Genomes and Genes
Nikola A Bowden
Affiliation: University of Newcastle
- The Role of Altered Nucleotide Excision Repair and UVB-Induced DNA Damage in MelanomagenesisTimothy Budden
Centre for Information Based Medicine, Hunter Medical Research Institute, and School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Newcastle, NSW 2289, Australia
Int J Mol Sci 14:1132-51. 2013..This review discusses the current research surrounding UVB radiation and NER capacity and how further investigation of NER could elucidate the role of NER in avoiding UV-induced cellular death resulting in melanomagenesis...
- Nucleotide excision repair gene expression after Cisplatin treatment in melanomaNikola A Bowden
Centre for Information Based Medicine, University of Newcastle, Newcastle, New South Wales, Australia
Cancer Res 70:7918-26. 2010..Our findings suggest a possible mechanistic explanation for the limited efficacy of cisplatin treatment and the possible role of UV light in melanoma...
- Preliminary investigation of gene expression profiles in peripheral blood lymphocytes in schizophreniaNikola A Bowden
Neuroscience Institute of Schizophrenia and Allied Disorders, Australia
Schizophr Res 82:175-83. 2006..The validity of this approach may lead to better methods of defining this enigmatic disease...
- Altered expression of regulator of G-protein signalling 4 (RGS4) mRNA in the superior temporal gyrus in schizophreniaNikola A Bowden
Neuroscience Institute of Schizophrenia and Allied Disorders, Sydney, Australia
Schizophr Res 89:165-8. 2007..Altered expression of RGS4 in cortical regions previously implicated in schizophrenia, such as the STG further supports the notion of RGS4 as a potential genetic and functional biological marker of schizophrenia...
- Altered gene expression in the superior temporal gyrus in schizophreniaNikola A Bowden
Neuroscience Institute of Schizophrenia and Allied Disorders, Sydney, NSW, Australia
BMC Genomics 9:199. 2008..The STG connects to the limbic system (hippocampus and amygdala), the thalamus and neocortical association areas in the prefrontal cortex, all of which have been implicated in schizophrenia...
- Gene expression profiling of xeroderma pigmentosumNikola A Bowden
Hunter Medical Research Institute, John Hunter Hospital, Lookout Rd, New Lambton Heights, NSW, 2305, Australia
Hered Cancer Clin Pract 4:103-10. 2006..Therefore, this analysis has revealed distinct gene expression profiles for the XP complementation groups and the first step towards understanding the neurological symptoms of XP...
- P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferationKelly A Avery-Kiejda
Oncology and Immunology, Calvary Mater Newcastle Hospital, University of Newcastle, Newcastle, NSW, Australia
BMC Cancer 11:203. 2011..While mutation of the P53 tumour suppressor gene is a common feature of many types of cancer, mutational inactivation of P53 in melanoma is uncommon; however, its function often appears abnormal...
- Regulators of global genome repair do not respond to DNA damaging therapy but correlate with survival in melanomaNikola A Bowden
School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Australia and Hunter Medical Research Institute, Newcastle, NSW, Australia
PLoS ONE 8:e70424. 2013..Taken together, these findings provide evidence of the mechanisms underlying NER deficiency in melanoma. ..
- Altered gene expression in the amygdala in schizophrenia: up-regulation of genes located in the cytomatrix active zoneJudith Weidenhofer
Neuroscience Institute of Schizophrenia and Allied Disorders NISAD, NSW, Australia
Mol Cell Neurosci 31:243-50. 2006..These results implicate for the first time the dysfunction of the cytomatrix active zone of synapses in the amygdala in the pathophysiology of schizophrenia...
- Altered expression of the plasminogen activation pathway in peripheral blood mononuclear cells in multiple sclerosis: possible pathomechanism of matrix metalloproteinase activationMathew B Cox
Hunter Medical Research Institute, Australia Faculty of Health, University of Newcastle, Australia
Mult Scler 19:1268-74. 2013..Multiple sclerosis (MS) is an autoimmune disorder where a breakdown in the integrity of the blood-brain barrier is thought to allow lymphocytes to enter the central nervous system...
- Potential association of vitamin D receptor polymorphism Taq1 with multiple sclerosisMathew B Cox
University of Newcastle and Hunter Medical Research Institute, Newcastle, Australia
Mult Scler 18:16-22. 2012..Current evidence based on genetic and epidemiological studies indicate that vitamin D is implicated in the aetiology of this disease...
- BRIP1, PALB2, and RAD51C mutation analysis reveals their relative importance as genetic susceptibility factors for breast cancerMichelle W Wong
Discipline of Medical Genetics and Centre for Information Based Medicine, The University of Newcastle, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW 2305, Australia
Breast Cancer Res Treat 127:853-9. 2011....
- Whole genome amplification and its impact on CGH array profilesBente A Talseth-Palmer
School of Biomedical Sciences, Faculty of Health, University of Newcastle and the Hunter Medical Research Institute, NSW, Australia
BMC Res Notes 1:56. 2008..Four experiments were conducted on amplified DNA compared to unamplified DNA and two experiments on unamplified DNA compared to unamplified DNA...
- Gene expression profiling in familial adenomatous polyposis adenomas and desmoid diseaseNikola A Bowden
School of Biomedical Sciences, University of Newcastle, Callaghan, NSW, Australia
Hered Cancer Clin Pract 5:79-96. 2007..This study furthers our understanding of the mechanisms underlying FAP and desmoid tumour formation...