes mellitus and systolic heart failure does not worsen glycaemic control
    Bryan Wai
    Department of Cardiology, Austin Health, Heidelberg, Vic, Australia
    Cardiovasc Diabetol 11:14. 2012
    ..nonselective BB (Carvedilol)...
  28. ncbi Early undernutrition leads to long-lasting reductions in body weight and adiposity whereas increased intake increases cardiac fibrosis in male rats
    Elena Velkoska
    Department of Pharmacology, University of Melbourne, Parkville, 3010, Australia
    J Nutr 138:1622-7. 2008
    ..This highlights the importance of identifying potential early life risk factors involved in the modulation of childhood nutrition...
  29. ncbi Neurohormonal antagonism in heart failure; beneficial effects of vasopressin V(1a) and V(2) receptor blockade and ACE inhibition
    Mareo Naitoh
    Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria 3084, Australia
    Cardiovasc Res 54:51-7. 2002
    ..These results suggest conivaptan may be a useful addition to ACE inhibitors in the management of vasoconstriction and fluid retention that characterizes CHF...
  30. ncbi Upregulation of cardiac insulin-like growth factor-I receptor by ACE inhibition after myocardial infarction: potential role in remodeling
    Rachael G Dean
    Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Australia
    J Histochem Cytochem 51:831-9. 2003
    ....
  31. ncbi Co-localization of angiotensin-converting enzyme 2-, octomer-4- and CD34-positive cells in rabbit atherosclerotic plaques
    Anthony Zulli
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Melbourne, Victoria, Australia
    Exp Physiol 93:564-9. 2008
    ..Further studies aimed at establishing the effects of all-trans retinoic acid on blood pressure and atherosclerotic cell differentiation are warranted...
  32. ncbi A breaker of advanced glycation end products attenuates diabetes-induced myocardial structural changes
    Riccardo Candido
    Division of Diabetes, Lipoproteins and Metabolism, Baker Heart Research Institute, Prahran, Victoria, Australia
    Circ Res 92:785-92. 2003
    ..This provides a potential new therapeutic approach for cardiovascular disease in human diabetes...
  33. ncbi Vasopressin receptor expression in the placenta
    Irene Koukoulas
    Howard Florey Institute of Experimental Physiology and Medicine, The University of Melbourne, 3010 Victoria, Australia
    Biol Reprod 69:679-86. 2003
    ....
  34. ncbi ACE2 and diabetic complications
    Rachael G Dean
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg 3081, Victoria, Australia
    Curr Pharm Des 13:2730-5. 2007
    ....
  35. ncbi Update on new aspects of the renin-angiotensin system in liver disease: clinical implications and new therapeutic options
    Josephine A Grace
    Department of Medicine, The University of Melbourne, Austin Hospital, Heidelberg, Melbourne, Victoria, Australia
    Clin Sci (Lond) 123:225-39. 2012
    ..The present review outlines new aspects of the RAS and explores its role in the pathogenesis and treatment of liver fibrosis and portal hypertension...
  36. ncbi Inhibition of peptidases in the control of blood pressure
    Eiji Kubota
    Department of Medicine, University of Melbourne, Austin, Australia
    Essays Biochem 38:129-39. 2002
    ....
  37. ncbi ACE inhibition reduces infarction in normotensive but not hypertensive rats: correlation with cortical ACE activity
    Michelle J Porritt
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
    J Cereb Blood Flow Metab 30:1520-6. 2010
    ..The beneficial effects of ACE inhibition on infarct volume in normotensive rats do not correlate with changes in blood pressure. However, WKY rats have ACE inhibitor-sensitive cortical ACE activity that is lacking in the SHR...
  38. ncbi Vascular neutral endopeptidase inhibition improves endothelial function and reduces intimal hyperplasia
    Melissa N Barber
    Howard Florey Institute, University of Melbourne, Victoria, 3010, Australia
    Cardiovasc Res 71:179-88. 2006
    ..This is of particular relevance to using adventitial therapies to prevent intimal hyperplasia leading to restenosis...
  39. ncbi Circulating high-molecular-weight RAGE ligands activate pathways implicated in the development of diabetic nephropathy
    Sally A Penfold
    Division of Diabetes Complications, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Kidney Int 78:287-95. 2010
    ..These data show that ligands that activate RAGE present in the circulation of patients with type 2 diabetes and nephropathy are predominantly of high molecular weight...
