Gary P Anderson

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi request reprint Granulocyte/macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFkappa B and AP-1 in vivo
    Steven Bozinovski
    Arthritis and Inflammation Research Center, Department of Medicine, Cooperative Research Center CRC for Chronic Inflammatory Diseases, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3010, Australia
    J Biol Chem 277:42808-14. 2002
  2. ncbi request reprint Current issues with beta2-adrenoceptor agonists: pharmacology and molecular and cellular mechanisms
    Gary P Anderson
    Lung Disease Research Group, Cooperative Research Centre for Chronic Inflammatory Diseases, Departments of Medicine and Pharmacology, The University of Melbourne, Parkville, Australia
    Clin Rev Allergy Immunol 31:119-30. 2006
  3. ncbi request reprint The immunobiology of early asthma
    Gary P Anderson
    Department of Medicine, University of Melbourne, Parkville, Vic
    Med J Aust 177:S47-9. 2002
  4. ncbi request reprint Therapeutic prospects for early asthma
    Gary P Anderson
    Department of Medicine, University of Melbourne, Parkville, Vic
    Med J Aust 177:S66-9. 2002
  5. ncbi request reprint Acquired somatic mutations in the molecular pathogenesis of COPD
    Gary P Anderson
    Department of Pharmacology, Cooperative Research Center for Chronic Inflammatory Diseases, The University of Melbourne, Parkville, Australia
    Trends Pharmacol Sci 24:71-6. 2003
  6. ncbi request reprint Innate immune responses to LPS in mouse lung are suppressed and reversed by neutralization of GM-CSF via repression of TLR-4
    Steven Bozinovski
    Lung Disease Research Group, Dept of Pharmacology, Cooperative Research Center for Chronic Inflammatory Diseases, Univ of Melbourne, Parkville 3010, Victoria, Australia
    Am J Physiol Lung Cell Mol Physiol 286:L877-85. 2004
  7. ncbi request reprint Cigarette smoke exposure reprograms the hypothalamic neuropeptide Y axis to promote weight loss
    Hui Chen
    Department of Physiology, CRC for Chronic Inflammatory Diseases, The University of Melbourne Hospital, Victoria, Australia
    Am J Respir Crit Care Med 173:1248-54. 2006
  8. doi request reprint Long-term cigarette smoke exposure increases uncoupling protein expression but reduces energy intake
    Hui Chen
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, NSW 2052, Australia
    Brain Res 1228:81-8. 2008
  9. doi request reprint Glutathione peroxidase-1 reduces influenza A virus-induced lung inflammation
    Selcuk Yatmaz
    Department of Pharmacology, The University of Melbourne, Parkville, Vic, Australia
    Am J Respir Cell Mol Biol 48:17-26. 2013
  10. pmc Serum amyloid A promotes lung neutrophilia by increasing IL-17A levels in the mucosa and γδ T cells
    Desiree Anthony
    Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, Victoria, Australia
    Am J Respir Crit Care Med 188:179-86. 2013

Detail Information

Publications54

  1. ncbi request reprint Granulocyte/macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFkappa B and AP-1 in vivo
    Steven Bozinovski
    Arthritis and Inflammation Research Center, Department of Medicine, Cooperative Research Center CRC for Chronic Inflammatory Diseases, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3010, Australia
    J Biol Chem 277:42808-14. 2002
    ..Inhibition of GM-CSF may be of therapeutic benefit in inflammatory diseases in which LPS contributes to lung damage...
  2. ncbi request reprint Current issues with beta2-adrenoceptor agonists: pharmacology and molecular and cellular mechanisms
    Gary P Anderson
    Lung Disease Research Group, Cooperative Research Centre for Chronic Inflammatory Diseases, Departments of Medicine and Pharmacology, The University of Melbourne, Parkville, Australia
    Clin Rev Allergy Immunol 31:119-30. 2006
    ..The clinical implications of these uncouplings, crosstalk, and atypical coupling possibilities are not well-understood...
  3. ncbi request reprint The immunobiology of early asthma
    Gary P Anderson
    Department of Medicine, University of Melbourne, Parkville, Vic
    Med J Aust 177:S47-9. 2002
    ..If so, how might this induction be achieved safely in infants? Can the in-utero environment be subtly manipulated to minimise asthma risk? Does early childhood treatment with current anti-asthma drugs lead to long-term immune changes?..
