A R Bauskin

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. ncbi GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation
    Jian Xu
    Department of Pediatrics, University of Cincinnati, Division of Molecular Cardiovascular Biology, Children s Hospital Medical Center, Ohio 45229 3039, USA
    Circ Res 98:342-50. 2006
  2. ncbi Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1
    Heiko Johnen
    Centre for Immunology, St Vincent s Hospital and University of New South Wales, Sydney, New South Wales 2010, Australia
    Nat Med 13:1333-40. 2007
  3. doi The TGF-beta superfamily cytokine MIC-1/GDF15: secretory mechanisms facilitate creation of latent stromal stores
    Asne R Bauskin
    St Vincent s Centre for Applied Medical Research, St Vincent s Hospital and University of New South Wales, Sydney, Australia
    J Interferon Cytokine Res 30:389-97. 2010
  4. pmc The propeptide of macrophage inhibitory cytokine (MIC-1), a TGF-beta superfamily member, acts as a quality control determinant for correctly folded MIC-1
    A R Bauskin
    Centre for Immunology, St Vincent s Hospital and University of New South Wales, Sydney, NSW 2010, Australia
    EMBO J 19:2212-20. 2000
  5. ncbi Role of macrophage inhibitory cytokine-1 in tumorigenesis and diagnosis of cancer
    Asne R Bauskin
    Centre for Immunology, St Vincent s Hospital and University of New South Wales, Sydney, Australia
    Cancer Res 66:4983-6. 2006
  6. ncbi The propeptide mediates formation of stromal stores of PROMIC-1: role in determining prostate cancer outcome
    Asne R Bauskin
    Centre for Immunology, St Vincent s Hospital and University of New South Wales, Australia
    Cancer Res 65:2330-6. 2005
  7. ncbi The propeptide of the transforming growth factor-beta superfamily member, macrophage inhibitory cytokine-1 (MIC-1), is a multifunctional domain that can facilitate protein folding and secretion
    W D Fairlie
    Centre for Immunology, Saint Vincent s Hospital and University of New South Wales, Victoria Street, Sydney, New South Wales 2010, Australia
    J Biol Chem 276:16911-8. 2001
  8. ncbi Epitope mapping of the transforming growth factor-beta superfamily protein, macrophage inhibitory cytokine-1 (MIC-1): identification of at least five distinct epitope specificities
    W D Fairlie
    Centre for Immunology, St Vincent s Hospital and University of New South Wales, Victoria St, Sydney, New South Wales, Australia, 2010
    Biochemistry 40:65-73. 2001
  9. ncbi The transforming growth factor-ss superfamily cytokine macrophage inhibitory cytokine-1 is present in high concentrations in the serum of pregnant women
    A G Moore
    Centre for Immunology, St Vincent s Hospital and University of New South Wales, Sydney, New South Wales, Australia
    J Clin Endocrinol Metab 85:4781-8. 2000
  10. ncbi Antibody-based approach to high-volume genotyping for MIC-1 polymorphism
    D A Brown
    St Vincent s Hospital, Sydney, Australia
    Biotechniques 33:118-20, 122, 124 passim. 2002

