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Genomes and Genes | Katherine BelovSummaryAffiliation: University of Sydney Country: Australia Publications
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Publications
Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complexKatherine Belov
Centre for Advanced Technologies in Animal Genetics and Reproduction, Faculty of Veterinary Science, The University of Sydney, Camden, Australia
PLoS Biol 4:e46. 2006....- Characterization of the opossum immune genome provides insights into the evolution of the mammalian immune systemKatherine Belov
Faculty of Veterinary Science, University of Sydney, Sydney, NSW, Australia
Genome Res 17:982-91. 2007..Given the similarities in the genomic architecture of the marsupial and eutherian immune systems, we propose that marsupials are ideal model organisms for the study of developmental immunology... 
High levels of genetic variation at MHC class II DBB loci in the tammar wallaby (Macropus eugenii)Yuanyuan Cheng
Faculty of Veterinary Science, RMC Gunn B19, The University of Sydney, Sydney, Australia
Immunogenetics 61:111-8. 2009....- The tammar wallaby major histocompatibility complex shows evidence of past genomic instabilityHannah V Siddle
Faculty of Veterinary Science, University of Sydney, NSW 2006, Australia
BMC Genomics 12:421. 2011..The tammar wallaby (Macropus eugenii), an Australian marsupial, provides a unique model for understanding MHC gene evolution, as many of its antigen presenting genes are not linked to the MHC, but are scattered around the genome... - Identification of natural killer cell receptor clusters in the platypus genome reveals an expansion of C-type lectin genesEmily S W Wong
Faculty of Veterinary Science, University of Sydney, B19 RMC Gunn, Sydney, NSW, 2006, Australia
Immunogenetics 61:565-79. 2009..We have used this new data from platypus to trace the possible evolutionary history of the NK receptor clusters... - MHC gene copy number variation in Tasmanian devils: implications for the spread of a contagious cancerHannah V Siddle
Faculty of Veterinary Science, University of Sydney, New South Wales, Australia
Proc Biol Sci 277:2001-6. 2010..The implication of these results for management of DFTD and this endangered species are discussed... - Novel venom gene discovery in the platypusCamilla M Whittington
Faculty of Veterinary Science, The University of Sydney, Regimental Crescent, Camperdown, NSW 2006, Australia
Genome Biol 11:R95. 2010..We have constructed and sequenced a cDNA library from an active platypus venom gland to identify the remaining components... - Understanding and utilising mammalian venom via a platypus venom transcriptomeCamilla M Whittington
Faculty of Veterinary Science, The University of Sydney, NSW 2006, Australia
J Proteomics 72:155-64. 2009..It is therefore hoped that this basic research to identify the constituents of platypus venom will eventually yield novel drugs and new targets for painkillers... - A limited role for gene duplications in the evolution of platypus venomEmily S W Wong
Faculty of Veterinary Science, The University of Sydney, Sydney, New South Wales, Australia
Mol Biol Evol 29:167-77. 2012..However, gene duplications alone do not explain the "venome" of the platypus. Other mechanisms, such as alternative splicing and mutation, may be important in venom innovation... - MHC-linked and un-linked class I genes in the wallabyHannah V Siddle
Faculty of Veterinary Science, University of Sydney, NSW 2006, Australia
BMC Genomics 10:310. 2009..We investigated this hypothesis by characterizing the class I genes of the tammar wallaby, a model marsupial that has a novel MHC organization, with class I genes located within the MHC and 10 other chromosomal locations... - Expression patterns of platypus defensin and related venom genes across a range of tissue types reveal the possibility of broader functions for OvDLPs than previously suspectedCamilla M Whittington
Faculty of Veterinary Science, RMC Gunn B19, University of Sydney, NSW 2006, Australia
Toxicon 52:559-65. 2008.... - New insights into the role of MHC diversity in devil facial tumour diseaseAmanda Lane
Faculty of Veterinary Science, University of Sydney, Sydney, Australia
PLoS ONE 7:e36955. 2012..Here we test the hypothesis that animals that remain healthy and tumour free show predictable differences at MHC loci compared to animals that develop the disease... - Antigen-presenting genes and genomic copy number variations in the Tasmanian devil MHCYuanyuan Cheng
Faculty of Veterinary Science, University of Sydney, Sydney, NSW, Australia
BMC Genomics 13:87. 2012..DFTD is caused by a clonal tumour cell line that is transmitted between unrelated individuals as an allograft without triggering immune rejection due to low levels of Major Histocompatibility Complex (MHC) diversity in Tasmanian devils... - Low MHC class II diversity in the Tasmanian devil (Sarcophilus harrisii)Yuanyuan Cheng
Faculty of Veterinary Science, University of Sydney, RMC Gunn B19, Sydney, NSW 2006, Australia
Immunogenetics 64:525-33. 2012..These findings further support the view that this species has a compromised capacity to respond to pathogen evolution, emerging infectious diseases and environmental changes... - Contagious cancer: lessons from the devil and the dogKatherine Belov
Faculty of Veterinary Science, University of Sydney, Sydney, Australia
Bioessays 34:285-92. 2012..A greater understanding of these contagious cancers will provide unique insights into the role of the immune system in shaping tumour evolution and may uncover novel approaches for treating human cancer... 
