W J Britton

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. ncbi request reprint Improving vaccines against tuberculosis
    Warwick J Britton
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    Immunol Cell Biol 81:34-45. 2003
  2. ncbi request reprint Sensitivity of human gamma interferon assay and tuberculin skin testing for detecting infection with Mycobacterium tuberculosis in patients with culture positive tuberculosis
    W J Britton
    Centenary Institute of Cancer, Medicine and Cell Biology, Locked Bag No 6, Newtown NSW 2042, Australia
    Tuberculosis (Edinb) 85:137-45. 2005
  3. pmc A tumor necrosis factor mimetic peptide activates a murine macrophage cell line to inhibit mycobacterial growth in a nitric oxide-dependent fashion
    W J Britton
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    Infect Immun 66:2122-7. 1998
  4. ncbi request reprint Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin
    A G Bean
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, Australia
    J Immunol 162:3504-11. 1999
  5. pmc Molecular and immunological analyses of the Mycobacterium avium homolog of the immunodominant Mycobacterium leprae 35-kilodalton protein
    J A Triccas
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales 2042, Australia
    Infect Immun 66:2684-90. 1998
  6. ncbi request reprint Inactivation of the Mycobacterium tuberculosis fadB4 gene results in increased virulence in host cell and mice
    G M Scandurra
    Centenary Institute of Cancer Medicine and Cell Biology, University of Sydney, NSW 2006, Australia
    Microbes Infect 10:38-44. 2008
  7. pmc Independent protective effects for tumor necrosis factor and lymphotoxin alpha in the host response to Listeria monocytogenes infection
    D R Roach
    Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No 6, Newtown, NSW 2042, Australia
    Infect Immun 73:4787-92. 2005
  8. ncbi request reprint Dendritic cells infected with Mycobacterium bovis bacillus Calmette Guerin activate CD8(+) T cells with specificity for a novel mycobacterial epitope
    C G Feng
    Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No. 6, Newtown, NSW 2042, Australia
    Int Immunol 13:451-8. 2001
  9. pmc A 35-kilodalton protein is a major target of the human immune response to Mycobacterium leprae
    J A Triccas
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    Infect Immun 64:5171-7. 1996
  10. ncbi request reprint DNA encoding a single mycobacterial antigen protects against leprosy infection
    E Martin
    Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No. 6, NSW 2042, Newtown, Australia
    Vaccine 19:1391-6. 2001

Collaborators

Detail Information

Publications67

  1. ncbi request reprint Improving vaccines against tuberculosis
    Warwick J Britton
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    Immunol Cell Biol 81:34-45. 2003
    ..Therefore it is possible to achieve a greater level of protection against tuberculosis than with BCG, and this highlights the potential for new tuberculosis vaccines in humans...
  2. ncbi request reprint Sensitivity of human gamma interferon assay and tuberculin skin testing for detecting infection with Mycobacterium tuberculosis in patients with culture positive tuberculosis
    W J Britton
    Centenary Institute of Cancer, Medicine and Cell Biology, Locked Bag No 6, Newtown NSW 2042, Australia
    Tuberculosis (Edinb) 85:137-45. 2005
    ..Nine university-affiliated chest clinics in Australia...
  3. pmc A tumor necrosis factor mimetic peptide activates a murine macrophage cell line to inhibit mycobacterial growth in a nitric oxide-dependent fashion
    W J Britton
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    Infect Immun 66:2122-7. 1998
    ..The mimetic effects of TNF(70-80) on macrophage activation in vitro suggest that treatment with TNF(70-80) may modulate mycobacterial infections in vivo...
  4. ncbi request reprint Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin
    A G Bean
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, Australia
    J Immunol 162:3504-11. 1999
    ..Thus, the enhanced susceptibility of TNF-/- is not compensated for by the presence of LT alpha, and the critical role of TNF is not in the activation of T cells and macrophages but in the local organization of granulomas...
  5. pmc Molecular and immunological analyses of the Mycobacterium avium homolog of the immunodominant Mycobacterium leprae 35-kilodalton protein
    J A Triccas
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales 2042, Australia
    Infect Immun 66:2684-90. 1998
    ..Strong delayed-type hypersensitivity was elicited by the protein in guinea pigs sensitized with M. avium...
