A G Baxter

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. ncbi The role of NK cells in autoimmune disease
    Alan G Baxter
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, Australia
    Autoimmunity 35:1-14. 2002
  2. ncbi Louis Pasteur's beer of revenge
    A G Baxter
    Autoimmunity Research Group, Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    Nat Rev Immunol 1:229-32. 2001
  3. ncbi Association between alphabetaTCR+CD4-CD8- T-cell deficiency and IDDM in NOD/Lt mice
    A G Baxter
    Centenary Institute of Cancer Medicine and Cell Biology, Camperdown, Australia
    Diabetes 46:572-82. 1997
  4. ncbi Immunogenetics and the cause of autoimmune disease
    A G Baxter
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown NSW, Australia
    Autoimmunity 25:177-89. 1997
  5. ncbi Modelling the effects of genetic and environmental factors on the risk of autoimmune disease
    A G Baxter
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, 2042, Australia
    J Autoimmun 16:331-5. 2001
  6. ncbi Activation rules: the two-signal theories of immune activation
    Alan G Baxter
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    Nat Rev Immunol 2:439-46. 2002
  7. ncbi A major linkage region on distal chromosome 4 confers susceptibility to mouse autoimmune gastritis
    P A Silveira
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, Australia
    J Immunol 162:5106-11. 1999
  8. ncbi Linkage analysis of systemic lupus erythematosus induced in diabetes-prone nonobese diabetic mice by Mycobacterium bovis
    M A Jordan
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, Australia
    J Immunol 165:1673-84. 2000
  9. ncbi Identification of the Gasa3 and Gasa4 autoimmune gastritis susceptibility genes using congenic mice and partitioned, segregative and interaction analyses
    P A Silveira
    Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag 6, Newtown, NSW 2042, Australia
    Immunogenetics 53:741-50. 2001
  10. ncbi Cytometric and functional analyses of NK and NKT cell deficiencies in NOD mice
    L D Poulton
    Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag 6, Newtown, NSW 2042, Australia
    Int Immunol 13:887-96. 2001

