Research Topics
Genomes and Genes | Gary P AndersonSummaryAffiliation: University of Melbourne Country: Australia Publications
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Publications
Granulocyte/macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFkappa B and AP-1 in vivoSteven Bozinovski
Arthritis and Inflammation Research Center, Department of Medicine, Cooperative Research Center CRC for Chronic Inflammatory Diseases, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3010, Australia
J Biol Chem 277:42808-14. 2002..Inhibition of GM-CSF may be of therapeutic benefit in inflammatory diseases in which LPS contributes to lung damage...- Current issues with beta2-adrenoceptor agonists: pharmacology and molecular and cellular mechanismsGary P Anderson
Lung Disease Research Group, Cooperative Research Centre for Chronic Inflammatory Diseases, Departments of Medicine and Pharmacology, The University of Melbourne, Parkville, Australia
Clin Rev Allergy Immunol 31:119-30. 2006..The clinical implications of these uncouplings, crosstalk, and atypical coupling possibilities are not well-understood... - The immunobiology of early asthmaGary P Anderson
Department of Medicine, University of Melbourne, Parkville, Vic
Med J Aust 177:S47-9. 2002..If so, how might this induction be achieved safely in infants? Can the in-utero environment be subtly manipulated to minimise asthma risk? Does early childhood treatment with current anti-asthma drugs lead to long-term immune changes?.. - Therapeutic prospects for early asthmaGary P Anderson
Department of Medicine, University of Melbourne, Parkville, Vic
Med J Aust 177:S66-9. 2002..changes in lung structure that are observed in chronic asthma really dependent on T cell mechanisms? Can abnormal lung structure be improved or normalised? Would any of these strategies be safer and more effective than current therapies?.. - Acquired somatic mutations in the molecular pathogenesis of COPDGary P Anderson
Department of Pharmacology, Cooperative Research Center for Chronic Inflammatory Diseases, The University of Melbourne, Parkville, Australia
Trends Pharmacol Sci 24:71-6. 2003.... - Innate immune responses to LPS in mouse lung are suppressed and reversed by neutralization of GM-CSF via repression of TLR-4Steven Bozinovski
Lung Disease Research Group, Dept of Pharmacology, Cooperative Research Center for Chronic Inflammatory Diseases, Univ of Melbourne, Parkville 3010, Victoria, Australia
Am J Physiol Lung Cell Mol Physiol 286:L877-85. 2004..These data expand the understanding of the contribution of GM-CSF to innate immune responses in lung and suggest that blocking GM-CSF might benefit some lung diseases where LPS has been implicated in etiology... - Cigarette smoke exposure reprograms the hypothalamic neuropeptide Y axis to promote weight lossHui Chen
Department of Physiology, CRC for Chronic Inflammatory Diseases, The University of Melbourne Hospital, Victoria, Australia
Am J Respir Crit Care Med 173:1248-54. 2006..These findings may contribute to understanding weight loss in smoking-related lung disease and in the design of more effective smoking cessation strategies... 
Long-term cigarette smoke exposure increases uncoupling protein expression but reduces energy intakeHui Chen
Department of Pharmacology, School of Medical Sciences, University of New South Wales, NSW 2052, Australia
Brain Res 1228:81-8. 2008..These findings contribute to our understanding of weight loss in smoking-related lung disease, suggesting a greater impact than that due to anorexia alone...- Glutathione peroxidase-1 reduces influenza a virus-induced lung inflammationSelcuk Yatmaz
Department of Pharmacology, The University of Melbourne, Parkville, Vic, Australia
Am J Respir Cell Mol Biol 48:17-26. 2013..GPx-1(-/-) mice had more MIP-2 protein in BALF at Day 3 and more active MMP-9 protease in BALF at Days 3 and 7 than WT mice. These data indicate that GPx-1 reduces influenza A virus-induced lung inflammation... 