  6. ncbi request reprint Inactivation of the Mycobacterium tuberculosis fadB4 gene results in increased virulence in host cell and mice
    G M Scandurra
    Centenary Institute of Cancer Medicine and Cell Biology, University of Sydney, NSW 2006, Australia
    Microbes Infect 10:38-44. 2008
    ..tuberculosis lacking the fadB4 gene. Therefore fadB4 is part of the family of genes whose expression serves to regulate the virulence of M. tuberculosis within the host...
  7. pmc Independent protective effects for tumor necrosis factor and lymphotoxin alpha in the host response to Listeria monocytogenes infection
    D R Roach
    Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No 6, Newtown, NSW 2042, Australia
    Infect Immun 73:4787-92. 2005
    ..Therefore, in addition to TNF, soluble LTalpha(3) plays a separate essential role in control of listerial infection through control of leukocyte accumulation and organization in infected organs...
  8. ncbi request reprint Dendritic cells infected with Mycobacterium bovis bacillus Calmette Guerin activate CD8(+) T cells with specificity for a novel mycobacterial epitope
    C G Feng
    Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No. 6, Newtown, NSW 2042, Australia
    Int Immunol 13:451-8. 2001
    ..These data suggest that mycobacteria-specific CD8(+) T cells are primed during infection. Therefore, anti-mycobacterial vaccine strategies targeting the activation of specific CD8(+) T cells by DC may have improved protective efficacy...
  9. pmc A 35-kilodalton protein is a major target of the human immune response to Mycobacterium leprae
    J A Triccas
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    Infect Immun 64:5171-7. 1996
    ..leprae 35-kDa protein appears to be a major and relatively specific target of the human immune response to M. leprae and is a potential component of a diagnostic test to detect exposure to leprosy or a vaccine to combat the disease...
  10. ncbi request reprint DNA encoding a single mycobacterial antigen protects against leprosy infection
    E Martin
    Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No. 6, NSW 2042, Newtown, Australia
    Vaccine 19:1391-6. 2001
    ..Therefore, DNA immunization with the 35 kDa antigen is effective against M. leprae infection and genetic immunization with a combination of antigens holds the potential for an improved vaccine against leprosy...
  11. pmc Comparative protective effects of recombinant DNA and Mycobacterium bovis bacille Calmette-Guérin vaccines against M. avium infection
    E Martin
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, Australia
    Clin Exp Immunol 126:482-7. 2001
    ..Therefore, recombinant BCG-35 and BCG induced similar levels of protection in this model, and maximal protection against M. avium infection was attained by immunization with DNA encoding the 35 kDa protein...
  12. ncbi request reprint Mycobacterium tuberculosis defective in phthiocerol dimycocerosate translocation provides greater protective immunity against tuberculosis than the existing bacille Calmette-Guérin vaccine
    Rachel Pinto
    Mycobacterial Research Group, Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    J Infect Dis 189:105-12. 2004
    ....
  13. ncbi request reprint TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infection
    Daniel R Roach
    Centenary Institute of Cancer Medicine and Cell Biology, Newton, Sydney, New South Wales, Australia
    J Immunol 168:4620-7. 2002
    ..Therefore, TNF orchestrates early induction of chemokines and initial leukocyte recruitment, but has an additional role in the aggregation of leukocytes into functional granulomas capable of controlling virulent mycobacterial infection...
  14. pmc The combination of plasmid interleukin-12 with a single DNA vaccine is more effective than Mycobacterium bovis (bacille Calmette-Guèrin) in protecting against systemic Mycobacterim avium infection
    Ela Martin
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, Australia
    Immunology 109:308-14. 2003
    ..avium infection above that achieved by BCG, and this strategy may improve the efficacy of subunit vaccines against M. leprae and M. tuberculosis...
  15. pmc Protection against virulent Mycobacterium avium infection following DNA vaccination with the 35-kilodalton antigen is accompanied by induction of gamma interferon-secreting CD4(+) T cells
    E Martin
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales 2042, Australia
    Infect Immun 68:3090-6. 2000
    ..These results illustrate the importance of the 35-kDa protein in the protective response to M. avium infection and indicate that DNA vaccination successfully promotes a sustained level of protection during chronic M. avium infection...
