Simon G A Brown

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. ncbi request reprint Anaphylaxis to bull dog ant and jumper ant stings around Perth, Western Australia
    Yuri Gilhotra
    Department of Emergency Medicine, Fremantle Hospital, Fremantle, Western Australia, Australia
    Emerg Med Australas 18:15-22. 2006
  2. ncbi request reprint Causes of ant sting anaphylaxis in Australia: the Australian Ant Venom Allergy Study
    Simon G A Brown
    Western Australian Institute for Medical Research, University of Western Australia, Perth, WA, Australia
    Med J Aust 195:69-73. 2011
  3. ncbi request reprint Ant venom immunotherapy in Australia: the unmet need
    Raymond J Mullins
    John James Medical Centre, Canberra, ACT, Australia
    Med J Aust 201:33-4. 2014
  4. doi request reprint Anaphylaxis: clinical patterns, mediator release, and severity
    Simon G A Brown
    Centre for Clinical Research in Emergency Medicine, Western Australian Institute for Medical Research, Perth, Australia University of Western Australia, Crawley, Australia Royal Perth Hospital, Perth, Australia Fremantle Hospital, Fremantle, Australia Electronic address
    J Allergy Clin Immunol 132:1141-1149.e5. 2013
  5. doi request reprint Ultrarush versus semirush initiation of insect venom immunotherapy: a randomized controlled trial
    Simon G A Brown
    Jack Jumper Allergy Program, Royal Hobart Hospital, Hobart, Australia
    J Allergy Clin Immunol 130:162-8. 2012
  6. ncbi request reprint Anaphylaxis: clinical concepts and research priorities
    Simon G A Brown
    Discipline of Emergency Medicine, The University of Western Australia and Fremantle Hospital, Fremantle, Western Australia, Australia
    Emerg Med Australas 18:155-69. 2006
  7. ncbi request reprint The pathophysiology of shock in anaphylaxis
    Simon G A Brown
    Emergency Medicine Research Unit, The University of Western Australia and Fremantle Hospital, Alma Street, Fremantle, WA 6160, Australia
    Immunol Allergy Clin North Am 27:165-75, v. 2007
  8. ncbi request reprint Route of administration of redback spider bite antivenom: determining clinician beliefs to facilitate Bayesian analysis of a clinical trial
    Simon G A Brown
    Discipline of Emergency Medicine, University of Western Australia and Fremantle Hospital, Fremantle, West Australia, Australia
    Emerg Med Australas 19:458-63. 2007
  9. doi request reprint Clotting factor replacement and recovery from snake venom-induced consumptive coagulopathy
    Simon G A Brown
    Discipline of Emergency Medicine, University of Western Australia, Crawley, WA, Australia
    Intensive Care Med 35:1532-8. 2009
  10. ncbi request reprint Cardiovascular aspects of anaphylaxis: implications for treatment and diagnosis
    Simon G A Brown
    Discipline of Emergency Medicine, The University of Western Australia at Fremantle Hospital, Fremantle, Western Australia, Australia
    Curr Opin Allergy Clin Immunol 5:359-64. 2005

Detail Information

Publications36

  1. ncbi request reprint Anaphylaxis to bull dog ant and jumper ant stings around Perth, Western Australia
    Yuri Gilhotra
    Department of Emergency Medicine, Fremantle Hospital, Fremantle, Western Australia, Australia
    Emerg Med Australas 18:15-22. 2006
    ..To determine the main causative species, reaction characteristics and geographical locations of ant sting anaphylaxis around Perth, Western Australia (WA)...
  2. ncbi request reprint Causes of ant sting anaphylaxis in Australia: the Australian Ant Venom Allergy Study
    Simon G A Brown
    Western Australian Institute for Medical Research, University of Western Australia, Perth, WA, Australia
    Med J Aust 195:69-73. 2011
    ..To determine the Australian native ant species associated with ant sting anaphylaxis, geographical distribution of allergic reactions, and feasibility of diagnostic venom-specific IgE (sIgE) testing...
  3. ncbi request reprint Ant venom immunotherapy in Australia: the unmet need
    Raymond J Mullins
    John James Medical Centre, Canberra, ACT, Australia
    Med J Aust 201:33-4. 2014
    ..The tolerability and safety of JJA VIT are comparable with those of honeybee VIT. ..
