Maxwell R Bennett

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. doi request reprint Synapse regression in depression: the role of 5-HT receptors in modulating NMDA receptor function and synaptic plasticity
    Maxwell R Bennett
    Brain and Mind Research Institute, University Sydney, 100 Mallett Street, Camperdown, NSW 2050, Australia
    Aust N Z J Psychiatry 44:301-8. 2010
  2. doi request reprint Origins of the BOLD changes due to synaptic activity at astrocytes abutting arteriolar smooth muscle
    M R Bennett
    The Brain and Mind Research Institute, University of Sydney, NSW 2006, Australia
    J Theor Biol 252:123-30. 2008
  3. ncbi request reprint Synaptic P2X7 receptor regenerative-loop hypothesis for depression
    Maxwell R Bennett
    Brain and Mind Research Institute, University of Sydney, Camperdown, Australia
    Aust N Z J Psychiatry 41:563-71. 2007
  4. ncbi request reprint Origins of blood volume change due to glutamatergic synaptic activity at astrocytes abutting on arteriolar smooth muscle cells
    M R Bennett
    The Neurobiology Laboratory, Department of Physiology, University of Sydney, NSW 2006, Australia
    J Theor Biol 250:172-85. 2008
  5. ncbi request reprint Development of the concept of mind
    Maxwell R Bennett
    Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia
    Aust N Z J Psychiatry 41:943-56. 2007
  6. pmc A quantitative model of purinergic junctional transmission of calcium waves in astrocyte networks
    M R Bennett
    The Neurobiology Laboratory, Institute for Biomedical Research, Department of Physiology, University of Sydney, New South Wales, Australia
    Biophys J 89:2235-50. 2005
  7. pmc Purinergic junctional transmission and propagation of calcium waves in spinal cord astrocyte networks
    Max R Bennett
    The Neurobiology Laboratory, Department of Physiology, Institute for Biomedical Research, The School of Mathematics and Statistics, The University of Sydney, New South Wales, Australia
    Biophys J 91:3560-71. 2006
  8. ncbi request reprint Language and cortical function: conceptual developments
    M R Bennett
    The Neurobiology Laboratory, Department of Physiology, Institute for Biomedical Research, University of Sydney, Sydney, NSW 2006, Australia
    Prog Neurobiol 80:20-52. 2006
  9. ncbi request reprint Mechanisms of calcium sequestration during facilitation at active zones of an amphibian neuromuscular junction
    M R Bennett
    The Neurobiology Laboratory, Department of Physiology, The Institute for Biomedical Research, University of Sydney, New South Wales 2006, Australia
    J Theor Biol 247:230-41. 2007
  10. pmc Purinergic junctional transmission and propagation of calcium waves in cultured spinal cord microglial networks
    Max R Bennett
    The Neurobiology Laboratory, Department of Physiology, The University of Sydney, New South Wales, 2006, Australia
    Purinergic Signal 4:47-59. 2008

Collaborators

Detail Information

Publications44

  1. doi request reprint Synapse regression in depression: the role of 5-HT receptors in modulating NMDA receptor function and synaptic plasticity
    Maxwell R Bennett
    Brain and Mind Research Institute, University Sydney, 100 Mallett Street, Camperdown, NSW 2050, Australia
    Aust N Z J Psychiatry 44:301-8. 2010
    ..This allows dorsal regions to once more exert their inhibitory influence over ventral regions. In this way, SSRIs may exert their effect in normalizing dorsal hypometabolism and ventral hypermetabolism in those suffering from depression...
  2. doi request reprint Origins of the BOLD changes due to synaptic activity at astrocytes abutting arteriolar smooth muscle
    M R Bennett
    The Brain and Mind Research Institute, University of Sydney, NSW 2006, Australia
    J Theor Biol 252:123-30. 2008
    ....
  3. ncbi request reprint Synaptic P2X7 receptor regenerative-loop hypothesis for depression
    Maxwell R Bennett
    Brain and Mind Research Institute, University of Sydney, Camperdown, Australia
    Aust N Z J Psychiatry 41:563-71. 2007
    ..Polymorphisms in the P2X7 gene that modify operation of the regenerative loop or the release of cytokines, as can infections, change the functional state of neural networks, which may then lead to vulnerability to mood disorders...