  16. pmc Priming by DNA immunization augments protective efficacy of Mycobacterium bovis Bacille Calmette-Guerin against tuberculosis
    C G Feng
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales 2042, Australia
    Infect Immun 69:4174-6. 2001
    ..Depletion of the CD8(+) T cells in the immunized mice impaired protection in their spleens, indicating that this improved efficacy was partially mediated by CD8(+) T cells...
  17. ncbi request reprint Sequence and expression of the Mycobacterium leprae dnaJ gene
    S S Harvey
    Centenary Institute of Cancer Medicine and Cell Biology, University of Sydney, NSW, Australia
    J Gen Microbiol 139:2003-8. 1993
    ..leprae and M. tuberculosis (89%) with significant divergence between the two occurring only at the C-terminal end. The expressed recombinant DnaJ protein had a molecular mass of 42 kDa...
  18. pmc Plasmid interleukin-23 (IL-23), but not plasmid IL-27, enhances the protective efficacy of a DNA vaccine against Mycobacterium tuberculosis infection
    Teresa M Wozniak
    Centenary Institute of Cancer Medicine and Cell Biology, Mycobacterial Research Laboratory, Locked Bag No 6, Newtown, NSW 2042, Australia
    Infect Immun 74:557-65. 2006
    ..tuberculosis challenge. Therefore, both p2AIL-23 and p2AIL-12 are valuable as cytokine adjuvants for increasing the protective antituberculosis immunity induced by DNA vaccines...
  19. pmc Immunological diversity within a family of cutinase-like proteins of Mycobacterium tuberculosis
    Nicholas P West
    Mycobacterial Research Program, Centenary Institute of Cancer Medicine and Cell Biology Locked Bag 6, Newtown, NSW 2042, Australia
    Vaccine 26:3853-9. 2008
    ..Finally, following delivery of DNA vaccines, Clp1, 2 and 6, conferred a moderate yet reproducible and significant level of protection in a murine aerosol model of M. tuberculosis infection...
  20. pmc Co-immunization with DNA vaccines expressing granulocyte-macrophage colony-stimulating factor and mycobacterial secreted proteins enhances T-cell immunity, but not protective efficacy against Mycobacterium tuberculosis
    A T Kamath
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown NSW, Australia
    Immunology 96:511-6. 1999
    ..Therefore, despite modifying the cellular immune response to DNA vaccines, GM-CSF does not improve their protective efficacy at the peak of infection after an aerosol challenge with 100 c.f.u. of M. tuberculosis...
  21. ncbi request reprint Induction of CD8+ T-lymphocyte responses to a secreted antigen of Mycobacterium tuberculosis by an attenuated vaccinia virus
    C G Feng
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, Australia
    Immunol Cell Biol 79:569-75. 2001
    ....
  22. pmc T cell-derived tumour necrosis factor is essential, but not sufficient, for protection against Mycobacterium tuberculosis infection
    B M Saunders
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, Australia
    Clin Exp Immunol 137:279-87. 2004
    ..Therefore, both T cell- and macrophage-derived TNF play distinct roles in orchestrating the protective inflammatory response and enhancing survival during M. tuberculosis infection...
  23. ncbi request reprint Autocrine IL-10 impairs dendritic cell (DC)-derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12 production
    Caroline Demangel
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, Australia
    Eur J Immunol 32:994-1002. 2002
    ....
  24. ncbi request reprint A polymorphism in the P2X7 gene increases susceptibility to extrapulmonary tuberculosis
    Suran L Fernando
    Mycobacterial Research Programme, Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No 6, Newtown, NSW, Australia
    Am J Respir Crit Care Med 175:360-6. 2007
    ..Activation of the P2X(7) receptor on human macrophages induces killing of mycobacteria. We have identified polymorphisms in the P2X(7) gene that markedly reduce this killing...
  25. pmc Secreted lymphotoxin-alpha is essential for the control of an intracellular bacterial infection
    D R Roach
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown NSW 2042, Australia
    J Exp Med 193:239-46. 2001
    ..Therefore, LTalpha3is essential for the control of pulmonary tuberculosis, and its critical role lies not in the activation of T cells and macrophages per se but in the local organization of the granulomatous response...
  26. pmc Specific serological diagnosis of leprosy with a recombinant Mycobacterium leprae protein purified from a rapidly growing mycobacterial host
    J A Triccas
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    J Clin Microbiol 36:2363-5. 1998
    ..The assay proved highly specific (97.5%) and sensitive (90%) and compared favorably with two other established methods routinely utilized for leprosy serodiagnosis...