  4. ncbi request reprint Therapeutic prospects for early asthma
    Gary P Anderson
    Department of Medicine, University of Melbourne, Parkville, Vic
    Med J Aust 177:S66-9. 2002
    ..changes in lung structure that are observed in chronic asthma really dependent on T cell mechanisms? Can abnormal lung structure be improved or normalised? Would any of these strategies be safer and more effective than current therapies?..
  5. ncbi request reprint Acquired somatic mutations in the molecular pathogenesis of COPD
    Gary P Anderson
    Department of Pharmacology, Cooperative Research Center for Chronic Inflammatory Diseases, The University of Melbourne, Parkville, Australia
    Trends Pharmacol Sci 24:71-6. 2003
    ....
  6. ncbi request reprint Innate immune responses to LPS in mouse lung are suppressed and reversed by neutralization of GM-CSF via repression of TLR-4
    Steven Bozinovski
    Lung Disease Research Group, Dept of Pharmacology, Cooperative Research Center for Chronic Inflammatory Diseases, Univ of Melbourne, Parkville 3010, Victoria, Australia
    Am J Physiol Lung Cell Mol Physiol 286:L877-85. 2004
    ..These data expand the understanding of the contribution of GM-CSF to innate immune responses in lung and suggest that blocking GM-CSF might benefit some lung diseases where LPS has been implicated in etiology...
  7. ncbi request reprint Cigarette smoke exposure reprograms the hypothalamic neuropeptide Y axis to promote weight loss
    Hui Chen
    Department of Physiology, CRC for Chronic Inflammatory Diseases, The University of Melbourne Hospital, Victoria, Australia
    Am J Respir Crit Care Med 173:1248-54. 2006
    ..Neuropeptide Y (NPY) is an orexigenic neuropeptide, whose activity in the hypothalamic paraventricular nucleus governs appetite...
  8. doi request reprint Long-term cigarette smoke exposure increases uncoupling protein expression but reduces energy intake
    Hui Chen
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, NSW 2052, Australia
    Brain Res 1228:81-8. 2008
    ..These findings contribute to our understanding of weight loss in smoking-related lung disease, suggesting a greater impact than that due to anorexia alone...
  9. doi request reprint Glutathione peroxidase-1 reduces influenza A virus-induced lung inflammation
    Selcuk Yatmaz
    Department of Pharmacology, The University of Melbourne, Parkville, Vic, Australia
    Am J Respir Cell Mol Biol 48:17-26. 2013
    ..GPx-1(-/-) mice had more MIP-2 protein in BALF at Day 3 and more active MMP-9 protease in BALF at Days 3 and 7 than WT mice. These data indicate that GPx-1 reduces influenza A virus-induced lung inflammation...
  10. pmc Serum amyloid A promotes lung neutrophilia by increasing IL-17A levels in the mucosa and γδ T cells
    Desiree Anthony
    Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, Victoria, Australia
    Am J Respir Crit Care Med 188:179-86. 2013
    ..Serum amyloid A (SAA) promotes neutrophilic inflammation by its interaction with lung mucosal ALX/FPR2 receptors. However, little is known about how this endogenous mediator regulates IL-17A immunity...
  11. pmc Cigarette smoke worsens lung inflammation and impairs resolution of influenza infection in mice
    Rosa C Gualano
    Department of Pharmacology, The University of Melbourne, Parkville 3010, Victoria, Australia
    Respir Res 9:53. 2008
    ..We hypothesized, based on prior gene expression profiling studies, that upregulation of pro-inflammatory mediators by short term smoke exposure would be protective against a subsequent influenza infection...
  12. ncbi request reprint Cigarette smoke inhibits lipopolysaccharide-induced production of inflammatory cytokines by suppressing the activation of activator protein-1 in bronchial epithelial cells
    Martti Laan
    Lung Disease Research Group, Department of University of Melbourne, Parkville, Australia
    J Immunol 173:4164-70. 2004
    ..Hence, this study suggests a novel mechanism by which cigarette smoke may contribute to chronic colonization and chronic obstructive pulmonary disease in smokers...
  13. ncbi request reprint Detrimental metabolic effects of combining long-term cigarette smoke exposure and high-fat diet in mice
    Hui Chen
    Dept of Pharmacology, Univ of New South Wales, NSW 2052, Australia
    Am J Physiol Endocrinol Metab 293:E1564-71. 2007
    ..Our data support a powerful health message that smoking in the presence of an unhealthy Western diet increases metabolic disorders and fat accumulation...