  4. ncbi request reprint Origins of blood volume change due to glutamatergic synaptic activity at astrocytes abutting on arteriolar smooth muscle cells
    M R Bennett
    The Neurobiology Laboratory, Department of Physiology, University of Sydney, NSW 2006, Australia
    J Theor Biol 250:172-85. 2008
    ..This model predicts a linear increase in blood flow with increasing numbers of activated astrocytes, but a non-linear increase with increasing glutamate release...
  5. ncbi request reprint Development of the concept of mind
    Maxwell R Bennett
    Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia
    Aust N Z J Psychiatry 41:943-56. 2007
    ..It is the role of neuropsychiatry to identify the changes in the corporeal that need to be put aright when these psychological capacities go awry...
  6. pmc A quantitative model of purinergic junctional transmission of calcium waves in astrocyte networks
    M R Bennett
    The Neurobiology Laboratory, Institute for Biomedical Research, Department of Physiology, University of Sydney, New South Wales, Australia
    Biophys J 89:2235-50. 2005
    ..The properties of purinergic transmission at astrocyte junctions may determine many of the characteristics of Ca2+ propagation in networks of these cells...
  7. pmc Purinergic junctional transmission and propagation of calcium waves in spinal cord astrocyte networks
    Max R Bennett
    The Neurobiology Laboratory, Department of Physiology, Institute for Biomedical Research, The School of Mathematics and Statistics, The University of Sydney, New South Wales, Australia
    Biophys J 91:3560-71. 2006
    ....
  8. ncbi request reprint Language and cortical function: conceptual developments
    M R Bennett
    The Neurobiology Laboratory, Department of Physiology, Institute for Biomedical Research, University of Sydney, Sydney, NSW 2006, Australia
    Prog Neurobiol 80:20-52. 2006
    ..We seek to clarify what can be substantiated concerning the workings of the brain and the exercise of linguistic skills...
  9. ncbi request reprint Mechanisms of calcium sequestration during facilitation at active zones of an amphibian neuromuscular junction
    M R Bennett
    The Neurobiology Laboratory, Department of Physiology, The Institute for Biomedical Research, University of Sydney, New South Wales 2006, Australia
    J Theor Biol 247:230-41. 2007
    ..Biophys. J. 86(5), 2674-2690], with the single plasmalemma pump in that model now replaced by separate pumps for the plasmalemma and endoplasmic reticulum, as well as the introduction of a mitochondrial uniporter...
  10. pmc Purinergic junctional transmission and propagation of calcium waves in cultured spinal cord microglial networks
    Max R Bennett
    The Neurobiology Laboratory, Department of Physiology, The University of Sydney, New South Wales, 2006, Australia
    Purinergic Signal 4:47-59. 2008
    ....
  11. doi request reprint Dual constraints on synapse formation and regression in schizophrenia: neuregulin, neuroligin, dysbindin, DISC1, MuSK and agrin
    Maxwell R Bennett A O
    Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, NSW 2006, Australia
    Aust N Z J Psychiatry 42:662-77. 2008
    ....
  12. doi request reprint Consciousness and hallucinations in schizophrenia: the role of synapse regression
    Maxwell R Bennett A O
    Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia
    Aust N Z J Psychiatry 42:915-31. 2008
    ..Finally the neural basis of attention and awareness of these hallucinations are considered for subjects suffering from schizophrenia, and a set of important questions posed that await elucidation through future experimental studies...
  13. pmc A quantitative model of cortical spreading depression due to purinergic and gap-junction transmission in astrocyte networks
    Max R Bennett
    The Brain and Mind Research Institute, The Centre for Mathematical Biology, and The School of Mathematics and Statistics, The University of Sydney, New South Wales 2006, Australia
    Biophys J 95:5648-60. 2008
    ..Furthermore, these models give quantitative accounts of the effects on the characteristics of SD of agents toxic for astrocytes and of gap-junction blockers. Finally, an additional series of critical tests of the model is suggested...