  4. doi request reprint Anaphylaxis: clinical patterns, mediator release, and severity
    Simon G A Brown
    Centre for Clinical Research in Emergency Medicine, Western Australian Institute for Medical Research, Perth, Australia University of Western Australia, Crawley, Australia Royal Perth Hospital, Perth, Australia Fremantle Hospital, Fremantle, Australia Electronic address
    J Allergy Clin Immunol 132:1141-1149.e5. 2013
    ..Prospective human studies of anaphylaxis and its mechanisms have been limited, with few severe cases or examining only 1 or 2 mediators...
  5. doi request reprint Ultrarush versus semirush initiation of insect venom immunotherapy: a randomized controlled trial
    Simon G A Brown
    Jack Jumper Allergy Program, Royal Hobart Hospital, Hobart, Australia
    J Allergy Clin Immunol 130:162-8. 2012
    ..Venom immunotherapy can be initiated by different schedules, but randomized comparisons have not been performed...
  6. ncbi request reprint Anaphylaxis: clinical concepts and research priorities
    Simon G A Brown
    Discipline of Emergency Medicine, The University of Western Australia and Fremantle Hospital, Fremantle, Western Australia, Australia
    Emerg Med Australas 18:155-69. 2006
    ..A systematic approach with multicentre collaboration is required to improve our understanding and management of this disease...
  7. ncbi request reprint The pathophysiology of shock in anaphylaxis
    Simon G A Brown
    Emergency Medicine Research Unit, The University of Western Australia and Fremantle Hospital, Alma Street, Fremantle, WA 6160, Australia
    Immunol Allergy Clin North Am 27:165-75, v. 2007
    ..Where these measures fail, pathophysiologic considerations and anecdotal evidence support the consideration of selective vasoconstrictors as the next step in treatment...
  8. ncbi request reprint Route of administration of redback spider bite antivenom: determining clinician beliefs to facilitate Bayesian analysis of a clinical trial
    Simon G A Brown
    Discipline of Emergency Medicine, University of Western Australia and Fremantle Hospital, Fremantle, West Australia, Australia
    Emerg Med Australas 19:458-63. 2007
    ..To determine current beliefs of Australasian emergency physicians, to form the basis of 'stopping rules' for a clinical trial of intravenous (i.v.) versus intramuscular (i.m.) redback spider antivenom...
  9. doi request reprint Clotting factor replacement and recovery from snake venom-induced consumptive coagulopathy
    Simon G A Brown
    Discipline of Emergency Medicine, University of Western Australia, Crawley, WA, Australia
    Intensive Care Med 35:1532-8. 2009
    ..We aimed to determine if factor replacement after antivenom is associated with an earlier return of coagulation function...
  10. ncbi request reprint Cardiovascular aspects of anaphylaxis: implications for treatment and diagnosis
    Simon G A Brown
    Discipline of Emergency Medicine, The University of Western Australia at Fremantle Hospital, Fremantle, Western Australia, Australia
    Curr Opin Allergy Clin Immunol 5:359-64. 2005
    ..The purpose of this review is to examine recent studies relevant to the management and diagnosis of this condition...
  11. ncbi request reprint Anaphylaxis: diagnosis and management
    Simon G A Brown
    University of Western Australia, Fremantle Hospital, Fremantle, WA, Australia
    Med J Aust 185:283-9. 2006
    ..Provision of a MedicAlert bracelet should also be arranged...
  12. ncbi request reprint Elevated serum cytokines during human anaphylaxis: Identification of potential mediators of acute allergic reactions
    Shelley F Stone
    Centre for Clinical Research in Emergency Medicine, Western Australian Institute for Medical Research, Royal Perth Hospital and The University of Western Australia, Perth, Australia
    J Allergy Clin Immunol 124:786-92.e4. 2009
    ..Anaphylaxis is generally unanticipated and requires emergency management. Therefore, the biological mediators in human beings have been difficult to define...
  13. pmc Immune response to snake envenoming and treatment with antivenom; complement activation, cytokine production and mast cell degranulation
    Shelley F Stone
    Centre for Clinical Research in Emergency Medicine, Western Australian Institute for Medical Research and the University of Western Australia, Perth, Western Australia, Australia
    PLoS Negl Trop Dis 7:e2326. 2013
    ..We aimed to investigate the immune responses to Sri Lankan snake envenoming (predominantly by Russell's viper) and antivenom treatment...