  14. doi request reprint Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant mice
    Saleela M Ruwanpura
    Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash Univ, Clayton, Victoria, Australia
    Am J Physiol Lung Cell Mol Physiol 302:L627-39. 2012
    ..We propose that while discrete targeting of Stat3 may alleviate pulmonary inflammation, global targeting of IL-6 potentially represents a therapeutically advantageous approach to combat COPD phenotypes where emphysema predominates...
  15. pmc Glutathione peroxidase-1 primes pro-inflammatory cytokine production after LPS challenge in vivo
    Steven Bozinovski
    Department of Pharmacology, The University of Melbourne, Victoria, Australia
    PLoS ONE 7:e33172. 2012
    ..Thus, these data suggest that gpx-1 primes pro-inflammatory cytokine production after LPS challenge in vivo...
  16. pmc Serum amyloid A opposes lipoxin A₄ to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease
    Steven Bozinovski
    Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia 3010
    Proc Natl Acad Sci U S A 109:935-40. 2012
    ..Taken together, these findings identify SAA as a therapeutic target for inhibition and implicate SAA as a mediator of GC-resistant lung inflammation that can overwhelm organ protective signaling by lipoxins at ALX/FPR2 receptors...
  17. doi request reprint Glutathione peroxidase-1 protects against cigarette smoke-induced lung inflammation in mice
    Chi Duong
    Department of Pharmacology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Am J Physiol Lung Cell Mol Physiol 299:L425-33. 2010
    ..These data show that gpx-1 protects against cigarette smoke-induced lung inflammation, and agents that mimic the actions of gpx-1 may have therapeutic utility in inflammatory lung diseases where cigarette smoke plays a role...
  18. doi request reprint Epidermal growth factor receptor signaling to Erk1/2 and STATs control the intensity of the epithelial inflammatory responses to rhinovirus infection
    Kenneth Liu
    Departments of Pharmacology and Medicine, University of Melbourne, Melbourne, Victoria 3010, Australia
    J Biol Chem 283:9977-85. 2008
    ..These results suggest that targeting EGFR may provide a selective therapy that dampens neutrophil-driven inflammation without compromising essential antiviral pathways mediated by pathogen recognition receptors such as TLR3...
  19. doi request reprint Autoimmune disease in Lyn-deficient mice is dependent on an inflammatory environment established by IL-6
    Evelyn Tsantikos
    Signal Transduction Laboratory, Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia
    J Immunol 184:1348-60. 2010
    ..These findings improve our understanding of the mode of action of anti-IL-6 and B cell-directed therapies in autoimmune and inflammatory disease treatment...
  20. doi request reprint Perturbation of the CD4 T cell compartment and expansion of regulatory T cells in autoimmune-prone Lyn-deficient mice
    Evelyn Tsantikos
    Signal Transduction Laboratory, Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Royal Melbourne Hospital, Parkville, Victoria, Australia
    J Immunol 183:2484-94. 2009
    ..This study highlights the role of the inflammatory setting in autoimmune disease and its consideration when contemplating the use of Tregs as an autoimmune therapy...
  21. pmc Glucocorticosteroids differentially regulate MMP-9 and neutrophil elastase in COPD
    Ross Vlahos
    Department of Pharmacology, The University of Melbourne, Victoria, Australia
    PLoS ONE 7:e33277. 2012
    ..Gelatinase and azurophilic granules within neutrophils are a major source of matrix metalloproteinase (MMP)-9 and neutrophil elastase (NE), respectively, which are elevated in COPD...
  22. doi request reprint Control of macrophage lineage populations by CSF-1 receptor and GM-CSF in homeostasis and inflammation
    Jason C Lenzo
    Arthritis and Inflammation Research Centre, Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
    Immunol Cell Biol 90:429-40. 2012
    ..A correlation has been observed between macrophage numbers and the severity of certain inflammatory conditions, and it could be that CSF-1 and GM-CSF contribute to the control of these numbers in the ways proposed...
  23. ncbi request reprint Regulation of hypothalamic NPY by diet and smoking
    Hui Chen
    Department of Pharmacology, The University of Melbourne, Victoria 3010, Australia
    Peptides 28:384-9. 2007
    ..Thus, consumption of a high fat diet and smoke exposure reprogram hypothalamic NPY. Reduced NPY may contribute to the anorexic effect of smoke exposure...