  14. doi request reprint Stress and anxiety in schizophrenia and depression: glucocorticoids, corticotropin-releasing hormone and synapse regression
    Maxwell R Bennett A O
    Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia
    Aust N Z J Psychiatry 42:995-1002. 2008
    ....
  15. ncbi request reprint Synapse formation and regression in the cortex during adolescence and in schizophrenia
    Maxwell R Bennett
    Department of Physiology, University of Sydney, Sydney, NSW
    Med J Aust 190:S14-6. 2009
    ..Further research in this field could examine when synapse loss in the DLPC of patients with schizophrenia occurs, and further elucidate how these molecules are involved in the development of schizophrenia...
  16. doi request reprint Criminal law as it pertains to 'mentally incompetent defendants': a McNaughton rule in the light of cognitive neuroscience
    Maxwell Bennett A O
    Brain and Mind Research Institute, University of Sydney, NSW, Australia
    Aust N Z J Psychiatry 43:289-99. 2009
    ..This raises the question as to what level of synaptic loss will the legislature and the courts rule as sufficient for a subject to be no longer held responsible for their lack of restraint...
  17. doi request reprint Positive and negative symptoms in schizophrenia: the NMDA receptor hypofunction hypothesis, neuregulin/ErbB4 and synapse regression
    Maxwell Bennett
    Brain and Mind Research Institute, University of Sydney, NSW, Australia
    Aust N Z J Psychiatry 43:711-21. 2009
    ....
  18. doi request reprint P2X7 regenerative-loop potentiation of glutamate synaptic transmission by microglia and astrocytes
    Max R Bennett
    The Brain and Mind Research Institute, The University of Sydney, New South Wales 2006, Australia
    J Theor Biol 261:1-16. 2009
    ....
  19. ncbi request reprint A quantitative description of the contraction of blood vessels following the release of noradrenaline from sympathetic varicosities
    M R Bennett
    The Neurobiology Laboratory, Department of Physiology, and Institute for Biomedical Research, University of Sydney, NSW, 2006, Australia
    J Theor Biol 234:107-22. 2005
    ..The model thus provides a quantitative account of vascular smooth muscle contraction upon sympathetic nerve stimulation...
  20. ncbi request reprint Emotion and cortical-subcortical function: conceptual developments
    M R Bennett
    The Neurobiology Laboratory, Department of Physiology, Institute for Biomedical Research, University of Sydney, Sydney, NSW 2006, Australia
    Prog Neurobiol 75:29-52. 2005
    ..We attempt to clarify what can and cannot be justified as established concerning the workings of the brain and emotions...
  21. pmc The probability of quantal secretion within an array of calcium channels of an active zone
    M R Bennett
    The Neurobiology Laboratory, Institute for Biomedical Research, Department of Physiology, University of Sydney, New South Wales 2006, Australia
    Biophys J 78:2222-40. 2000
    ....
  22. pmc The probability of quantal secretion near a single calcium channel of an active zone
    M R Bennett
    The Neurobiology Laboratory, Institute for Biomedical Research, Department of Physiology, University of Sydney, New South Wales 2006, Australia
    Biophys J 78:2201-21. 2000
    ....
  23. ncbi request reprint Statistics of transmitter release at nerve terminals
    M R Bennett
    Department of Physiology, Institute for Biomedical Research, University of Sydney, NSW, Australia
    Prog Neurobiol 60:545-606. 2000
    ..This offers the possibility in the near future of identifying the kinetic interaction of these proteins with the parameters of the stochastic process of exocytosis which confer a particular probability on individual synapses...
  24. ncbi request reprint The concept of transmitter receptors: 100 years on
    M R Bennett
    The Neurobiology Laboratory, Institute for Biomedical Research and Department of Physiology, University of Sydney, NSW, Australia
    Neuropharmacology 39:523-46. 2000
    ..The review concludes with the triumph of the first recordings of the electrical signs of single channel openings by Neher and Sakmann (1976) at the receptors which Langley had first described...
