Janette K Burgess

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. ncbi request reprint Extracellular matrix regulates enhanced eotaxin expression in asthmatic airway smooth muscle cells
    Vivien Chan
    King s College London School of Medicine, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Thomas Guy House, Guy s Hospital Campus, London SE1 9RT, UK
    Am J Respir Crit Care Med 174:379-85. 2006
  2. ncbi request reprint Connective tissue growth factor induces extracellular matrix in asthmatic airway smooth muscle
    Peter R A Johnson
    Department of Pharmacology, The University of Sydney, NSW, Australia
    Am J Respir Crit Care Med 173:32-41. 2006
  3. ncbi request reprint New developments in the analysis of gene expression
    J K Burgess
    Department of Pharmacology, University of Sydney, New South Wales, Australia
    Redox Rep 5:63-73. 2000
  4. ncbi request reprint CD40 and OX40 ligand are increased on stimulated asthmatic airway smooth muscle
    Janette K Burgess
    Department of Pharmacology, University of Sydney, Sydney, NSW, Australia
    J Allergy Clin Immunol 115:302-8. 2005
  5. ncbi request reprint Connective tissue growth factor: a role in airway remodelling in asthma?
    Janette K Burgess
    Department of Pharmacology, University of Sydney and Woolcock Institute of Medical Research, Sydney, New South Wales, Australia
    Clin Exp Pharmacol Physiol 32:988-94. 2005
  6. ncbi request reprint A phosphodiesterase 4 inhibitor inhibits matrix protein deposition in airways in vitro
    Janette K Burgess
    Department of Pharmacology, University of Sydney, NSW, Australia
    J Allergy Clin Immunol 118:649-57. 2006
  7. doi request reprint Tissue and matrix influences on airway smooth muscle function
    Janette K Burgess
    Discipline of Pharmacology, Bosch Institute, University of Sydney, Sydney, Australia
    Pulm Pharmacol Ther 22:379-87. 2009
  8. doi request reprint The role of the extracellular matrix and specific growth factors in the regulation of inflammation and remodelling in asthma
    Janette K Burgess
    Discipline of Pharmacology, The University of Sydney, Woolcock Institute of Medical Research and the Cooperative Research Centre for Asthma and Airways, Sydney, NSW Australia
    Pharmacol Ther 122:19-29. 2009
  9. doi request reprint Reduction of tumstatin in asthmatic airways contributes to angiogenesis, inflammation, and hyperresponsiveness
    Janette K Burgess
    Respiratory Research Group, Discipline of Pharmacology, Bosch Building, D05, University of Sydney, Sydney, NSW, Australia 2006
    Am J Respir Crit Care Med 181:106-15. 2010
  10. ncbi request reprint Expression of connective tissue growth factor in asthmatic airway smooth muscle cells
    Janette K Burgess
    Department of Pharmacology, University of Sydney, Sydney, Australia
    Am J Respir Crit Care Med 167:71-7. 2003

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Extracellular matrix regulates enhanced eotaxin expression in asthmatic airway smooth muscle cells
    Vivien Chan
    King s College London School of Medicine, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Thomas Guy House, Guy s Hospital Campus, London SE1 9RT, UK
    Am J Respir Crit Care Med 174:379-85. 2006
    ..Altered airway smooth muscle (ASM) function and enrichment of the extracellular matrix (ECM) with fibronectin and collagen are key features of asthma. Previously, we have reported these ECM proteins enhance ASM synthetic function...
  2. ncbi request reprint Connective tissue growth factor induces extracellular matrix in asthmatic airway smooth muscle
    Peter R A Johnson
    Department of Pharmacology, The University of Sydney, NSW, Australia
    Am J Respir Crit Care Med 173:32-41. 2006
    ..Our results suggest that these two cytokines may be important in the deposition of extracellular matrix proteins and that the signal transduction pathways may be different in asthmatic and nonasthmatic cells...