  27. pmc Stimulation of dendritic cells via CD40 enhances immune responses to Mycobacterium tuberculosis infection
    C Demangel
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, Australia
    Infect Immun 69:2456-61. 2001
    ..Therefore, although the manipulation of DC via CD40 is effective for enhancing immune responses to mycobacteria in vivo, additional strategies are required to increase protection against virulent M. tuberculosis infection...
  28. ncbi request reprint Improved protection against disseminated tuberculosis by Mycobacterium bovis bacillus Calmette-Guerin secreting murine GM-CSF is associated with expansion and activation of APCs
    Anthony A Ryan
    Centenary Institute of Cancer Medicine and Cell Biology, University of Sydney, Camperdown, Australia
    J Immunol 179:8418-24. 2007
    ..tuberculosis infection in humans...
  29. pmc Differential requirements for soluble and transmembrane tumor necrosis factor in the immunological control of primary and secondary Listeria monocytogenes infection
    Korana Musicki
    Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No 6, Newtown, NSW 2042, Australia
    Infect Immun 74:3180-9. 2006
    ..By contrast, memTNF alone is sufficient for resolution of a secondary, high-dose infection and for the transfer of protective immunity with memory T cells...
  30. doi request reprint Cutinase-like protein-6 of Mycobacterium tuberculosis is recognised in tuberculosis patients and protects mice against pulmonary infection as a single and fusion protein vaccine
    Erin R Shanahan
    Mycobacterial Research Program, Centenary Institute, New South Wales, Australia
    Vaccine 28:1341-6. 2010
    ..The data presented here may indicate that the cell wall-associated, putatively essential protein Culp6, shown here for the first time to be recognised in TB patients, is an attractive candidate for inclusion in future subunit vaccines...
  31. ncbi request reprint Effect of phthiocerol dimycocerosate deficiency on the transcriptional response of human macrophages to Mycobacterium tuberculosis
    G M Scandurra
    Mycobacterial Research Group, Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No 6, Newtown, NSW 2042, Australia
    Microbes Infect 9:87-95. 2007
    ..Therefore, although fadD26 deficiency is responsible for the early attenuation of the growth of M. tuberculosis in vivo, this effect is not associated with differences in the initial macrophage transcriptional response...
  32. ncbi request reprint Epitope-tagging vectors for the expression and detection of recombinant proteins in mycobacteria
    Joanne M Spratt
    Mycobacterial Research Group, Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No 6, Newtown, NSW 2042, Australia
    Plasmid 53:269-73. 2005
    ..The vectors described in this study will facilitate the expression of foreign proteins in mycobacterial host systems...
  33. ncbi request reprint Gene dosage determines the negative effects of polymorphic alleles of the P2X7 receptor on adenosine triphosphate-mediated killing of mycobacteria by human macrophages
    Suran L Fernando
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, Australia
    J Infect Dis 192:149-55. 2005
    ..We examined the effect of polymorphisms in the P2X7 gene (P2X7) on the capacity of macrophages to kill mycobacteria...
  34. pmc Mycobacterium bovis BCG-specific Th17 cells confer partial protection against Mycobacterium tuberculosis infection in the absence of gamma interferon
    Teresa M Wozniak
    Centenary Institute, Newtown, NSW, Australia
    Infect Immun 78:4187-94. 2010
    ..Therefore, Th17 cells can provide IFN-γ-independent protection against M. tuberculosis, and this effect may contribute to the early control of M. tuberculosis infection...
  35. pmc Coexpression of interleukin-12 chains by a self-splicing vector increases the protective cellular immune response of DNA and Mycobacterium bovis BCG vaccines against Mycobacterium tuberculosis
    Umaimainthan Palendira
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales 2042, Australia
    Infect Immun 70:1949-56. 2002
    ..tuberculosis to the level achieved with BCG. Therefore, codelivery of an IL-12-secreting plasmid may be a potent strategy for enhancing the protective efficacy of vaccines against M. tuberculosis...
  36. ncbi request reprint The genetic control of susceptibility to Mycobacterium tuberculosis
    W J Britton
    Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag 6, Newtown, NSW, Australia
    Novartis Found Symp 281:79-89; discussion 89-92, 208-9. 2007
    ..Insights into the genetic regulation of susceptibility to human TB may identify novel methods for controlling latent M. tuberculosis and reducing the burden of tuberculosis...
