Research Topics
| David BurkeSummaryAffiliation: University of New South Wales Country: Australia Publications
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Detail Information
Publications
Threshold behaviour of human axons explored using subthreshold perturbations to membrane potentialDavid Burke
Institute of Clinical Neurosciences, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia
J Physiol 587:491-504. 2009..By extrapolation, we suggest that, when human axons discharge, nodal slow K+ currents will be activated sufficiently early to contribute to the early changes in excitability following the action potential...
Unit identification, sampling bias and technical issues in microneurographic recordings from muscle spindle afferentsD Burke
Prince of Wales Medical Research Institute, Randwick, NSW, Australia
J Neurosci Methods 74:137-44. 1997....- Effects of activity on axonal excitability: implications for motor control studiesDavid Burke
Spinal Injuries Research Centre, Prince of Wales Medical Research Institute, University of New South Wales, Sydney, Australia
Adv Exp Med Biol 508:33-7. 2002..These data need to be considered when interpreting human reflex studies... - Excitability of human axonsD Burke
Department of Neurology, Prince of Wales Hospital and Medical Research Institute, University of New South Wales, Barker Street, Randwick, Sydney, N S W, Australia
Clin Neurophysiol 112:1575-85. 2001..Each of these measurements depends on membrane potential and on other biophysical properties of the axons. Together they can provide new information about the pathophysiology underlying abnormalities in excitability in neuropathy... - Strength-duration properties and their voltage dependence as measures of a threshold conductance at the node of Ranvier of single motor axonsI Mogyoros
Department of Neurology, Prince of Wales Hospital and Prince of Wales Medical Research Institute, University of New South Wales, Sydney, Australia
Muscle Nerve 23:1719-26. 2000..There is a reciprocal relationship between tau(SD) and rheobase for single motor units at different membrane potentials, and this relationship may allow changes in tau(SD) due to depolarization and demyelination to be differentiated... - The effects of a volatile anaesthetic on the excitability of human corticospinal axonsD Burke
Departments of Clinical Neurophysiology, Anaesthesia and Intensive Care, and Orthopaedics, Prince of Wales Hospital, Prince of Wales Medical Research Institute, University of New South Wales, Sydney, Australia
Brain 123:992-1000. 2000..It is suggested that the increase in threshold produced by sevoflurane is due to depression of Na(+) currents at the nodes of Ranvier of corticospinal axons... - Quantitative description of the voltage dependence of axonal excitability in human cutaneous afferentsD Burke
Department of Neurology, Prince of Wales Hospital and Prince of Wales Medical Research Institute, Randwick, Sydney, Australia
Brain 121:1975-83. 1998.... - Inflections in threshold electrotonus to depolarizing currents in sensory axonsDavid Burke
Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, University of Sydney, Sydney, NSW 2006, Australia
Muscle Nerve 36:849-52. 2007..When large, the notch can distort subsequent phases of threshold electrotonus and could complicate quantitative measurements and modeling studies... - Excitability of human muscle afferents studied using threshold tracking of the H reflexCindy S-Y Lin
Prince of Wales Medical Research Institute, University of New South Wales, and College of Health Sciences, University of Sydney, Sydney, Australia
J Physiol 545:661-9. 2002..Finally, the difference in latent addition suggests that the longer tau(SD) of the soleus H reflex may indeed be due to greater activity of a persistent Na(+) conductance on Ia afferents than on soleus alpha motor axons... - Properties of low-threshold motor axons in the human median nerveLouise Trevillion
Institute of Clinical Neurosciences, Royal Prince Alfred Hospital and the University of Sydney, Sydney, Australia
J Physiol 588:2503-15. 2010..We suggest that the hyperpolarization-activated cyclic nucleotide-gated (HCN) channel(s) expressed on human motor axons may be active at rest and contribute to resting membrane potential... 
