Katherine J Baines

Summary

Affiliation: University of Newcastle
Country: Australia

Publications

  1. doi request reprint Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples
    Katherine J Baines
    Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, University of Newcastle, Callaghan, Australia
    J Allergy Clin Immunol 127:153-60, 160.e1-9. 2011
  2. doi request reprint Systemic upregulation of neutrophil α-defensins and serine proteases in neutrophilic asthma
    Katherine J Baines
    Priority Research Centre forAsthma and Respiratory Diseases, The University of Newcastle, Callaghan, Australia
    Thorax 66:942-7. 2011
  3. doi request reprint Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, Australia Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, Australia Electronic address
    J Allergy Clin Immunol 133:997-1007. 2014
  4. pmc Novel immune genes associated with excessive inflammatory and antiviral responses to rhinovirus in COPD
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, The University of Newcastle, Callaghan, NSW, Australia
    Respir Res 14:15. 2013
  5. doi request reprint The nutrigenomics of asthma: molecular mechanisms of airway neutrophilia following dietary antioxidant withdrawal
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, University of Newcastle, Callaghan NSW Australia
    OMICS 13:355-65. 2009
  6. doi request reprint Differential gene expression and cytokine production from neutrophils in asthma phenotypes
    K J Baines
    Level 3, Hunter Medical Research Institute, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, Newcastle, NSW 2310, Australia
    Eur Respir J 35:522-31. 2010
  7. ncbi request reprint Immune responses of airway neutrophils are impaired in asthma
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, The University of Newcastle, Callaghan, New South Wales, Australia
    Exp Lung Res 35:554-69. 2009
  8. pmc Innate immune responses are increased in chronic obstructive pulmonary disease
    Katherine Joanne Baines
    Priority Research Centre for Asthma and Respiratory Diseases, The University of Newcastle, Callaghan, New South Wales, Australia
    PLoS ONE 6:e18426. 2011
  9. doi request reprint Systemic inflammation is associated with differential gene expression and airway neutrophilia in asthma
    Juan Juan Fu
    Priority Research Centre for Asthma and Respiratory Diseases, University of Newcastle, Newcastle, Australia
    OMICS 17:187-99. 2013
  10. doi request reprint The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma
    Lisa G Wood
    Centre for Asthma and Respiratory Diseases, University of Newcastle, Australia
    Chest 142:86-93. 2012

