Osvaldo P Almeida

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. doi request reprint Homocysteine and depression in later life
    Osvaldo P Almeida
    FRANZCP, Western Australian Centre for Health and Ageing, University of Western Australia, Mail Box M573, 35 Stirling Hwy, Crawley, WA 6009, Australia
    Arch Gen Psychiatry 65:1286-94. 2008
  2. pmc The B-VITAGE trial: a randomized trial of homocysteine lowering treatment of depression in later life
    Andrew H Ford
    Western Australian Centre for Health and Ageing, Centre for Medical Research, University of Western Australia, Perth, Australia
    Trials 11:8. 2010
  3. ncbi request reprint Cognitive bias modification to prevent depression (COPE): study protocol for a randomised controlled trial
    Osvaldo P Almeida
    Western Australian Centre for Health and Ageing M573, Centre for Medical Research of the Perkins Institute for Medical Research, University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    Trials 15:282. 2014
  4. pmc Body adiposity in later life and the incidence of dementia: the health in men study
    Brian D Power
    Department of Psychiatry, Royal Perth Hospital, Perth, Western Australia, Australia
    PLoS ONE 6:e17902. 2011
  5. pmc Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism and cognitive impairment: the health in men study
    A H Ford
    WA Centre for Health and Ageing, Centre for Medical Research and School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, WA, Australia
    Mol Psychiatry 17:559-66. 2012
  6. ncbi request reprint Dementia: What is it All About?
    O P Almeida
    University of Western Australia and Royal Perth Hospital Crawley, Perth, Australia
    Neuroradiol J 19:433-40. 2006
  7. ncbi request reprint A risk table to assist health practitioners assess and prevent the onset of depression in later life
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia WA Centre for Health and Ageing, Centre for Medical Research, University of Western Australia, Perth, Australia Department of Psychiatry, Royal Perth Hospital, Perth, Australia Electronic address
    Prev Med 57:878-82. 2013
  8. doi request reprint Brain and mood changes over 2 years in healthy controls and adults with heart failure and ischaemic heart disease
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia
    Eur J Heart Fail 15:850-8. 2013
  9. pmc Impact of behavioural risk factors on death within 10 years for women and men in their 70s: absolute risk charts
    Annette Dobson
    The University of Queensland, School of Population Health, Herston, Australia
    BMC Public Health 12:669. 2012
  10. doi request reprint Two-year course of cognitive function and mood in adults with congestive heart failure and coronary artery disease: the Heart-Mind Study
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia
    Int Psychogeriatr 24:38-47. 2012

Detail Information

Publications126 found, 100 shown here

  1. doi request reprint Homocysteine and depression in later life
    Osvaldo P Almeida
    FRANZCP, Western Australian Centre for Health and Ageing, University of Western Australia, Mail Box M573, 35 Stirling Hwy, Crawley, WA 6009, Australia
    Arch Gen Psychiatry 65:1286-94. 2008
    ..Genetic association studies are not prone to the same sources of error and offer an opportunity to explore the consistency and external validity of this association...
  2. pmc The B-VITAGE trial: a randomized trial of homocysteine lowering treatment of depression in later life
    Andrew H Ford
    Western Australian Centre for Health and Ageing, Centre for Medical Research, University of Western Australia, Perth, Australia
    Trials 11:8. 2010
    ..We designed the B-VITAGE trial to determine whether adjunctive treatment with vitamins B6, B12 and folate increases the efficacy of standard antidepressant treatment...
  3. ncbi request reprint Cognitive bias modification to prevent depression (COPE): study protocol for a randomised controlled trial
    Osvaldo P Almeida
    Western Australian Centre for Health and Ageing M573, Centre for Medical Research of the Perkins Institute for Medical Research, University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    Trials 15:282. 2014
    ..The primary aim of this trial is to determine if CBM decreases the one-year onset of a major depressive episode among adults with subsyndromal depression...
  4. pmc Body adiposity in later life and the incidence of dementia: the health in men study
    Brian D Power
    Department of Psychiatry, Royal Perth Hospital, Perth, Western Australia, Australia
    PLoS ONE 6:e17902. 2011
    ..To determine if adiposity in later life increases dementia hazard...
  5. pmc Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism and cognitive impairment: the health in men study
    A H Ford
    WA Centre for Health and Ageing, Centre for Medical Research and School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, WA, Australia
    Mol Psychiatry 17:559-66. 2012
    ..46, 95% CI 1.01-2.11, P=0.043). The results of this study are consistent with, but do not prove the hypothesis that high tHcy causes cognitive impairment in later life...
  6. ncbi request reprint Dementia: What is it All About?