Different mechanisms underlying changes in excitability of peripheral nerve sensory and motor axons in multiple sclerosisKarl Ng
Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, NSW, Australia
Muscle Nerve 47:53-60. 2013..Motor excitability studies have suggested upregulation of slow K+ currents, probably secondary to altered motoneuron properties resulting from the central lesion. This study concentrates on sensory axons...- Responses of human sensory and motor axons to the release of ischaemia and to hyperpolarizing currentsCindy S-Y Lin
Prince of Wales Medical Research Institute, University of New South Wales, Australia
J Physiol 541:1025-39. 2002.... - Axonal excitability in the forearm: normal data and differences along the median nerveS K Jankelowitz
Institute of Clinical Neurosciences, Royal Prince Alfred Hospital and University of Sydney, Medical Foundation Building K 25, Sydney, NSW 2006, Australia
Clin Neurophysiol 120:167-73. 2009..The differences in measures of excitability due to different sites of stimulation or a different test muscle group was also determined... - Postactivation depression of the soleus H reflex measured using threshold trackingPenelope A McNulty
Institute of Clinical Neurosciences, The University of Sydney, Royal Prince Alfred Hospital, Sydney, Australia
J Neurophysiol 100:3275-84. 2008..Using threshold tracking, HD was maximal at lower frequencies than previously emphasized, probably because HD is greater the larger the test H reflex. This would reinforce the greater sensitivity of small motoneurons to reflex inputs... - Motoneuron excitability and the F waveM Geraldine Espiritu
Department of Clinical Neurophysiology, Prince of Wales Hospital, and Prince of Wales Medical Research Institute, University of New South Wales, Sydney, Australia
Muscle Nerve 27:720-7. 2003..The findings also suggest that F waves provide a flawed measure of the excitability of the motoneuron pool... - Abnormalities of axonal excitability are not generalized in early multifocal motor neuropathyCecilia Cappelen-Smith
Department of Clinical Neurophysiology, Prince of Wales Hospital and Prince of Wales Medical Research Institute, University of New South Wales, Barker Street, Randwick, Sydney, New South Wales 2031, Australia
Muscle Nerve 26:769-76. 2002..Again no differences were detected. This study provides no evidence for a generalized subclinical abnormality in MMN, at least when disease duration is less than 6 years... - Acute tetrodotoxin-induced neurotoxicity after ingestion of puffer fishMatthew C Kiernan
Prince of Wales Medical Research Institute, University of New South Wales, Barker Street, Randwick, Sydney NSW 2031, Australia
Ann Neurol 57:339-48. 2005..It demonstrates the ability of noninvasive nerve excitability studies to detect Na(+) channel blockade in vivo and also the utility of mathematical modeling to aid interpretation of altered excitability properties in disease... - The voltage dependence of I(h) in human myelinated axonsJames Howells
Institute of Clinical Neurosciences, Royal Prince Alfred Hospital and the University of Sydney, Sydney, Australia
J Physiol 590:1625-40. 2012.... - Activity-dependent hyperpolarization and impulse conduction in motor axons in patients with carpal tunnel syndromeCecilia Cappelen-Smith
Prince of Wales Medical Research Institute, University of New South Wales and Department of Clinical Neurophysiology, Prince of Wales Hospital, Sydney, Australia
Brain 126:1001-8. 2003..These studies support the view that demyelination may not be a critical factor in the slowing of impulse conduction in mild to moderate carpal tunnel syndrome... - Mutation in the Na+ channel subunit SCN1B produces paradoxical changes in peripheral nerve excitabilityMatthew C Kiernan
Prince of Wales Medical Research Institute, Prince of Wales Clinical School, University of New South Wales, Sydney, Australia
Brain 128:1841-6. 2005.... - Differences in activity-dependent hyperpolarization in human sensory and motor axonsMatthew C Kiernan
Prince of Wales Medical Research Institute, University of New South Wales and Institute of Neurological Sciences, Prince of Wales Hospital, Sydney, Australia
J Physiol 558:341-9. 2004.... - Outwardly rectifying deflections in threshold electrotonus due to K+ conductancesLouise Trevillion
