Affiliation: University of Melbourne
- Implications of lipid biology for the pathogenesis of schizophreniaGregor E Berger
Early Psychosis Prevention and Intervention Centre, MH SKY EPPIC, Victoria
Aust N Z J Psychiatry 36:355-66. 2002..Both aspects are proposed as being important in the pathogenesis of schizophrenia. The purpose of this paper is to examine the implications of lipid biology, in particular the role of essential fatty acids (EFA), for schizophrenia...
- Incipient neurovulnerability and neuroprotection in early psychosisGregor E Berger
ORYGEN Research Centre, University of Melbourne, Parkville, Victoria, Australia
Psychopharmacol Bull 37:79-101. 2003..Neuroprotective strategies counteracting the loss or supporting the generation of progenitor cells may therefore be a potent therapeutic avenue to explore...
- Bioactive lipids in schizophreniaGregor E Berger
ORYGEN Youth Health and ORYGEN Research Centre, Department of Psychiatry, University of Melbourne, Australia
Int Rev Psychiatry 18:85-98. 2006..This review investigates the role of bioactive lipids in schizophrenia and its treatment, as well as its potential use in prevention...
- Emerging psychosis in young people - Part 1 - key issues for detection and assessmentGregor Berger
ORYGEN Youth Health, Melbourne, Victoria
Aust Fam Physician 35:315-21. 2006..General practitioners are ideally placed to identify early changes that may herald an emergent psychotic illness and to bridge the existing gap between patients, their families and specialist mental health services...
- Caudate nucleus volume in individuals at ultra-high risk of psychosis: a cross-sectional magnetic resonance imaging studyKatrina L Hannan
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Parkville, Victoria, Australia
Psychiatry Res 182:223-30. 2010..Future research should examine changes longitudinally together with analysis of shape to assess subregions of the caudate that connect with prefrontal cortex...
- Randomized controlled trial of interventions for young people at ultra high risk for psychosis: 6-month analysisAlison R Yung
ORYGEN Research Centre and University of Melbourne, Department of Psychiatry, 35 Poplar Rd, Parkville 3052, Victoria, Australia
J Clin Psychiatry 72:430-40. 2011..However, it is unclear which of these treatments are most effective, how long treatment should be given, and whether effects will be sustained over a prolonged period...
- PACE: a specialised service for young people at risk of psychotic disordersAlison R Yung
PACE Clinic, ORYGEN Youth Health, Melbourne, Vic, Australia
Med J Aust 187:S43-6. 2007....
- Structural abnormalities in the cuneus associated with Herpes Simplex Virus (type 1) infection in people at ultra high risk of developing psychosisThomas J Whitford
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, VIC 3053, Australia
Schizophr Res 135:175-80. 2012....
- Declining transition rate in ultra high risk (prodromal) services: dilution or reduction of risk?Alison R Yung
ORYGEN Research Centre, 35 Poplar Road, Parkville 3052, Victoria, Australia
Schizophr Bull 33:673-81. 2007..Patients presenting to them need help. It may be that we need to aim to prevent a range of target syndromes...
- Emerging psychosis in young people - Part 2 - key issues for acute managementRichard Fraser
ORYGEN, Youth Health, Melbourne, Victoria
Aust Fam Physician 35:323-7. 2006..Most GPs will at some point be faced with the reality of personally managing young patients with emerging psychotic disorders on their own, sometimes with very limited support...
- Intervention in individuals at ultra-high risk for psychosis: a review and future directionsPatrick D McGorry
Centre for Youth Mental Health, Orygen Youth Health Research Centre, University of Melbourne, Victoria, Australia
J Clin Psychiatry 70:1206-12. 2009..This article reviews intervention research in the ultra-high-risk phase of psychotic disorders...
- Emerging psychosis in young people - Part 3 - key issues for prolonged recoveryRichard Fraser
ORYGEN, Youth Health, Melbourne, Victoria
Aust Fam Physician 35:329-33. 2006..These patients need special attention in order to minimise the burden of disease and prolonged disability...
- Stress, the hippocampus and the hypothalamic-pituitary-adrenal axis: implications for the development of psychotic disordersLisa J Phillips
Department of Psychology, University of Melbourne, Parkville, Victoria, Australia
Aust N Z J Psychiatry 40:725-41. 2006..This paper summarizes and discusses evidence supporting a role for HPA-axis dysfunction in the early phase of schizophrenia and related disorders...
- Structural brain imaging evidence for multiple pathological processes at different stages of brain development in schizophreniaChristos Pantelis
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Royal Melbourne Hospital, Sunshine Hospital, Victoria
Schizophr Bull 31:672-96. 2005....
