G J Atkins

Summary

Affiliation: University of Adelaide
Country: Australia

Publications

  1. ncbi request reprint Osteocyte regulation of bone mineral: a little give and take
    G J Atkins
    Bone Cell Biology Group, Discipline of Orthopaedics and Trauma, The University of Adelaide, North Terrace, Adelaide, SA 5005, Australia
    Osteoporos Int 23:2067-79. 2012
  2. pmc Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway
    Asiri R Wijenayaka
    Bone Cell Biology Group, Discipline of Orthopaedics and Trauma, University of Adelaide, and the Hanson Institute, Adelaide, Australia
    PLoS ONE 6:e25900. 2011
  3. pmc Critical role of p38 MAPK for regeneration of the sciatic nerve following crush injury in vivo
    Naoki Kato
    Department of Orthopaedic Surgery, Saitama Medical University, Saitama, Japan
    J Neuroinflammation 10:1. 2013
  4. pmc TWEAK and Fn14 expression in the pathogenesis of joint inflammation and bone erosion in rheumatoid arthritis
    Anak A S S K Dharmapatni
    Discipline of Anatomy and Pathology, School of Medical Sciences, University of Adelaide, Frome Road, Adelaide, SA 5005, Australia
    Arthritis Res Ther 13:R51. 2011
  5. ncbi request reprint Human trabecular bone-derived osteoblasts support human osteoclast formation in vitro in a defined, serum-free medium
    Gerald J Atkins
    Department of Orthopaedics and Trauma, University of Adelaide, and the Hanson Institute, Adelaide, South Australia, Australia
    J Cell Physiol 203:573-82. 2005
  6. doi request reprint Strontium ranelate treatment of human primary osteoblasts promotes an osteocyte-like phenotype while eliciting an osteoprotegerin response
    G J Atkins
    Bone Cell Biology Group, Discipline of Orthopaedics and Trauma, University of Adelaide and Hanson Institute, Adelaide, Australia
    Osteoporos Int 20:653-64. 2009
  7. ncbi request reprint Metabolism of vitamin D3 in human osteoblasts: evidence for autocrine and paracrine activities of 1 alpha,25-dihydroxyvitamin D3
    Gerald J Atkins
    Department of Orthopaedics and Trauma, University of Adelaide, Adelaide, South Australia 5000, Australia
    Bone 40:1517-28. 2007
  8. doi request reprint The induction of a catabolic phenotype in human primary osteoblasts and osteocytes by polyethylene particles
    Gerald J Atkins
    Discipline of Orthopaedics and Trauma, The University of Adelaide, Adelaide, SA 5005, Australia
    Biomaterials 30:3672-81. 2009
  9. doi request reprint Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by {gamma}-carboxylation-dependent and -independent mechanisms
    Gerald J Atkins
    Univ of Adelaide, Hanson Institute, SA, Australia
    Am J Physiol Cell Physiol 297:C1358-67. 2009
  10. pmc Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism
    Gerald J Atkins
    Bone Cell Biology Group, Discipline of Orthopaedics and Trauma, University of Adelaide, and the Hanson Institute, Adelaide, Australia
    J Bone Miner Res 26:1425-36. 2011

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Osteocyte regulation of bone mineral: a little give and take
    G J Atkins
    Bone Cell Biology Group, Discipline of Orthopaedics and Trauma, The University of Adelaide, North Terrace, Adelaide, SA 5005, Australia
    Osteoporos Int 23:2067-79. 2012
    ..The sheer number of osteocytes in bone means that "a little give and take" in terms of regulation of bone mineral content translates into a powerful whole organism effect...
  2. pmc Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway
    Asiri R Wijenayaka
    Bone Cell Biology Group, Discipline of Orthopaedics and Trauma, University of Adelaide, and the Hanson Institute, Adelaide, Australia
    PLoS ONE 6:e25900. 2011
    ..Together, these results suggest that sclerostin may have a catabolic action through promotion of osteoclast formation and activity by osteocytes, in a RANKL-dependent manner...
