M R Bennett

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. pmc Synaptic transmission at visualized sympathetic boutons: stochastic interaction between acetylcholine and its receptors
    M R Bennett
    Department of Physiology, University of Sydney, New South Wales, Australia
    Biophys J 72:1595-606. 1997
  2. pmc Quantal transmitter release at somatic motor-nerve terminals: stochastic analysis of the subunit hypothesis
    M R Bennett
    Department of Physiology, University of Sydney, New South Wales, Australia
    Biophys J 70:654-68. 1996
  3. ncbi request reprint Monoaminergic synapses and schizophrenia: 45 years of neuroleptics
    M R Bennett
    Institute for Biomedical Research and Department of Physiology, University of Sydney, NSW, Australia
    J Psychopharmacol 12:289-304. 1998
  4. ncbi request reprint The concept of long term potentiation of transmission at synapses
    M R Bennett
    The Neurobiology Laboratory, Institute for Biomedical Research and The Department of Physiology, University of Sydney, NSW, Australia
    Prog Neurobiol 60:109-37. 2000
  5. pmc Probabilistic secretion of quanta and the synaptosecretosome hypothesis: evoked release at active zones of varicosities, boutons, and endplates
    M R Bennett
    Department of Physiology, Institute for Biomedical Research, University of Sydney, New South Wales, Australia
    Biophys J 73:1815-29. 1997
  6. pmc Quantal and non-quantal current and potential fields around individual sympathetic varicosities on release of ATP
    M R Bennett
    The Neurobiology Laboratory, Institute for Biomedical Research, and Department of Physiology, Sydney, New South Wales 2006, Australia
    Biophys J 80:1311-28. 2001
  7. pmc The effect of nitric oxide on the efficacy of synaptic transmission through the chick ciliary ganglion
    T R Scott
    Department of Physiology, University of Sydney, Australia
    Br J Pharmacol 110:627-32. 1993
  8. pmc The probability of quantal secretion near a single calcium channel of an active zone
    M R Bennett
    The Neurobiology Laboratory, Institute for Biomedical Research, Department of Physiology, University of Sydney, New South Wales 2006, Australia
    Biophys J 78:2201-21. 2000
  9. pmc The probability of quantal secretion within an array of calcium channels of an active zone
    M R Bennett
    The Neurobiology Laboratory, Institute for Biomedical Research, Department of Physiology, University of Sydney, New South Wales 2006, Australia
    Biophys J 78:2222-40. 2000
  10. pmc The facilitated probability of quantal secretion within an array of calcium channels of an active zone at the amphibian neuromuscular junction
    M R Bennett
    Department of Physiology, The Institute for Biomedical Research, and The School of Mathematics and Statistics, University of Sydney, New South Wales, 2006, Australia
    Biophys J 86:2674-90. 2004

Collaborators

Detail Information

Publications51

  1. pmc Synaptic transmission at visualized sympathetic boutons: stochastic interaction between acetylcholine and its receptors
    M R Bennett
    Department of Physiology, University of Sydney, New South Wales, Australia
    Biophys J 72:1595-606. 1997
    ..The amplitude of the simulated EPSC then exhibited stochastic fluctuations similar to those of the experimental EPSC...
  2. pmc Quantal transmitter release at somatic motor-nerve terminals: stochastic analysis of the subunit hypothesis
    M R Bennett
    Department of Physiology, University of Sydney, New South Wales, Australia
    Biophys J 70:654-68. 1996
    ..This did not provide evidence for a subunit structure...
  3. ncbi request reprint Monoaminergic synapses and schizophrenia: 45 years of neuroleptics
    M R Bennett
    Institute for Biomedical Research and Department of Physiology, University of Sydney, NSW, Australia
    J Psychopharmacol 12:289-304. 1998
    ..This historical review ends with a consideration of the possibility that in addition to DA receptors, serotonin and perhaps other transmitter receptors are involved in the aetiology of schizophrenia...
  4. ncbi request reprint The concept of long term potentiation of transmission at synapses
    M R Bennett
    The Neurobiology Laboratory, Institute for Biomedical Research and The Department of Physiology, University of Sydney, NSW, Australia
    Prog Neurobiol 60:109-37. 2000
    ..There is more agreement on the important role or protein kinases in the maintenance phase of LTP. The role of LTP in memory is just now being elucidated...
  5. pmc Probabilistic secretion of quanta and the synaptosecretosome hypothesis: evoked release at active zones of varicosities, boutons, and endplates
    M R Bennett
    Department of Physiology, Institute for Biomedical Research, University of Sydney, New South Wales, Australia
    Biophys J 73:1815-29. 1997
    ..The concept of the stochastic operation of a synaptosecretosome can accommodate most phenomena involving the release of transmitter quanta at these synapses...
