J B Bremner

Summary

Affiliation: University of Wollongong
Country: Australia

Publications

  1. ncbi request reprint In vitro cytotoxicity evaluation of some substituted isatin derivatives
    Kara L Vine
    School of Biological Sciences, University of Wollongong, NSW 2522, Australia
    Bioorg Med Chem 15:931-8. 2007
  2. ncbi request reprint An investigation into the cytotoxicity and mode of action of some novel N-alkyl-substituted isatins
    Kara L Vine
    School of Biological Sciences, and Department of Chemistry, University of Wollongong, NSW 2522, Australia
    J Med Chem 50:5109-17. 2007
  3. doi request reprint Synthesis and structural characterization of 1-[2-(5-nitro-1H-indol-2-yl)phenyl]methylpyridinium chloride
    John B Bremner
    School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    Molecules 16:7627-33. 2011
  4. ncbi request reprint Dual action-based approaches to antibacterial agents
    John B Bremner
    Department of Chemistry, University of Wollongong, Wollongong, NSW, 2522, Australia
    Curr Med Chem 14:1459-77. 2007
  5. ncbi request reprint Synthesis and nicotinic receptor activity of a hydroxylated tropane
    John B Bremner
    Department of Chemistry and Institute for Biomolecular Science, University of Wollongong, Wollongong, NSW 2522, Australia
    Bioorg Med Chem Lett 14:271-3. 2004
  6. ncbi request reprint Ligand design for alpha(1) adrenoceptors
    J B Bremner
    Department of Chemistry, University of Wollongong, Wollongong, NSW, 2522, Australia
    Curr Med Chem 8:607-20. 2001
  7. ncbi request reprint Ligand design for alpha1 adrenoceptor subtype selective antagonists
    J B Bremner
    Department of Chemistry, University of Wollongong, NSW, Australia
    Bioorg Med Chem 8:201-14. 2000
  8. ncbi request reprint Chemical defense in the egg masses of benthic invertebrates: an assessment of antibacterial activity in 39 mollusks and 4 polychaetes
    K Benkendorff
    Department of Biological Sciences, University of Wollongong, New South Wales, 2522, Australia
    J Invertebr Pathol 78:109-18. 2001
  9. doi request reprint Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1
    John B Bremner
    School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    Bioorg Med Chem 18:2611-20. 2010
  10. doi request reprint N-phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents
    Lidia Matesic
    School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    Bioorg Med Chem 16:3118-24. 2008

Collaborators

  • Kara L Vine
  • Marie Ranson
  • P A Keller
  • R Griffith
  • Kim Lewis
  • Siritron Samosorn
  • Anders A Jensen
  • Danielle Skropeta
  • Lidia Matesic
  • Jennifer L Beck
  • Phurpa Wangchuk
  • Danuta Tomkiewicz
  • Gabriele Casadei
  • Timothy P Boyle
  • Michael J Kelso
  • Julie M Locke
  • Stephen G Pyne
  • John Deadman
  • Adel Garas
  • Joseph I Ambrus
  • Karina C Gornall
  • Y Berry
  • Susan J McGinty
  • Kirsten Benkendorff
  • K Benkendorff
  • Allan H White
  • Roonglawan Rattanajak
  • Sumalee Kamchonwongpaisan
  • - Samten
  • Brian W Skelton
  • Terence I Moy
  • Frederick M Ausubel
  • Jonah Larkins-Ford
  • James Garner
  • Philip R Clingan
  • David I Rhodes
  • Tamantha K Stutchbury
  • Jonathan Coates
  • Allan B Gamble
  • Kittiya Somphol
  • Jonathan A Coates
  • Anthony R Ball
  • Jihan Talib
  • A Davis
  • Robert M Graham
  • Angela Finch
  • Ramesh Pillai
  • A R Davis