  3. ncbi request reprint New developments in the analysis of gene expression
    J K Burgess
    Department of Pharmacology, University of Sydney, New South Wales, Australia
    Redox Rep 5:63-73. 2000
    ..Molecules found to be associated with defined pathological lesions may provide clues about new therapeutic targets in the future...
  4. ncbi request reprint CD40 and OX40 ligand are increased on stimulated asthmatic airway smooth muscle
    Janette K Burgess
    Department of Pharmacology, University of Sydney, Sydney, NSW, Australia
    J Allergy Clin Immunol 115:302-8. 2005
    ..These cytokines have the potential to alter the expression of surface receptors such as CD40 and OX40 ligand on the airway smooth muscle cell...
  5. ncbi request reprint Connective tissue growth factor: a role in airway remodelling in asthma?
    Janette K Burgess
    Department of Pharmacology, University of Sydney and Woolcock Institute of Medical Research, Sydney, New South Wales, Australia
    Clin Exp Pharmacol Physiol 32:988-94. 2005
    ..5. Current asthma therapies do not inhibit CTGF induction. 6. Understanding the mechanisms underlying the role of CTGF in airway remodelling may lead to new therapeutic strategies for asthma...
  6. ncbi request reprint A phosphodiesterase 4 inhibitor inhibits matrix protein deposition in airways in vitro
    Janette K Burgess
    Department of Pharmacology, University of Sydney, NSW, Australia
    J Allergy Clin Immunol 118:649-57. 2006
    ..Airway smooth muscle (ASM) cells may contribute to airway remodeling through the release of growth factors, cytokines, and extracellular matrix (ECM) proteins. The effect of current asthma therapies on this release is not known...
  7. doi request reprint Tissue and matrix influences on airway smooth muscle function
    Janette K Burgess
    Discipline of Pharmacology, Bosch Institute, University of Sydney, Sydney, Australia
    Pulm Pharmacol Ther 22:379-87. 2009
    ..This review summarises our current understanding of the influence of the ECM on ASM function...
  8. doi request reprint The role of the extracellular matrix and specific growth factors in the regulation of inflammation and remodelling in asthma
    Janette K Burgess
    Discipline of Pharmacology, The University of Sydney, Woolcock Institute of Medical Research and the Cooperative Research Centre for Asthma and Airways, Sydney, NSW Australia
    Pharmacol Ther 122:19-29. 2009
    ..This review aims to summarise the role growth factors and extracellular matrix proteins play in the regulation of inflammation and airway remodelling in the asthmatic airway...
  9. doi request reprint Reduction of tumstatin in asthmatic airways contributes to angiogenesis, inflammation, and hyperresponsiveness
    Janette K Burgess
    Respiratory Research Group, Discipline of Pharmacology, Bosch Building, D05, University of Sydney, Sydney, NSW, Australia 2006
    Am J Respir Crit Care Med 181:106-15. 2010
    ..Collagen IV is decreased in the airway basement membrane in asthma. It has six alpha chains, of which the noncollagenous domain-1 domains have endogenous antiangiogenic properties...
  10. ncbi request reprint Expression of connective tissue growth factor in asthmatic airway smooth muscle cells
    Janette K Burgess
    Department of Pharmacology, University of Sydney, Sydney, Australia
    Am J Respir Crit Care Med 167:71-7. 2003
    ....
  11. ncbi request reprint Molecular mechanisms of drug-induced thrombocytopenia
    J K Burgess
    Department of Pharmacology, University of Sydney, Sydney, New South Wales, Australia
    Curr Opin Hematol 8:294-8. 2001
    ..Identification of antibody binding sites will enhance our understanding of the pathogenesis of immune drug-induced thrombocytopenia...
  12. ncbi request reprint Gene expression studies using microarrays
    J K Burgess
    Respiratory Research Group, Department of Pharmacology, University of Sydney, New South Wales, Australia
    Clin Exp Pharmacol Physiol 28:321-8. 2001
    ..This increase in knowledge about gene function will allow new targeted approaches for the development of drugs and/or gene therapies...