  3. pmc Critical role of p38 MAPK for regeneration of the sciatic nerve following crush injury in vivo
    Naoki Kato
    Department of Orthopaedic Surgery, Saitama Medical University, Saitama, Japan
    J Neuroinflammation 10:1. 2013
    ..However, the results regarding whether p38α promotes or inhibits nerve regeneration in vivo have been controversial...
  4. pmc TWEAK and Fn14 expression in the pathogenesis of joint inflammation and bone erosion in rheumatoid arthritis
    Anak A S S K Dharmapatni
    Discipline of Anatomy and Pathology, School of Medical Sciences, University of Adelaide, Frome Road, Adelaide, SA 5005, Australia
    Arthritis Res Ther 13:R51. 2011
    ..Effects of sTWEAK on osteoclasts and osteoblasts were investigated in vitro...
  5. ncbi request reprint Human trabecular bone-derived osteoblasts support human osteoclast formation in vitro in a defined, serum-free medium
    Gerald J Atkins
    Department of Orthopaedics and Trauma, University of Adelaide, and the Hanson Institute, Adelaide, South Australia, Australia
    J Cell Physiol 203:573-82. 2005
    ..This study demonstrates that under the appropriate conditions, adult human primary osteoblasts can support de novo osteoclast formation, and this model will enable the detailed study of the role of both cell types in this process...
  6. doi request reprint Strontium ranelate treatment of human primary osteoblasts promotes an osteocyte-like phenotype while eliciting an osteoprotegerin response
    G J Atkins
    Bone Cell Biology Group, Discipline of Orthopaedics and Trauma, University of Adelaide and Hanson Institute, Adelaide, Australia
    Osteoporos Int 20:653-64. 2009
    ..SR also elicited an osteoprotegerin (OPG) secretory response. We conclude that SR promotes the osteoblast maturation and osteocyte differentiation while promoting an additional antiresorptive effect...
  7. ncbi request reprint Metabolism of vitamin D3 in human osteoblasts: evidence for autocrine and paracrine activities of 1 alpha,25-dihydroxyvitamin D3
    Gerald J Atkins
    Department of Orthopaedics and Trauma, University of Adelaide, Adelaide, South Australia 5000, Australia
    Bone 40:1517-28. 2007
    ..Our results are therefore consistent with the reported benefits of maintaining a healthy vitamin D status in the elderly to reduce the risk of fractures...
  8. doi request reprint The induction of a catabolic phenotype in human primary osteoblasts and osteocytes by polyethylene particles
    Gerald J Atkins
    Discipline of Orthopaedics and Trauma, The University of Adelaide, Adelaide, SA 5005, Australia
    Biomaterials 30:3672-81. 2009
    ..Overall, our results suggest that PE particles directly induce a change in the phenotype of mature osteoblasts and osteocytes, consistent with the net loss of bone near orthopaedic implants...
  9. doi request reprint Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by {gamma}-carboxylation-dependent and -independent mechanisms
    Gerald J Atkins
    Univ of Adelaide, Hanson Institute, SA, Australia
    Am J Physiol Cell Physiol 297:C1358-67. 2009
    ..These may be mechanisms by which vitamin K optimizes bone formation and integrity in vivo and may help explain the net positive effect of vitamin K on bone formation...
  10. pmc Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism
    Gerald J Atkins
    Bone Cell Biology Group, Discipline of Orthopaedics and Trauma, University of Adelaide, and the Hanson Institute, Adelaide, Australia
    J Bone Miner Res 26:1425-36. 2011
    ....
  11. ncbi request reprint RANKL expression is related to the differentiation state of human osteoblasts
    Gerald J Atkins
    Department of Orthopaedics and Trauma, University of Adelaide, Adelaide, South Australia, Australia
    J Bone Miner Res 18:1088-98. 2003
    ..Additionally, the dual roles of osteoblasts, in supporting osteoclastogenesis or forming bone, may be performed by the same lineage of cells at different stages of their maturation...