Characterization of major histocompatibility complex class I and class II genes from the Tasmanian devil (Sarcophilus harrisii)Hannah V Siddle
Centre for Advanced Technologies in Animal Genetics and Reproduction, Faculty of Veterinary Science, University of Sydney, RMC Gunn B19, Sydney, NSW, 2006, Australia
Immunogenetics 59:753-60. 2007..The MHC genes described here are most likely involved in antigen presentation and are an important first step for studying MHC diversity and immune response in the devil...- The role of the Major Histocompatibility Complex in the spread of contagious cancersKatherine Belov
Faculty of Veterinary Science, RMC Gunn B19, University of Sydney, Sydney, NSW 2006, Australia
Mamm Genome 22:83-90. 2011..Transmissible cancers are rare but they can provide unique insights into the genetics and immunology of tumours and organ transplants... - Transmission of a fatal clonal tumor by biting occurs due to depleted MHC diversity in a threatened carnivorous marsupialHannah V Siddle
Faculty of Veterinary Science, University of Sydney, Sydney, NSW 2006, Australia
Proc Natl Acad Sci U S A 104:16221-6. 2007..The neoplastic clone continues to spread although the population, and, without active disease control by removal of affected animals and the isolation of disease-free animals, the Tasmanian devil faces extinction... - Evolution of viviparity and uterine angiogenesis: vascular endothelial growth factor (VEGF) in oviparous and viviparous skinksBridget F Murphy
Integrative Physiology Research Group, School of Biological Sciences, University of Sydney, Sydney, Australia
J Exp Zool B Mol Dev Evol 314:148-56. 2010..The presence of VEGF(111) in S. equalis may be an opportunity to investigate the function of this unique transcript in a whole animal system... - Defensins and the convergent evolution of platypus and reptile venom genesCamilla M Whittington
Faculty of Veterinary Science, University of Sydney, Sydney, New South Wales 2006, Australia
Genome Res 18:986-94. 2008..Convergent evolution has repeatedly selected genes coding for proteins containing specific structural motifs as templates for venom molecules... - Isolation of major histocompatibility complex Class I genes from the tammar wallaby (Macropus eugenii)Hannah V Siddle
Centre for Advanced Technologies in Animal Genetics and Reproduction, Faculty of Veterinary Science, University of Sydney, Sydney, Australia
Immunogenetics 58:487-93. 2006..Phylogenetic analysis of tammar wallaby Class I sequences and other mammalian Class I sequences suggests that some tammar wallaby and red-necked wallaby loci evolved from common ancestral genes... - Diversity at the major histocompatibility complex Class II in the platypus, Ornithorhynchus anatinusMette Lillie
Faculty of Veterinary Science, University of Sydney, Sydney, NSW 2006, Australia
J Hered 103:467-78. 2012..Loss of MHC diversity on King Island is of concern, as the population may have compromised immunological fitness and reduced ability to resist changing environmental conditions... - Proteomics and deep sequencing comparison of seasonally active venom glands in the platypus reveals novel venom peptides and distinct expression profilesEmily S W Wong
Faculty of Veterinary Science, The University of Sydney, Camperdown, NSW 2006, Australia
Mol Cell Proteomics 11:1354-64. 2012..These novel venom proteins have potential biomedical and therapeutic applications and provide insights into venom evolution... - Identification of natural killer cell receptor genes in the genome of the marsupial Tasmanian devil (Sarcophilus harrisii)Lauren E van der Kraan
Faculty of Veterinary Science, University of Sydney, B19 RMC Gunn, Sydney, NSW 2006, Australia
Immunogenetics 65:25-35. 2013..Understanding the functional role of these genes is also important for the development of therapeutic agents against Devil Facial Tumour Disease, a contagious cancer that threatens the Tasmanian devil with extinction... - Low major histocompatibility complex diversity in the Tasmanian devil predates European settlement and may explain susceptibility to disease epidemicsKatrina Morris
Faculty of Veterinary Science, University of Sydney, Sydney, New South Wales 2006, Australia
Biol Lett 9:20120900. 2013..We conclude that low MHC diversity has been a feature of devil populations since at least the Mid-Holocene and could explain their tumultuous history of population crashes... - Evolution of the major histocompatibility complex: Isolation of class II beta cDNAs from two monotremes, the platypus and the short-beaked echidnaKatherine Belov