  24. pmc Akt in the pathogenesis of COPD
    Steven Bozinovski
    The Lung Disease Research Laboratories, Cooperative Research Centre for Chronic Inflammatory Diseases, Department of Pharmacology, The University of Melbourne, Vic, Australia
    Int J Chron Obstruct Pulmon Dis 1:31-8. 2006
    ..Interestingly, current knowledge suggests that both inhibitors and activators of Akt may be useful for treating different clinical subpopulations of COPD patients...
  25. ncbi request reprint S100A8 chemotactic protein is abundantly increased, but only a minor contributor to LPS-induced, steroid resistant neutrophilic lung inflammation in vivo
    Steven Bozinovski
    Lung Disease Research Group, Departments of Pharmacology and Medicine, The University of Melbourne, Parkville 3010 VIC Australia
    J Proteome Res 4:136-45. 2005
    ....
  26. doi request reprint Community care assessment of exacerbations of chronic obstructive pulmonary disease
    Anastasia F Hutchinson
    Clinical Epidemiology and Health Service Evaluation Unit, Melbourne Health and Department of Medicine Northern, The University of Melbourne, Australia
    J Adv Nurs 66:2490-9. 2010
    ..The aim of this study was to develop a clinical algorithm to assess chronic obstructive pulmonary disease exacerbation severity in a community setting...
  27. doi request reprint Carbonylation caused by cigarette smoke extract is associated with defective macrophage immunity
    Steven Bozinovski
    Department of Pharmacology, University of Melbourne, Victoria, Australia
    Am J Respir Cell Mol Biol 45:229-36. 2011
    ..Oxidants in cigarette smoke drive a rapid, persistent, and global protein carbonylation that may represent a common pathway to altered immunity in disease...
  28. doi request reprint Neutralizing granulocyte/macrophage colony-stimulating factor inhibits cigarette smoke-induced lung inflammation
    Ross Vlahos
    Department of Pharmacology, The University of Melbourne, VIC 3010, Australia
    Am J Respir Crit Care Med 182:34-40. 2010
    ..We have previously shown that granulocyte/macrophage colony-stimulating factor (GM-CSF) regulates lung innate immunity to LPS through Akt/Erk activation of nuclear factor-kappaB and activator protein (AP)-1...
  29. ncbi request reprint Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity
    Sarah Jane E Beavitt
    Lung Disease Research Group, Department of Medicine, University of Melbourne, Victoria, Australia
    J Immunol 175:1867-75. 2005
    ..Our results show that Lyn regulates the intensity and duration of multiple asthmatic traits and indicate that Lyn is an important negative regulator of Th2 immune responses...
  30. doi request reprint IL-6/Stat3-driven pulmonary inflammation, but not emphysema, is dependent on interleukin-17A in mice
    Saleela M Ruwanpura
    Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
    Respirology 19:419-27. 2014
    ..We therefore evaluated a causal role for IL-17A in the IL-6-driven gp130(F) (/) (F) mouse model for spontaneous pulmonary inflammation and emphysema...
  31. pmc The lung inflammation and skeletal muscle wasting induced by subchronic cigarette smoke exposure are not altered by a high-fat diet in mice
    Michelle J Hansen
    Lung Health Research Centre, Department of Pharmacology and Therapeutics, The University of Melbourne, Victoria, Australia
    PLoS ONE 8:e80471. 2013
    ..05). In conclusion, these findings suggest that a down-regulation in local IGF-1 may be responsible for the loss of skeletal muscle mass following cigarette smoke exposure in mice. ..
  32. doi request reprint Distinct macrophage subpopulations characterize acute infection and chronic inflammatory lung disease
    Mubing Duan
    Ludwig Institute for Cancer Research, Melbourne, Victoria, Australia
    J Immunol 189:946-55. 2012
    ..These findings may help better understand the roles of MΦ subpopulations in lung homeostasis and disease...
  33. ncbi request reprint Effect of short-term cigarette smoke exposure on body weight, appetite and brain neuropeptide Y in mice
    Hui Chen
    Department of Pharmacology, The University of Melbourne, Victoria, Australia
    Neuropsychopharmacology 30:713-9. 2005
    ..The reduction in plasma leptin concentration may have been too modest to increase NPY production; alternatively, change in NPY or its function might have been offset by nicotine or other elements in cigarette smoke...