Cigarette smoke worsens lung inflammation and impairs resolution of influenza infection in miceRosa C Gualano
Department of Pharmacology, The University of Melbourne, Parkville 3010, Victoria, Australia
Respir Res 9:53. 2008..We hypothesized, based on prior gene expression profiling studies, that upregulation of pro-inflammatory mediators by short term smoke exposure would be protective against a subsequent influenza infection...- Detrimental metabolic effects of combining long-term cigarette smoke exposure and high-fat diet in miceHui Chen
Dept of Pharmacology, Univ of New South Wales, NSW 2052, Australia
Am J Physiol Endocrinol Metab 293:E1564-71. 2007..Our data support a powerful health message that smoking in the presence of an unhealthy Western diet increases metabolic disorders and fat accumulation... - Cigarette smoke inhibits lipopolysaccharide-induced production of inflammatory cytokines by suppressing the activation of activator protein-1 in bronchial epithelial cellsMartti Laan
Lung Disease Research Group, Department of University of Melbourne, Parkville, Australia
J Immunol 173:4164-70. 2004..Hence, this study suggests a novel mechanism by which cigarette smoke may contribute to chronic colonization and chronic obstructive pulmonary disease in smokers... - Glutathione peroxidase-1 primes pro-inflammatory cytokine production after LPS challenge in vivoSteven Bozinovski
Department of Pharmacology, The University of Melbourne, Victoria, Australia
PLoS ONE 7:e33172. 2012..Thus, these data suggest that gpx-1 primes pro-inflammatory cytokine production after LPS challenge in vivo... - Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant miceSaleela M Ruwanpura
Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash Univ, Clayton, Victoria, Australia
Am J Physiol Lung Cell Mol Physiol 302:L627-39. 2012..We propose that while discrete targeting of Stat3 may alleviate pulmonary inflammation, global targeting of IL-6 potentially represents a therapeutically advantageous approach to combat COPD phenotypes where emphysema predominates... - Serum amyloid A opposes lipoxin A₄ to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary diseaseSteven Bozinovski
Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia 3010
Proc Natl Acad Sci U S A 109:935-40. 2012..Taken together, these findings identify SAA as a therapeutic target for inhibition and implicate SAA as a mediator of GC-resistant lung inflammation that can overwhelm organ protective signaling by lipoxins at ALX/FPR2 receptors... - Glutathione peroxidase-1 protects against cigarette smoke-induced lung inflammation in miceChi Duong
Department of Pharmacology, The University of Melbourne, Parkville, Victoria 3010, Australia
Am J Physiol Lung Cell Mol Physiol 299:L425-33. 2010..These data show that gpx-1 protects against cigarette smoke-induced lung inflammation, and agents that mimic the actions of gpx-1 may have therapeutic utility in inflammatory lung diseases where cigarette smoke plays a role... - Autoimmune disease in Lyn-deficient mice is dependent on an inflammatory environment established by IL-6Evelyn Tsantikos
Signal Transduction Laboratory, Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia
J Immunol 184:1348-60. 2010..These findings improve our understanding of the mode of action of anti-IL-6 and B cell-directed therapies in autoimmune and inflammatory disease treatment... - Perturbation of the CD4 T cell compartment and expansion of regulatory T cells in autoimmune-prone Lyn-deficient miceEvelyn Tsantikos
Signal Transduction Laboratory, Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Royal Melbourne Hospital, Parkville, Victoria, Australia
J Immunol 183:2484-94. 2009..This study highlights the role of the inflammatory setting in autoimmune disease and its consideration when contemplating the use of Tregs as an autoimmune therapy... - Epidermal growth factor receptor signaling to Erk1/2 and STATs control the intensity of the epithelial inflammatory responses to rhinovirus infectionKenneth Liu
Departments of Pharmacology and Medicine, University of Melbourne, Melbourne, Victoria 3010, Australia
J Biol Chem 283:9977-85. 2008..These results suggest that targeting EGFR may provide a selective therapy that dampens neutrophil-driven inflammation without compromising essential antiviral pathways mediated by pathogen recognition receptors such as TLR3... - Glucocorticosteroids differentially regulate MMP-9 and neutrophil elastase in COPDRoss Vlahos
Department of Pharmacology, The University of Melbourne, Victoria, Australia
PLoS ONE 7:e33277. 2012..Gelatinase and azurophilic granules within neutrophils are a major source of matrix metalloproteinase (MMP)-9 and neutrophil elastase (NE), respectively, which are elevated in COPD... - Control of macrophage lineage populations by CSF-1 receptor and GM-CSF in homeostasis and inflammationJason C Lenzo
Arthritis and Inflammation Research Centre, Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
Immunol Cell Biol 90:429-40. 2012..A correlation has been observed between macrophage numbers and the severity of certain inflammatory conditions, and it could be that CSF-1 and GM-CSF contribute to the control of these numbers in the ways proposed... - Regulation of hypothalamic NPY by diet and smokingHui Chen