  6. pmc Quantal and non-quantal current and potential fields around individual sympathetic varicosities on release of ATP
    M R Bennett
    The Neurobiology Laboratory, Institute for Biomedical Research, and Department of Physiology, Sydney, New South Wales 2006, Australia
    Biophys J 80:1311-28. 2001
    ..This work provides an internally consistent description of quantal potential and current fields about the varicosities of sympathetic nerve terminals and provides evidence for a non-quantal form of transmitter release...
  7. pmc The effect of nitric oxide on the efficacy of synaptic transmission through the chick ciliary ganglion
    T R Scott
    Department of Physiology, University of Sydney, Australia
    Br J Pharmacol 110:627-32. 1993
    ..6. These results suggest that nitric oxide modulates synaptic transmission through the ganglion by acting on an endogenous guanylate cyclase that produces cyclic GMP...
  8. pmc The probability of quantal secretion near a single calcium channel of an active zone
    M R Bennett
    The Neurobiology Laboratory, Institute for Biomedical Research, Department of Physiology, University of Sydney, New South Wales 2006, Australia
    Biophys J 78:2201-21. 2000
    ....
  9. pmc The probability of quantal secretion within an array of calcium channels of an active zone
    M R Bennett
    The Neurobiology Laboratory, Institute for Biomedical Research, Department of Physiology, University of Sydney, New South Wales 2006, Australia
    Biophys J 78:2222-40. 2000
    ....
  10. pmc The facilitated probability of quantal secretion within an array of calcium channels of an active zone at the amphibian neuromuscular junction
    M R Bennett
    Department of Physiology, The Institute for Biomedical Research, and The School of Mathematics and Statistics, University of Sydney, New South Wales, 2006, Australia
    Biophys J 86:2674-90. 2004
    ..In addition, it accounts for the relative invariance of the kinetics of quantal release due to test-conditioning sequences of impulses as well as due to change in the extent of calcium influx during an impulse...
  11. doi request reprint Origins of the BOLD changes due to synaptic activity at astrocytes abutting arteriolar smooth muscle
    M R Bennett
    The Brain and Mind Research Institute, University of Sydney, NSW 2006, Australia
    J Theor Biol 252:123-30. 2008
    ....
  12. ncbi request reprint Sympathetic neuromuscular transmission at a varicosity in a syncytium
    M R Bennett
    Department of Physiology, Institute for Biomedical Research, University of Sydney, NSW, Australia
    Microsc Res Tech 42:433-50. 1998
    ....
  13. pmc A quantitative model of purinergic junctional transmission of calcium waves in astrocyte networks
    M R Bennett
    The Neurobiology Laboratory, Institute for Biomedical Research, Department of Physiology, University of Sydney, New South Wales, Australia
    Biophys J 89:2235-50. 2005
    ..The properties of purinergic transmission at astrocyte junctions may determine many of the characteristics of Ca2+ propagation in networks of these cells...
  14. ncbi request reprint A quantitative description of the contraction of blood vessels following the release of noradrenaline from sympathetic varicosities
    M R Bennett
    The Neurobiology Laboratory, Department of Physiology, and Institute for Biomedical Research, University of Sydney, NSW, 2006, Australia
    J Theor Biol 234:107-22. 2005
    ..The model thus provides a quantitative account of vascular smooth muscle contraction upon sympathetic nerve stimulation...
  15. ncbi request reprint Mechanisms of calcium sequestration during facilitation at active zones of an amphibian neuromuscular junction
    M R Bennett
    The Neurobiology Laboratory, Department of Physiology, The Institute for Biomedical Research, University of Sydney, New South Wales 2006, Australia
    J Theor Biol 247:230-41. 2007
    ..Biophys. J. 86(5), 2674-2690], with the single plasmalemma pump in that model now replaced by separate pumps for the plasmalemma and endoplasmic reticulum, as well as the introduction of a mitochondrial uniporter...
  16. ncbi request reprint Depression of transmitter release at synapses in the rat superior cervical ganglion: the role of transmitter depletion
    Y Q Lin
    Department of Physiology, University of Sydney, NSW, Australia
    Auton Neurosci 88:16-24. 2001
    ..Depletion of the docked vesicles during exocytosis then leads to depression of transmitter release during a train of impulses...
  17. ncbi request reprint Vesicle-associated proteins and transmitter release from sympathetic ganglionic boutons
    D H Blair
    Neurobiology Laboratory, University of Sydney, NSW, Australia
    Neuroreport 12:607-10. 2001
    ....