  13. ncbi request reprint Connective tissue growth factor and vascular endothelial growth factor from airway smooth muscle interact with the extracellular matrix
    Janette K Burgess
    Respiratory Research Group, Department of Pharmacology, University of Sydney, Sydney, NSW, Australia 2006
    Am J Physiol Lung Cell Mol Physiol 290:L153-61. 2006
    ..This relationship has the potential to contribute to the changes that constitute airway remodeling, therefore providing a novel focus for therapeutic intervention in asthma...
  14. doi request reprint TGFβ1 induces IL-6 and inhibits IL-8 release in human bronchial epithelial cells: the role of Smad2/3
    Qi Ge
    Respiratory Research Group, Discipline of Pharmacology, Faculty of Medicine, The University of Sydney, Sydney, NSW, Australia
    J Cell Physiol 225:846-54. 2010
    ..Understanding the mechanism of aberrant pro-inflammatory cytokine production in asthmatic airways will allow the development of alternative ways to control airway inflammation...
  15. doi request reprint The phosphoinositide 3'-kinase p110δ modulates contractile protein production and IL-6 release in human airway smooth muscle
    Qi Ge
    Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia
    J Cell Physiol 227:3044-52. 2012
    ....
  16. doi request reprint Rhinovirus infection induces extracellular matrix protein deposition in asthmatic and nonasthmatic airway smooth muscle cells
    Curtis Kuo
    Discipline of Pharmacology, University of Sydney, Camperdown, Australia
    Am J Physiol Lung Cell Mol Physiol 300:L951-7. 2011
    ..Our results suggest that viruses may contribute to airway remodeling through increased ECM deposition, which in turn may contribute to increased ASM mass via increased cell migration...
  17. ncbi request reprint Dysfunctional interaction of C/EBPalpha and the glucocorticoid receptor in asthmatic bronchial smooth-muscle cells
    Michael Roth
    Department of Pharmacology and the Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia
    N Engl J Med 351:560-74. 2004
    ..We examined the signaling pathway controlling the inhibitory effect of glucocorticoids on cell proliferation and interleukin-6 synthesis in bronchial smooth-muscle cells of subjects with asthma and those without asthma...
  18. doi request reprint β2-Agonists upregulate PDE4 mRNA but not protein or activity in human airway smooth muscle cells from asthmatic and nonasthmatic volunteers
    Kyoko Niimi
    Cell Biology Group, Woolcock Institute of Medical Research, School of Medical Sciences, The Univ of Sydney, Sydney, NSW, Australia
    Am J Physiol Lung Cell Mol Physiol 302:L334-42. 2012
    ..This leads us to speculate that continual therapy with β2AR agonists is unlikely to cause PDE4-mediated tachyphylaxis...
  19. doi request reprint TGF-β enhances deposition of perlecan from COPD airway smooth muscle
    Yukikazu Ichimaru
    Cell Biology Group, Woolcock Institute of Medical Research, NSW, Australia
    Am J Physiol Lung Cell Mol Physiol 302:L325-33. 2012
    ..Seeding on perlecan domains did not increase proliferation of any ASMC type. TGF-β(1)-induced perlecan deposition may enhance attachment of migrating ASMC in vivo and thus may be a mechanism for ASMC layer hypertrophy in COPD...
  20. doi request reprint Phosphatidylinositol 3-kinase isoform-specific effects in airway mesenchymal cell function
    Lyn M Moir
    Woolcock Institute of Medical Research, Sydney, Australia
    J Pharmacol Exp Ther 337:557-66. 2011
    ..In addition, PIK75 decreased cell survival in TGFβ-stimulated asthmatic, but not nonasthmatic, ASM cells. In conclusion, specific PI3K isoforms may play a role in pathophysiological events relevant to airway wall remodeling...