  12. ncbi request reprint Bidirectional signaling between stromal and hemopoietic cells regulates interleukin-1 expression during human osteoclast formation
    D R Haynes
    Department of Pathology, University of Adelaide, SA, Australia
    Bone 25:269-78. 1999
    ..These results provide novel evidence that bidirectional signaling between stromal and hemopoietic cells may be important in the generation of human osteoclasts...
  13. ncbi request reprint Osteoprotegerin inhibits osteoclast formation and bone resorbing activity in giant cell tumors of bone
    G J Atkins
    Department of Orthopaedics, University of Adelaide, Adelaide, SA, Australia
    Bone 28:370-7. 2001
    ..The demonstration of these relationships is important in developing approaches to limit tumor-induced osteolysis...
  14. ncbi request reprint Expression of alternatively-spliced MDM2 transcripts in giant cell tumours of bone
    A Evdokiou
    Department of Orthopaedics and Trauma, Level 4, Bice Building, Royal Adelaide Hospital, North Terrace, Adelaide 5000, South Australia, Australia
    Int J Oncol 19:625-32. 2001
    ....
  15. ncbi request reprint The osteoclastogenic molecules RANKL and RANK are associated with periprosthetic osteolysis
    D R Haynes
    Department of Pathology, University of Adelaide, South Australia, Australia
    J Bone Joint Surg Br 83:902-11. 2001
    ..Our results suggest that ingestion of prosthetic wear particles by macrophages results in expression of osteoclast-differentiating molecules and the stimulation of macrophage differentiation into osteoclasts...
  16. ncbi request reprint Osteoprotegerin and receptor activator of nuclear factor kappaB ligand (RANKL) regulate osteoclast formation by cells in the human rheumatoid arthritic joint
    D R Haynes
    Department of Pathology and. Department of Orthopaedics and Trauma, The University of Adelaide and The Royal Adelaide Hospital, Adelaide 5000, SA, Australia
    Rheumatology (Oxford) 40:623-30. 2001
    ..028). CONCLUSION: These data suggest that RANKL is an essential factor for osteoclast formation by cells in the rheumatic joint and that OPG may prevent the bone erosion seen in RA joints...
  17. ncbi request reprint Sensitivity of fresh isolates of soft tissue sarcoma, osteosarcoma and giant cell tumour cells to Apo2L/TRAIL and doxorubicin
    S Bouralexis
    Department of Orthopaedics, Royal Adelaide Hospital, Adelaide University, Hanson Institute, Adelaide, South Australia, Australia
    Int J Oncol 24:1263-70. 2004
    ..The synergistic action between these two different classes of agents has yet to be tested in vivo but may prove clinically relevant in the treatment of this refractive class of malignancies...
  18. doi request reprint The metabolism of 25-(OH)vitamin D3 by osteoclasts and their precursors regulates the differentiation of osteoclasts
    M Kogawa
    Bone Cell Biology Group, Discipline of Orthopaedics and Trauma, University of Adelaide, Adelaide, South Australia 5000, Australia
    J Steroid Biochem Mol Biol 121:277-80. 2010
    ..These results suggest that vitamin D metabolism by osteoclast lineage cells is an important regulator of osteoclast formation...
  19. ncbi request reprint Osteoprotegerin (OPG) is localized to the Weibel-Palade bodies of human vascular endothelial cells and is physically associated with von Willebrand factor
    A C W Zannettino
    Myeloma and Mesenchymal Research Laboratory, Division of Haematology, Institute of Medical and Veterinary Science, and Hanson Institute, Adelaide, South Australia, Australia
    J Cell Physiol 204:714-23. 2005
    ....
  20. doi request reprint Polyethylene particles stimulate expression of ITAM-related molecules in peri-implant tissues and when stimulating osteoclastogenesis in vitro
    E Alias
    Discipline of Anatomy and Pathology, The University of Adelaide, North Terrace, Adelaide, South Australia 5005, Australia
    Acta Biomater 8:3104-12. 2012
    ..These findings suggest that the ITAM signalling molecules and their co-receptors have a role in pathogenic bone loss associated with implant PE wear...