Detail Information

Publications16

  1. doi request reprint Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples
    Katherine J Baines
    Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, University of Newcastle, Callaghan, Australia
    J Allergy Clin Immunol 127:153-60, 160.e1-9. 2011
    ..Previous studies have identified clinical or inflammatory phenotypes of asthma on the basis of clinical and demographic parameters or sputum cell counts; however, few studies have defined transcriptional phenotypes of asthma...
  2. doi request reprint Systemic upregulation of neutrophil α-defensins and serine proteases in neutrophilic asthma
    Katherine J Baines
    Priority Research Centre forAsthma and Respiratory Diseases, The University of Newcastle, Callaghan, Australia
    Thorax 66:942-7. 2011
    ..Systemic inflammation is now recognised as an important part of some airway diseases, but the involvement of systemic inflammation in the pathogenesis of airway inflammatory phenotypes of asthma remains unknown...
  3. doi request reprint Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, Australia Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, Australia Electronic address
    J Allergy Clin Immunol 133:997-1007. 2014
    ..Airway inflammation is associated with asthma exacerbation risk, treatment response, and disease mechanisms...
  4. pmc Novel immune genes associated with excessive inflammatory and antiviral responses to rhinovirus in COPD
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, The University of Newcastle, Callaghan, NSW, Australia
    Respir Res 14:15. 2013
    ..The objective of this study is to investigate innate immune responses to RV infection in COPD primary BECs (pBECs) in comparison to healthy controls...
  5. doi request reprint The nutrigenomics of asthma: molecular mechanisms of airway neutrophilia following dietary antioxidant withdrawal
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, University of Newcastle, Callaghan NSW Australia
    OMICS 13:355-65. 2009
    ..A diet low in antioxidants may be contributing to the development of neutrophilic asthma through activation of the innate immune response...
  6. doi request reprint Differential gene expression and cytokine production from neutrophils in asthma phenotypes
    K J Baines
    Level 3, Hunter Medical Research Institute, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, Newcastle, NSW 2310, Australia
    Eur Respir J 35:522-31. 2010
    ..The mechanisms of non-eosinophilic asthma may involve enhancement of blood neutrophil chemotaxis and survival...
  7. ncbi request reprint Immune responses of airway neutrophils are impaired in asthma
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, The University of Newcastle, Callaghan, New South Wales, Australia
    Exp Lung Res 35:554-69. 2009
    ..Innate immune responses of airway neutrophil cells are impaired in asthmatic subjects on prophylactic therapy and may impact on susceptibility to, and severity of, airway infections...
  8. pmc Innate immune responses are increased in chronic obstructive pulmonary disease
    Katherine Joanne Baines
    Priority Research Centre for Asthma and Respiratory Diseases, The University of Newcastle, Callaghan, New South Wales, Australia
    PLoS ONE 6:e18426. 2011
    ....
  9. doi request reprint Systemic inflammation is associated with differential gene expression and airway neutrophilia in asthma
    Juan Juan Fu
    Priority Research Centre for Asthma and Respiratory Diseases, University of Newcastle, Newcastle, Australia
    OMICS 17:187-99. 2013
    ..Our findings suggest that targeting systemic inflammation might provide a novel therapeutic strategy for neutrophilic asthma...
  10. doi request reprint The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma
    Lisa G Wood
    Centre for Asthma and Respiratory Diseases, University of Newcastle, Australia
    Chest 142:86-93. 2012
    ..The role of systemic inflammation in asthma is unclear. The aim of this study was to compare systemic inflammation in subjects with stable asthma, categorized by airway inflammatory phenotype, with healthy control subjects...
  11. doi request reprint Oncostatin M (OSM) is increased in asthma with incompletely reversible airflow obstruction
    Jodie L Simpson
    Centre for Asthma and Respiratory Disease, School of Medicine and Public Health, The University of Newcastle, Callaghan NSW, Australia
    Exp Lung Res 35:781-94. 2009
    ..Sputum oncostatin M is increased in asthma with irreversible airflow obstruction and is present in airway neutrophils and macrophages. Oncostatin M may link airway inflammation to remodeling in asthma...
  12. pmc Influence of age, past smoking, and disease severity on TLR2, neutrophilic inflammation, and MMP-9 levels in COPD
    Jodie L Simpson
    NHMRC Centre for Respiratory and Sleep Medicine, Faculty of Health, School of Medicine and Public Health, The University of Newcastle, Callaghan, NSW 2308, Australia
    Mediators Inflamm 2013:462934. 2013
    ..TLR2 stimulation activates neutrophils for MMP-9 release. Efforts to understand the mechanisms of TLR2 signalling and subsequent MMP-9 production in COPD may assist in understanding neutrophilic inflammation in COPD...
  13. doi request reprint IL-27/IFN-γ induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages
    Jing Jing Li
    Centre for Asthma and Respiratory Disease, University of Newcastle and Hunter Medical Research Institute, Callaghan, New South Wales, Australia
    J Immunol 185:4401-9. 2010
    ....
  14. doi request reprint Elevated expression of the NLRP3 inflammasome in neutrophilic asthma
    Jodie L Simpson
    Centre for Asthma and Respiratory Diseases and Hunter Medical Research Institute, Faculty of Health, School of Medicine and Public Health, The University of Newcastle, Callaghan
    Eur Respir J 43:1067-76. 2014
    ..NLRP3 inflammasome is upregulated in neutrophilic asthma and may regulate the inflammation process observed in this asthma phenotype through production of IL-1β. ..
  15. doi request reprint Respiratory viral infections in pregnant women with asthma are associated with wheezing in the first 12 months of life
    Vanessa E Murphy
    Centre for Asthma and Respiratory Diseases, University of Newcastle and Hunter Medical Research Institute, Newcastle, NSW, Australia
    Pediatr Allergy Immunol 25:151-8. 2014
    ..Infants of mothers with asthma are more likely to wheeze and have a higher risk of developing asthma than infants of non-asthmatic mothers...
  16. doi request reprint Neutrophilic asthma is characterised by increased rhinosinusitis with sleep disturbance and GERD
    Jodie L Simpson
    Centre for Asthma and Respiratory Disease, The University of Newcastle, NSW
    Asian Pac J Allergy Immunol 32:66-74. 2014
    ..While clinically similar to eosinophilic asthma, patients with non-eosinophilic asthma have different responses to treatment and little is known about the triggers of symptoms and inflammation...