Department of Pharmacology, The University of Melbourne, Victoria 3010, Australia
Peptides 28:384-9. 2007..Thus, consumption of a high fat diet and smoke exposure reprogram hypothalamic NPY. Reduced NPY may contribute to the anorexic effect of smoke exposure... - Community care assessment of exacerbations of chronic obstructive pulmonary diseaseAnastasia F Hutchinson
Clinical Epidemiology and Health Service Evaluation Unit, Melbourne Health and Department of Medicine Northern, The University of Melbourne, Australia
J Adv Nurs 66:2490-9. 2010..The aim of this study was to develop a clinical algorithm to assess chronic obstructive pulmonary disease exacerbation severity in a community setting... - S100A8 chemotactic protein is abundantly increased, but only a minor contributor to LPS-induced, steroid resistant neutrophilic lung inflammation in vivoSteven Bozinovski
Lung Disease Research Group, Departments of Pharmacology and Medicine, The University of Melbourne, Parkville 3010 VIC Australia
J Proteome Res 4:136-45. 2005.... - Akt in the pathogenesis of COPDSteven Bozinovski
The Lung Disease Research Laboratories, Cooperative Research Centre for Chronic Inflammatory Diseases, Department of Pharmacology, The University of Melbourne, Vic, Australia
Int J Chron Obstruct Pulmon Dis 1:31-8. 2006..Interestingly, current knowledge suggests that both inhibitors and activators of Akt may be useful for treating different clinical subpopulations of COPD patients... - Neutralizing granulocyte/macrophage colony-stimulating factor inhibits cigarette smoke-induced lung inflammationRoss Vlahos
Department of Pharmacology, The University of Melbourne, VIC 3010, Australia
Am J Respir Crit Care Med 182:34-40. 2010..We have previously shown that granulocyte/macrophage colony-stimulating factor (GM-CSF) regulates lung innate immunity to LPS through Akt/Erk activation of nuclear factor-kappaB and activator protein (AP)-1... - Carbonylation caused by cigarette smoke extract is associated with defective macrophage immunitySteven Bozinovski
Department of Pharmacology, University of Melbourne, Victoria, Australia
Am J Respir Cell Mol Biol 45:229-36. 2011..Oxidants in cigarette smoke drive a rapid, persistent, and global protein carbonylation that may represent a common pathway to altered immunity in disease... - Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunitySarah Jane E Beavitt
Lung Disease Research Group, Department of Medicine, University of Melbourne, Victoria, Australia
J Immunol 175:1867-75. 2005..Our results show that Lyn regulates the intensity and duration of multiple asthmatic traits and indicate that Lyn is an important negative regulator of Th2 immune responses... - Distinct macrophage subpopulations characterize acute infection and chronic inflammatory lung diseaseMubing Duan
Ludwig Institute for Cancer Research, Melbourne, Victoria, Australia
J Immunol 189:946-55. 2012..These findings may help better understand the roles of MΦ subpopulations in lung homeostasis and disease... - Effect of short-term cigarette smoke exposure on body weight, appetite and brain neuropeptide Y in miceHui Chen
Department of Pharmacology, The University of Melbourne, Victoria, Australia
Neuropsychopharmacology 30:713-9. 2005..The reduction in plasma leptin concentration may have been too modest to increase NPY production; alternatively, change in NPY or its function might have been offset by nicotine or other elements in cigarette smoke... - Interleukin-6 promotes pulmonary emphysema associated with apoptosis in miceSaleela M Ruwanpura
Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, 27 31 Wright Street, Clayton 3168, Victoria, Australia
Am J Respir Cell Mol Biol 45:720-30. 2011..We propose that the discrete targeting of IL-6 signaling may provide an effective therapeutic strategy against human lung disease... - DNA vector augments inflammation in epithelial cells via EGFR-dependent regulation of TLR4 and TLR2Kenneth Liu
Department of Pharmacology, The University of Melbourne, Melbourne, Victoria, Australia
Am J Respir Cell Mol Biol 39:305-11. 2008..Targeting the EGFR system may improve the efficiency, tolerability, and safety of gene therapy strategies... - Oseltamivir treatment of mice before or after mild influenza infection reduced cellular and cytokine inflammation in the lungZi Xin Wong
Department of Pharmacology, University of Melbourne, Parkville, Melbourne, Vic, Australia Department of Medicine, University of Melbourne, Parkville, Melbourne, Vic, Australia
Influenza Other Respi Viruses 5:343-50. 2011..Lung inflammation is a critical determinant of influenza infection outcomes but is seldom evaluated in animal studies of oseltamivir (OS), which have focused on viral titre and survival... - Identifying viral infections in vaccinated Chronic Obstructive Pulmonary Disease (COPD) patients using clinical features and inflammatory markersAnastasia F Hutchinson
Department of Medicine, Melbourne University, Parkville, Melbourne, Victoria, 3056, Australia
Influenza Other Respi Viruses 4:33-9. 2010..To overcome this, we developed a multi-factorial prediction model combining viral symptoms with inflammatory markers... - What is the contribution of respiratory viruses and lung proteases to airway remodelling in asthma and chronic obstructive pulmonary disease?Rosa C Gualano