  21. ncbi request reprint Extracellular matrix proteins modulate asthmatic airway smooth muscle cell proliferation via an autocrine mechanism
    Peter R A Johnson
    Department of Pharmacology, University of Sydney, Sydney, NSW 2006, Australia
    J Allergy Clin Immunol 113:690-6. 2004
    ..We have previously shown that nonasthmatic ASM cells in culture produce a range of extracellular matrix protein proteins and that asthmatic ASM cells proliferate faster than cells from nonasthmatic patients...
  22. pmc The expression and activity of cathepsins D, H and K in asthmatic airways
    Alen Faiz
    Cell Biology, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia
    PLoS ONE 8:e57245. 2013
    ..This indicates that while CTSD possesses the potential to directly regulate tumstatin, and thus angiogenesis through this mechanism however, it is not likely to be involved in the dysregulation of tumstatin found in asthmatic airways...
  23. pmc Asthmatic airway smooth muscle CXCL10 production: mitogen-activated protein kinase JNK involvement
    Yazan A Alrashdan
    Respiratory Research Group, Faculty of Pharmacy, University of Sydney, Sydney, NSW 2006, Australia
    Am J Physiol Lung Cell Mol Physiol 302:L1118-27. 2012
    ..However, in both, JNK activation did not regulate early events leading to NF-κB activation. Thus JNK and NF-κB provide independent therapeutic targets for limiting CXCL10 production and mast cell migration to the ASM in asthma...
  24. doi request reprint Rhinovirus-induced exacerbations of asthma: How is the {beta}2-adrenoceptor implicated?
    Thomas Trian
    The University of Sydney, NSW, Australia
    Am J Respir Cell Mol Biol 43:227-33. 2010
    ....
  25. doi request reprint Dual ERK and phosphatidylinositol 3-kinase pathways control airway smooth muscle proliferation: differences in asthma
    Janette K Burgess
    Respiratory Research Group, Discipline of Pharmacology, Faculty of Medicine, University of Sydney, Sydney, NSW, Australia
    J Cell Physiol 216:673-9. 2008
    ..This study suggests that the PI 3-kinase pathway may be an attractive target for reversing hyperplasia in asthma...
  26. pmc Increased proinflammatory responses from asthmatic human airway smooth muscle cells in response to rhinovirus infection
    Brian G G Oliver
    Department of Pharmacology, University of Sydney, NSW, 2006, Australia
    Respir Res 7:71. 2006
    ..We hypothesised that rhinovirus induction of inflammatory cytokine release from airway smooth muscle is augmented and differentially regulated in asthmatic compared to normal HASM cells...
  27. pmc Is low dose inhaled corticosteroid therapy as effective for inflammation and remodeling in asthma? A randomized, parallel group study
    Melissa Baraket
    Woolcock Institute of Medical Research, Sydney, NSW, Australia
    Respir Res 13:11. 2012
    ..Although symptom/lung function response to low and high dose ICS medication is comparable, it is uncertain whether low dose ICSs are as effective as high dose in the treatment of inflammation and remodeling...
  28. doi request reprint The effect of asthma therapeutics on signalling and transcriptional regulation of airway smooth muscle function
    Alaina J Ammit
    Respiratory Research Group, Faculty of Pharmacy, University of Sydney, NSW, Australia
    Pulm Pharmacol Ther 22:446-54. 2009
    ..This review is an overview of the effects of current therapies, and some of those in development, on key signalling pathways and transcription factors involved in these ASM functions...
  29. pmc Fibulin-1 is increased in asthma--a novel mediator of airway remodeling?
    Justine Y Lau
    Cooperative Research Centre for Asthma and Airways, Sydney, New South Wales, Australia
    PLoS ONE 5:e13360. 2010
    ..There are four isoforms in humans (A-D) of which fibulin-1C and 1D predominate. The objective of this study was to study the expression of fibulin-1 in volunteers with and without asthma, and to examine its function in vitro...