Collaborators

Detail Information

Publications18

  1. ncbi GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation
    Jian Xu
    Department of Pediatrics, University of Cincinnati, Division of Molecular Cardiovascular Biology, Children s Hospital Medical Center, Ohio 45229 3039, USA
    Circ Res 98:342-50. 2006
    ..These results identify GDF15 as a novel autocrine/endocrine factor that antagonizes the hypertrophic response and loss of ventricular performance, possibly through a mechanism involving SMAD proteins...
  2. ncbi Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1
    Heiko Johnen
    Centre for Immunology, St Vincent s Hospital and University of New South Wales, Sydney, New South Wales 2010, Australia
    Nat Med 13:1333-40. 2007
    ..Thus, MIC-1 is a newly defined central regulator of appetite and a potential target for the treatment of both cancer anorexia and weight loss, as well as of obesity...
  3. doi The TGF-beta superfamily cytokine MIC-1/GDF15: secretory mechanisms facilitate creation of latent stromal stores
    Asne R Bauskin
    St Vincent s Centre for Applied Medical Research, St Vincent s Hospital and University of New South Wales, Sydney, Australia
    J Interferon Cytokine Res 30:389-97. 2010
    ....
  4. pmc The propeptide of macrophage inhibitory cytokine (MIC-1), a TGF-beta superfamily member, acts as a quality control determinant for correctly folded MIC-1
    A R Bauskin
    Centre for Immunology, St Vincent s Hospital and University of New South Wales, Sydney, NSW 2010, Australia
    EMBO J 19:2212-20. 2000
    ..This is the first demonstration, to our knowledge, of a quality control function in a propeptide domain of a secretory protein and represents an additional mechanism to ensure correct folding of proteins leaving the ER...
  5. ncbi Role of macrophage inhibitory cytokine-1 in tumorigenesis and diagnosis of cancer
    Asne R Bauskin
    Centre for Immunology, St Vincent s Hospital and University of New South Wales, Sydney, Australia
    Cancer Res 66:4983-6. 2006
    ....
  6. ncbi The propeptide mediates formation of stromal stores of PROMIC-1: role in determining prostate cancer outcome
    Asne R Bauskin
    Centre for Immunology, St Vincent s Hospital and University of New South Wales, Australia
    Cancer Res 65:2330-6. 2005
    ..The secretion and ECM association of unprocessed proMIC-1 is likely to play a central role in modulating local bioavailability of MIC-1 which can affect patient outcome in prostate cancer and other epithelial tumors...
  7. ncbi The propeptide of the transforming growth factor-beta superfamily member, macrophage inhibitory cytokine-1 (MIC-1), is a multifunctional domain that can facilitate protein folding and secretion
    W D Fairlie
    Centre for Immunology, Saint Vincent s Hospital and University of New South Wales, Victoria Street, Sydney, New South Wales 2010, Australia
    J Biol Chem 276:16911-8. 2001
    ..Cotransfection experiments demonstrated that the propeptide must be in cis with the mature peptide for this phenomenon to occur. These results suggest a model for TGF-beta superfamily protein folding...
  8. ncbi Epitope mapping of the transforming growth factor-beta superfamily protein, macrophage inhibitory cytokine-1 (MIC-1): identification of at least five distinct epitope specificities
    W D Fairlie
    Centre for Immunology, St Vincent s Hospital and University of New South Wales, Victoria St, Sydney, New South Wales, Australia, 2010
    Biochemistry 40:65-73. 2001
    ..Finally, the use of another mutant in which Cys 77 was replaced by serine enabled confirmation of the location of the MIC-1 interchain disulfide bond...
  9. ncbi The transforming growth factor-ss superfamily cytokine macrophage inhibitory cytokine-1 is present in high concentrations in the serum of pregnant women
    A G Moore
    Centre for Immunology, St Vincent s Hospital and University of New South Wales, Sydney, New South Wales, Australia
    J Clin Endocrinol Metab 85:4781-8. 2000
    ..We suggest that MIC-1 may promote fetal survival by suppressing the production of maternally derived proinflammatory cytokines within the uterus...
  10. ncbi Antibody-based approach to high-volume genotyping for MIC-1 polymorphism
    D A Brown
    St Vincent s Hospital, Sydney, Australia
    Biotechniques 33:118-20, 122, 124 passim. 2002
    ..This novel antibody-based assay confidently determines the genotype of MIC-1. It offers the advantages of an ELISA-ease of automation, high-volume throughput of samples, and ease of use in a routine, clinical laboratory...
  11. pmc MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily
    M R Bootcov
    Centre for Immunology, St Vincent s Hospital, and University of New South Wales, Sydney, 2010, Australia
    Proc Natl Acad Sci U S A 94:11514-9. 1997
    ..Its production in response to secreted proinflammatory cytokines and TGF-beta may serve to limit the later phases of macrophage activation...
  12. ncbi Macrophage inhibitory cytokine 1 reduces cell adhesion and induces apoptosis in prostate cancer cells
    Tao Liu
    Centre for Immunology, St Vincent s Hospital and University of New South Wales, Victoria Street, Sydney, NSW 2010, Australia
    Cancer Res 63:5034-40. 2003
    ..It is likely that caspase-dependent apoptosis is secondary to loss of cell adhesion and may suggest a role for MIC-1 in tumor dissemination in vivo...
  13. ncbi Measurement of serum levels of macrophage inhibitory cytokine 1 combined with prostate-specific antigen improves prostate cancer diagnosis
    David A Brown
    Centre for Immunology at St Vincent s Hospital, Sydney, Australia
    Clin Cancer Res 12:89-96. 2006
    ..Consequently, we sought to assess serum MIC-1 measurement as a diagnostic tool...
  14. ncbi MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma
    David A Brown
    Centre for Immunology, St Vincent s Hospital and University of New South Wales, Sydney NSW, Australia
    Clin Cancer Res 9:2642-50. 2003
    ..In a separate cohort of 224 patients, we evaluated the relationship of MIC-1 serum level and genotype to standard tumor parameters and outcome measures...
  15. ncbi Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: a nested case-control study
    David A Brown
    Centre for Immunology, St Vincent s Hospital and University of New South Wales, Sydney, NSW, Australia
    Lancet 359:2159-63. 2002
    ..Raised concentrations of MIC-1 in serum arise in several disease states, can be detected in normal individuals, and can partly be genetically determined. We aimed to investigate whether MIC-1 has a role in atherothrombosis...
  16. ncbi Serum macrophage inhibitory cytokine 1 in rheumatoid arthritis: a potential marker of erosive joint destruction
    David A Brown
    St Vincent s Hospital and University of New South Wales, Sydney, New South Wales, Australia
    Arthritis Rheum 56:753-64. 2007
    ..Since rheumatoid arthritis (RA) shares similar etiopathologic mechanisms with the above diseases, we sought to determine the clinical utility of determining MIC-1 serum levels and MIC-1 genotype in the management of RA...
  17. pmc Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum
    John B Welsh
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 100:3410-5. 2003
    ....
  18. ncbi Recombinant CLIC1 (NCC27) assembles in lipid bilayers via a pH-dependent two-state process to form chloride ion channels with identical characteristics to those observed in Chinese hamster ovary cells expressing CLIC1
    Kristina Warton
    Centre for Immunology, St Vincent s Hospital and University of New South Wales, Sydney NSW 2010, Australia
    J Biol Chem 277:26003-11. 2002
    ....