Detail Information

Publications24

  1. ncbi request reprint In vitro cytotoxicity evaluation of some substituted isatin derivatives
    Kara L Vine
    School of Biological Sciences, University of Wollongong, NSW 2522, Australia
    Bioorg Med Chem 15:931-8. 2007
    ..These results indicate that di- and tri-substituted isatins may be useful leads for anticancer drug development in the future...
  2. ncbi request reprint An investigation into the cytotoxicity and mode of action of some novel N-alkyl-substituted isatins
    Kara L Vine
    School of Biological Sciences, and Department of Chemistry, University of Wollongong, NSW 2522, Australia
    J Med Chem 50:5109-17. 2007
    ..49 muM. Various N-alkylisatins were also found to dramatically alter lymphocyte morphology, destabilize microtubules, inhibit tubulin polymerization, induce G2/M cell cycle arrest, and activate the effector caspase-3 and -7...
  3. doi request reprint Synthesis and structural characterization of 1-[2-(5-nitro-1H-indol-2-yl)phenyl]methylpyridinium chloride
    John B Bremner
    School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    Molecules 16:7627-33. 2011
    ..u.) = 4; R1 = 0.048, and wR2 = 0.13. Of interest in the single crystal X-ray structure is the (intramolecular) disposition of the pyridinium plane over the indole heterocyclic residue [interplanar dihedral angle 17.91(4)°]...
  4. ncbi request reprint Dual action-based approaches to antibacterial agents
    John B Bremner
    Department of Chemistry, University of Wollongong, Wollongong, NSW, 2522, Australia
    Curr Med Chem 14:1459-77. 2007
    ..In particular the areas reviewed include the use of two drugs in combination, dual action prodrugs, and dual action drugs (or hybrid drugs)...
  5. ncbi request reprint Synthesis and nicotinic receptor activity of a hydroxylated tropane
    John B Bremner
    Department of Chemistry and Institute for Biomolecular Science, University of Wollongong, Wollongong, NSW 2522, Australia
    Bioorg Med Chem Lett 14:271-3. 2004
    ..Compound 4 also displayed generally similar binding and selectivity profiles at alpha(4)beta(2), alpha(2)beta(4), alpha(3)beta(4), and alpha(4)beta(4) nAChR subtypes to those for nicotine...
  6. ncbi request reprint Ligand design for alpha(1) adrenoceptors
    J B Bremner
    Department of Chemistry, University of Wollongong, Wollongong, NSW, 2522, Australia
    Curr Med Chem 8:607-20. 2001
    ..A new combined approach using pharmacophores and receptor docking affords possibilities for deeper insights into achieving small molecule binding selectivity...
  7. ncbi request reprint Ligand design for alpha1 adrenoceptor subtype selective antagonists
    J B Bremner
    Department of Chemistry, University of Wollongong, NSW, Australia
    Bioorg Med Chem 8:201-14. 2000
    ..The first preliminary antagonist pharmacophore model for the alpha1D adrenoceptor subtype is also reported...
  8. ncbi request reprint Chemical defense in the egg masses of benthic invertebrates: an assessment of antibacterial activity in 39 mollusks and 4 polychaetes
    K Benkendorff
    Department of Biological Sciences, University of Wollongong, New South Wales, 2522, Australia
    J Invertebr Pathol 78:109-18. 2001
    ..The results of this study indicate that a wide range of invertebrates use chemical defense to protect their early stage embryos against bacterial infection...
  9. doi request reprint Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1
    John B Bremner
    School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    Bioorg Med Chem 18:2611-20. 2010
    ..9-3.9microg/mL against Staphylococcus aureus. One peptoid had a MIC value of 6microg/mL against a methicillin-resistant strain of S. aureus (MRSA) and a MIC value of 2microg/mL against vancomycin-resistant strains of enterococci (VRE)...
  10. doi request reprint N-phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents
    Lidia Matesic
    School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    Bioorg Med Chem 16:3118-24. 2008
    ..The results allowed further development of structure-activity relationships. The compound 5,7-dibromo-N-(1-naphthylmethyl)-1H-indole-2,3-dione 5a was the most potent against U937 cells with an IC(50) value of 0.19 microM...
  11. ncbi request reprint Synthesis and biological evaluation of bicyclic and tricyclic substituted nortropane derivatives: discovery of a novel selective alpha1D-adrenergic receptor ligand
    Susan J McGinty
    Institute for Biomolecular Science and Department of Chemistry, University of Wollongong, Northfields Ave, Wollongong, NSW 2522, Australia
    Bioorg Med Chem 12:5639-50. 2004
    ..2.1]octan-3-spiro-2'-(1',3'-dioxolane)-6-ol, a novel lead compound selective for the alpha(1D)-adrenergic receptor, is reported...
  12. pmc Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components
    Danuta Tomkiewicz
    School of Chemistry, University of Wollongong, Northfields Ave, NSW 2522, Australia
    Antimicrob Agents Chemother 54:3219-24. 2010
    ..In summary, subtle repositioning of the pump-blocking INF55 moiety in berberine-INF55 hybrids was found to have a minimal effect on their antibacterial activities but to significantly alter their effects on MDR pumps...
