Bignold L. Initiation of genetic instability and tumour formation: a review and hypothesis of a nongenotoxic mechanism. Cell Mol Life Sci. 2003;60:1107-17 pubmed
..However, the acquired genetic instability in this cell line causes secondary mutations which lead to uncontrolled growth, and the heterogeneous morphologic and behavioural features of a tumour resembling the parent cell type. ..