Research Topics
Species | A G BaxterSummaryAffiliation: University of Sydney Country: Australia Publications
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Detail Information
Publications
The role of NK cells in autoimmune diseaseAlan G Baxter
Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, Australia
Autoimmunity 35:1-14. 2002..In each case, we present the evidence for an association between disease and deficiencies in NK cells. The prospect of clinical interventions that stimulate NK cell activity are discussed and the current status described...- Louis Pasteur's beer of revengeA G Baxter
Autoimmunity Research Group, Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
Nat Rev Immunol 1:229-32. 2001..Surprisingly, the relationship between the two founders of microbiology and immunology was far from friendly... - Association between alphabetaTCR+CD4-CD8- T-cell deficiency and IDDM in NOD/Lt miceA G Baxter
Centenary Institute of Cancer Medicine and Cell Biology, Camperdown, Australia
Diabetes 46:572-82. 1997..The deficiency of these cells observed in NOD mice may therefore contribute to destruction of pancreatic islet cells by conventional T-cells... - Immunogenetics and the cause of autoimmune diseaseA G Baxter
Centenary Institute of Cancer Medicine and Cell Biology, Newtown NSW, Australia
Autoimmunity 25:177-89. 1997..Finally, the physiological significance of liability is considered and its significance to the cause of autoimmunity discussed... - Modelling the effects of genetic and environmental factors on the risk of autoimmune diseaseA G Baxter
Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, 2042, Australia
J Autoimmun 16:331-5. 2001..Specifically, a logistic model, allied to that used to assess the influence of genetic risk factors, is suggested. The limits of modelling autoimmune disease and the requirements for data collection are also briefly discussed... - Activation rules: the two-signal theories of immune activationAlan G Baxter
Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
Nat Rev Immunol 2:439-46. 2002..We also propose that more-rigorous quantitative methods are required to sustain theoretical development in the future... - A major linkage region on distal chromosome 4 confers susceptibility to mouse autoimmune gastritisP A Silveira
Centenary Institute of Cancer Medicine and Cell Biology, Newtown, Australia
J Immunol 162:5106-11. 1999..This is the first linkage analysis study of autoimmune gastritis in any organism and as such makes an important and novel contribution to our understanding of the etiology of this disease... - Linkage analysis of systemic lupus erythematosus induced in diabetes-prone nonobese diabetic mice by Mycobacterium bovisM A Jordan
Centenary Institute of Cancer Medicine and Cell Biology, Newtown, Australia
J Immunol 165:1673-84. 2000..However, three of the four regions identified had been previously implicated in other autoimmune diseases... - Identification of the Gasa3 and Gasa4 autoimmune gastritis susceptibility genes using congenic mice and partitioned, segregative and interaction analysesP A Silveira
Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag 6, Newtown, NSW 2042, Australia
Immunogenetics 53:741-50. 2001..Epistatic interactions between the Gasa2 EAG susceptibility gene and the H2 were also identified, and the presence of an H2-linked susceptibility gene (Gasa4) confirmed by analysis of H2 congenic mice... - Cytometric and functional analyses of NK and NKT cell deficiencies in NOD miceL D Poulton
Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag 6, Newtown, NSW 2042, Australia
Int Immunol 13:887-96. 2001..As both NK and NKT cells play roles in regulating immune responses, we postulate that the synergistic defects reported here contribute to the susceptibility of NOD mice to autoimmune disease... - Clinical application of NKT cell assays to the prediction of type 1 diabetesL D Poulton
Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, Australia
Diabetes Metab Res Rev 17:429-35. 2001..Here, we describe methods appropriate to the clinical assessment of NKT cells and discuss the steps required in the assessment and validation of NKT cell assays as a predictor of type 1 diabetes... - The NOD mouse as a model of SLEP A Silveira
Centenary Institute of Cancer Medicine and Cell Biology, Newtown NSW, Australia
Autoimmunity 34:53-64. 2001.... - The genetics of the NOD mouseA G Baxter
Centenary Institute of Cancer Medicine and Cell Biology, Newtown, Australia
Diabetes Metab Rev 11:315-35. 1995 - Clonal cytotoxic T cells are expanded in myeloma and reside in the CD8(+)CD57(+)CD28(-) compartmentD M Sze
Institute of Haematology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
Blood 98:2817-27. 2001.... - Quantitative and qualitative approaches to GOD: the first 10 years of the clonal selection theoryMargaret A Jordan
Comparative Genomics Centre, James Cook University, Molecular Sciences Bldg 21, Townsville, Queensland, Australia
Immunol Cell Biol 86:72-9. 2008..This methodological difference between the two men, and the mechanistic difference between their models, is key to the understanding of the clonal selection theory, its later acceptance and the proportion of credit paid to Burnet... - Genetic control of NKT cell numbersMargaret A Jordan
Comparative Genomics Centre, James Cook University, Townsville, Queensland, Australia
Immunol Cell Biol 82:276-84. 2004..Of great interest is a third locus on chromosome 18, identified in a novel congenic line, which can confer an absolute deficiency in this important immunoregulatory lymphocyte population... - Genetic control of NKT cell numbers maps to major diabetes and lupus lociLuis M Esteban
Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
J Immunol 171:2873-8. 2003..The second most significant locus (Nkt2) mapped to the same region as Idd13, a NOD-derived diabetes susceptibility gene on chromosome 2... - Congenic analysis of the NKT cell control gene Nkt2 implicates the peroxisomal protein Pxmp4Julie M Fletcher
Comparative Genomics Centre, James Cook University, Townsville, Queensland, Australia
J Immunol 181:3400-12. 2008..These findings raise the possibility that peroxisomes play a role in modulating glycolipid availability for CD1d presentation, thereby influencing NKT cell function... - Immunopathogenesis, loss of T cell tolerance and genetics of autoimmune gastritisIan R van Driel
The Russell Grimwade School of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Victoria 3010, Australia
Autoimmun Rev 1:290-7. 2002..The highlights of these recent advances are the subject of this review... 