University of Sydney, Royal Prince Alfred Hospital, Sydney, NSW 2006, Australia
J Physiol 580:685-96. 2007..This may also explain the notch in demyelinating diseases... - Effects of voluntary activity on the excitability of motor axons in the peroneal nerveSatoshi Kuwabara
Prince of Wales Medical Research Institute, University of New South Wales, Barker Street, Randwick, Sydney, NSW 2031, Australia
Muscle Nerve 25:176-84. 2002..Third, TA is probably not optimal for testing for activity-dependent conduction block... - Up-regulation of slow K(+) channels in peripheral motor axons: a transcriptional channelopathy in multiple sclerosisKarl Ng
Institute of Clinical Neurosciences, Royal Prince Alfred Hospital and the University of Sydney, Sydney, NSW, Australia
Brain 131:3062-71. 2008..This study thus provides evidence for plasticity in motoneuronal properties at a molecular level, the first such evidence for intact human subjects... - In vivo loss of slow potassium channel activity in individuals with benign familial neonatal epilepsy in remissionSusan E Tomlinson
Department of Neurology, Royal Prince Alfred Hospital, University of Sydney, NSW, Australia
Brain 135:3144-52. 2012..We conclude that subclinical dysfunction of K(v)7.2 in peripheral axons can be reliably detected non-invasively in adulthood. Related alterations in neuronal excitability may contribute to epilepsy associated with KCNQ2 mutations... - Pathophysiology of spasticity in strokeDavid Burke
Department of Neurology, Royal Prince Alfred Hospital and University of Sydney, Australia
Neurology 80:S20-6. 2013..Managing a patient with impairment after a stroke requires therapy tailored to that particular patient because the mechanisms contributing to the disability experienced by one patient may differ from those affecting another... - Excitability changes in human peripheral nerve axons in a paradigm mimicking paired-pulse transcranial magnetic stimulationJane H L Chan
Prince of Wales Medical Research Institute, University of New South Wales and College of Health Sciences, University of Sydney, Sydney, Australia
J Physiol 542:951-61. 2002..This study supports the view that changes in excitability of the stimulated axons should be considered before synaptic mechanisms are invoked in the interpretation of findings from paired-pulse TMS studies... - Conduction block during and after ischaemia in chronic inflammatory demyelinating polyneuropathyCecilia Cappelen-Smith
Prince of Wales Medical Research Institute, University of New South Wales and Department of Clinical Neurophysiology, The Prince of Wales Hospital, Sydney, NSW, Australia
Brain 125:1850-8. 2002.... - The stability of M(max) and H (max) amplitude over timePenelope A McNulty
Neuroscience Research Australia, University of New South Wales, Barker Street, Randwick, Sydney, NSW 2031, Australia
Exp Brain Res 218:601-7. 2012..On average, there was no change in the H(max)/M(max) ratio over time. While both M(max) and H(max) may change in response to many factors, these results suggest that, typically, time is not one of them... - Axonal hyperpolarization in inclusion-body myopathy, Paget disease of the bone, and frontotemporal dementia (IBMPFD)Kishore R Kumar
Department of Neurology and Clinical Neurophysiology and Kolling Institute of Medical Research, Royal North Shore Hospital, and University of Sydney, NSW, Australia
Muscle Nerve 44:191-6. 2011..Patients with this disorder may have neuropathic or myopathic features... - Axonal excitability in viral polyneuropathy and nucleoside neuropathy in HIV patientsKarl Ng
Royal North Shore Hospital, University of Sydney, Sydney, Australia
J Neurol Neurosurg Psychiatry 82:978-80. 2011..Confirmation of these findings may allow neurophysiological distinction between these entities... - Changes in measures of motor axon excitability with ageS K Jankelowitz
Institute of Clinical Neurosciences, University of Sydney and Royal Prince Alfred Hospital, Sydney, Australia
Clin Neurophysiol 118:1397-404. 2007..Protocols have been validated for sensory and motor axons, but there are limited data on the changes in the excitability of motor axons with age. This study aimed to determine such changes from the third to the eighth decades... - Conduction block in demyelinated axons precipitated by normally innocuous physiological processesDavid Burke