  30. ncbi request reprint Effect of IL-6 trans-signaling on the pro-remodeling phenotype of airway smooth muscle
    Alaina J Ammit
    Faculty of Pharmacy, University of Sydney, Sydney, NSW 2006, Australia
    Am J Physiol Lung Cell Mol Physiol 292:L199-206. 2007
    ..As levels of sIL-6Ralpha are increased in asthma, this demonstration of IL-6 trans-signaling in ASM has relevance to the development of airway remodeling...
  31. ncbi request reprint Detection and characterization of OX40 ligand expression in human airway smooth muscle cells: a possible role in asthma?
    Janette K Burgess
    Respiratory Research Group, Department of Pharmacology, Bosch Building D05, University of Sydney, Sydney, NSW 2006, Australia
    J Allergy Clin Immunol 113:683-9. 2004
    ..Cell-surface molecules play an important role in the development of an immune response. A number of cell-surface molecules are expressed on ASM cells, and these might contribute to the inflammatory reaction...
  32. pmc β2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D
    Thomas Trian
    Cell Biology, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia
    PLoS ONE 6:e20000. 2011
    ..In addition, some studies have suggested impaired β-agonist induced ASM relaxation in asthmatics, but the mechanism is not known...
  33. doi request reprint Rhinovirus infection induces expression of airway remodelling factors in vitro and in vivo
    Curtis Kuo
    Discipline of Pharmacology, The University of Sydney, Camperdown, UK
    Respirology 16:367-77. 2011
    ..Viral infections may promote the development of asthma and are the most common causes of asthma exacerbations. We evaluated whether rhinovirus (RV) infection induces airway remodelling, as assessed by ECM deposition...
  34. ncbi request reprint Increased sensitivity of asthmatic airway smooth muscle cells to prostaglandin E2 might be mediated by increased numbers of E-prostanoid receptors
    Janette K Burgess
    Respiratory Research Group, Department of Pharmacology, Bosch Building D05, University of Sydney, Sydney, NSW 2006, Australia
    J Allergy Clin Immunol 113:876-81. 2004
    ..We have previously shown that ASM cells from asthmatic individuals proliferate more than those from nonasthmatic subjects. This increased growth might be due to compromised inhibitory mechanisms within the ASM of asthmatic subjects...
  35. pmc Comparison of gel contraction mediated by airway smooth muscle cells from patients with and without asthma
    Hisako Matsumoto
    Discipline of Pharmacology, University of Sydney, NSW 2006, Australia
    Thorax 62:848-54. 2007
    ..The purpose of this study was to establish a method to measure contraction of ASM cells by embedding them into a collagen gel, and to compare the contraction between subjects with and without asthma...
  36. pmc Characterising the mechanism of airway smooth muscle β2 adrenoceptor desensitization by rhinovirus infected bronchial epithelial cells
    David Van Ly
    Woolcock Institute of Medical Research, Sydney, Australia
    PLoS ONE 8:e56058. 2013
    ..It was deduced that the mechanism by which β2 adrenoceptor desensitization occurs was by pattern recognition receptor activation of COX-2 induced prostaglandins...
  37. doi request reprint Matrix proteins from smoke-exposed fibroblasts are pro-proliferative
    David I Krimmer
    Woolcock Institute of Medical Research Cell Biology, Sydney, New South Wales, Australia
    Am J Respir Cell Mol Biol 46:34-9. 2012
    ..ECM produced from COPD fibroblasts after CSE exposure has proproliferative effects. Thus, the ECM in patients with COPD may create an environment that promotes airway remodeling...
  38. ncbi request reprint Interaction between glucocorticoids and beta2 agonists on bronchial airway smooth muscle cells through synchronised cellular signalling
    Michael Roth
    Department of Pharmacology and the Woolcock Institute of Medical Research, University of Sydney, NSW 2006, Australia
    Lancet 360:1293-9. 2002
    ..Our aim was to elucidate how glucocorticoids and beta2 agonists affect the growth of human bronchial airway smooth muscle cells...