    O P Almeida
    University of Western Australia and Royal Perth Hospital Crawley, Perth, Australia
    Neuroradiol J 19:433-40. 2006
    ..Other less frequent causes of dementia include dementia with Lewy bodies and frontotemporal dementia. This paper reviews the clinical, pathophysiological and neuroimaging aspects of these four prevalent causes of dementia. ..
  7. ncbi request reprint A risk table to assist health practitioners assess and prevent the onset of depression in later life
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia WA Centre for Health and Ageing, Centre for Medical Research, University of Western Australia, Perth, Australia Department of Psychiatry, Royal Perth Hospital, Perth, Australia Electronic address
    Prev Med 57:878-82. 2013
    ....
  8. doi request reprint Brain and mood changes over 2 years in healthy controls and adults with heart failure and ischaemic heart disease
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia
    Eur J Heart Fail 15:850-8. 2013
    ....
  9. pmc Impact of behavioural risk factors on death within 10 years for women and men in their 70s: absolute risk charts
    Annette Dobson
    The University of Queensland, School of Population Health, Herston, Australia
    BMC Public Health 12:669. 2012
    ..The aim of this paper is to calculate population based estimates and display them using simple charts that may be useful communication tools for public health authorities, health care providers and policy makers...
  10. doi request reprint Two-year course of cognitive function and mood in adults with congestive heart failure and coronary artery disease: the Heart-Mind Study
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia
    Int Psychogeriatr 24:38-47. 2012
    ..We designed this study to determine if adults with CHF show evidence of cognitive decline compared with adults with and without coronary artery disease (CAD)...
  11. doi request reprint Cardiovascular diseases do not influence the mental health outcome of older men with depression over 6 years
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Australia
    J Affect Disord 144:248-52. 2013
    ....
  12. doi request reprint Approaches to decrease the prevalence of depression in later life
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia
    Curr Opin Psychiatry 25:451-6. 2012
    ..Current strategies to decrease the personal and societal burden of depression in older age rely on the management of people with depression or of those at risk, but benefits have been limited and data remain scant...
  13. doi request reprint Factors associated with suicidal thoughts in a large community study of older adults
    Osvaldo P Almeida
    Western Australia Centre for Health and Ageing M573, University of Western Australia, 35 Stirling Highway, Crawley, Perth, WA 6009, Australia
    Br J Psychiatry 201:466-72. 2012
    ..Thoughts about death and self-harm in old age have been commonly associated with the presence of depression, but other risk factors may also be important...
  14. pmc Older men who use computers have lower risk of dementia
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Western Australia, Australia
    PLoS ONE 7:e44239. 2012
    ..To determine if older men who use computers have lower risk of developing dementia...
  15. ncbi request reprint Anxiety, depression, and comorbid anxiety and depression: risk factors and outcome over two years
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Perth, WA, Australia
    Int Psychogeriatr 24:1622-32. 2012
    ..This study aimed to determine: (1) the prevalence of depression, anxiety, and depression associated with anxiety (DA); (2) the risk factor profile of depression, anxiety, and DA; (3) the course of depression, anxiety, and DA over 24 months...
  16. pmc Aspirin decreases the risk of depression in older men with high plasma homocysteine
    O P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, WA, Australia
    Transl Psychiatry 2:e151. 2012
    ..Randomized trials are required to confirm the antidepressant effect of aspirin in people with high tHcy...
  17. doi request reprint Cognitive and brain changes associated with ischaemic heart disease and heart failure
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Perth, Australia
    Eur Heart J 33:1769-76. 2012
    ..This study aimed to determine whether, compared with controls with and without IHD, adults with systolic HF show evidence of cognitive impairment and cerebral grey matter (GM) loss...
  18. pmc A randomized trial to reduce the prevalence of depression and self-harm behavior in older primary care patients
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia
    Ann Fam Med 10:347-56. 2012
    ..We wanted to determine whether an educational intervention targeting general practitioners reduces the 2-year prevalence of depression and self-harm behavior among their older patients...
  19. ncbi request reprint Cardiovascular disease, depression and mortality: the Health In Men Study
    Osvaldo P Almeida
    Western Australia Centre for Health and Ageing, University of Western Australia, Australia
    Am J Geriatr Psychiatry 20:433-40. 2012
    ..One way to further elucidate the nature of this relationship is by determining the joint effect of CVD and depression on a common outcome, such as mortality...
  20. doi request reprint Socioeconomic disadvantage increases risk of prevalent and persistent depression in later life
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, WA, Australia
    J Affect Disord 138:322-31. 2012
    ..This study aimed to determine the independent association between socioeconomic disadvantage and depression...
  21. doi request reprint CRP 1846G>A polymorphism increases risk of frailty
    Osvaldo P Almeida
    Western Australian Centre for Health and Ageing, Western Australian Institute for Medical Research, Australia
    Maturitas 71:261-6. 2012
    ....