Evolutionary Biology Unit, Australian Museum, 6 College St, Sydney, NSW 2010, Australia
Immunogenetics 55:402-11. 2003..However, within the mammalian clade, monophyletic clades are not robust, and elucidation of the order of gene duplication that gave rise to the present-day gene clusters is not yet possible... - Unusually similar patterns of antibody V segment diversity in distantly related marsupialsMichelle L Baker
Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
J Immunol 174:5665-71. 2005..All marsupial V(H) sequences isolated so far form a common clade of closely related sequences, and in contrast to the V(L) genes, the V(H) likely underwent a major loss of diversity early in marsupial evolution... - Characterization of MHC class II genes from an ancient reptile lineage, Sphenodon (tuatara)Hilary C Miller
Allan Wilson Centre for Molecular Ecology and Evolution, School of Biological Sciences, Victoria University of Wellington, New Zealand
Immunogenetics 57:883-91. 2005..The tuatara sequences do not strongly group with other reptile sequences on a phylogenetic tree, reflecting the antiquity of the Sphenodon lineage and the lack of closely related sequences for comparison... - Proceedings of the SMBE Tri-National Young Investigators' Workshop 2005. MHC Class I genes in the Tuatara (Sphenodon spp.): evolution of the MHC in an ancient reptilian orderHilary C Miller
Allan Wilson Centre for Molecular Ecology and Evolution, School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand
Mol Biol Evol 23:949-56. 2006..However, the evolutionary relationships among sequences from different reptilian orders cannot be resolved, reflecting the antiquity of the major reptile lineages... - Evolution and comparative analysis of the MHC Class III inflammatory regionJanine E Deakin
ARC Centre for Kangaroo Genomics, Research School of Biological Sciences, The Australian National University, Canberra, ACT 0200, Australia
BMC Genomics 7:281. 2006..We also discuss the extent of sequence conservation across the entire region and identify elements conserved in evolution... - Genome analysis of the platypus reveals unique signatures of evolutionWesley C Warren
Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
Nature 453:175-83. 2008..Sequencing of this genome now provides a valuable resource for deep mammalian comparative analyses, as well as for monotreme biology and conservation... - Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequencesTarjei S Mikkelsen
Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nature 447:167-77. 2007..A substantial proportion of these eutherian-specific CNEs arose from sequence inserted by transposable elements, pointing to transposons as a major creative force in the evolution of mammalian gene regulation... - Isolation of monotreme T-cell receptor alpha and beta chainsKatherine Belov
Evolutionary Biology Unit, Australian Museum, 6 College St, 2010, Sydney, NSW, Australia
Immunogenetics 56:164-9. 2004..Southern blot analysis indicates that, like in other mammalian species, there is only one TCRA constant region copy in the echidna genome, but at least two TCRB constant regions... - Immunoglobulin genetics of Ornithorhynchus anatinus (platypus) and Tachyglossus aculeatus (short-beaked echidna)Katherine Belov
Evolutionary Biology Unit, Australian Museum, 6 College Street, Sydney 2010, Australia
Comp Biochem Physiol A Mol Integr Physiol 136:811-9. 2003..The constant region of IgM has proven to be a useful marker for estimating the time of divergence of mammalian lineages... - Echidna IgA supports mammalian unity and traditional Therian relationshipKatherine Belov
Evolutionary Biology Unit, Australian Museum, 6 College St, Sydney, Australia 2010
Mamm Genome 13:656-63. 2002.... - Characterisation of echidna IgM provides insights into the time of divergence of extant mammalsKatherine Belov
Evolutionary Biology Unit, Australian Museum, 6 College Street, Sydney, NSW 2010, Australia
Dev Comp Immunol 26:831-9. 2002..Cmu sequences suggest that monotremes and therians separated approximately 170 million years ago (mya), marsupials and eutherians separated approximately 130mya, and Australian and American marsupials separated approximately 65mya... - Characterization of immunoglobulin gamma 1 from a monotreme, Tachyglossus aculeatusKatherine Belov
Department of Biological Sciences, Macquarie University, NSW 2109, Australia
Immunogenetics 53:1065-71. 2002..Phylogenetic analyses using the immunoglobulin sequence data strongly support the 'Theria' hypothesis, with the monotreme lineage diverging prior to the separation of the marsupial and eutherian lineages...