  25. ncbi request reprint Forty years of amino acid transmission in the brain
    M R Bennett
    The Institute for Biomedical Research, The University of Sydney, NSW, Australia
    Neurochem Int 35:269-80. 1999
    ..The relationship is also explored between these early findings and those of the present era characterised by extensive use of techniques of molecular biology and the development of drugs against targets identified 30 to 40 years ago...
  26. ncbi request reprint One hundred years of adrenaline: the discovery of autoreceptors
    M R Bennett
    Institute for Biomedical Research and The Department of Physiology, University of Sydney, Australia
    Clin Auton Res 9:145-59. 1999
    ..This paper assesses the contributions that established the idea of the adrenergic autoreceptor, 100 years after the discovery of adrenaline...
  27. ncbi request reprint Synapse formation molecules in muscle and autonomic ganglia: the dual constraint hypothesis
    M R Bennett
    Neurobiology Laboratory, University of Sydney, NSW, Australia
    Prog Neurobiol 57:225-87. 1999
    ..The extent to which there is evidence for similar molecules at neuronal synapses such as those in autonomic ganglia is also considered...
  28. ncbi request reprint Sympathetic neuromuscular transmission at a varicosity in a syncytium
    M R Bennett
    Department of Physiology, Institute for Biomedical Research, University of Sydney, NSW, Australia
    Microsc Res Tech 42:433-50. 1998
    ....
  29. pmc Quantal and non-quantal current and potential fields around individual sympathetic varicosities on release of ATP
    M R Bennett
    The Neurobiology Laboratory, Institute for Biomedical Research, and Department of Physiology, Sydney, New South Wales 2006, Australia
    Biophys J 80:1311-28. 2001
    ..This work provides an internally consistent description of quantal potential and current fields about the varicosities of sympathetic nerve terminals and provides evidence for a non-quantal form of transmitter release...
  30. ncbi request reprint The formation and function of single transmitter release sites at mature amphibian motor-nerve terminals
    Maxwell R Bennett
    The Neurobiology Laboratory, Department of Physiology and Institute for Biomedical Research, University of Sydney, NSW 2006, Australia
    J Neurocytol 32:447-72. 2003
    ..These were accompanied by changes in the configuration of terminal Schwann cells, which generally occurred prior to changes in the length of nerve terminal branches...
  31. ncbi request reprint Perception and memory in neuroscience: a conceptual analysis
    M R Bennett
    The Neurobiology Laboratory, Department of Physiology, Institute for Biomedical Research, University of Sydney, NSW 2006, Sydney, Australia
    Prog Neurobiol 65:499-543. 2001
    ..Subsequently, we outline what we take to be the appropriate conceptual scheme for neuroscientists to adopt...
  32. ncbi request reprint Neuronal cell death, nerve growth factor and neurotrophic models: 50 years on
    M R Bennet
    Department of Physiology, Institute for Biomedical Research, University of Sydney, New South Wales, Australia
    Auton Neurosci 95:1-23. 2002
    ....
  33. ncbi request reprint A quantitative description of the diffusion of noradrenaline in the media of blood vessels following its release from sympathetic varicosities
    M R Bennett
    The Neurobiology Laboratory, Department of Physiology, The Institute for Biomedical Research, University of Sydney, Sydney, New South Wales 2006, Australia
    J Theor Biol 226:359-72. 2004
    ....
  34. ncbi request reprint The motor system in neuroscience: a history and analysis of conceptual developments
    M R Bennett
    Neurobiology Laboratory, Department of Physiology, Institute for Biomedical Research, University of Sydney, Sydney 2006, NSW, Australia
    Prog Neurobiol 67:1-52. 2002
    ..The review concludes with what we take to be an appropriate basis for rejecting the Cartesian paradigm that we hope will assist neuroscientists in understanding the integrative action of the nervous system...
  35. pmc The facilitated probability of quantal secretion within an array of calcium channels of an active zone at the amphibian neuromuscular junction
    M R Bennett
    Department of Physiology, The Institute for Biomedical Research, and The School of Mathematics and Statistics, University of Sydney, New South Wales, 2006, Australia
    Biophys J 86:2674-90. 2004
    ..In addition, it accounts for the relative invariance of the kinetics of quantal release due to test-conditioning sequences of impulses as well as due to change in the extent of calcium influx during an impulse...