Department of Pharmacology, Co Operative Research Centre CRC for Chronic Inflammatory Diseases, The University of Melbourne, Parkville 3010, Victoria, Australia
Pulm Pharmacol Ther 19:18-23. 2006.... - Therapeutic prospects to treat skeletal muscle wasting in COPD (chronic obstructive lung disease)Michelle J Hansen
Lung Disease Research Laboratory, Department of Pharmacology, Cooperative Research Centre for Chronic Inflammatory Diseases, The University of Melbourne, Victoria 3010, Australia
Pharmacol Ther 109:162-72. 2006.... - Neutrophils ameliorate lung injury and the development of severe disease during influenza infectionMichelle D Tate
Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
J Immunol 183:7441-50. 2009..Thus, while it is well established that neutrophils contribute to lung injury in a range of pathological conditions, reduced numbers or impaired neutrophil function can facilitate progression of mild influenza to severe clinical disease... - Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous diseaseGary P Anderson
Lung Disease Research Group, Departments of Medicine and Pharmacology, University of Melbourne, Parkville, Vic, Australia
Lancet 372:1107-19. 2008.... - GM-CSF BiologyJohn A Hamilton
Department of Medicine, Arthritis and Inflammation Research Centre, The Royal Melbourne Hospital, University of Melbourne, Parkville 3010 Vic, Australia
Growth Factors 22:225-31. 2004..g. as an adjuvant, and also includes those observed in depletion studies, e.g. during inflammatory reactions where GM-CSF can be shown to have a proinflammatory action... - Prospects for an asthma vaccineGary P Anderson
Department of Medicine, The University of Melbourne, Parkville, Victoria
Respirology 15:902-8. 2010.... - Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosisRobert J J O'Donoghue
Ludwig Institute for Cancer Research, Melbourne Parkville Branch, Parkville, Victoria, Australia
EMBO Mol Med 4:939-51. 2012..These findings are of therapeutic relevance, since we confirmed abundant STAT3 activation in fibrotic lungs from IPF patients and showed that genetic reduction of Stat3 protected mice from bleomycin-induced lung fibrosis... - Sarcoidal reactions in regional lymph nodes of patients with early stage non-small cell lung cancer predict improved disease-free survival: a pilot case-control studyDaniel P Steinfort
Department of Respiratory Medicine, Royal Melbourne Hospital Victoria 3050, Australia
Hum Pathol 43:333-8. 2012..The exact mechanism by which antitumor immunity is achieved remains to be elucidated... - Serum amyloid a is a biomarker of acute exacerbations of chronic obstructive pulmonary diseaseSteven Bozinovski
Department of Pharmacology, Medical Building Level 8, University of Melbourne, Parkville, 3010 Australia
Am J Respir Crit Care Med 177:269-78. 2008..Serum amyloid A (SAA) is a novel candidate exacerbation biomarker identified by proteomic screening... - Severe asthma in adults: what are the important questions?Pascal Chanez
INSERM U454 and Clinique des Maladies Respiratoires, Montpellier, France
J Allergy Clin Immunol 119:1337-48. 2007..Inhaled corticosteroids and bronchodilators are the mainstay of treatment, but patients with SRA remain uncontrolled, indicating a need for new therapies... - Constitutive activation of the SRC family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune responseMatthias Ernst
Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria 3050, Australia
J Exp Med 196:589-604. 2002..Thus, our observations collectively suggest an enhanced innate immune response in Hck(F/F) mice thereby skewing innate immunity from a reversible physiological host defense response to one causing irreversible tissue damage... - Involvement of CCR3-reactive chemokines in eosinophil survivalKazuhiko Shinagawa
Pharmacology Laboratory, Kissei Pharmaceutical Co Ltd, Minamiazumi, Nagano, Japan
Int Arch Allergy Immunol 130:150-7. 2003..The aim of the present study was to investigate what kind of factor(s) is associated with this spontaneous survival of eosinophils... - Functional relevance of the IL-23-IL-17 axis in lungs in vivoStefan Ivanov
Lung Pharmacology and Immunology Groups, Department of Internal Medicine Respiratory Medicine and Allergology, Institute of Medicine, Sahlgrenska Academy at Goteborg University, Guldhedsgatan 10A, S 413 46 Gothenburg, Sweden
Am J Respir Cell Mol Biol 36:442-51. 2007..These findings support that IL-23 and IL-17 form a functionally relevant "immunological axis" in the lungs in vivo... - A community-based, time-matched, case-control study of respiratory viruses and exacerbations of COPDAnastasia F Hutchinson
Department of Respiratory Medicine, Melbourne Health, Victoria 3050, Australia
Respir Med 101:2472-81. 2007..These data support the causative role of viruses in triggering COPD exacerbations in the community... - The role of gp130/IL-6 cytokines in the development of pulmonary fibrosis: critical determinants of disease susceptibility and progression?Darryl A Knight
Asthma and Allergy Research Institute, Sir Charles Gairdner Hospital, Ground Floor, E Block, Verdun Street, Nedlands, Western Australia, 6009, Australia
Pharmacol Ther 99:327-38. 2003..This may provide guides for the development of novel pharmacological treatment for fibroproliferative diseases...