Affiliation: University of Melbourne
- Relevant assay to study the adhesion of Plasmodium falciparum-infected erythrocytes to the placental epitheliumPhilippe Boeuf
Department of Medicine RMH WH, The University of Melbourne, Royal Melbourne Hospital, Melbourne, Australia
PLoS ONE 6:e21126. 2011..This demonstrates the power of this assay to advance our understanding of epithelial adhesion of infected erythrocytes and in the design of intervention strategies...
- Plasmodium falciparum malaria elicits inflammatory responses that dysregulate placental amino acid transportPhilippe Boeuf
The University of Melbourne, Department of Medicine RMH, Parkville, Victoria, Australia
PLoS Pathog 9:e1003153. 2013..However, IV more profoundly compromises placental amino acid transport function, leading to FGR. Our study offers the first pathogenetic explanation for FGR in PM...
- Placental hypoxia during placental malariaPhilippe Boeuf
Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
J Infect Dis 197:757-65. 2008..We investigated whether parasite or monocyte infiltrates were associated with placental hypoxia, as a potential mechanism underlying malarial FGR...
- Monocytes and macrophages in malaria: protection or pathology?Caroline Lin Lin Chua
The University of Melbourne, Department of Medicine Royal Melbourne Hospital, Parkville, Australia
Trends Parasitol 29:26-34. 2013..Knowledge of the factors influencing the balance between protection and pathology can assist in the design of therapeutics aimed at modulating monocyte and macrophage functions to improve outcomes...
- Placental malaria-associated inflammation disturbs the insulin-like growth factor axis of fetal growth regulationAlexandra J Umbers
Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Royal Parade, Parkville Victoria 3050, Australia
J Infect Dis 203:561-9. 2011..We sought to determine whether placental malaria and related inflammation were associated with disturbances in the insulin-like growth factor (IGF) axis, a major regulator of fetal growth...
- CyProQuant-PCR: a real time RT-PCR technique for profiling human cytokines, based on external RNA standards, readily automatable for clinical usePhilippe Boeuf
Unité d Immunologie Moléculaire des Parasites, URA CNRS 2581, Département de Parasitologie et de Médecine Moléculaire, Institut Pasteur, 28 rue du Dr, Roux, 75724 Paris Cedex 15, France
BMC Immunol 6:5. 2005..The techniques currently used for "absolute quantification" of cytokine mRNA are based on a DNA standard curve and do not take into account the critical impact of RT efficiency...