  34. doi request reprint Interleukin-6 promotes pulmonary emphysema associated with apoptosis in mice
    Saleela M Ruwanpura
    Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, 27 31 Wright Street, Clayton 3168, Victoria, Australia
    Am J Respir Cell Mol Biol 45:720-30. 2011
    ..We propose that the discrete targeting of IL-6 signaling may provide an effective therapeutic strategy against human lung disease...
  35. doi request reprint DNA vector augments inflammation in epithelial cells via EGFR-dependent regulation of TLR4 and TLR2
    Kenneth Liu
    Department of Pharmacology, The University of Melbourne, Melbourne, Victoria, Australia
    Am J Respir Cell Mol Biol 39:305-11. 2008
    ..Targeting the EGFR system may improve the efficiency, tolerability, and safety of gene therapy strategies...
  36. doi request reprint Treating neutrophilic inflammation in COPD by targeting ALX/FPR2 resolution pathways
    Steven Bozinovski
    Department of Pharmacology and Therapeutics, The University of Melbourne, Victoria, Australia Electronic address
    Pharmacol Ther 140:280-9. 2013
    ..These insights open the possibility of targeting ALX/FPR2 receptors using synthetic agonists to resolve persistent neutrophilic inflammation without compromising essential host defense mechanisms. ..
  37. doi request reprint Oseltamivir treatment of mice before or after mild influenza infection reduced cellular and cytokine inflammation in the lung
    Zi Xin Wong
    Department of Pharmacology, University of Melbourne, Parkville, Melbourne, Vic, Australia Department of Medicine, University of Melbourne, Parkville, Melbourne, Vic, Australia
    Influenza Other Respir Viruses 5:343-50. 2011
    ..Lung inflammation is a critical determinant of influenza infection outcomes but is seldom evaluated in animal studies of oseltamivir (OS), which have focused on viral titre and survival...
  38. ncbi request reprint What is the contribution of respiratory viruses and lung proteases to airway remodelling in asthma and chronic obstructive pulmonary disease?
    Rosa C Gualano
    Department of Pharmacology, Co Operative Research Centre CRC for Chronic Inflammatory Diseases, The University of Melbourne, Parkville 3010, Victoria, Australia
    Pulm Pharmacol Ther 19:18-23. 2006
    ....
  39. doi request reprint Identifying viral infections in vaccinated Chronic Obstructive Pulmonary Disease (COPD) patients using clinical features and inflammatory markers
    Anastasia F Hutchinson
    Department of Medicine, Melbourne University, Parkville, Melbourne, Victoria, 3056, Australia
    Influenza Other Respir Viruses 4:33-9. 2010
    ..To overcome this, we developed a multi-factorial prediction model combining viral symptoms with inflammatory markers...
  40. ncbi request reprint Therapeutic prospects to treat skeletal muscle wasting in COPD (chronic obstructive lung disease)
    Michelle J Hansen
    Lung Disease Research Laboratory, Department of Pharmacology, Cooperative Research Centre for Chronic Inflammatory Diseases, The University of Melbourne, Victoria 3010, Australia
    Pharmacol Ther 109:162-72. 2006
    ....
  41. pmc Non-essential role for TLR2 and its signaling adaptor Mal/TIRAP in preserving normal lung architecture in mice
    Saleela M Ruwanpura
    Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
    PLoS ONE 8:e78095. 2013
    ..In addition, we reveal that Mal differentially facilitates the anti-apoptotic, but not oxidant suppressive, activities of TLR4 in the lung, both of which appear to be essential for TLR4 to prevent the onset of emphysema. ..
  42. pmc Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis
    Robert J J O'Donoghue
    Ludwig Institute for Cancer Research, Melbourne Parkville Branch, Parkville, Victoria, Australia
    EMBO Mol Med 4:939-51. 2012
    ..These findings are of therapeutic relevance, since we confirmed abundant STAT3 activation in fibrotic lungs from IPF patients and showed that genetic reduction of Stat3 protected mice from bleomycin-induced lung fibrosis...
  43. doi request reprint Neutrophils ameliorate lung injury and the development of severe disease during influenza infection
    Michelle D Tate
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    J Immunol 183:7441-50. 2009
    ..Thus, while it is well established that neutrophils contribute to lung injury in a range of pathological conditions, reduced numbers or impaired neutrophil function can facilitate progression of mild influenza to severe clinical disease...
