Minoti Apte

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. ncbi request reprint Polymorphism in alcohol-metabolizing enzymes, glutathione S-transferases and apolipoprotein E and susceptibility to alcohol-induced cirrhosis and chronic pancreatitis
    Andreas Frenzer
    Department of Gastroenterology, The Queen Elizabeth Hospital, Adelaide, SA, Australia
    J Gastroenterol Hepatol 17:177-82. 2002
  2. ncbi request reprint Battle-scarred pancreas: role of alcohol and pancreatic stellate cells in pancreatic fibrosis
    Minoti V Apte
    Pancreatic Research Group, South Western Sydney Clinical School, Liverpool Hospital, Sydney, Australia
    J Gastroenterol Hepatol 21:S97-S101. 2006
  3. doi request reprint Extracellular matrix composition significantly influences pancreatic stellate cell gene expression pattern: role of transgelin in PSC function
    Minoti V Apte
    South Western Sydney Clinical School, Faculty of Medicine, Univ of New South Wales, Liverpool Hospital, Liverpool, NSW 2170 Australia
    Am J Physiol Gastrointest Liver Physiol 305:G408-17. 2013
  4. doi request reprint Dangerous liaisons: pancreatic stellate cells and pancreatic cancer cells
    Minoti V Apte
    Pancreatic Research Group, South Western Sydney Clinical School, University of New South Wales, Sydney, New South Wales, Australia
    J Gastroenterol Hepatol 27:69-74. 2012
  5. doi request reprint Mechanisms of alcoholic pancreatitis
    Minoti V Apte
    Pancreatic Research Group, South Western Sydney Clinical School, Liverpool Hospital and School of Medical Sciences, University of New South Wales, Sydney, Australia
    J Gastroenterol Hepatol 25:1816-26. 2010
  6. doi request reprint New insights into alcoholic pancreatitis and pancreatic cancer
    Minoti Apte
    Pancreatic Research Group, South Western Sydney Clinical School, University of New South Wales, Sydney, New South Wales, Australia
    J Gastroenterol Hepatol 24:S51-6. 2009
  7. ncbi request reprint Molecular mechanisms of alcoholic pancreatitis
    M V Apte
    Pancreatic Research Group, University of New South Wales, Sydney, Australia
    Dig Dis 23:232-40. 2005
  8. pmc The importance of keeping in touch: regulation of cell-cell contact in the exocrine pancreas
    M V Apte
    Pancreatic Research Group, The University of New South Wales, Sydney, Australia
    Gut 54:1358-9. 2005
  9. ncbi request reprint Mechanisms of pancreatic fibrosis
    M V Apte
    Pancreatic Research Group, University of New South Wales, Sydney, Australia
    Dig Dis 22:273-9. 2004
  10. ncbi request reprint Stellate cell activation in alcoholic pancreatitis
    M V Apte
    Pancreatic Research Group, Department of Gastroenterology, Bankstown Lidcombe and Liverpool Hospitals and The University of New South Wales, Sydney, Australia
    Pancreas 27:316-20. 2003

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Polymorphism in alcohol-metabolizing enzymes, glutathione S-transferases and apolipoprotein E and susceptibility to alcohol-induced cirrhosis and chronic pancreatitis
    Andreas Frenzer
    Department of Gastroenterology, The Queen Elizabeth Hospital, Adelaide, SA, Australia
    J Gastroenterol Hepatol 17:177-82. 2002
    ....
  2. ncbi request reprint Battle-scarred pancreas: role of alcohol and pancreatic stellate cells in pancreatic fibrosis
    Minoti V Apte
    Pancreatic Research Group, South Western Sydney Clinical School, Liverpool Hospital, Sydney, Australia
    J Gastroenterol Hepatol 21:S97-S101. 2006
    ....