  39. ncbi request reprint Airway smooth muscle--its relationship to the extracellular matrix
    Judith L Black
    Department of Pharmacology, Woolcock Institute of Medical Research, University of Sydney, Sydney, NSW 2006, Australia
    Respir Physiol Neurobiol 137:339-46. 2003
    ..It is unlikely that current therapy is effective in preventing or reversing remodeling, and therefore, understanding the pathophysiological events, which underlie its mechanism is critical...
  40. ncbi request reprint Airway smooth muscle and fibroblasts in the pathogenesis of asthma
    Peter R A Johnson
    Department of Pharmacology, The University of Sydney, NSW Australia 2006
    Curr Allergy Asthma Rep 4:102-8. 2004
    ..Current asthma therapies lack the ability to completely prevent or reverse the remodeling of the airways, therefore indicating the need for new therapeutic strategies to counter this important aspect of asthma...
  41. doi request reprint Transforming growth factor beta 1 increases fibronectin deposition through integrin receptor alpha 5 beta 1 on human airway smooth muscle
    Lyn M Moir
    Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia
    J Allergy Clin Immunol 121:1034-9.e4. 2008
    ..Altered expression of the integrin receptors, such as the fibronectin receptor alpha(5)beta(1), might be implicated in extracellular matrix accumulation in airway remodeling in asthma...
  42. doi request reprint Differential expression of peroxisome proliferator activated receptor gamma and cyclin D1 does not affect proliferation of asthma- and non-asthma-derived airway smooth muscle cells
    Justine Y Lau
    Cooperative Research Centre for Asthma and Airways, The University of Sydney, Sydney, New South Wales, Australia
    Respirology 15:303-12. 2010
    ..In the presence of FBS, PPARgamma levels were higher in subconfluent asthma-derived cells but lower in confluent cells compared with non-asthma-derived. However, PPARgamma activation did not alter cell proliferation...
  43. pmc Thiazolidinediones inhibit airway smooth muscle release of the chemokine CXCL10: in vitro comparison with current asthma therapies
    Petra Seidel
    Respiratory Research Group, Faculty of Pharmacy, The University of Sydney, A15, Science Rd, Sydney, NSW 2006, Australia
    Respir Res 13:90. 2012
    ....
  44. doi request reprint Elastin in asthma
    Caroline J Reddel
    School of Molecular Bioscience, University of Sydney, Sydney, NSW 2006, Australia
    Pulm Pharmacol Ther 25:144-53. 2012
    ..This review summarises the current understanding of the role of elastin in the asthmatic airway...
  45. ncbi request reprint Cyclosporine A mediates fibroproliferation through epithelial cells
    Katrin E Hostettler
    Respiratory Research Group, Department of Pharmacology, University of Sydney, New South Wales 2006, Australia
    Transplantation 77:1886-93. 2004
    ..Epithelium-fibroblast interactions have been suggested to play a crucial role in the course of fibroproliferation, which is a major feature of OB...
  46. ncbi request reprint ERK1/2 and p38 MAP kinase control MMP-2, MT1-MMP, and TIMP action and affect cell migration: a comparison between mesothelioma and mesothelial cells
    Jun Zhong
    Department of Pharmacology, The Woolcock Institute of Medical Research, University of Sydney, New South Wales, Australia
    J Cell Physiol 207:540-52. 2006
    ..Mesothelioma progression depends on an interaction with mesothelial cells that provide MT1-MMP necessary to activate pro-MMP-2 to facilitate migration through an extracellular matrix (ECM) layer...
  47. doi request reprint LF-15 & T7, Synthetic Peptides Derived from Tumstatin, Attenuate Aspects of Airway Remodelling in a Murine Model of Chronic OVA-Induced Allergic Airway Disease
    Karryn T Grafton
    Woolcock Institute of Medical Research, Sydney, New South Wales, Australia Discipline of Pharmacology, The University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 9:e85655. 2014
    ..This study assessed the anti-angiogenic properties of smaller peptides derived from tumstatin, which contain the interface tumstatin uses to interact with the αVβ3 integrin...