  21. ncbi request reprint The ratio of messenger RNA levels of receptor activator of nuclear factor kappaB ligand to osteoprotegerin correlates with bone remodeling indices in normal human cancellous bone but not in osteoarthritis
    N L Fazzalari
    Division of Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, Australia
    J Bone Miner Res 16:1015-27. 2001
    ..We propose that the effective concentration of RANKL is related causally to bone turnover...
  22. ncbi request reprint RNAi-mediated silencing of CYP27B1 abolishes 1,25(OH)2D3 synthesis and reduces osteocalcin and CYP24 mRNA expression in human osteosarcoma (HOS) cells
    P H Anderson
    Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, SA 5000, Australia
    J Steroid Biochem Mol Biol 103:601-5. 2007
    ....
  23. doi request reprint Critical molecular regulators, histomorphometric indices and their correlations in the trabecular bone in primary hip osteoarthritis
    D D Kumarasinghe
    Bone and Joint Research Laboratory, Surgical Pathology, SA Pathology, Adelaide, South Australia, Australia
    Osteoarthritis Cartilage 18:1337-44. 2010
    ....
  24. doi request reprint Modulation of osteoclastic migration by metabolism of 25OH-vitamin D3
    M Kogawa
    Bone Cell Biology Group, Discipline of Orthopaedics and Trauma, University of Adelaide, Adelaide 5000, Australia
    J Steroid Biochem Mol Biol 136:59-61. 2013
    ..These observations suggest that 25D metabolism by osteoclasts reduces their resorptive capacity, in part by modifying their surface adhesion and migration properties. This article is part of a Special Issue entitled "Vitamin D Workshop"...
  25. doi request reprint Evidence for the dysregulated expression of TWIST1, TGFβ1 and SMAD3 in differentiating osteoblasts from primary hip osteoarthritis patients
    D D Kumarasinghe
    Bone Cell Biology Group, Discipline of Orthopaedics and Trauma, The University of Adelaide, Adelaide, South Australia 5005, Australia
    Osteoarthritis Cartilage 20:1357-66. 2012
    ....
  26. pmc Progressive resistance of BTK-143 osteosarcoma cells to Apo2L/TRAIL-induced apoptosis is mediated by acquisition of DcR2/TRAIL-R4 expression: resensitisation with chemotherapy
    S Bouralexis
    Department of Orthopaedics and Trauma, University of Adelaide, Level 4, Bice Building, Royal Adelaide Hospital, North Terrace, Adelaide 5000, South Australia, Australia
    Br J Cancer 89:206-14. 2003
    ..BTK-143 cells thus represent a useful model system to investigate both the mechanisms of acquisition of resistance of tumour cells to Apo2L/TRAIL and the use of conventional drugs and novel agents to overcome resistance to Apo2L/TRAIL...
  27. ncbi request reprint Osteoprotegerin expression in synovial tissue from patients with rheumatoid arthritis, spondyloarthropathies and osteoarthritis and normal controls
    D R Haynes
    Department of Pathology, University of Adelaide, Repatriation General Hospital, Daws Road, Daw Park, South Australia 5041, Australia
    Rheumatology (Oxford) 42:123-34. 2003
    ....
  28. ncbi request reprint The correlation of RANK, RANKL and TNFalpha expression with bone loss volume and polyethylene wear debris around hip implants
    Christopher A Holding
    Department of Pathology, The University of Adelaide, North Terrace, Adelaide, South Australia 5000, Australia
    Biomaterials 27:5212-9. 2006
    ..This suggests that the interaction of TNFalpha and RANKL promotes osteoclast activity associated with polyethylene wear and therapies targeting TNF activity may be useful to treat peri-implant osteolysis...