  14. ncbi request reprint Myrmecia pilosula (Jack Jumper) ant venom: validation of a procedure to standardise an allergy vaccine
    Michael D Wiese
    Royal Hobart Hospital, Department of Pharmacy, GPO Box 1061L, Hobart, TAS 7001, Australia
    J Pharm Biomed Anal 46:58-65. 2008
    ..Techniques used to determine the content of some of the other minor allergens could be developed, which would further improve the standardisation methodology...
  15. pmc Using time-resolved fluorescence to measure serum venom-specific IgE and IgG
    Pauline E van Eeden
    Centre for Clinical Research in Emergency Medicine, Western Australian Institute for Medical Research, University of Western Australia, Perth, Australia
    PLoS ONE 6:e16741. 2011
    ..DELFIA was easily adapted for detecting sIgE to a panel of other native ant venoms...
  16. doi request reprint Mediators released during human anaphylaxis
    Shelley F Stone
    Centre for Clinical Research in Emergency Medicine, Western Australian Institute for Medical Research, University of Western Australia, Perth, Western Australia, Australia
    Curr Allergy Asthma Rep 12:33-41. 2012
    ..As our knowledge of the mechanisms of activation, key mediators, and the regulation of mediator release improves, new treatments for prevention and acute management may emerge...
  17. ncbi request reprint Ant venom immunotherapy: a double-blind, placebo-controlled, crossover trial
    Simon G A Brown
    Department of Emergency Medicine, Royal Hobart Hospital, Hobart, Tasmania, Australia
    Lancet 361:1001-6. 2003
    ..We aimed to establish whether M pilosula venom immunotherapy (VIT) prevents lifethreatening sting anaphylaxis in otherwise healthy adults...
  18. ncbi request reprint Genomic Responses during Acute Human Anaphylaxis Are Characterized by Upregulation of Innate Inflammatory Gene Networks
    Shelley F Stone
    Centre for Clinical Research in Emergency Medicine, Harry Perkins Institute of Medical Research and the University of Western Australia, Perth, Australia Department of Emergency Medicine, Royal Perth Hospital, Perth, Australia
    PLoS ONE 9:e101409. 2014
    ..Systemic spread of immune activation and mediator release is required for the development of anaphylaxis in humans. We hypothesized that peripheral blood leukocyte (PBL) activation plays a key role...
  19. doi request reprint Serial multiple biomarkers in the assessment of suspected acute coronary syndrome: multiple infarct markers in chest pain (MIMIC) study
    Stephen P J Macdonald
    Centre for Clinical Research in Emergency Medicine, Royal Perth Hospital, Perth, Australia
    Emerg Med J 30:149-54. 2013
    ..To evaluate the accuracy of a 2-h serial multiple biomarker (SMB) protocol for exclusion of myocardial infarction (MI) in the Emergency Department...
  20. ncbi request reprint Prevention of anaphylaxis with ant venom immunotherapy
    Simon G A Brown
    Department of Emergency Medicine, Fremantle Hospital, Alma Street, Fremantle, Western Australia
    Curr Opin Allergy Clin Immunol 3:511-6. 2003
    ..Until recently only whole ant body extracts have been used for immunotherapy. The purpose of this review is to examine recent advances in the understanding of ant venom allergy and treatment using venom immunotherapy...
  21. doi request reprint Determinants of severe hypoglycemia complicating type 2 diabetes: the Fremantle diabetes study
    Timothy M E Davis
    University of Western Australia, School of Medicine and Pharmacology, Fremantle Hospital, P O Box 480, Fremantle, Western Australia 6959, Australia
    J Clin Endocrinol Metab 95:2240-7. 2010
    ..There are limited published data characterizing severe hypoglycemia complicating type 2 diabetes...
  22. doi request reprint Modified TIMI risk score cannot be used to identify low-risk chest pain in the emergency department: a multicentre validation study
    Stephen P J Macdonald
    Centre for Clinical Research in Emergency Medicine, Western Australian Institute for Medical Research, Perth, Western Australia, Australia
    Emerg Med J 31:281-5. 2014
    ..A modified TIMI score (mTIMI, range 0-10), which gives increased weighting to these variables, has been proposed. We aimed to evaluate the performance of the mTIMI score in ED patients with suspected ACS...
  23. ncbi request reprint Immediate-type hypersensitivity drug reactions
    Shelley F Stone
    Centre for Clinical Research in Emergency Medicine, Harry Perkins Institute of Medical Research and the University of Western Australia, Perth, Western Australia Department of Emergency Medicine, Royal Perth Hospital, Perth, Western Australia
    Br J Clin Pharmacol 78:1-13. 2014
    ..There is an urgent need to improve and standardize diagnostic testing and desensitization protocols as other diagnostic tests currently available for assessment of immediate drug allergy are not highly predictive. ..