  44. doi request reprint Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease
    Gary P Anderson
    Lung Disease Research Group, Departments of Medicine and Pharmacology, University of Melbourne, Parkville, Vic, Australia
    Lancet 372:1107-19. 2008
    ....
  45. ncbi request reprint Serum amyloid a is a biomarker of acute exacerbations of chronic obstructive pulmonary disease
    Steven Bozinovski
    Department of Pharmacology, Medical Building Level 8, University of Melbourne, Parkville, 3010 Australia
    Am J Respir Crit Care Med 177:269-78. 2008
    ..Serum amyloid A (SAA) is a novel candidate exacerbation biomarker identified by proteomic screening...
  46. ncbi request reprint GM-CSF Biology
    John A Hamilton
    Department of Medicine, Arthritis and Inflammation Research Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville 3010 Vic, Australia
    Growth Factors 22:225-31. 2004
    ..g. as an adjuvant, and also includes those observed in depletion studies, e.g. during inflammatory reactions where GM-CSF can be shown to have a proinflammatory action...
  47. doi request reprint Prospects for an asthma vaccine
    Gary P Anderson
    Department of Medicine, The University of Melbourne, Parkville, Victoria
    Respirology 15:902-8. 2010
    ....
  48. doi request reprint Sarcoidal reactions in regional lymph nodes of patients with early stage non-small cell lung cancer predict improved disease-free survival: a pilot case-control study
    Daniel P Steinfort
    Department of Respiratory Medicine, Royal Melbourne Hospital Victoria 3050, Australia
    Hum Pathol 43:333-8. 2012
    ..The exact mechanism by which antitumor immunity is achieved remains to be elucidated...
  49. ncbi request reprint A community-based, time-matched, case-control study of respiratory viruses and exacerbations of COPD
    Anastasia F Hutchinson
    Department of Respiratory Medicine, Melbourne Health, Victoria 3050, Australia
    Respir Med 101:2472-81. 2007
    ..These data support the causative role of viruses in triggering COPD exacerbations in the community...
  50. ncbi request reprint Involvement of CCR3-reactive chemokines in eosinophil survival
    Kazuhiko Shinagawa
    Pharmacology Laboratory, Kissei Pharmaceutical Co Ltd, Minamiazumi, Nagano, Japan
    Int Arch Allergy Immunol 130:150-7. 2003
    ..The aim of the present study was to investigate what kind of factor(s) is associated with this spontaneous survival of eosinophils...
  51. ncbi request reprint Severe asthma in adults: what are the important questions?
    Pascal Chanez
    INSERM U454 and Clinique des Maladies Respiratoires, Montpellier, France
    J Allergy Clin Immunol 119:1337-48. 2007
    ..Inhaled corticosteroids and bronchodilators are the mainstay of treatment, but patients with SRA remain uncontrolled, indicating a need for new therapies...
  52. pmc Constitutive activation of the SRC family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune response
    Matthias Ernst
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria 3050, Australia
    J Exp Med 196:589-604. 2002
    ..Thus, our observations collectively suggest an enhanced innate immune response in Hck(F/F) mice thereby skewing innate immunity from a reversible physiological host defense response to one causing irreversible tissue damage...
  53. ncbi request reprint Functional relevance of the IL-23-IL-17 axis in lungs in vivo
    Stefan Ivanov
    Lung Pharmacology and Immunology Groups, Department of Internal Medicine Respiratory Medicine and Allergology, Institute of Medicine, Sahlgrenska Academy at Goteborg University, Guldhedsgatan 10A, S 413 46 Gothenburg, Sweden
    Am J Respir Cell Mol Biol 36:442-51. 2007
    ..These findings support that IL-23 and IL-17 form a functionally relevant "immunological axis" in the lungs in vivo...
  54. ncbi request reprint The role of gp130/IL-6 cytokines in the development of pulmonary fibrosis: critical determinants of disease susceptibility and progression?
    Darryl A Knight
    Asthma and Allergy Research Institute, Sir Charles Gairdner Hospital, Ground Floor, E Block, Verdun Street, Nedlands, Western Australia, 6009, Australia
    Pharmacol Ther 99:327-38. 2003
    ..This may provide guides for the development of novel pharmacological treatment for fibroproliferative diseases...