  29. doi request reprint Pro-inflammatory cytokines TNF-related weak inducer of apoptosis (TWEAK) and TNFalpha induce the mitogen-activated protein kinase (MAPK)-dependent expression of sclerostin in human osteoblasts
    Cristina Vincent
    Bone Cell Biology Group, Discipline of Orthopaedics and Trauma, University of Adelaide, and the Hanson Institute, Adelaide, Australia
    J Bone Miner Res 24:1434-49. 2009
    ..Together, our findings suggest that TWEAK, alone and with TNF, can regulate osteoblast function, at least in part by inducing sclerostin expression. Our results also suggest new roles and modes of action for sclerostin...
  30. ncbi request reprint Increased expression of IL-6 and RANK mRNA in human trabecular bone from fragility fracture of the femoral neck
    Helen Tsangari
    Division of Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, Australia
    Bone 35:334-42. 2004
    ....
  31. doi request reprint Differential effects of 1,25-dihydroxyvitamin D on mineralisation and differentiation in two different types of osteoblast-like cultures
    D Yang
    Discipline of Medicine, University of Adelaide, Adelaide, SA 5005, Australia Endocrine Bone Research, Chemical Pathology, SA Pathology, Adelaide, SA 5000, Australia
    J Steroid Biochem Mol Biol 136:166-70. 2013
    ..1,25D exerts differential effects on osteoblast-like cells depending on their stage of maturation and possibly their skeletal origin. This article is part of a Special Issue entitled 'Vitamin D Workshop'...
  32. doi request reprint Changes in osteocyte density correspond with changes in osteoblast and osteoclast activity in an osteoporotic sheep model
    M R Zarrinkalam
    The Adelaide Centre for Spinal Research, SA Pathology, Institute of Medical and Veterinary Science IMVS, Frome Road, Adelaide, SA 5000, Australia
    Osteoporos Int 23:1329-36. 2012
    ..In contrast, eroded surface area and empty lacunae density were increased. Changes in osteocyte density correlated with changes in osteoblast and osteoclast activity...
  33. doi request reprint Expression of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor, fibroblast growth factor-inducible 14 protein (Fn14), in healthy tissues and in tissues affected by periodontitis
    N G Kataria
    Colgate Australian Clinical Dental Research Centre, School of Dentistry, University of Adelaide, Adelaide, SA, Australia
    J Periodontal Res 45:564-73. 2010
    ..The aim of the present study was to investigate the expression of TWEAK and Fn14 at the protein and mRNA levels in gingival biopsies from periodontitis patients and from clinically healthy patients...
  34. doi request reprint Relationship between serum RANKL and RANKL in bone
    D M Findlay
    Discipline of Orthopaedics and Trauma, University of Adelaide, Level 4 Bice Building, Royal Adelaide Hospital, Adelaide 5000, SA, Australia
    Osteoporos Int 22:2597-602. 2011
    ..This review explores this subject, documenting the possible origins of circulating RANKL and suggesting additional information that is required before serum RANKL levels can provide useful diagnostic or research information...
  35. doi request reprint Osteoclastic metabolism of 25(OH)-vitamin D3: a potential mechanism for optimization of bone resorption
    Masakazu Kogawa
    Bone Cell Biology Group, Discipline of Orthopaedics and Trauma, University of Adelaide, North Terrace, Adelaide, South Australia, Australia 5000
    Endocrinology 151:4613-25. 2010
    ..We conclude that 25D metabolism is an important intrinsic mechanism for optimizing osteoclast differentiation, ameliorating osteoclast activity, and potentially promoting the coupling of bone resorption to formation...
  36. ncbi request reprint Calcitonin decreases the adherence and survival of HEK-293 cells by a caspase-independent mechanism
    D M Findlay
    Department of Orthopaedics and Trauma, University of Adelaide, The Royal Adelaide Hospital, Adelaide 5000, South Australia, Australia
    J Endocrinol 175:715-25. 2002
    ..These results demonstrate that CT can negatively affect cell survival and they identify roles for cell adherence and MAP kinase activation in this process...
