Nikola A Bowden

Summary

Affiliation: University of Newcastle
Country: Australia

Publications

  1. ncbi request reprint Nucleotide excision repair: why is it not used to predict response to platinum-based chemotherapy?
    Nikola A Bowden
    Centre for Information Based Medicine, University of Newcastle, Australia School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Australia Hunter Medical Research Institute, Newcastle, NSW, Australia Electronic address
    Cancer Lett 346:163-71. 2014
  2. pmc Regulators of global genome repair do not respond to DNA damaging therapy but correlate with survival in melanoma
    Nikola A Bowden
    School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Australia and Hunter Medical Research Institute, Newcastle, NSW, Australia
    PLoS ONE 8:e70424. 2013
  3. pmc The Role of Altered Nucleotide Excision Repair and UVB-Induced DNA Damage in Melanomagenesis
    Timothy Budden
    Centre for Information Based Medicine, Hunter Medical Research Institute, and School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Newcastle, NSW 2289, Australia
    Int J Mol Sci 14:1132-51. 2013
  4. ncbi request reprint Preliminary investigation of gene expression profiles in peripheral blood lymphocytes in schizophrenia
    Nikola A Bowden
    Neuroscience Institute of Schizophrenia and Allied Disorders, Australia
    Schizophr Res 82:175-83. 2006
  5. ncbi request reprint Altered expression of regulator of G-protein signalling 4 (RGS4) mRNA in the superior temporal gyrus in schizophrenia
    Nikola A Bowden
    Neuroscience Institute of Schizophrenia and Allied Disorders, Sydney, Australia
    Schizophr Res 89:165-8. 2007
  6. pmc Altered gene expression in the superior temporal gyrus in schizophrenia
    Nikola A Bowden
    Neuroscience Institute of Schizophrenia and Allied Disorders, Sydney, NSW, Australia
    BMC Genomics 9:199. 2008
  7. pmc Gene expression profiling of xeroderma pigmentosum
    Nikola A Bowden
    Hunter Medical Research Institute, John Hunter Hospital, Lookout Rd, New Lambton Heights, NSW, 2305, Australia
    Hered Cancer Clin Pract 4:103-10. 2006
  8. doi request reprint Nucleotide excision repair gene expression after Cisplatin treatment in melanoma
    Nikola A Bowden
    Centre for Information Based Medicine, University of Newcastle, Newcastle, New South Wales, Australia
    Cancer Res 70:7918-26. 2010
  9. doi request reprint Low prevalence of germline PALB2 mutations in Australian triple-negative breast cancer
    Michelle W Wong-Brown
    School of Biomedical Sciences and Pharmacy Centre for Information Based Medicine, University of Newcastle, Hunter Medical Research Institute, Newcastle, NSW, Australia
    Int J Cancer 134:301-5. 2014
  10. pmc P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation
    Kelly A Avery-Kiejda
    Oncology and Immunology, Calvary Mater Newcastle Hospital, University of Newcastle, Newcastle, NSW, Australia
    BMC Cancer 11:203. 2011