Office of Research and Development, College of Health Sciences, University of Sydney, Sydney, NSW 2006, Australia
Suppl Clin Neurophysiol 57:191-4. 2004 - Activity-dependent conduction failure: molecular insightsSusanna B Park
Prince of Wales Clinical School, University of New South Wales, Sydney, Australia
J Peripher Nerv Syst 16:159-68. 2011.... - Do the motor manifestations of Parkinson disease alter motor axon excitability?Stacey K Jankelowitz
Department of Neurology, Royal Prince Alfred Hospital, Sydney, Australia
Muscle Nerve 45:43-7. 2012..Given the motor neuron changes in the presence of rigidity and tremor in Parkinson disease, we examine whether there are also changes in motor axon excitability... - Fatigue in multiple sclerosis: mechanisms and managementSteve Vucic
Department of Neurology, Westmead Hospital and Western Clinical School, University of Sydney, Sydney, NSW, Australia
Clin Neurophysiol 121:809-17. 2010.... - The effects of alterations in conditioning stimulus intensity on short interval intracortical inhibitionSteve Vucic
Department of Neurology, Westmead Hospital and Western Clinical School, University of Sydney, Australia
Brain Res 1273:39-47. 2009..8%]. Facilitation was evident at 1 ms. The findings from the present study suggest that inhibitory circuits with different thresholds underlie the phases of SICI, with synaptic mechanisms also critical to the development of SICI at 1 ms... - Augmentation of the contraction force of human thenar muscles by and during brief discharge trainsJames Howells
Institute of Clinical Neurosciences, University of Sydney and Royal Prince Alfred Hospital, Sydney, NSW 2006, Australia
Muscle Nerve 33:384-92. 2006..Discharge rates of 15-20 HZ appear to be optimal for force generation by APB during steady contractions... - Sodium channel function and the excitability of human cutaneous afferents during ischaemiaCindy S-Y Lin
Prince of Wales Medical Research Institute, University of New South Wales and Department of Neurology, The Prince of Wales Hospital, Sydney, Australia
J Physiol 538:435-46. 2002..Without these processes, the ischaemic change in threshold would be much greater than that actually recorded, probably sufficient to produce prominent ectopic impulse activity... - The properties of axons differ according to their functionDavid Burke
Institute of Clinical Neurosciences, University of Sydney and Royal Prince Alfred Hospital, Sydney, New South Wales 2006, Australia
J Physiol 578:1-2. 2007 - Corticospinal volleys and compound muscle action potentials produced by repetitive transcranial stimulation during spinal surgeryKathleen Bartley
Department of Clinical Neurophysiology, Prince of Wales and Sydney Children's Hospitals, Sydney, Australia
Clin Neurophysiol 113:78-90. 2002..Under the anaesthetic conditions used in the present study, the optimal stimulus parameters consist of a train of 5 stimuli of 50 micros duration at an interstimulus interval of 5 ms and an intensity of 500 V... - Forces consistent with plateau-like behaviour of spinal neurons evoked in patients with spinal cord injuriesP Nickolls
Spinal Injuries Research Center, Prince of Wales Medical Research Institute and University of New South Wales, Australia
Brain 127:660-70. 2004..These contractions are consistent with the activation of plateau potentials in spinal neurons and, if so, plateau potentials may contribute to a patient's clinical manifestations... - Riluzole therapy for motor neurone disease: an early Australian experience (1996-2002)Margie C Zoing
Multidisciplinary Motor Neurone Disease Service, Institute of Neurological Sciences, Prince of Wales Hospital, Sydney, New South Wales, Australia
J Clin Neurosci 13:78-83. 2006..Issues related to patient perceptions of efficacy highlight the need for patients and treating physicians to maintain realistic expectations of riluzole therapy... - Cytoplasmic body myopathy masquerading as motor neuron diseaseArun V Krishnan
Multidisciplinary Motor Neuron Disease Service, Institute of Neurological Sciences, Prince of Wales Hospital, High Street, Randwick, Sydney, NSW 2031, Australia
Muscle Nerve 30:667-72. 2004..The case highlights a further diagnostic possibility in the assessment of patients with "possible" motor neuron disease. The clinical features of CBM are briefly reviewed... - Early intervention for cognitive decline: is there a role for multiple medical or behavioural interventions?Sharon L Naismith