  37. pmc Differential protective efficacy of DNA vaccines expressing secreted proteins of Mycobacterium tuberculosis
    A T Kamath
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales 2042, Australia
    Infect Immun 67:1702-7. 1999
    ..The efficacy of these DNA vaccines suggests that multisubunit vaccination may contribute to future vaccine strategies against TB...
  38. ncbi request reprint Characterization of the gene encoding the immunodominant 35 kDa protein of Mycobacterium leprae
    N Winter
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    Mol Microbiol 16:865-76. 1995
    ..smegmatis. The availability of the recombinant 35 kDa protein will permit dissection of both antibody- and T-cell-mediated immune responses in leprosy patients...
  39. ncbi request reprint A novel tumor necrosis factor (TNF) mimetic peptide prevents recrudescence of Mycobacterium bovis bacillus Calmette-Guerin (BCG) infection in CD4+ T cell-depleted mice
    H Briscoe
    Department of Medicine, University of Sydney, NSW, Australia
    J Leukoc Biol 68:538-44. 2000
    ..Granuloma number and bacterial load were comparable in treated, T cell-depleted mice and in chronically infected, intact animals. Thus, TNF70-80 and hTNF can modulate recrudescent BCG infection in CD4+ T cell-deficient mice...
  40. ncbi request reprint Isolation of strong expression signals of Mycobacterium tuberculosis
    J A Triccas
    Unite de Genetique Mycobacterienne, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Microbiology 147:1253-8. 2001
    ..Furthermore, this study demonstrated that FACS provides a sensitive and efficient technique to measure and select strong mycobacterial expression signals...
  41. doi request reprint Gene expression in HIV-1/Mycobacterium tuberculosis co-infected macrophages is dominated by M. tuberculosis
    Susan Maddocks
    HIV Molecular Pathogenesis Group, Centre for Virus Research, Westmead Millennium Institute, University of Sydney, Westmead NSW 2145, Australia
    Tuberculosis (Edinb) 89:285-93. 2009
    ..Thus, the effects of M. tuberculosis infection on global gene expression dominated the effects of HIV-1 in co-infected primary human macrophages...
  42. ncbi request reprint Interleukin-23 restores immunity to Mycobacterium tuberculosis infection in IL-12p40-deficient mice and is not required for the development of IL-17-secreting T cell responses
    Teresa M Wozniak
    Mycobacterial Research Group, Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    J Immunol 177:8684-92. 2006
    ..Therefore, exogenous IL-23 can complement IL-12 deficiency for the initial expansion of Ag-specific T cells and is not essential for the development of potentially protective IL-17-secreting T cells...
  43. pmc Effects of DNA- and Mycobacterium bovis BCG-based delivery of the Flt3 ligand on protective immunity to Mycobacterium tuberculosis
    James A Triccas
    Microbial Pathogenesis and Immunity Group, Discipline of Infectious Diseases and Immunology, University of Sydney, Sydney, Australia
    Infect Immun 75:5368-75. 2007
    ..These results demonstrate the potential of in vivo targeting of DCs to improve antimycobacterial vaccine efficacy...
  44. ncbi request reprint Life and death in the granuloma: immunopathology of tuberculosis
    Bernadette M Saunders
    Mycobacterial Research Programme, Centenary Institute, Newtown, New South Wales, Australia
    Immunol Cell Biol 85:103-11. 2007
    ..The immunological factors controlling the development and maintenance of the granuloma will be reviewed...
  45. ncbi request reprint A loss-of-function polymorphism in the human P2X7 receptor abolishes ATP-mediated killing of mycobacteria
    Bernadette M Saunders
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW Australia
    J Immunol 171:5442-6. 2003
    ..These data demonstrate that a single nucleotide polymorphism in the P2X7 gene can allow survival of mycobacteria within infected host cells...
  46. ncbi request reprint Identification of strong promoter elements of Mycobacterium smegmatis and their utility for foreign gene expression in mycobacteria
    Joanne M Spratt
    Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No 6, Newtown, NSW 2042, Australia
    FEMS Microbiol Lett 224:139-42. 2003
    ..The utility of one of these promoters for the over-expression of foreign genes in mycobacteria was demonstrated by the efficient purification of the Mycobacterium leprae 35-kDa antigen from recombinant M. smegmatis...
