Julie D Atkin

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi request reprint Properties of slow- and fast-twitch muscle fibres in a mouse model of amyotrophic lateral sclerosis
    Julie D Atkin
    Motor Neuron Disease Research Laboratory, Brain Injury and Repair Group, Howard Florey Institute, University of Melbourne, Parkville, VIC 3010, Australia
    Neuromuscul Disord 15:377-88. 2005
  2. ncbi request reprint Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1
    Julie D Atkin
    Brain Injury and Repair Group, Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, USA
    J Biol Chem 281:30152-65. 2006
  3. ncbi request reprint Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis
    Bradley J Turner
    Motor Neuron Disease Research Laboratory, Brain Injury and Repair Group, Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Victoria 3010, Australia
    J Neurosci 25:108-17. 2005
  4. doi request reprint Serum matrix metalloproteinase-9 activity is dysregulated with disease progression in the mutant SOD1 transgenic mice
    Cynthia P W Soon
    Department of Pathology, The University of Melbourne, Parkville, VIC 3010, Australia
    Neuromuscul Disord 20:260-6. 2010
  5. ncbi request reprint Mutant SOD1 inhibits ER-Golgi transport in amyotrophic lateral sclerosis
    Julie D Atkin
    Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Melbourne, Australia Department of Florey Neuroscience, University of Melbourne, Parkville, Melbourne, Australia
    J Neurochem 129:190-204. 2014
  6. ncbi request reprint Brain beta-amyloid accumulation in transgenic mice expressing mutant superoxide dismutase 1
    Bradley J Turner
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Victoria 3010, Australia
    Neurochem Res 29:2281-6. 2004
  7. doi request reprint Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis
    Julie D Atkin
    Howard Florey Institute, University of Melbourne, Parkville, VIC 3010, Australia
    Neurobiol Dis 30:400-7. 2008
  8. doi request reprint Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis
    Adam K Walker
    Florey Neuroscience Institutes, The University of Melbourne, Parkville, Victoria 3010, Australia
    Brain 133:105-16. 2010
  9. ncbi request reprint Sex-specific behavioural effects of environmental enrichment in a transgenic mouse model of amyotrophic lateral sclerosis
    Nathan C Stam
    Howard Florey Institute, and Department of Anatomy and Cell Biology, University of Melbourne, Parkville, VIC 3010, Australia
    Eur J Neurosci 28:717-23. 2008
  10. pmc ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation
    Adam K Walker
    Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria, Australia Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia
    PLoS ONE 8:e81170. 2013

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Properties of slow- and fast-twitch muscle fibres in a mouse model of amyotrophic lateral sclerosis
    Julie D Atkin
    Motor Neuron Disease Research Laboratory, Brain Injury and Repair Group, Howard Florey Institute, University of Melbourne, Parkville, VIC 3010, Australia
    Neuromuscul Disord 15:377-88. 2005
    ..Hence, there is no simple correlation between SOD1 protein expression/activity, and muscle fibre type vulnerability in SOD1 G93A mice...
  2. ncbi request reprint Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1
    Julie D Atkin
    Brain Injury and Repair Group, Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, USA
    J Biol Chem 281:30152-65. 2006
    ..The possibility that PDI may be a therapeutic target to prevent SOD1 aggregation is also raised by this study...
  3. ncbi request reprint Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis
    Bradley J Turner
    Motor Neuron Disease Research Laboratory, Brain Injury and Repair Group, Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Victoria 3010, Australia
    J Neurosci 25:108-17. 2005
    ..Collectively, these results suggest novel extracellular roles for SOD1 in ALS and support a causal relationship between mutant SOD1 secretion and intraneuronal toxicity...
  4. doi request reprint Serum matrix metalloproteinase-9 activity is dysregulated with disease progression in the mutant SOD1 transgenic mice
    Cynthia P W Soon
    Department of Pathology, The University of Melbourne, Parkville, VIC 3010, Australia
    Neuromuscul Disord 20:260-6. 2010
    ..These data indicate that circulating MMP-9 is altered throughout the course of disease progression in mice. Further studies in human ALS may validate the suitability of serum MMP-9 activity as a biomarker for early stage disease...
  5. ncbi request reprint Mutant SOD1 inhibits ER-Golgi transport in amyotrophic lateral sclerosis
    Julie D Atkin
    Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Melbourne, Australia Department of Florey Neuroscience, University of Melbourne, Parkville, Melbourne, Australia
    J Neurochem 129:190-204. 2014
    ..These findings thus link several cellular events in amyotrophic lateral sclerosis into a single mechanism occurring early in mSOD1 expressing cells...
  6. ncbi request reprint Brain beta-amyloid accumulation in transgenic mice expressing mutant superoxide dismutase 1
    Bradley J Turner
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Victoria 3010, Australia
    Neurochem Res 29:2281-6. 2004
    ..We therefore conclude that mutant SOD1 overexpression promotes neither Abeta toxicity nor brain accumulation in these ALS models...
  7. doi request reprint Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis
    Julie D Atkin
    Howard Florey Institute, University of Melbourne, Parkville, VIC 3010, Australia
    Neurobiol Dis 30:400-7. 2008
    ..We also show up-regulation of UPR prior to the onset of symptoms in SOD1 rodents, implying an active role in disease. This study offers new insights into pathogenesis, placing ER stress onto a generic pathophysiology for ALS...
  8. doi request reprint Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis
    Adam K Walker
    Florey Neuroscience Institutes, The University of Melbourne, Parkville, Victoria 3010, Australia
    Brain 133:105-16. 2010
    ....
  9. ncbi request reprint Sex-specific behavioural effects of environmental enrichment in a transgenic mouse model of amyotrophic lateral sclerosis
    Nathan C Stam
    Howard Florey Institute, and Department of Anatomy and Cell Biology, University of Melbourne, Parkville, VIC 3010, Australia
    Eur J Neurosci 28:717-23. 2008
    ....
  10. pmc ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation
    Adam K Walker
    Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria, Australia Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia
    PLoS ONE 8:e81170. 2013
    ..This study provides evidence for ER stress as a pathogenic pathway in TDP-43-mediated disease. ..
  11. ncbi request reprint ER stress and UPR in familial amyotrophic lateral sclerosis
    Bradley J Turner
    Howard Florey Institute, University of Melbourne, Victoria, Australia
    Curr Mol Med 6:79-86. 2006
    ..We propose that ER stress and UPR may be coupled to GA dysfunction in mutant SOD1-mediated toxicity, promoting ER-initiated cell death signalling in FALS...
  12. doi request reprint N-linked glycosylation modulates dimerization of protein disulfide isomerase family A member 2 (PDIA2)
    Adam K Walker
    Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria, Australia
    FEBS J 280:233-43. 2013
    ..These results further characterize this poorly defined member of the PDI family...