  48. pmc Combined Beta-agonists and corticosteroids do not inhibit extracellular matrix protein production in vitro
    Qi Ge
    Division of Cell Biology, Woolcock Institute of Medical Research, Sydney, P O Box M77, Missenden Road, NSW 2050, Australia
    J Allergy (Cairo) 2012:403059. 2012
    ..TGFβ1-induced IL-6 release was inhibited by the combination of drugs. Conclusion. Current combination asthma therapies are unable to prevent or reverse remodeling events regulated by ASM cells...
  49. ncbi request reprint Analysis of gene expression
    Janette K Burgess
    Respiratory Research Group, Department of Pharmacology, University of Sydney, Sydney, New South Wales, 2006 Australia
    Methods Enzymol 356:259-70. 2002
  50. pmc Effects of β(2) Agonists, Corticosteroids, and Novel Therapies on Rhinovirus-Induced Cytokine Release and Rhinovirus Replication in Primary Airway Fibroblasts
    David Van Ly
    Respiratory Research Group, Discipline of Pharmacology, The University of Sydney, Sydney, NSW 2006, Australia
    J Allergy (Cairo) 2011:457169. 2011
    ..Dimethylfumarate increased RV replication whilst other drugs did not alter RV replication. These data suggest that inhibition of NF-κB alone is unlikely to be an effective treatment compared to current asthma therapeutics...
  51. pmc Differential regulation of extracellular matrix and soluble fibulin-1 levels by TGF-β₁ in airway smooth muscle cells
    Ling Chen
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Shapingba, Chongqing, China
    PLoS ONE 8:e65544. 2013
    ..Therefore the increased deposition of FBLN-1 by ASM cells into the ECM following treatment with TGF-β1 is likely due to incorporation of soluble FBLN-1 rather than de-novo synthesis...
  52. doi request reprint Matrikines and the lungs
    Janette K Burgess
    Cell Biology, Woolcock Institute of Medical Research, Sydney, NSW, Australia
    Pharmacol Ther 134:317-37. 2012
    ..The focus of this review will be to summarise our current understanding of the role, and potential for highly relevant actions, of matrikines in lung health and disease...
  53. doi request reprint Inhibition of phosphodiesterase 4 modulates cytokine induction from toll like receptor activated, but not rhinovirus infected, primary human airway smooth muscle
    David Van Ly
    Woolcock Institute of Medical Research, Sydney, Australia
    Respir Res 14:127. 2013
    ..Given that phophodiesterase 4 (PDE4) inhibitors have an anti-inflammatory effect in patients with COPD they present a potential therapy prior to, and during, these exacerbations...
  54. ncbi request reprint Disease-specific expression and regulation of CCAAT/enhancer-binding proteins in asthma and chronic obstructive pulmonary disease
    Peter Borger
    Pulmonary Cell Research, Department of Research and Pneumology, Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    J Allergy Clin Immunol 119:98-105. 2007
    ..CCAAT/enhancer-binding proteins (C/EBPs) control cell proliferation; lack of C/EBPalpha correlates with increased proliferation of bronchial smooth muscle cells (BSMCs) of asthmatic patients...
  55. ncbi request reprint PAR-2 activation, PGE2, and COX-2 in human asthmatic and nonasthmatic airway smooth muscle cells
    Linda S Chambers
    Dept of Pharmacology, Univ of Sydney, New South Wales 2006, Australia
    Am J Physiol Lung Cell Mol Physiol 285:L619-27. 2003
    ..In addition, ASM cells from asthmatic patients produce significantly less PGE2 and COX-2 compared with nonasthmatic cells. These findings may contribute to the increase in muscle mass evident in asthmatic airways...