  47. ncbi request reprint Characterization of immune responses during infection with Mycobacterium avium strains 100, 101 and the recently sequenced 104
    Bernadette M Saunders
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    Immunol Cell Biol 80:544-9. 2002
    ..avium strain 101 and, with the availability of its sequence, should be a useful tool for designing new vaccines or drugs therapies to treat the increasing incidence of M. avium infection in humans...
  48. ncbi request reprint Vaccines for other neonatal infections: neonatal BCG vaccination against tuberculosis
    Warwick J Britton
    Centenary Institute of Cancer Medicine and Cell Biology and Department of Medicine, University of Sydney, Bld DO6, Sydney, NSW 2006, Australia
    Expert Rev Vaccines 3:365-9. 2004
    ....
  49. ncbi request reprint Destabilized green fluorescent protein for monitoring transient changes in mycobacterial gene expression
    James A Triccas
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown NSW, Australia
    Res Microbiol 153:379-83. 2002
    ..This system will facilitate studies exploring dynamic changes in mycobacterial gene expression...
  50. ncbi request reprint Comparative affects of plasmid-encoded interleukin 12 and interleukin 18 on the protective efficacy of DNA vaccination against Mycobacterium tuberculosis
    James A Triccas
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    Immunol Cell Biol 80:346-50. 2002
    ..tuberculosis infection. Therefore co-administration of plasmid-encoded cytokines provides a potential method for optimizing the protective efficacy of DNA vaccination against tuberculosis...
  51. ncbi request reprint Expanding the antigenic repertoire of BCG improves protective efficacy against aerosol Mycobacterium tuberculosis infection
    Umaimainthan Palendira
    Mycobacterial Research Group, Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No 6, Newtown, NSW 2042, Australia
    Vaccine 23:1680-5. 2005
    ..These results suggest that BCG85B-ES warrants further investigation to determine its suitability to control tuberculosis in humans...
  52. pmc Lymphocyte recruitment and protective efficacy against pulmonary mycobacterial infection are independent of the route of prior Mycobacterium bovis BCG immunization
    Umaimainthan Palendira
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales 2042, Australia
    Infect Immun 70:1410-6. 2002
    ..tuberculosis or BCG challenge in both the lungs and spleen. Therefore, recruitment of effector T lymphocytes and protective efficacy against pulmonary mycobacterial infection are independent of the route of prior BCG immunization...
  53. ncbi request reprint Transmembrane TNF is sufficient to initiate cell migration and granuloma formation and provide acute, but not long-term, control of Mycobacterium tuberculosis infection
    Bernadette M Saunders
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    J Immunol 174:4852-9. 2005
    ..tuberculosis-infected recipient mice, as the transfer of WT T cells. Therefore, memTNF, in the absence of soluble TNF, is sufficient to control acute, but not chronic, M. tuberculosis infection, in part through its expression on T cells...
  54. ncbi request reprint Leprosy
    Warwick J Britton
    Centenary Institute of Cancer Medicine and Cell Biology and Department of Medicine, University of Sydney, NSW 2006, Australia
    Lancet 363:1209-19. 2004
    ..Thus, leprosy control activities must be maintained for decades to interrupt transmission of infection...
  55. pmc Secretion of functional monocyte chemotactic protein 3 by recombinant Mycobacterium bovis BCG attenuates vaccine virulence and maintains protective efficacy against M. tuberculosis infection
    Anthony A Ryan
    Mycobacterial Research Group, Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No 6, Newtown, NSW 2042, Australia
    Infect Immun 75:523-6. 2007
    ..Therefore, BCG(MCP-3) may be a safer alternative than conventional BCG for vaccination of immunocompromised individuals...
  56. ncbi request reprint Contribution of L-alanine dehydrogenase to in vivo persistence and protective efficacy of the BCG vaccine
    Gabriella M Scandurra
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW 2042, Australia
    Microbiol Immunol 50:805-10. 2006
    ..These results demonstrate that the inability to utilise L-alanine is not a contributing factor to the attenuated phenotype of BCG and does not influence the protective efficacy of the vaccine against TB...