  3. doi request reprint Extracellular matrix composition significantly influences pancreatic stellate cell gene expression pattern: role of transgelin in PSC function
    Minoti V Apte
    South Western Sydney Clinical School, Faculty of Medicine, Univ of New South Wales, Liverpool Hospital, Liverpool, NSW 2170 Australia
    Am J Physiol Gastrointest Liver Physiol 305:G408-17. 2013
    ..These findings suggest that transgelin is a potentially useful target protein to modulate PSC function so as to ameliorate pancreatic fibrosis. ..
  4. doi request reprint Dangerous liaisons: pancreatic stellate cells and pancreatic cancer cells
    Minoti V Apte
    Pancreatic Research Group, South Western Sydney Clinical School, University of New South Wales, Sydney, New South Wales, Australia
    J Gastroenterol Hepatol 27:69-74. 2012
    ..The challenge is to translate these developments into clinically applicable treatments for patients...
  5. doi request reprint Mechanisms of alcoholic pancreatitis
    Minoti V Apte
    Pancreatic Research Group, South Western Sydney Clinical School, Liverpool Hospital and School of Medical Sciences, University of New South Wales, Sydney, Australia
    J Gastroenterol Hepatol 25:1816-26. 2010
    ..Thus, while the molecular effects of alcohol on the pancreas have been increasingly clarified in recent years, identification of predisposing or triggering factors remains a challenge...
  6. doi request reprint New insights into alcoholic pancreatitis and pancreatic cancer
    Minoti Apte
    Pancreatic Research Group, South Western Sydney Clinical School, University of New South Wales, Sydney, New South Wales, Australia
    J Gastroenterol Hepatol 24:S51-6. 2009
    ....
  7. ncbi request reprint Molecular mechanisms of alcoholic pancreatitis
    M V Apte
    Pancreatic Research Group, University of New South Wales, Sydney, Australia
    Dig Dis 23:232-40. 2005
    ..Here the current concepts regarding the mechanisms/pathways mediating alcohol-induced pancreatic injury are outlined...
  8. pmc The importance of keeping in touch: regulation of cell-cell contact in the exocrine pancreas
    M V Apte
    Pancreatic Research Group, The University of New South Wales, Sydney, Australia
    Gut 54:1358-9. 2005
  9. ncbi request reprint Mechanisms of pancreatic fibrosis
    M V Apte
    Pancreatic Research Group, University of New South Wales, Sydney, Australia
    Dig Dis 22:273-9. 2004
    ....
  10. ncbi request reprint Stellate cell activation in alcoholic pancreatitis
    M V Apte
    Pancreatic Research Group, Department of Gastroenterology, Bankstown Lidcombe and Liverpool Hospitals and The University of New South Wales, Sydney, Australia
    Pancreas 27:316-20. 2003
    ....
  11. pmc Rat pancreatic stellate cells secrete matrix metalloproteinases: implications for extracellular matrix turnover
    P A Phillips
    Pancreatic Research Group, Department of Gastroenterology, Bankstown Lidcombe and Liverpool Hospitals, and University of New South Wales, Sydney, Australia
    Gut 52:275-82. 2003
    ..However, the role of these cells in ECM protein degradation has not been fully elucidated...
  12. doi request reprint Withdrawal of alcohol promotes regression while continued alcohol intake promotes persistence of LPS-induced pancreatic injury in alcohol-fed rats
    Alain Vonlaufen
    Pancreatic Research Group, South Western Sydney Clinical School and School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
    Gut 60:238-46. 2011
    ....
  13. ncbi request reprint Alcohol-induced pancreatic injury
    M V Apte
    Pancreatic Research Group, Department of Gastroenterology, Bankstown Lidcombe, Australia
    Best Pract Res Clin Gastroenterol 17:593-612. 2003
    ..This chapter summarizes the natural history, clinical features, current trends in treatment as well as recent advances in our understanding of the pathogenesis of alcoholic pancreatitis...
  14. pmc Vitamin A inhibits pancreatic stellate cell activation: implications for treatment of pancreatic fibrosis
    J A McCarroll
    Pancreatic Research Group, Room 463, Level 4, Health Services Building, Liverpool Hospital, Campbell Street, Liverpool, NSW 2170, Australia
    Gut 55:79-89. 2006
    ....