Brain and Mind Research Institute, The George Institute for International Health, University of Sydney, Sydney, New South Wales, Australia
Early Interv Psychiatry 3:19-27. 2009..Evidence for the beneficial effects of providing relevant interventions is assessed... - Clinical neurophysiology of the episodic ataxias: insights into ion channel dysfunction in vivoSusan E Tomlinson
Institute of Clinical Neurosciences, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia
Clin Neurophysiol 120:1768-76. 2009..The clinical, genetic and electrophysiological features of EA1 and EA2 are outlined, and a protocol for the assessment of these patients is proposed... - Suppression of the H reflex in humans by disynaptic autogenetic inhibitory pathways activated by the test volleyVéronique Marchand-Pauvert
Reeducation, Neurophysiologie Clinique UPRES EA 2393, Hopital de la Salpetriere, 75651 Paris Cedex 13, France
J Physiol 542:963-76. 2002..It is concluded that the size of the H reflex is limited by disynaptic inhibition, and that changes in the excitability of this inhibitory pathway can produce prominent changes in the H reflex... - Axonal excitability measured by tracking twitch contraction forceLouise Trevillion
Institute of Clinical Neurosciences, University of Sydney, NSW 2006, Australia
Muscle Nerve 30:437-43. 2004..Thus, tracking twitch contraction force is a potentially valuable alternative to tracking the CMAP, but is more complicated and the results need to be interpreted with caution... - Plasticity of inwardly rectifying conductances following a corticospinal lesion in human subjectsStacey K Jankelowitz
Medical Foundation Building K25, The University of Sydney, NSW 2006, Australia
J Physiol 581:927-40. 2007..In human subjects studies of motor axon properties may allow insight into processes affecting the motoneuron... - Task-related changes in propriospinal excitation from hand muscles to human flexor carpi radialis motoneuronesCaroline Iglesias
INSERM, U731, Paris, F 75013 France
J Physiol 582:1361-79. 2007..The resulting more effective background excitation of propriospinal neurones by the peripheral input from hand muscles could contribute to stabilizing the wrist during grip... - The refractory period of transmission is impaired in axonal Guillain-Barré syndromeSatoshi Kuwabara
Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
Muscle Nerve 28:683-9. 2003..In addition to axonal degeneration, the critically but reversibly reduced safety factor is important in the pathophysiology of AMAN, and consistent with the rapid resolution of distal conduction block often seen in AMAN patients... - Differences in membrane properties of axonal and demyelinating Guillain-Barré syndromesSatoshi Kuwabara
Department of Neurology, Chiba University School of Medicine, Chiba, Japan
Ann Neurol 52:180-7. 2002..These results support the view that the predominantly distal targets of immune attack are different for AMAN and AIDP. Possible mechanisms for the reduced safety factor in AMAN are discussed... - Axonal hyperpolarization associated with acute hypokalemia: multiple excitability measurements as indicators of the membrane potential of human axonsSatoshi Kuwabara
Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
Muscle Nerve 26:283-7. 2002..Multiple excitability measurements can be used as a tool to identify changes in membrane potential of human axons... - Recent evidence for plateau potentials in human motoneuronesDavid F Collins
Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Canada
Adv Exp Med Biol 508:227-35. 2002..The extent to which the nervous system uses this as a gain control mechanism to tailor motor output for a given task needs to be further explored... - After-effects of near-threshold stimulation in single human motor axonsHugh Bostock
Sobell Department of Neurophysiology, Institute of Neurology, Queen Square, London WC1N 3BG, UK
J Physiol 564:931-40. 2005.... - Frequency-dependent conduction block in carpal tunnel syndromeDavid Burke
Muscle Nerve 33:587-8. 2006 - Symptoms of thoracic outlet syndrome in women with carpal tunnel syndromeDavid Burke
Clin Neurophysiol 117:930-1. 2006