  13. ncbi request reprint Synthesis of functionalized 2-aryl-5-nitro-1H-indoles and their activity as bacterial NorA efflux pump inhibitors
    Siritron Samosorn
    Institute for Biomolecular Science, Department of Chemistry, University of Wollongong, NSW 2522, Australia
    Bioorg Med Chem 14:857-65. 2006
    ..The compound [4-benzyloxy-2-(5-nitro-1H-2-yl)-phenyl]-methanol was the most potent pump inhibitor...
  14. pmc Structure-activity relationships of 2-aryl-1H-indole inhibitors of the NorA efflux pump in Staphylococcus aureus
    Joseph I Ambrus
    School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    Bioorg Med Chem Lett 18:4294-7. 2008
    ..A promising new antibacterial lead compound against S. aureus (2-phenyl-1H-indol-5-yl)-methanol, was also found...
  15. doi request reprint Synthesis of novel N-protected hydrophobic phenylalanines and their application in potential antibacterials
    Timothy P Boyle
    School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    Eur J Med Chem 44:1001-9. 2009
    ..An efficient synthesis of two new N-acetyl-4'-arylphenylalanines is described together with their incorporation into a number of cationic peptoid antibacterial agents, one of which had an MIC of 7.8 microg/mL against Staphylococcus aureus...
  16. ncbi request reprint Modelling of adrenoceptor ligand targets based on novel medium- or macro-sized fused nitrogen heterocyclic systems
    R Griffith
    Department of Chemistry, University of Wollongong, NSW, Australia
    J Comput Aided Mol Des 13:69-78. 1999
    ..None of the potential targets were closely enough related in this case to the lead compound to warrant synthesis...
  17. ncbi request reprint Mining the Chemical Abstracts database with pharmacophore-based queries
    John B Bremner
    Department of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    J Mol Graph Model 21:185-94. 2002
    ..Several structurally novel rigid ring skeletons were found with this new database mining technique which are potentially useful as leads in the design of alpha1B selective adrenergic receptor antagonists...
  18. doi request reprint Binaphthyl scaffolded peptoids via ring-closing metathesis reactions and their anti-bacterial activities
    Adel Garas
    School of Chemistry, University of Wollongong, Wollongong, NSW, Australia
    Bioorg Med Chem Lett 19:3010-3. 2009
    ..An efficient synthesis of four new acyclic and four new cyclic binaphthyl-based cationic peptoids is described. These compounds had anti-bacterial activities with MIC values of 4-62 microg/mL against Staphylococcus aureus...
  19. ncbi request reprint Isolation and NMR spectroscopic clarification of the alkaloid 1,3,7-trimethylguanine from the ascidian Eudistoma maculosum
    Y Berry
    Department of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    Nat Prod Res 20:479-83. 2006
    ..The alkaloid 1,3,7-trimethylguanine was isolated from the ascidian Eudistoma maculosum, and differences in the NMR spectroscopic data for this compound compared with data in the literature are due to ammonium salt formation...
  20. doi request reprint Development and assessment of novel all-in-one parenteral formulations with integrated anticoagulant properties for the concomitant delivery of 5-fluorouracil and calcium folinate
    Julie M Locke
    School of Chemistry, University of Wollongong, Wollongong, New South Wales, Australia
    Anticancer Drugs 20:822-31. 2009
    ....
  21. ncbi request reprint 2,4,5-Tribromo-1H-imidazole in the egg masses of three muricid molluscs
    Kirsten Benkendorff
    Department of Chemistry and Institute for Biomolecular Science, University of Wollongong, NSW, Australia, 2522
    Nat Prod Res 18:427-31. 2004
    ..This imidazole is likely to be responsible for some of the antimicrobial activity observed in the egg extracts. This is the first report of this compound from a natural source...
  22. doi request reprint Selective targeting of 2'-deoxy-5-fluorouridine to urokinase positive malignant cells in vitro
    Kara L Vine
    School of Biological Sciences and Centre for Medical Bioscience, University of Wollongong, NSW 2522, Australia v
    Bioorg Med Chem Lett 20:2908-11. 2010
    ..Up to 7 molecules of 5-FUdr were incorporated per PAI-2 molecule without affecting protein activity. This is the first time a small organic cytotoxin has been conjugated to PAI-2...
  23. ncbi request reprint Selectivity of an indolyl berberine derivative for tetrameric G-quadruplex DNA
    Karina C Gornall
    Department of Chemistry, University of Wollongong, NSW 2522, Australia
    Rapid Commun Mass Spectrom 21:1759-66. 2007
    ..These investigations show that SS14 is a promising lead compound for drugs that may selectively bind quadruplex over duplex DNA...
  24. doi request reprint Antiplasmodial activity of atisinium chloride from the Bhutanese medicinal plant, Aconitum orochryseum
    Phurpa Wangchuk
    School of Chemistry, University of Wollongong, Wollongong, NSW, Australia
    J Ethnopharmacol 130:559-62. 2010
    ..The plant Aconitum orochryseum Stapf. (Ranunculaceae) is employed together with other plants in Bhutanese traditional medicine and is indicated for malaria-associated fever...