  18. pmc Effect of nitric oxide synthase inhibition on long-term potentiation at associational-commissural and mossy fibre synapses on CA3 pyramidal neurones
    P J Nicolarakis
    Department of Physiology, University of Sydney, Australia
    Br J Pharmacol 111:521-4. 1994
    ..6 +/- 9.5% (n = 5 cells, P > 0.05). 4. These results suggest that LTP at associational-commissural synapses (fimbrial input) is significantly depressed in the presence of the NOS inhibitor L-NAME, while mossy fibre LTP is unchanged...
  19. pmc Calcium mobilization and spontaneous transient outward current characteristics upon agonist activation of P2Y2 receptors in smooth muscle cells
    G Lemon
    The School of Mathematics and Statistics, University of Sydney, New South Wales, Australia
    Biophys J 88:1507-23. 2005
    ..With these values, the model gives a good quantitative prediction of the dynamic changes in STOC amplitude observed upon activation of metabotropic P2Y(2) receptors in the vascular smooth muscle cell line...
  20. pmc Adenosine modulation of calcium currents in postganglionic neurones of avian cultured ciliary ganglia
    M R Bennett
    Neurobiology Research Centre, University of Sydney, Australia
    Br J Pharmacol 106:25-32. 1992
    ..7. These observations of the effects of 2-chloroadenosine on the transient and sustained currents are discussed in relation to the different calcium channel types at preganglionic nerve terminals...
  21. pmc The effect of ions and second messengers on long-term potentiation of chemical transmission in avian ciliary ganglia
    T R Scott
    Department of Physiology, University of Sydney, Australia
    Br J Pharmacol 110:461-9. 1993
    ....
  22. ncbi request reprint A quantitative description of the diffusion of noradrenaline in the media of blood vessels following its release from sympathetic varicosities
    M R Bennett
    The Neurobiology Laboratory, Department of Physiology, The Institute for Biomedical Research, University of Sydney, Sydney, New South Wales 2006, Australia
    J Theor Biol 226:359-72. 2004
    ....
  23. pmc The development of topographical maps and fibre types in toad (Bufo marinus) glutaeus muscle during synapse elimination
    M R Bennett
    Neurobiology Research Centre, University of Sydney, NSW, Australia
    J Physiol 409:43-61. 1989
    ..5. The glutaeus in post-metamorphic toads (0.15 g body weight) had only a small number of tonic and slow-twitch fibres in the very dorsal layer of cells; the muscle was largely type 1.(ABSTRACT TRUNCATED AT 400 WORDS)..
  24. pmc Autoradiography of P2x ATP receptors in the rat brain
    V J Balcar
    Department of Anatomy and Histology, University of Sydney, Australia
    Br J Pharmacol 115:302-6. 1995
    ..4. The highest density of P2x binding sites was found to be in the cerebellar cortex but the binding sites were present in all major brain regions, especially in areas known to receive strong excitatory innervation...
  25. ncbi request reprint Varicosity-Schwann cell interactions mediated by ATP in the mouse vas deferens
    Y Q Lin
    The Neurobiology Laboratory, Department of Physiology and Institute for Biomedical Research, University of Sydney, NSW, Australia
    J Neurophysiol 93:2787-96. 2005
    ..This work suggests the possibility that Schwann cells are active participants in the process of junctional transmission in the autonomic nervous system...
  26. ncbi request reprint Sympathetic innervation of the surface of the mouse vas deferens
    N A Lavidis
    Department of Physiology, University of Sydney, N S W, Australia
    J Auton Nerv Syst 45:87-100. 1993
    ..Serial thin sections through small axon bundles and single axons, viewed with the electron microscope, confirmed the dimensions of varicosities along axons observed following DiOC2(5) staining or use of the FAGLU method...
  27. ncbi request reprint Origins of blood volume change due to glutamatergic synaptic activity at astrocytes abutting on arteriolar smooth muscle cells
    M R Bennett
    The Neurobiology Laboratory, Department of Physiology, University of Sydney, NSW 2006, Australia
    J Theor Biol 250:172-85. 2008
    ..This model predicts a linear increase in blood flow with increasing numbers of activated astrocytes, but a non-linear increase with increasing glutamate release...
  28. pmc Nitric oxide modulation of calcium-activated potassium channels in postganglionic neurones of avian cultured ciliary ganglia
    M Cetiner
    Department of Physiology, University of Sydney, Australia
    Br J Pharmacol 110:995-1002. 1993
    ..8 ms into a depolarizing pulse, at a time that would decrease the rate of repolarization of the action potential. Ik(Ca) is also reduced at longer times (350 ms), indicating an affect on the inactivating process...