  24. ncbi request reprint Can serum mast cell tryptase help diagnose anaphylaxis?
    Simon G A Brown
    Department of Emergency Medicine, Royal Hobart Hospital, Hobart, Tasmania, Australia
    Emerg Med Australas 16:120-4. 2004
    ..We aimed to determine the utility of serum mast cell tryptase to diagnose anaphylaxis...
  25. ncbi request reprint Prevalence, severity, and natural history of jack jumper ant venom allergy in Tasmania
    Simon G A Brown
    Department of Emergency Medicine, Royal Hobart Hospital, Hobart, Tasmania, Australia
    J Allergy Clin Immunol 111:187-92. 2003
    ..The jack jumper ant (Myrmecia pilosula) is responsible for greater than 90% of Australian ant venom allergy. However, deaths have only been recorded in the island of Tasmania...
  26. doi request reprint Angiotensin-converting enzyme insertion/deletion polymorphism and severe hypoglycemia complicating type 2 diabetes: the Fremantle Diabetes Study
    Wendy A Davis
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, PO Box 480, Fremantle, Western Australia 6959, Australia
    J Clin Endocrinol Metab 96:E696-700. 2011
    ..The aim of this study was to determine whether the angiotensin-converting enzyme (ACE) gene I/D polymorphisms independently predict severe hypoglycemia in community-dwelling type 2 patients...
  27. ncbi request reprint Anaphylaxis--recognition and management
    Shelley J Kirkbright
    Royal Perth Hospital, Perth, Western Australia, Australia
    Aust Fam Physician 41:366-70. 2012
    ..Anaphylaxis is a rapid onset, multisystem hypersensitivity reaction. The diagnosis is usually straightforward, but may be difficult when skin signs are absent...
  28. ncbi request reprint Parallel infusion of hydrocortisone with/without chlorpheniramine bolus injection to prevent acute adverse reactions to antivenom for snakebites
    Simon G A Brown
    Med J Aust 180:428; author reply 428-9; discussion 429. 2004
  29. ncbi request reprint Efficacy of antivenom against the procoagulant effect of Australian brown snake (Pseudonaja sp.) venom: in vivo and in vitro studies
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, NSW, Australia
    Toxicon 49:57-67. 2007
    ..One vial of antivenom appears to be sufficient to bind and neutralise all venom in patients with severe brown snake envenoming...
  30. ncbi request reprint Clinically applicable laboratory end-points for treating snakebite coagulopathy
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Pathology 38:568-72. 2006
    ..To determine which coagulation tests best reflect the return of clotting function after snakebite venom induced consumptive coagulopathy (VICC)...
  31. ncbi request reprint High rate of immediate systemic hypersensitivity reactions to tiger snake antivenom
    Geoffrey K Isbister
    Med J Aust 184:419-20.. 2006
  32. ncbi request reprint Second symposium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium
    Hugh A Sampson
    Division of Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 117:391-7. 2006
    ....
  33. pmc A comparison of serum antivenom concentrations after intravenous and intramuscular administration of redback (widow) spider antivenom
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Br J Clin Pharmacol 65:139-43. 2008
    ..There are no studies measuring antivenom concentrations following intramuscular administration. This study aimed to compare antivenom concentrations following intravenous and intramuscular administration of redback spider antivenom (RBSAV)...
  34. ncbi request reprint Efficacy of ant venom immunotherapy and whole body extracts
    Simon G A Brown
    J Allergy Clin Immunol 116:464-5; author reply 465-6. 2005
  35. ncbi request reprint Clinical features and severity grading of anaphylaxis
    Simon G A Brown
    Department of Emergency Medicine, Royal Hobart Hospital Australia
    J Allergy Clin Immunol 114:371-6. 2004
    ..Existing grading systems for acute systemic hypersensitivity reactions vary considerably, have a number of deficiencies, and lack a consistent definition of anaphylaxis...
  36. ncbi request reprint Enzyme immunoassays in brown snake (Pseudonaja spp.) envenoming: detecting venom, antivenom and venom-antivenom complexes
    Margaret A O'Leary
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, Waratah NSW, Australia
    Toxicon 48:4-11. 2006
    ..Quantification of venom and antivenom will help to determine the dose of antivenom required to bind venom and to establish appropriate end points for antivenom treatment...