  36. doi request reprint Rottlerin inhibits (Na+, K+)-ATPase activity in brain tissue and alters D-aspartate dependent redistribution of glutamate transporter GLAST in cultured astrocytes
    Khoa T D Nguyen
    School of Medical Sciences and Bosch Institute for Biomedical Research, The University of Sydney, Sydney, NSW 2006, Australia
    Neurochem Res 34:1767-74. 2009
    ....
  37. doi request reprint Distribution of glutamate transporter GLAST in membranes of cultured astrocytes in the presence of glutamate transport substrates and ATP
    Jae Won Shin
    Anatomy and Histology, School of Medical Sciences and Bosch Institute for Biomedical Research, The University of Sydney, Sydney, NSW 2006, Australia
    Neurochem Res 34:1758-66. 2009
    ..The present data suggest that GLAST can rapidly and specifically respond to changes in the cellular environment thus potentially helping to fine-tune the functions of astrocytes...
  38. doi request reprint Purinergic P2X(7) receptor antagonists: Chemistry and fundamentals of biological screening
    Hendra Gunosewoyo
    School of Chemistry, University of Sydney, NSW 2006, Australia
    Bioorg Med Chem 17:4861-5. 2009
    ..This perspective will attempt to highlight some of the most recent key findings in both the biology and chemistry...
  39. ncbi request reprint Differential sensitivity to calcium and osmotic pressure of fast and slow ATP currents at sympathetic varicosities in mouse vas deferens
    Duncan H Blair
    Department of Physiology and Institute for Biomedical Research, University of Sydney, Sydney, NSW 2006, Australia
    Auton Neurosci 105:45-52. 2003
    ..These observations point to two classes of exocytosis from sympathetic nerve terminals that parallel those of exocytosis from chromaffin cells...
  40. pmc Correlating anterior insula gray matter volume changes in young people with clinical and neurocognitive outcomes: an MRI study
    Sean N Hatton
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia
    BMC Psychiatry 12:45. 2012
    ..This study examined the relationship between anterior insula GMV, clinical symptom severity and neuropsychological performance in a heterogeneous cohort of young people presenting for mental health care...
  41. doi request reprint Cubyl amides: novel P2X7 receptor antagonists
    Hendra Gunosewoyo
    School of Chemistry, University of Sydney, NSW 2006, Australia
    Bioorg Med Chem Lett 18:3720-3. 2008
    ..All synthesised compounds possessed P2X7R antagonistic properties when tested on rat spinal cord microglia cells. Extensive screening for binding to other neuroreceptor subtypes demonstrated their P2X7 selectivity...
  42. ncbi request reprint P2X1 receptor currents after disruption of the PKC site and its surroundings by dominant negative mutations in HEK293 cells
    Guo Jun Liu
    The Neurobiology Laboratory, Department of Physiology and Institute for Biomedical Research, University of Sydney, New South Wales 2006, Australia
    Auton Neurosci 108:12-6. 2003
    ..We conclude that T18P19R20 is phosphorylated following P2X1 binding of ligand but that the three PKC sites function to different degree...
  43. doi request reprint Development of ramified microglia from early macrophages in the zebrafish optic tectum
    Adam J Svahn
    Brain and Mind Research Institute, Sydney Medical School, University of Sydney, 100 Mallett St, Camperdown, New South Wales 2050, Australia
    Dev Neurobiol 73:60-71. 2013
    ..Thus, the development of zebrafish microglia and their cellular interactions was studied in the intact developing brain in real time and at cellular resolution...
  44. doi request reprint Stress-induced grey matter loss determined by MRI is primarily due to loss of dendrites and their synapses
    Mustafa S Kassem
    The Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, NSW 2050, Australia
    Mol Neurobiol 47:645-61. 2013
    ..8 mm in ACC and hippocampus, respectively, with no changes in the amygdala or RSG. This quantitative study is the first to relate GMV changes in the cortex measured with MRI to volume changes in cellular constituents of the grey matter...