  15. ncbi request reprint Alcohol and the pancreas
    P Haber
    Drug and Alcohol Department PSH, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia
    Alcohol Clin Exp Res 25:244S-250S. 2001
    ..Yokoyama, Y. Nakamura, K. Shirakura, and H. Ishii; and (5) Alcohol consumption and incidence of type 2 diabetes, by Katherine M. Conigrave, B. Frank Hu, Carlos A. Camargo Jr, Meir J. Stampfer, Walter C. Willett, and Eric B. Rimm...
  16. ncbi request reprint The role of inflammatory and parenchymal cells in acute pancreatitis
    A Vonlaufen
    Pancreatic Research Group, South Western Sydney Clinical School, University of New South Wales, Sydney, Australia
    J Pathol 213:239-48. 2007
    ..Studies to date suggest that combination therapy targeting different steps of the inflammatory cascade may be the treatment of choice for this disease...
  17. ncbi request reprint Role of alcohol metabolism in alcoholic pancreatitis
    J S Wilson
    Pancreatic Research Group, Department of Gastroenterology, Bankstown Lidcombe and Liverpool Hospitals and The University of New South Wales, Sydney, Australia
    Pancreas 27:311-5. 2003
    ....
  18. ncbi request reprint Pancreatic stellate cell activation by ethanol and acetaldehyde: is it mediated by the mitogen-activated protein kinase signaling pathway?
    J A McCarroll
    Pancreatic Research Group, The University of New South Wales, Sydney, Australia
    Pancreas 27:150-60. 2003
    ..One of the major signaling pathways known to regulate protein synthesis in mammalian cells is the mitogen-activated protein kinase (MARK) pathway...
  19. doi request reprint The fibrosis of chronic pancreatitis: new insights into the role of pancreatic stellate cells
    Minoti Apte
    Pancreatic Research Group, South Western Sydney Clinical School, University of New South Wales, Sydney, Australia
    Antioxid Redox Signal 15:2711-22. 2011
    ..During pancreatic injury, PSCs transform into an activated phenotype that secretes excessive amounts of the ECM proteins that comprise fibrous tissue...
  20. pmc Recruitment and activation of pancreatic stellate cells from the bone marrow in pancreatic cancer: a model of tumor-host interaction
    Christopher J Scarlett
    Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, Australia
    PLoS ONE 6:e26088. 2011
    ..Recent evidence has suggested that circulating bone marrow derived stem cells (BMDC) contribute to solid organs. We aimed to define the role of circulating haematopoietic cells in the normal and diseased pancreas...
  21. ncbi request reprint Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells
    M V Apte
    Pancreatic Research Group, Department of Gastroenterology, Bankstown Lidcombe and Liverpool Hospitals, NSW, Sydney, Australia
    Pancreas 29:179-87. 2004
    ....
  22. pmc Cell migration: a novel aspect of pancreatic stellate cell biology
    P A Phillips
    Pancreatic Research Group, Department of Gastroenterology, Bankstown Lidcombe and Liverpool Hospitals and The University of New South Wales, Sydney, Australia
    Gut 52:677-82. 2003
    ..The ability of PSCs to proliferate has been well established but their potential for migration has not been examined...
  23. doi request reprint A fire inside: current concepts in chronic pancreatitis
    S J N Tattersall
    Department of Gastroenterology, Liverpool Hospital, Liverpool, Australia
    Intern Med J 38:592-8. 2008
    ..We have also reviewed current practices with respect to diagnosis and management of chronic pancreatitis...