  37. ncbi request reprint Primary human osteoblasts grow into porous tantalum and maintain an osteoblastic phenotype
    Katie J Welldon
    Department of Orthopaedics and Trauma, University of Adelaide, Adelaide, South Australia, Australia
    J Biomed Mater Res A 84:691-701. 2008
    ..No substrate-dependent differences were seen in the extent of in vitro mineralization by HOB. These results indicate that porous Ta is a good substrate for the attachment, growth, and differentiated function of HOB...
  38. ncbi request reprint RANK Expression as a cell surface marker of human osteoclast precursors in peripheral blood, bone marrow, and giant cell tumors of bone
    Gerald J Atkins
    Department of Orthopaedics and Trauma, University of Adelaide, Adelaide, South Australia, Australia
    J Bone Miner Res 21:1339-49. 2006
    ..We describe the lineages that express RANK in bone marrow, peripheral blood, and GCTs. We show that CD14(+)RANK(high) cells constitute a circulating pre-osteoclast pool...
  39. ncbi request reprint Receptor activator of nuclear factor-kappaB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo
    Amanda N Farrugia
    Myeloma and Mesenchymal Research Group, Matthew Roberts Foundation Laboratory, Division of Haematology, Institute of Medical and Veterinary Science, Adelaide, South Australia
    Cancer Res 63:5438-45. 2003
    ....
  40. ncbi request reprint The proliferation and phenotypic expression of human osteoblasts on tantalum metal
    David M Findlay
    Department of Orthopaedics and Trauma, University of Adelaide, South Australia
    Biomaterials 25:2215-27. 2004
    ..No substrate-dependent differences were seen in the extent of in vitro mineralisation by NHBC. These results indicate that Ta is a good substrate for the attachment, growth and differentiated function of human osteoblasts...
  41. ncbi request reprint An in vitro osteoclast-forming assay to measure myeloma cell-derived osteoclast-activating factors
    Andrew C W Zannettino
    Myeloma and Mesenchymal Research Laboratory, Institute of Medical and Veterinary Science, Adelaide, Australia
    Methods Mol Med 113:245-56. 2005
    ..This chapter describes one such in vitro model system...
  42. ncbi request reprint Chemotherapeutic agents sensitize osteogenic sarcoma cells, but not normal human bone cells, to Apo2L/TRAIL-induced apoptosis
    Andreas Evdokiou
    Department of Orthopaedics, Level 4 Bice Building, Royal Adelaide Hospital, North Terrace, Adelaide 5000, South Australia, Australia
    Int J Cancer 99:491-504. 2002
    ..Our results indicate that chemotherapy and Apo2L/TRAIL act synergistically to kill cancer cells but not normal bone-derived osteoblast-like cells, which has implications for future therapy of osteosarcoma...
  43. ncbi request reprint Human osteoblasts are resistant to Apo2L/TRAIL-mediated apoptosis
    G J Atkins
    Department of Orthopaedics and Trauma, Adelaide University and Royal Adelaide Hospital, Adelaide, SA, Australia
    Bone 31:448-56. 2002
    ..In addition, they predict that therapeutic use of recombinant Apo2L/TRAIL, in combination with chemotherapeutic agents to treat skeletal malignancies, would have limited toxic effects on normal osteoblastic cells...
  44. doi request reprint Apo2L/TRAIL inhibits tumor growth and bone destruction in a murine model of multiple myeloma
    Agatha Labrinidis
    Discipline of Orthopaedics and Trauma, The University of Adelaide, Royal Adelaide Hospital, and Hanson Institute, South Australia, Australia
    Clin Cancer Res 15:1998-2009. 2009
    ..Here, we report on the efficacy of recombinant soluble Apo2L/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to inhibit tumor progression and bone destruction in a xenogeneic model of human multiple myeloma...
  45. ncbi request reprint Expression of defensin antimicrobial peptides in the peritoneal cavity of patients on peritoneal dialysis
    K H Zarrinkalam
    Department of Renal Medicine, Royal Adelaide Hospital, South Australia, Australia
    Perit Dial Int 21:501-8. 2001
    ..Variable levels of expression of hbetaD-2 by mesothelial cells were seen, with evidence of regulation by cytokines and growth factors. This provides evidence for a previously unknown mechanism of innate immunity at that site...