Interactions between B-lymphocytes and type 1 NKT cells in autoimmune diabetesFrançois D Dufour
Comparative Genomics Centre, James Cook University, Townsville, Queensland, Australia
J Immunotoxicol 5:249-57. 2008..This review will analyze current knowledge on the roles of B-lymphocytes and Type 1 NKT cells in the onset of Type 1 Diabetes and explore possible outcomes of their interactions in relation to disease...
A natural killer T (NKT) cell developmental pathway iInvolving a thymus-dependent NK1.1(-)CD4(+) CD1d-dependent precursor stageDaniel G Pellicci
Department of Immunology and Pathology, Monash University Medical School, Prahran, Victoria 3181, Australia
J Exp Med 195:835-44. 2002..1(-). Further elucidation of this NKT cell developmental pathway should prove to be invaluable for studying the mechanisms that regulate the development of these cells...- The origin and application of experimental autoimmune encephalomyelitisAlan G Baxter
Comparative Genomics Centre, Molecular Sciences Building 21, James Cook University, Townsville, 4, 811, Queensland, Australia
Nat Rev Immunol 7:904-12. 2007.... - Two genetic loci independently confer susceptibility to autoimmune gastritisDesmond K Y Ang
Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, VIC 3010, Australia
Int Immunol 19:1135-44. 2007..This reduction was not significant compared with the reduction observed in BALB.B6 congenic mice, suggesting a difference in the genetic aetiology of autoimmune gastritis in NOD and BALB mice... - Deficiency of invariant NK T cells in Crohn's disease and ulcerative colitisRandall H Grose
Basil Hetzel Institute for Medical Research and Department of Medicine, University of Adelaide, Adelaide, Australia
Dig Dis Sci 52:1415-22. 2007..05). Intestinal Valpha24+ T cells were 23% in Crohn's disease but not reduced in ulcerative colitis. We conclude that invariant NK T cells are deficient in Crohn's disease and in ulcerative colitis... - Slamf1, the NKT cell control gene Nkt1Margaret A Jordan
Comparative Genomics Center, James Cook University, Townsville, Queensland, Australia
J Immunol 178:1618-27. 2007.... - Genetic control of susceptibility to autoimmune gastritisAlan G Baxter
Comparative Genomics Centre, James Cook University, Townsville, QLD, Australia
Int Rev Immunol 24:55-62. 2005.... - Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of BimAdrian Liston
Immunogenomics Laboratory, John Curtin School of Medical Research and The Australian Phenomics Facility, The Australian National University, Canberra, 2601, Australia
Immunity 21:817-30. 2004..These findings establish defects in thymic deletion and Bim induction as a key mechanism in the pathogenesis of autoimmunity... - On lawnmowers and lay-down misèresLisa Smallwood
Comparative Genomics Centre, James Cook University, Molecular Sciences Building 21, Townsville, Queensland 4811, Australia
Immunology 111:252-3. 2004 - Dermal enhancement: bacterial products on intact skin induce and augment organ-specific autoimmune diseaseD Sean Riminton
Comparative Genomics Centre, James Cook University, Townsville, Queensland 4811, Australia
J Immunol 172:302-9. 2004.... - Mycobacteria, an environmental enhancer of lupus nephritis in a mouse model of systemic lupus erythematosusChristine G Hawke
Autoimmunity Research Group, Centenary Institute of Cancer Medicine and Cell Biology, Newtown NSW, Australia
Immunology 108:70-8. 2003..The development of spontaneous mixed isotype IC in the glomeruli of some senescent NOD mice suggests that mycobacterial exposure is accelerating, rather than inducing, the development of GN in this model... - Natural killer T cells are targets for human immunodeficiency virus infectionNadine Y Crowe
Department of Pathology and Immunology, Central and Eastern Clinical School, Monash University, Prahran, Australia
Immunology 108:1-2. 2003