  24. pmc Where there's smoke there's not necessarily fire
    M V Apte
    South Western Sydney Clinical School, The University of New South Wales, Level 2, Thomas and Rachel Moore Education Centre, Liverpool Hospital, Liverpool, NSW 2170, Australia
    Gut 54:446-7. 2005
  25. ncbi request reprint Pancreatic stellate cell migration: role of the phosphatidylinositol 3-kinase(PI3-kinase) pathway
    Joshua A McCarroll
    University of New South Wales, Sydney, Australia
    Biochem Pharmacol 67:1215-25. 2004
    ..ii) The PI3-kinase pathway plays a role in PDGF-induced PSC migration and is partially involved in mediating ERK1/2 activation. (iii) PSC migration is dependent, at least in part, on cell proliferation...
  26. ncbi request reprint Non-oxidative metabolism of ethanol by rat pancreatic acini
    Paul S Haber
    Pancreatic Research Group, University of New South Wales, Sydney, Australia
    Pancreatology 4:82-9. 2004
    ..The aims of this study were to determine the rate of non-oxidative metabolism in isolated rat pancreatic acini and to compare this to the rate of ethanol oxidation...
  27. ncbi request reprint Signal transduction in alcohol-related diseases
    Minoti V Apte
    Pancreatic Research Group, The University of New South Wales, Sydney, Australia
    Alcohol Clin Exp Res 29:1299-1309. 2005
  28. ncbi request reprint Bacterial endotoxin: a trigger factor for alcoholic pancreatitis? Evidence from a novel, physiologically relevant animal model
    Alain Vonlaufen
    Pancreatic Research Group, South Western Sydney Clinical School, Sydney, Australia
    Gastroenterology 133:1293-303. 2007
    ....
  29. ncbi request reprint Role of alcohol metabolism in chronic pancreatitis
    Alain Vonlaufen
    South Western Sydney Clinical School, University of New South Wales, Sydney, Australia
    Alcohol Res Health 30:48-54. 2007
    ..Several studies have investigated whether variations in ethanol-metabolizing enzymes may be a trigger factor for chronic pancreatitis, but no definite relationship has been established so far...
  30. ncbi request reprint Asian-Oceanic Pancreatic Association: conception to actuality
    Yutaka Atomi
    Department of Surgery, Kyorin University School of Medicine, Tokyo, Japan
    Pancreas 31:405-12. 2005
    ..The second scientific meeting will be held during APDW 2007...
  31. ncbi request reprint Fatty acid ethyl esters--alcohol's henchmen in the pancreas?
    Minoti V Apte
    Gastroenterology 130:992-5. 2006
  32. pmc Ethanol augments PDGF-induced NADPH oxidase activity and proliferation in rat pancreatic stellate cells
    Richard Hu
    Department of Veterans Affairs University of California, Los Angeles Research Center for Alcoholic Liver and Pancreatic Diseases, Los Angeles, Calif 90073, USA
    Pancreatology 7:332-40. 2007
    ..The aims of this study were to determine the presence and role of the NADPH oxidase system in mediating alcohol effects on PaSCs with specific emphasis on proliferation...
  33. doi request reprint Improving outcomes for operable pancreatic cancer: is access to safer surgery the problem?
    David K Chang
    Upper Gastrointestinal Surgery Unit, Bankstown Hospital, Bankstown, Australia
    J Gastroenterol Hepatol 23:1036-45. 2008
    ....
  34. doi request reprint Pancreatic stellate cells: partners in crime with pancreatic cancer cells
    Alain Vonlaufen
    Pancreatic Research Group, South Western Sydney Clinical School, The University of New South Wales, Sydney, New South Wales 2052, Australia
    Cancer Res 68:2085-93. 2008
    ..Our studies indicate a significant interaction between pancreatic cancer cells and stromal cells (PSCs) and imply that pancreatic cancer cells recruit stromal cells to establish an environment that promotes cancer progression...
  35. doi request reprint Individual susceptibility to alcoholic pancreatitis
    Minoti V Apte
    Pancreatic Research Group, South Western Sydney Clinical School, Liverpool Hospital, The University of New South Wales, Sydney, Australia
    J Gastroenterol Hepatol 23:S63-8. 2008
    ....