  29. ncbi request reprint Quantal current fields around individual boutons in sympathetic ganglia
    J Kearns
    Department of Physiology, Institute for Biomedical Research, New South Wales, 2006, Australia
    J Theor Biol 214:135-46. 2002
    ..1 microm. Quantal release recorded from visualized boutons on rat monopolar pelvic ganglion cells with loose-patch electrodes is in agreement with the properties of the quantal potential field given in the theoretical analysis...
  30. ncbi request reprint Potential fields in vascular smooth muscle generated by transmitter release from sympathetic varicosities
    R Henery
    The Neurobiology Laboratory, Department of Physiology, Institute for Biomedical Research, University of Sydney, New South Wales 2006, Australia
    J Theor Biol 218:531-48. 2002
    ..The theory can be applied to the media of blood vessels of any size to determine the relative effectiveness of sympathetic nerves in controlling the excitability of smooth muscle cells through the media...
  31. ncbi request reprint NANC transmission at a varicosity: the individuality of single synapses
    M R Bennett
    The Neurobiology Laboratory, Department of Physiology, Institute for Biomedical Research, University of Sydney, NSW 2006, Sydney
    J Auton Nerv Syst 81:25-30. 2000
    ....
  32. ncbi request reprint Metabotropic receptor activation, desensitization and sequestration-II: modelling the dynamics of the pleckstrin homology domain
    G Lemon
    The School of Mathematics and Statistics, University of Sydney, NSW 2006, Australia
    J Theor Biol 223:113-29. 2003
    ..It is shown that it can correctly reproduce the dependence of GFP-PHD fluorescence on the concentration of P(2)Y(2) receptor ligand, as well as the temporal changes of GFP-PHD fluorescence following application of ligand...
  33. doi request reprint Schizophrenia: susceptibility genes, dendritic-spine pathology and gray matter loss
    M R Bennett
    Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, NSW 2050, Australia
    Prog Neurobiol 95:275-300. 2011
    ..This will help reestablish neural networks in the PTN and so the loss of gray matter in the PTN...
  34. pmc Adenosine modulation of potassium currents in postganglionic neurones of cultured avian ciliary ganglia
    M R Bennett
    Neurobiology Research Centre, University of Sydney, Australia
    Br J Pharmacol 104:459-65. 1991
    ..This IK(Na) was unaffected by adenosine (1O microM). 7. These results are discussed in relation to the role of adenosine in blocking Ca2 + channels and thereby modifying calcium-dependent components of K+ currents...
  35. ncbi request reprint Statistics of transmitter release at nerve terminals
    M R Bennett
    Department of Physiology, Institute for Biomedical Research, University of Sydney, NSW, Australia
    Prog Neurobiol 60:545-606. 2000
    ..This offers the possibility in the near future of identifying the kinetic interaction of these proteins with the parameters of the stochastic process of exocytosis which confer a particular probability on individual synapses...
  36. ncbi request reprint Formation and function of synapses with respect to Schwann cells at the end of motor nerve terminal branches on mature amphibian (Bufo marinus) muscle
    G T Macleod
    The Neurobiology Laboratory, Department of Physiology and Institute for Biomedical Research, University of Sydney, NSW 2006 Australia
    J Neurosci 21:2380-92. 2001
    ....
  37. ncbi request reprint Obituary: Sir Bernard Katz (1911-2003)
    M R Bennett
    University of Sydney, Sydney, Australia
    J Neurocytol 32:431-6. 2003
  38. ncbi request reprint Schwann cell dynamics with respect to newly formed motor-nerve terminal branches on mature (Bufo marinus) muscle fibers
    P Dickens
    The Neurobiology Laboratory, Department of Physiology and Institute for Biomedical Research, University of Sydney, NSW 2006, Australia
    J Neurocytol 32:381-92. 2003
    ..It is suggested that the mature motor-nerve terminal is a dynamic structure in which the formation of processes by TSCs guides nerve terminal sprouting...
  39. doi request reprint The prefrontal-limbic network in depression: Modulation by hypothalamus, basal ganglia and midbrain
    M R Bennett
    Brain and Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia
    Prog Neurobiol 93:468-87. 2011
    ..Here the likely mechanisms by which these modulations are affected are described and the implications of their failure for depression associated with suicidal diathesis, late-life and psychoses discussed...
  40. doi request reprint The prefrontal-limbic network in depression: A core pathology of synapse regression
    M R Bennett
    Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, NSW 2050, Australia
    Prog Neurobiol 93:457-67. 2011
    ..It is concluded that it is the loss of synapses and concomitantly that of the dendrites on which they normally impinge that accounts quantitatively for the major loss of grey matter in different components of the PLN in depression...
