David R Booth

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. pmc Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort
    Katherine R Smith
    Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, NSW 2145, Australia
    Genome Med 3:57. 2011
  2. pmc IL28B, HLA-C, and KIR variants additively predict response to therapy in chronic hepatitis C virus infection in a European Cohort: a cross-sectional study
    Vijayaprakash Suppiah
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Sydney, Australia
    PLoS Med 8:e1001092. 2011
  3. pmc Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease
    Mohammed Eslam
    Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney, Sydney, New South Wales 2145, Australia
    Nat Commun 6:6422. 2015
  4. doi The autoimmune disease-associated transcription factors EOMES and TBX21 are dysregulated in multiple sclerosis and define a molecular subtype of disease
    Grant P Parnell
    Institute for Immunology and Allergy Research, Westmead Millennium Institute University of Sydney, Sydney, New South Wales 2145, Australia
    Clin Immunol 151:16-24. 2014
  5. doi Will IL28B polymorphisms remain relevant to direct-acting antiviral treatment paradigms?
    Golo Ahlenstiel
    Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney, Sydney, Australia
    Antivir Ther 17:1163-70. 2012
  6. doi IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy
    Vijayaprakash Suppiah
    Storr Liver Unit, University of Sydney, Sydney, Australia
    Nat Genet 41:1100-4. 2009
  7. doi IFNL3 mediates interaction between innate immune cells: Implications for hepatitis C virus pathogenesis
    Kate S O'Connor
    Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia
    Innate Immun 20:598-605. 2014
  8. pmc Interaction of IFNL3 with insulin resistance, steatosis and lipid metabolism in chronic hepatitis C virus infection
    Mohammed Eslam
    Mohammed Eslam, Jacob George, Golo Ahlenstiel, Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney, Sydney, NSW 2145, Australia
    World J Gastroenterol 19:7055-61. 2013
  9. pmc IL7Rα expression and upregulation by IFNβ in dendritic cell subsets is haplotype-dependent
    Fiona C McKay
    Institute for Immunology and Allergy Research, Westmead Millennium Institute, Sydney, New South Whales, Australia Department of Medicine, University of Sydney, Sydney, New South Whales, Australia
    PLoS ONE 8:e77508. 2013
  10. doi The low EOMES/TBX21 molecular phenotype in multiple sclerosis reflects CD56+ cell dysregulation and is affected by immunomodulatory therapies
    Fiona C McKay
    Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales 2145, Australia Electronic address
    Clin Immunol 163:96-107. 2016