  40. ncbi Usefulness of N-terminal pro-brain natriuretic peptide to predict postoperative cardiac complications and long-term mortality after emergency lower limb orthopedic surgery
    Carol P Chong
    Department of Aged Care, The Northern Hospital, Epping, Victoria, Australia
    Am J Cardiol 106:865-72. 2010
    ..In conclusion, increase pre- and postoperative NT-pro-BNP levels are independent predictors of in-hospital cardiac events and 1- and 2-year mortality in older patients undergoing emergency orthopedic surgery...
  41. ncbi Up-regulation of components of the renin-angiotensin system in the bile duct-ligated rat liver
    Georgina Paizis
    Department of Medicine, University of Melbourne, Austin and Repatriation Medical Center, Victoria, Australia
    Gastroenterology 123:1667-76. 2002
    ..These findings are in keeping with recent experimental studies that have demonstrated antifibrotic effects of RAS blockade in the bile duct-ligated liver...
  42. ncbi An unexpected cause of macroscopic haematuria
    John S Lubel
    Department of Medicine, University of Melbourne, Repatriation Campus, Austin Health, West Heidelberg, VIC 3081, Australia
    Med J Aust 183:321-3. 2005
    ..The diagnosis of a profound malabsorption syndrome secondary to coeliac disease was confirmed by small bowel histology and positive coeliac serology...
  43. ncbi Diastolic dysfunction is associated with anaemia in patients with Type II diabetes
    Piyush M Srivastava
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Melbourne, Victoria 3084, Australia
    Clin Sci (Lond) 110:109-16. 2006
    ..Notably, the predictive utility of these markers was eliminated after adjusting for Hb. Consequently, the inexpensive measurement of Hb may be a useful tool to identify diabetic patients at increased risk of cardiac dysfunction...
  44. ncbi Immunolocalization of ACE2 and AT2 receptors in rabbit atherosclerotic plaques
    Anthony Zulli
    Division of Cardiovascular Research, Department of Cardiology, Austin Health, Heidelberg 3084, Australia
    J Histochem Cytochem 54:147-50. 2006
    ..Macrophages and alphaSMC actin-positive cells produce ACE2 and the AT2R in atherosclerotic plaques. Determining a role for these factors in the control of atherosclerosis will require additional studies...
  45. ncbi Lateral vs medial mitral annular tissue Doppler in the echocardiographic assessment of diastolic function and filling pressures: which should we use?
    Piyush M Srivastava
    Department of Medicine, University of Melbourne, Austin Health, Burgundy Street, Heidelberg, Melbourne, Victoria 3084, Australia
    Eur J Echocardiogr 6:97-106. 2005
    ..Whilst for diagnosing elevated filling pressures an E/E' medial ratio>8 provided values of 56%, 93% and 91%, respectively. In conclusion, although either annulus can be used, E' med provides better diagnostic utility...
  46. ncbi Validation of rapid automated tissue synchronization imaging for the assessment of cardiac dyssynchrony in sinus and non-sinus rhythm
    Leighton G Kearney
    The University of Melbourne, Austin Health and Northern Health, Melbourne, Australia
    Europace 13:270-6. 2011
    ..established manual tissue velocity imaging (TVI) techniques for the assessment of intra-ventricular dyssynchrony in sinus and non-sinus rhythm...
  47. ncbi Cardiovascular hypertrophy in diabetic spontaneously hypertensive rats: optimizing blockade of the renin-angiotensin system
    Markus Lassila
    Baker Heart Research Institute, P.O. Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Clin Sci (Lond) 104:341-7. 2003
    ..In contrast, calcium channel blockade, despite similar effects on blood pressure, confers less antitrophic effects in the diabetic heart and blood vessels...
  48. ncbi Anti-atherosclerotic and renoprotective effects of combined angiotensin-converting enzyme and neutral endopeptidase inhibition in diabetic apolipoprotein E-knockout mice
    Karin Jandeleit-Dahm
    The Baker Heart Research Institute, Vascular Division, Danielle Alberti Memorial Centre for Diabetes Complications, Melbourne, Australia
    J Hypertens 23:2071-82. 2005
    ....
  49. ncbi Diabetes mellitus: a cardiovascular disease
    Riccardo Candido
    Division of Diabetes, Metabolism and Lipoproteins, Baker Heart Research Institute, Melbourne, Victoria 8008, Australia
    Curr Opin Investig Drugs 4:1088-94. 2003
    ....
  50. ncbi Glomerular permeability defect in hypertension is dependent on renin angiotensin system activation
    Riccardo Candido
    Department of Medicina Clinica and Neurologia, University of Trieste, Trieste, Italy
    Am J Hypertens 18:844-50. 2005
    ....