  57. ncbi request reprint The Mycobacterium tuberculosis cysD and cysNC genes form a stress-induced operon that encodes a tri-functional sulfate-activating complex
    Rachel Pinto
    Mycobacterial Research Group, Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No 6, Newtown, NSW 2042, Australia
    Microbiology 150:1681-6. 2004
    ..The CysD and CysNC proteins were shown to form a multifunctional enzyme complex that exhibits the three linked catalytic activities that constitute the sulfate activation pathway...
  58. ncbi request reprint Genetic susceptibility to mycobacterial disease in humans
    Suran L Fernando
    Centenary Institute of Cancer Medicine and Cell Biology, Sydney, New South Wales, Australia
    Immunol Cell Biol 84:125-37. 2006
    ..These studies have defined immunological processes essential for the control of mycobacteria infections in humans...
  59. pmc Homology of the 70-kilodalton antigens from Mycobacterium leprae and Mycobacterium bovis with the Mycobacterium tuberculosis 71-kilodalton antigen and with the conserved heat shock protein 70 of eucaryotes
    R J Garsia
    Clinical Immunology Research Centre, University of Sydney, New South Wales, Australia
    Infect Immun 57:204-12. 1989
    ....
  60. pmc Cutinase-like proteins of Mycobacterium tuberculosis: characterization of their variable enzymatic functions and active site identification
    Nicholas P West
    Mycobacterial Research Program, Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag 6, Newtown, NSW, 2042, Australia
    FASEB J 23:1694-704. 2009
    ..tuberculosis, while Culp6, which is putatively essential for mycobacterial growth, was retained in the cell wall, suggesting the proteins play distinct roles in mycobacterial biology...
  61. ncbi request reprint Single chain antibody fragments for the selective targeting of antigens to dendritic cells
    Caroline Demangel
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, Australia
    Mol Immunol 42:979-85. 2005
    ..Further, this work suggests that scFvs fused to protein antigens and delivered as DNA vaccines may provide a generic means for delivering vaccinal molecules to selected cell populations...
  62. ncbi request reprint Priorities for the treatment of latent tuberculosis
    Guy B Marks
    N Engl J Med 351:832-4; author reply 832-4. 2004
  63. ncbi request reprint The effect of neonatal BCG vaccination on atopy and asthma at age 7 to 14 years: an historical cohort study in a community with a very low prevalence of tuberculosis infection and a high prevalence of atopic disease
    Guy B Marks
    Woolcock Institute of Medical Research, University of Sydney, Sydney, NSW, Australia
    J Allergy Clin Immunol 111:541-9. 2003
    ..There are no data on the effects of neonatal BCG vaccination on cytokine responses of lymphocytes that are exposed in vitro to allergens...
  64. ncbi request reprint A Thr357 to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophages
    Anne N Shemon
    Department of Medicine, University of Sydney, Level 5, Spurrett Building, Nepean Hospital, Penrith, New South Wales 2750, Australia
    J Biol Chem 281:2079-86. 2006
    ..Lymphocytes, monocytes, and macrophages from subjects homozygous for T357S or compound heterozygous for T357S and a second loss-of-function allele have reduced or absent P2X(7) receptor function...
  65. ncbi request reprint IL-5 T-cell responses to house dust mite are associated with the development of allergen-specific IgE responses and asthma in the first 5 years of life
    Christina Weber-Chrysochoou
    Woolcock Institute of Medical Research, Sydney, Australia
    J Allergy Clin Immunol 120:286-92. 2007
    ..Allergen-specific T(H)2-like cytokine responses are considered to be important in sensitization and allergic diseases...
  66. ncbi request reprint Comparison of IFN-gamma responses to mycobacterial antigens as markers of response to BCG vaccination
    Rosemary E Weir
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Tuberculosis (Edinb) 88:31-8. 2008
    ..We therefore conclude that Mtb PPD is the antigen preparation of choice for assessing the immunogenicity of BCG vaccination...
  67. ncbi request reprint Targeting dendritic cells with antigen-containing liposomes: a highly effective procedure for induction of antitumor immunity and for tumor immunotherapy
    Christina L van Broekhoven
    School of Biochemistry and Molecular Biology, Faculty of Science, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia
    Cancer Res 64:4357-65. 2004
    ..The results show that the targeting of antigen to DCs in this way is highly effective at inducing immunity and protection against the tumor, with protection being at least partially dependent on the eosinophil chemokine eotaxin...