Collaborators

Detail Information

Publications17

  1. pmc Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort
    Katherine R Smith
    Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, NSW 2145, Australia
    Genome Med 3:57. 2011
    ..In people of European ancestry, there are 6 common (more than 1%) haplotypes for IL28B, one tagged by the rs8099917 minor allele, four tagged by rs12979860...
  2. pmc IL28B, HLA-C, and KIR variants additively predict response to therapy in chronic hepatitis C virus infection in a European Cohort: a cross-sectional study
    Vijayaprakash Suppiah
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney, Sydney, Australia
    PLoS Med 8:e1001092. 2011
    ....
  3. pmc Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease
    Mohammed Eslam
    Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney, Sydney, New South Wales 2145, Australia
    Nat Commun 6:6422. 2015
    ..These findings establish rs12979860 genotype as a strong aetiology-independent predictor of tissue inflammation and fibrosis. ..
  4. doi The autoimmune disease-associated transcription factors EOMES and TBX21 are dysregulated in multiple sclerosis and define a molecular subtype of disease
    Grant P Parnell
    Institute for Immunology and Allergy Research, Westmead Millennium Institute University of Sydney, Sydney, New South Wales 2145, Australia
    Clin Immunol 151:16-24. 2014
    ..Expression was stable over time, but did not predict disease phenotype. Optimal response to therapy might be indicated by normalization of expression of these genes in blood. ..
  5. doi Will IL28B polymorphisms remain relevant to direct-acting antiviral treatment paradigms?
    Golo Ahlenstiel
    Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney, Sydney, Australia
    Antivir Ther 17:1163-70. 2012
    ....
  6. doi IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy
    Vijayaprakash Suppiah
    Storr Liver Unit, University of Sydney, Sydney, Australia
    Nat Genet 41:1100-4. 2009
    ..These data suggest that host genetics may be useful for the prediction of drug response, and they also support the investigation of the role of IL28B in the treatment of HCV and in other diseases treated with IFN-alpha...
  7. doi IFNL3 mediates interaction between innate immune cells: Implications for hepatitis C virus pathogenesis
    Kate S O'Connor
    Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia
    Innate Immun 20:598-605. 2014
    ..This makes innate immune cells the key players in determining the functional significance of INFL3 polymorphisms in patients with HCV. ..
  8. pmc Interaction of IFNL3 with insulin resistance, steatosis and lipid metabolism in chronic hepatitis C virus infection
    Mohammed Eslam
    Mohammed Eslam, Jacob George, Golo Ahlenstiel, Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney, Sydney, NSW 2145, Australia
    World J Gastroenterol 19:7055-61. 2013
    ..This review analyzes the current data regarding this interaction and its meaning for HCV pathogenesis and disease progression. ..
  9. pmc IL7Rα expression and upregulation by IFNβ in dendritic cell subsets is haplotype-dependent
    Fiona C McKay
    Institute for Immunology and Allergy Research, Westmead Millennium Institute, Sydney, New South Whales, Australia Department of Medicine, University of Sydney, Sydney, New South Whales, Australia
    PLoS ONE 8:e77508. 2013
    ..IL7Rα haplotype may contribute to MS susceptibility through reduced capacity for IL7Rα signalling in myeloid cells, especially in the presence of IFNβ, and is currently under investigation as a predictor of therapeutic response. ..
  10. doi The low EOMES/TBX21 molecular phenotype in multiple sclerosis reflects CD56+ cell dysregulation and is affected by immunomodulatory therapies
    Fiona C McKay
    Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales 2145, Australia Electronic address
    Clin Immunol 163:96-107. 2016
    ..ET expression was normalised to healthy control levels with natalizumab, and was highly variable for glatiramer acetate, fingolimod, interferon-beta, dimethyl fumarate. ..
  11. doi IFNL3 polymorphisms predict response to therapy in chronic hepatitis C genotype 2/3 infection
    Mohammed Eslam
    Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney, NSW, Australia
    J Hepatol 61:235-41. 2014
    ..This study sought to clarify in a large cohort, whether SNPs in the IFNL3 region are associated with treatment response in HCV-2/3 patients...
  12. pmc Hepatitis C Virus Driven AXL Expression Suppresses the Hepatic Type I Interferon Response
    Scott A Read
    Storr Liver Centre, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, Australia
    PLoS ONE 10:e0136227. 2015
    ....
  13. doi Ribosomal protein S6 mRNA is a biomarker upregulated in multiple sclerosis, downregulated by interferon treatment, and affected by season
    Grant P Parnell
    Westmead Millennium Institute, University of Sydney, Sydney, New South Wales, Australia
    Mult Scler 20:675-85. 2014
    ..Multiple Sclerosis (MS) is an immune-mediated disease of the central nervous system which responds to therapies targeting circulating immune cells...
  14. doi IL28B in hepatitis C virus infection: translating pharmacogenomics into clinical practice
    Golo Ahlenstiel
    Storr Liver Unit, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Hawkesbury Road, Westmead, NSW 2145, Australia
    J Gastroenterol 45:903-10. 2010
    ..It will conclude with a discussion on how the research observations may translate into clinical practice and drug development...
  15. doi Identifying key regulatory genes in the whole blood of septic patients to monitor underlying immune dysfunctions
    Grant P Parnell
    Department of Intensive Care Medicine, University of Sydney, Nepean Hospital and Nepean Clinical School, Sydney, Australia
    Shock 40:166-74. 2013
    ..Our study provides an experimental basis to support further study on the use of a gene expression-based assay, to assess immunosuppression, and to guide immunotherapy in future clinical trials. ..
  16. doi Whole blood transcriptomic analysis to identify clinical biomarkers of drug response
    Grant P Parnell
    Westmead Millennium Institute, University of Sydney, Hawkesbury Road, Sydney, NSW, 2145, Australia
    Methods Mol Biol 1175:35-43. 2014
    ....
  17. doi The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis
    Kaushal S Gandhi
    Westmead Millennium Institute, University of Sydney, Sydney, Darcy Rd, New South Wales 2145, Australia
    Hum Mol Genet 19:2134-43. 2010
    ..Overall, these data indicate dysregulation of T cells can be detected in the whole blood of untreated MS patients, and supports targeting of activated T cells in therapy for all forms of MS...