Collaborators

Detail Information

Publications31

  1. ncbi The role of NK cells in autoimmune disease
    Alan G Baxter
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, Australia
    Autoimmunity 35:1-14. 2002
    ..In each case, we present the evidence for an association between disease and deficiencies in NK cells. The prospect of clinical interventions that stimulate NK cell activity are discussed and the current status described...
  2. ncbi Louis Pasteur's beer of revenge
    A G Baxter
    Autoimmunity Research Group, Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    Nat Rev Immunol 1:229-32. 2001
    ..Surprisingly, the relationship between the two founders of microbiology and immunology was far from friendly...
  3. ncbi Association between alphabetaTCR+CD4-CD8- T-cell deficiency and IDDM in NOD/Lt mice
    A G Baxter
    Centenary Institute of Cancer Medicine and Cell Biology, Camperdown, Australia
    Diabetes 46:572-82. 1997
    ..The deficiency of these cells observed in NOD mice may therefore contribute to destruction of pancreatic islet cells by conventional T-cells...
  4. ncbi Immunogenetics and the cause of autoimmune disease
    A G Baxter
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown NSW, Australia
    Autoimmunity 25:177-89. 1997
    ..Finally, the physiological significance of liability is considered and its significance to the cause of autoimmunity discussed...
  5. ncbi Modelling the effects of genetic and environmental factors on the risk of autoimmune disease
    A G Baxter
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, 2042, Australia
    J Autoimmun 16:331-5. 2001
    ..Specifically, a logistic model, allied to that used to assess the influence of genetic risk factors, is suggested. The limits of modelling autoimmune disease and the requirements for data collection are also briefly discussed...
  6. ncbi Activation rules: the two-signal theories of immune activation
    Alan G Baxter
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    Nat Rev Immunol 2:439-46. 2002
    ..We also propose that more-rigorous quantitative methods are required to sustain theoretical development in the future...
  7. ncbi A major linkage region on distal chromosome 4 confers susceptibility to mouse autoimmune gastritis
    P A Silveira
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, Australia
    J Immunol 162:5106-11. 1999
    ..This is the first linkage analysis study of autoimmune gastritis in any organism and as such makes an important and novel contribution to our understanding of the etiology of this disease...
  8. ncbi Linkage analysis of systemic lupus erythematosus induced in diabetes-prone nonobese diabetic mice by Mycobacterium bovis
    M A Jordan
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, Australia
    J Immunol 165:1673-84. 2000
    ..However, three of the four regions identified had been previously implicated in other autoimmune diseases...
  9. ncbi Identification of the Gasa3 and Gasa4 autoimmune gastritis susceptibility genes using congenic mice and partitioned, segregative and interaction analyses
    P A Silveira
    Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag 6, Newtown, NSW 2042, Australia
    Immunogenetics 53:741-50. 2001
    ..Epistatic interactions between the Gasa2 EAG susceptibility gene and the H2 were also identified, and the presence of an H2-linked susceptibility gene (Gasa4) confirmed by analysis of H2 congenic mice...
  10. ncbi Cytometric and functional analyses of NK and NKT cell deficiencies in NOD mice
    L D Poulton
    Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag 6, Newtown, NSW 2042, Australia
    Int Immunol 13:887-96. 2001
    ..As both NK and NKT cells play roles in regulating immune responses, we postulate that the synergistic defects reported here contribute to the susceptibility of NOD mice to autoimmune disease...
  11. ncbi Clinical application of NKT cell assays to the prediction of type 1 diabetes
    L D Poulton
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, Australia
    Diabetes Metab Res Rev 17:429-35. 2001
    ..Here, we describe methods appropriate to the clinical assessment of NKT cells and discuss the steps required in the assessment and validation of NKT cell assays as a predictor of type 1 diabetes...
  12. ncbi The NOD mouse as a model of SLE
    P A Silveira
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown NSW, Australia
    Autoimmunity 34:53-64. 2001
    ....
  13. ncbi The genetics of the NOD mouse
    A G Baxter
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, Australia
    Diabetes Metab Rev 11:315-35. 1995
  14. ncbi Clonal cytotoxic T cells are expanded in myeloma and reside in the CD8(+)CD57(+)CD28(-) compartment
    D M Sze
    Institute of Haematology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Blood 98:2817-27. 2001
    ....
  15. ncbi Quantitative and qualitative approaches to GOD: the first 10 years of the clonal selection theory
    Margaret A Jordan
    Comparative Genomics Centre, James Cook University, Molecular Sciences Bldg 21, Townsville, Queensland, Australia
    Immunol Cell Biol 86:72-9. 2008
    ..This methodological difference between the two men, and the mechanistic difference between their models, is key to the understanding of the clonal selection theory, its later acceptance and the proportion of credit paid to Burnet...
  16. ncbi Genetic control of NKT cell numbers
    Margaret A Jordan