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Nucleotide excision repair: why is it not used to predict response to platinum-based chemotherapy?
    Nikola A Bowden
    Centre for Information Based Medicine, University of Newcastle, Australia School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Australia Hunter Medical Research Institute, Newcastle, NSW, Australia Electronic address
    Cancer Lett 346:163-71. 2014
    ..This review summarises the results of previous investigations into NER in cisplatin response and clinical trials where the expression of NER proteins were compared to the response to platinum therapies in treatment. ..
  2. pmc Regulators of global genome repair do not respond to DNA damaging therapy but correlate with survival in melanoma
    Nikola A Bowden
    School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Australia and Hunter Medical Research Institute, Newcastle, NSW, Australia
    PLoS ONE 8:e70424. 2013
    ..Taken together, these findings provide evidence of the mechanisms underlying NER deficiency in melanoma. ..
  3. pmc The Role of Altered Nucleotide Excision Repair and UVB-Induced DNA Damage in Melanomagenesis
    Timothy Budden
    Centre for Information Based Medicine, Hunter Medical Research Institute, and School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Newcastle, NSW 2289, Australia
    Int J Mol Sci 14:1132-51. 2013
    ..This review discusses the current research surrounding UVB radiation and NER capacity and how further investigation of NER could elucidate the role of NER in avoiding UV-induced cellular death resulting in melanomagenesis...
  4. ncbi request reprint Preliminary investigation of gene expression profiles in peripheral blood lymphocytes in schizophrenia
    Nikola A Bowden
    Neuroscience Institute of Schizophrenia and Allied Disorders, Australia
    Schizophr Res 82:175-83. 2006
    ..The validity of this approach may lead to better methods of defining this enigmatic disease...
  5. ncbi request reprint Altered expression of regulator of G-protein signalling 4 (RGS4) mRNA in the superior temporal gyrus in schizophrenia
    Nikola A Bowden
    Neuroscience Institute of Schizophrenia and Allied Disorders, Sydney, Australia
    Schizophr Res 89:165-8. 2007
    ..Altered expression of RGS4 in cortical regions previously implicated in schizophrenia, such as the STG further supports the notion of RGS4 as a potential genetic and functional biological marker of schizophrenia...
  6. pmc Altered gene expression in the superior temporal gyrus in schizophrenia
    Nikola A Bowden
    Neuroscience Institute of Schizophrenia and Allied Disorders, Sydney, NSW, Australia
    BMC Genomics 9:199. 2008
    ..The STG connects to the limbic system (hippocampus and amygdala), the thalamus and neocortical association areas in the prefrontal cortex, all of which have been implicated in schizophrenia...
  7. pmc Gene expression profiling of xeroderma pigmentosum
    Nikola A Bowden
    Hunter Medical Research Institute, John Hunter Hospital, Lookout Rd, New Lambton Heights, NSW, 2305, Australia
    Hered Cancer Clin Pract 4:103-10. 2006
    ..Therefore, this analysis has revealed distinct gene expression profiles for the XP complementation groups and the first step towards understanding the neurological symptoms of XP...
  8. doi request reprint Nucleotide excision repair gene expression after Cisplatin treatment in melanoma
    Nikola A Bowden
    Centre for Information Based Medicine, University of Newcastle, Newcastle, New South Wales, Australia
    Cancer Res 70:7918-26. 2010
    ..Our findings suggest a possible mechanistic explanation for the limited efficacy of cisplatin treatment and the possible role of UV light in melanoma...
  9. doi request reprint Low prevalence of germline PALB2 mutations in Australian triple-negative breast cancer
    Michelle W Wong-Brown
    School of Biomedical Sciences and Pharmacy Centre for Information Based Medicine, University of Newcastle, Hunter Medical Research Institute, Newcastle, NSW, Australia
    Int J Cancer 134:301-5. 2014
    ..Our study shows that the prevalence of PALB2 germline mutations in individuals with TNBC is ∼1%, similar to the prevalence of PALB2 germline mutation of 1% in familial non-BRCA1/2 breast cancer cohorts...
  10. pmc P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation
    Kelly A Avery-Kiejda
    Oncology and Immunology, Calvary Mater Newcastle Hospital, University of Newcastle, Newcastle, NSW, Australia
    BMC Cancer 11:203. 2011
    ..While mutation of the P53 tumour suppressor gene is a common feature of many types of cancer, mutational inactivation of P53 in melanoma is uncommon; however, its function often appears abnormal...
  11. ncbi request reprint Altered gene expression in the amygdala in schizophrenia: up-regulation of genes located in the cytomatrix active zone
    Judith Weidenhofer
    Neuroscience Institute of Schizophrenia and Allied Disorders NISAD, NSW, Australia
    Mol Cell Neurosci 31:243-50. 2006
    ..These results implicate for the first time the dysfunction of the cytomatrix active zone of synapses in the amygdala in the pathophysiology of schizophrenia...
  12. doi request reprint Common genetic variants in the plasminogen activation pathway are not associated with multiple sclerosis
    Mathew B Cox
    Hunter Medical Research Institute, and University of Newcastle, Australia
    Mult Scler 20:489-91. 2014
    ..This suggested there are other potentially modifiable factors influencing gene expression in MS. ..
  13. doi request reprint Altered expression of the plasminogen activation pathway in peripheral blood mononuclear cells in multiple sclerosis: possible pathomechanism of matrix metalloproteinase activation
    Mathew B Cox
    Hunter Medical Research Institute, Australia
    Mult Scler 19:1268-74. 2013
    ..Multiple sclerosis (MS) is an autoimmune disorder where a breakdown in the integrity of the blood-brain barrier is thought to allow lymphocytes to enter the central nervous system...
  14. pmc STaRRRT: a table of short tandem repeats in regulatory regions of the human genome
    Katherine A Bolton
    Centre for Information Based Medicine, Hunter Medical Research Institute, Newcastle, NSW, Australia
    BMC Genomics 14:795. 2013
    ..To study STRs located in regulatory regions, we have performed genome-wide analysis to identify all STRs present in a region that is 2 kilobases upstream and 1 kilobase downstream of the transcription start sites of genes...
  15. doi request reprint Potential association of vitamin D receptor polymorphism Taq1 with multiple sclerosis
    Mathew B Cox
    University of Newcastle and Hunter Medical Research Institute, Newcastle, Australia
    Mult Scler 18:16-22. 2012
    ..Current evidence based on genetic and epidemiological studies indicate that vitamin D is implicated in the aetiology of this disease...
  16. doi request reprint BRIP1, PALB2, and RAD51C mutation analysis reveals their relative importance as genetic susceptibility factors for breast cancer
    Michelle W Wong
    Discipline of Medical Genetics and Centre for Information Based Medicine, The University of Newcastle, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW 2305, Australia
    Breast Cancer Res Treat 127:853-9. 2011
    ....
  17. pmc Whole genome amplification and its impact on CGH array profiles
    Bente A Talseth-Palmer
    School of Biomedical Sciences, Faculty of Health, University of Newcastle and the Hunter Medical Research Institute, NSW, Australia
    BMC Res Notes 1:56. 2008
    ..Four experiments were conducted on amplified DNA compared to unamplified DNA and two experiments on unamplified DNA compared to unamplified DNA...
  18. pmc Gene expression profiling in familial adenomatous polyposis adenomas and desmoid disease
    Nikola A Bowden
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW, Australia
    Hered Cancer Clin Pract 5:79-96. 2007
    ..This study furthers our understanding of the mechanisms underlying FAP and desmoid tumour formation...