- Proton magnetic resonance spectroscopy in first episode psychosis and ultra high-risk individualsStephen J Wood
Melbourne Neuropsychiatry Centre, University of Melbourne and Sunshine Hospital, Melbourne, Australia
Schizophr Bull 29:831-43. 2003..This finding did not discriminate between those UHR individuals who later became psychotic and those who did not...
- The topical niacin sensitivity test: an inter- and intra-rater reliability study in healthy controlsMelissa Kerr
Department of Psychiatry, ORYGEN Research Centre, University of Melbourne, Locked Bag 10 35 Popular Road, Parkville, Victoria 3052, Australia
Prostaglandins Leukot Essent Fatty Acids 79:15-9. 2008..Intra-rater reliability estimates ranged from 0.63 to 0.93 for the total niacin sensitivity score. These data indicate that the 12-min topical niacin sensitivity test has excellent reliability...
- Investigating the effectiveness, safety and tolerability of quetiapine in the treatment of anorexia nervosa in young people: a pilot studyAndrew Court
ORYGEN Youth Health, Department of Psychiatry, University of Melbourne, 35 Poplar Road, Parkville, VIC 3052, Australia
J Psychiatr Res 44:1027-34. 2010..Further large-scale placebo-controlled clinical trials will be necessary to fully evaluate the benefits of quetiapine treatment for this disorder...
- Monitoring the safe use of clozapine: a consensus view from Victoria, AustraliaMichael Berk
Department of Clinical and Biomedical Sciences, Barwon Health, The University of Melbourne, Geelong, Melbourne, Victoria, Australia
CNS Drugs 21:117-27. 2007....
- The reliability and validity of the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) in first-episode psychosisLeanne Hides
Orygen Youth Health Research Centre, Centre for Youth Mental Health, University of Melbourne, Parkville Melbourne, Victoria 3052, Australia
Addict Behav 34:821-5. 2009..This study aims to determine the reliability and validity of the ASSIST for detecting substance use disorders in first-episode psychosis...
- Chronic modulation of serotonergic neurotransmission with sertraline attenuates the loudness dependence of the auditory evoked potential in healthy participantsJulian G Simmons
Orygen Youth Health Research Centre, Locked Bag 10, Parkville, Victoria 3052, Australia
Psychopharmacology (Berl) 217:101-10. 2011..However, acute manipulations of the serotonergic system in humans and animals have yielded inconsistent findings...
- Structural brain abnormalities in individuals with an at-risk mental state who later develop psychosisStefan J Borgwardt
Psychiatric Outpatient Department, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
Br J Psychiatry Suppl 51:s69-75. 2007..However, the timing of their emergence and the extent to which they are related to vulnerability to the disorder as opposed to psychotic illness itself is unclear...
- Increased calcium-independent phospholipase A2 activity in first but not in multiepisode chronic schizophreniaStefan Smesny
Department of Psychiatry, Friedrich Schiller University Jena, Jena, USA
Biol Psychiatry 57:399-405. 2005..Previous studies in chronic schizophrenia were less conclusive. To explore whether iPLA2 changes are stage dependent, we investigated serum iPLA2 activity in various stages of schizophrenia...
- Aneurysms of pericallosal cerebral artery haemorrhage with consecutive psychosisMurat Yildiz
Aust N Z J Psychiatry 41:554. 2007
- Potential use of the topical niacin skin test in early psychosis -- a combined approach using optical reflection spectroscopy and a descriptive rating scaleStefan Smesny
Department of Psychiatry, University of Jena, Philosophenweg 3, D 07743, Jena, Germany
J Psychiatr Res 37:237-47. 2003..Niacin sensitivity in high risk populations and the specificity of impaired skin response are subjects of further investigation...
- Risperidone, 2 mg/day vs. 4 mg/day, in first-episode, acutely psychotic patients: treatment efficacy and effects on fine motor functioningMarco C G Merlo
Hĵpitaux Universitaires de Genève, Departement de Psychiatrie, Chene Bourg, Switzerland
J Clin Psychiatry 63:885-91. 2002..The aim of this study was to examine differences in the improvement of clinical psychopathology and in fine motor functions at 2 doses of risperidone in first-episode, acutely psychotic patients...
- Neurobiology of early psychosisMatcheri S Keshavan
Department of Psychiatry and Behavioral Neurosciences, Wayne State University, UCH 9B, 4201 St Antoine Boulevard, Detroit, MI, USA
Br J Psychiatry Suppl 48:s8-18. 2005..Neurobiological studies of the early course of psychoses, such as schizophrenia, allow investigation of pathophysiology without the confounds of illness chronicity and treatment...