  41. ncbi request reprint Language and cortical function: conceptual developments
    M R Bennett
    The Neurobiology Laboratory, Department of Physiology, Institute for Biomedical Research, University of Sydney, Sydney, NSW 2006, Australia
    Prog Neurobiol 80:20-52. 2006
    ..We seek to clarify what can be substantiated concerning the workings of the brain and the exercise of linguistic skills...
  42. doi request reprint Resilience and reduced c-Fos expression in P2X7 receptor knockout mice exposed to repeated forced swim test
    A A Boucher
    Brain and Mind Research Institute, Faculty of Health Sciences, Department of Pharmacology, University of Sydney, Camperdown 2050 NSW, Australia
    Neuroscience 189:170-7. 2011
    ..This suggests that P2X7R antagonists may be useful therapeutics for the treatment of major depression, possibly by increasing resilience in the face of repeated stress...
  43. ncbi request reprint Emotion and cortical-subcortical function: conceptual developments
    M R Bennett
    The Neurobiology Laboratory, Department of Physiology, Institute for Biomedical Research, University of Sydney, Sydney, NSW 2006, Australia
    Prog Neurobiol 75:29-52. 2005
    ..We attempt to clarify what can and cannot be justified as established concerning the workings of the brain and emotions...
  44. ncbi request reprint Metabotropic receptor activation, desensitization and sequestration-I: modelling calcium and inositol 1,4,5-trisphosphate dynamics following receptor activation
    G Lemon
    The School of Mathematics and Statistics, University of Sydney, NSW 2006, Australia
    J Theor Biol 223:93-111. 2003
    ..Results of the modelling also reveal the importance of receptor recycling and PIP(2) resupply for maintaining Ca2+ and IP(3) levels during sustained application of agonist...
  45. ncbi request reprint Synapse formation molecules in muscle and autonomic ganglia: the dual constraint hypothesis
    M R Bennett
    Neurobiology Laboratory, University of Sydney, NSW, Australia
    Prog Neurobiol 57:225-87. 1999
    ..The extent to which there is evidence for similar molecules at neuronal synapses such as those in autonomic ganglia is also considered...
  46. ncbi request reprint One hundred years of adrenaline: the discovery of autoreceptors
    M R Bennett
    Institute for Biomedical Research and The Department of Physiology, University of Sydney, Australia
    Clin Auton Res 9:145-59. 1999
    ..This paper assesses the contributions that established the idea of the adrenergic autoreceptor, 100 years after the discovery of adrenaline...
  47. ncbi request reprint The concept of transmitter receptors: 100 years on
    M R Bennett
    The Neurobiology Laboratory, Institute for Biomedical Research and Department of Physiology, University of Sydney, NSW, Australia
    Neuropharmacology 39:523-46. 2000
    ..The review concludes with the triumph of the first recordings of the electrical signs of single channel openings by Neher and Sakmann (1976) at the receptors which Langley had first described...
  48. ncbi request reprint The motor system in neuroscience: a history and analysis of conceptual developments
    M R Bennett
    Neurobiology Laboratory, Department of Physiology, Institute for Biomedical Research, University of Sydney, Sydney 2006, NSW, Australia
    Prog Neurobiol 67:1-52. 2002
    ..The review concludes with what we take to be an appropriate basis for rejecting the Cartesian paradigm that we hope will assist neuroscientists in understanding the integrative action of the nervous system...
  49. doi request reprint The discovery of a new class of synaptic transmitters in smooth muscle 50 years ago and amelioration of coronary artery thrombosis
    M R Bennett
    Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia
    Acta Physiol (Oxf) 207:236-43. 2013
    ..The discovery of the role of P2Y(12) receptors in increasing thrombosis lead to the focused research that resulted in clopidogrel and ticagrelor...
  50. doi request reprint Lipopolysaccharide-stimulated interleukin-10 release from neonatal spinal cord microglia is potentiated by glutamate
    E L Werry
    The University of Sydney, NSW, Australia
    Neuroscience 175:93-103. 2011
    ..These results show that glutamate substantially increases the release of an anti-inflammatory cytokine from neonatal spinal cord microglia activated by a high concentration of LPS...
  51. ncbi request reprint Forty years of amino acid transmission in the brain
    M R Bennett
    The Institute for Biomedical Research, The University of Sydney, NSW, Australia
    Neurochem Int 35:269-80. 1999
    ..The relationship is also explored between these early findings and those of the present era characterised by extensive use of techniques of molecular biology and the development of drugs against targets identified 30 to 40 years ago...