  46. doi request reprint Biomimetic hydroxyapatite coating on glass coverslips for the assay of osteoclast activity in vitro
    Asiri K A R Wijenayaka
    Bone Cell Biology Group, Discipline of Orthopaedics and Trauma, University of Adelaide, Adelaide, SA 5005, Australia
    J Mater Sci Mater Med 20:1467-73. 2009
    ..This approach for the preparation of HA coatings on glass coverslips could have wide applicability for the study of osteoclast behaviour in vitro...
  47. doi request reprint The skeleton as an intracrine organ for vitamin D metabolism
    Paul H Anderson
    Discipline of Medicine, Faculty of Health Science, University of Adelaide and The Hanson Institute, Adelaide, South Australia 5000, Australia
    Mol Aspects Med 29:397-406. 2008
    ..We conclude that the skeleton is an intracrine organ for vitamin D metabolism, challenging the long-held notion that 1,25D is solely an endocrine hormone...
  48. doi request reprint The generation of osteoclasts from RAW 264.7 precursors in defined, serum-free conditions
    Cristina Vincent
    Bone Cell Biology Group, Discipline of Orthopaedics and Trauma, University of Adelaide and The Hanson Institute, North Terrace, Adelaide, SA 5000, Australia
    J Bone Miner Metab 27:114-9. 2009
    ..In conclusion, we describe a defined model for studying osteoclast differentiation and activity in the absence of serum, which will be ideal for studying the role of agonistic and antagonistic molecules in this process...
  49. ncbi request reprint The nitrogen-containing bisphosphonate, zoledronic acid, increases mineralisation of human bone-derived cells in vitro
    Beiqing Pan
    Myeloma and Mesenchymal Research Group, Matthew Roberts Foundation Laboratory, Division of Haematology, Institute of Medical and Veterinary Science, Adelaide 5000, Australia
    Bone 34:112-23. 2004
    ..These results show that, in addition to its direct effects on OCs, ZOL also directly affects the proliferation and differentiation of human OB-like cells in vitro and may enhance bone formation in vivo...
  50. ncbi request reprint Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts
    Yun Shan Hu
    Bone, Joint, and Cancer Unit, St Vincent s Institute of Medical Research, Fitzroy, Victoria, Australia
    J Bone Miner Res 19:89-99. 2004
    ..OCIL shows promise as a new antiresorptive...
  51. pmc Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice
    Rachel A Davey
    Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia
    J Bone Miner Res 23:1182-93. 2008
    ..These data provide strong evidence for a biological role of the CTR in regulating calcium homeostasis in states of calcium stress...
  52. pmc Molecular profiling of giant cell tumor of bone and the osteoclastic localization of ligand for receptor activator of nuclear factor kappaB
    Teresa Morgan
    Ian Potter Foundation Center for Cancer Genomics and Predictive Medicine and Research Division, Peter MacCallum Cancer Center, Melbourne, Australia
    Am J Pathol 167:117-28. 2005
    ..These data raise questions regarding the role of RANKL in GCTs that may be relevant to the development of molecularly targeted therapeutics for this disease...
  53. doi request reprint Bril: a novel bone-specific modulator of mineralization
    Pierre Moffatt
    Shriners Hospital for Children, Montreal, Quebec, Canada
    J Bone Miner Res 23:1497-508. 2008
    ..Thus, we identified Bril as a novel osteoblast protein and showed a role in mineralization, possibly identifying a new regulatory pathway in bone formation...
  54. ncbi request reprint TWEAK is a novel arthritogenic mediator
    Stuart J Perper
    Exploratory Sciences, Biogen Idec Inc, 14 Cambridge Center, Cambridge, MA 02142, USA
    J Immunol 177:2610-20. 2006
    ....
  55. ncbi request reprint Does Apo2L/TRAIL play any physiologic role in osteoclastogenesis?
    Agatha Labrinidis
    Blood 111:5411-2; autor reply 5413. 2008