    Comparative Genomics Centre, James Cook University, Townsville, Queensland, Australia
    Immunol Cell Biol 82:276-84. 2004
    ..Of great interest is a third locus on chromosome 18, identified in a novel congenic line, which can confer an absolute deficiency in this important immunoregulatory lymphocyte population...
  17. ncbi Genetic control of NKT cell numbers maps to major diabetes and lupus loci
    Luis M Esteban
    Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
    J Immunol 171:2873-8. 2003
    ..The second most significant locus (Nkt2) mapped to the same region as Idd13, a NOD-derived diabetes susceptibility gene on chromosome 2...
  18. ncbi Congenic analysis of the NKT cell control gene Nkt2 implicates the peroxisomal protein Pxmp4
    Julie M Fletcher
    Comparative Genomics Centre, James Cook University, Townsville, Queensland, Australia
    J Immunol 181:3400-12. 2008
    ..These findings raise the possibility that peroxisomes play a role in modulating glycolipid availability for CD1d presentation, thereby influencing NKT cell function...
  19. ncbi Immunopathogenesis, loss of T cell tolerance and genetics of autoimmune gastritis
    Ian R van Driel
    The Russell Grimwade School of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Autoimmun Rev 1:290-7. 2002
    ..The highlights of these recent advances are the subject of this review...
  20. doi Interactions between B-lymphocytes and type 1 NKT cells in autoimmune diabetes
    François D Dufour
    Comparative Genomics Centre, James Cook University, Townsville, Queensland, Australia
    J Immunotoxicol 5:249-57. 2008
    ..This review will analyze current knowledge on the roles of B-lymphocytes and Type 1 NKT cells in the onset of Type 1 Diabetes and explore possible outcomes of their interactions in relation to disease...
  21. pmc A natural killer T (NKT) cell developmental pathway iInvolving a thymus-dependent NK1.1(-)CD4(+) CD1d-dependent precursor stage
    Daniel G Pellicci
    Department of Immunology and Pathology, Monash University Medical School, Prahran, Victoria 3181, Australia
    J Exp Med 195:835-44. 2002
    ..1(-). Further elucidation of this NKT cell developmental pathway should prove to be invaluable for studying the mechanisms that regulate the development of these cells...
  22. ncbi The origin and application of experimental autoimmune encephalomyelitis
    Alan G Baxter
    Comparative Genomics Centre, Molecular Sciences Building 21, James Cook University, Townsville, 4, 811, Queensland, Australia
    Nat Rev Immunol 7:904-12. 2007
    ....
  23. ncbi Two genetic loci independently confer susceptibility to autoimmune gastritis
    Desmond K Y Ang
    Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, VIC 3010, Australia
    Int Immunol 19:1135-44. 2007
    ..This reduction was not significant compared with the reduction observed in BALB.B6 congenic mice, suggesting a difference in the genetic aetiology of autoimmune gastritis in NOD and BALB mice...
  24. ncbi Deficiency of invariant NK T cells in Crohn's disease and ulcerative colitis
    Randall H Grose
    Basil Hetzel Institute for Medical Research and Department of Medicine, University of Adelaide, Adelaide, Australia
    Dig Dis Sci 52:1415-22. 2007
    ..05). Intestinal Valpha24+ T cells were 23% in Crohn's disease but not reduced in ulcerative colitis. We conclude that invariant NK T cells are deficient in Crohn's disease and in ulcerative colitis...
  25. ncbi Slamf1, the NKT cell control gene Nkt1
    Margaret A Jordan
    Comparative Genomics Center, James Cook University, Townsville, Queensland, Australia
    J Immunol 178:1618-27. 2007
    ....
  26. ncbi Genetic control of susceptibility to autoimmune gastritis
    Alan G Baxter
    Comparative Genomics Centre, James Cook University, Townsville, QLD, Australia
    Int Rev Immunol 24:55-62. 2005
    ....
  27. ncbi Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim
    Adrian Liston
    Immunogenomics Laboratory, John Curtin School of Medical Research and The Australian Phenomics Facility, The Australian National University, Canberra, 2601, Australia
    Immunity 21:817-30. 2004
    ..These findings establish defects in thymic deletion and Bim induction as a key mechanism in the pathogenesis of autoimmunity...
  28. pmc On lawnmowers and lay-down misères
    Lisa Smallwood
    Comparative Genomics Centre, James Cook University, Molecular Sciences Building 21, Townsville, Queensland 4811, Australia
    Immunology 111:252-3. 2004
  29. ncbi Dermal enhancement: bacterial products on intact skin induce and augment organ-specific autoimmune disease
    D Sean Riminton
    Comparative Genomics Centre, James Cook University, Townsville, Queensland 4811, Australia
    J Immunol 172:302-9. 2004
    ....
  30. pmc Mycobacteria, an environmental enhancer of lupus nephritis in a mouse model of systemic lupus erythematosus
    Christine G Hawke
    Autoimmunity Research Group, Centenary Institute of Cancer Medicine and Cell Biology, Newtown NSW, Australia
    Immunology 108:70-8. 2003
    ..The development of spontaneous mixed isotype IC in the glomeruli of some senescent NOD mice suggests that mycobacterial exposure is accelerating, rather than inducing, the development of GN in this model...
  31. pmc Natural killer T cells are targets for human immunodeficiency virus infection
    Nadine Y Crowe
    Department of Pathology and Immunology, Central and Eastern Clinical School, Monash University, Prahran, Australia
    Immunology 108:1-2. 2003