  22. pmc The fitness for the Ageing Brain Study II (FABS II): protocol for a randomized controlled clinical trial evaluating the effect of physical activity on cognitive function in patients with Alzheimer's disease
    Elizabeth V Cyarto
    National Ageing Research Institute, Melbourne, Australia
    Trials 11:120. 2010
    ..This paper describes the background, objectives of the study, and an overview of the protocol including design, organization and data collection methods...
  23. pmc Recruiting and retaining GPs and patients in intervention studies: the DEPS-GP project as a case study
    Michelle K Williamson
    Centre for Health Policy, Programs and Economics, School of Population Health, University of Melbourne, Australia
    BMC Med Res Methodol 7:42. 2007
    ..The paper aims to outline experiences that may be of interest to others considering engaging GPs and/or their patients in primary care studies...
  24. ncbi request reprint The association between C-reactive protein concentration and depression in later life is due to poor physical health: results from the Health in Men Study (HIMS)
    Osvaldo P Almeida
    WA Centre for Health and Ageing, University of Western Australia, Australia
    Psychol Med 37:1775-86. 2007
    ..This study aimed to investigate the association between high CRP concentration and depression while taking physical health into account...
  25. ncbi request reprint Mortality associated with incident mental health disorders after stroke
    Osvaldo P Almeida
    WA Centre for Health and Aging, University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    Aust N Z J Psychiatry 41:274-81. 2007
    ..This study was designed to determine: (1) the incidence of first ever mental health disorder in amongst stroke patients; (2) the 10-year mortality associated with incident post-stroke mental health disorders...
  26. doi request reprint Smoking is associated with reduced cortical regional gray matter density in brain regions associated with incipient Alzheimer disease
    Osvaldo P Almeida
    Western Australia Centre for Health and Ageing, School of Psychiatry and Clinical Neurosciences, University of Western Australia, 35 Stirling Highway, Perth, Western Australia 6009, Australia
    Am J Geriatr Psychiatry 16:92-8. 2008
    ..The authors designed this study to determine if older people who smoke have decreased gray matter density in brain regions associated with incipient AD...
  27. doi request reprint KIBRA genetic polymorphism influences episodic memory in later life, but does not increase the risk of mild cognitive impairment
    O P Almeida
    WA Centre for Health and Ageing, Western Australian Institute for Medical Research, Australia
    J Cell Mol Med 12:1672-6. 2008
    ..Future studies should aim to clarify the long term implications of this polymorphism on cognitive function and to identify other genes involved in the modulation of memory that might confer greater risk of MCI in later life...
  28. ncbi request reprint Low free testosterone concentration as a potentially treatable cause of depressive symptoms in older men
    Osvaldo P Almeida
    WA Centre for Health and Ageing, University of Western Australia, Perth, Australia
    Arch Gen Psychiatry 65:283-9. 2008
    ..Serum concentrations of gonadal hormones have been associated with various measures of well-being, but it is unclear whether their association with mood is confounded by concurrent physical morbidity...
  29. pmc Polymorphisms of the CRP gene inhibit inflammatory response and increase susceptibility to depression: the Health in Men Study
    Osvaldo P Almeida
    Western Australian Centre for Health and Ageing, Perth, WA, Australia
    Int J Epidemiol 38:1049-59. 2009
    ..The aim of this study is to determine if polymorphisms of SNPs rs1130864 and rs1205 are associated with prevalent depression...
  30. doi request reprint Obesity and metabolic syndrome increase the risk of incident depression in older men: the health in men study
    Osvaldo P Almeida
    Western Australian Centre for Health and Ageing, Western Australian Institute for Medical Research, Australia
    Am J Geriatr Psychiatry 17:889-98. 2009
    ....
  31. doi request reprint B-vitamins reduce the long-term risk of depression after stroke: The VITATOPS-DEP trial
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Perth, WA, Australia
    Ann Neurol 68:503-10. 2010
    ..The purpose of this research was to determine if treatment with B-vitamins reduces the hazard of poststroke depression compared with placebo...
  32. ncbi request reprint Association of cardiovascular risk factors and disease with depression in later life
    Osvaldo P Almeida
    Unit of Geriatric Psychiatry, University of Western Australia and Royal Perth Hospital, Perth, WA, Australia
    Am J Geriatr Psychiatry 15:506-13. 2007
    ..The objective of this study is to determine the association between established cardiovascular risk factors and depression among older men...
  33. doi request reprint Thyroid hormones and depression: the Health in Men study
    Osvaldo P Almeida
    WA Centre for Health and Ageing, Centre for Medical Research, University of Western Australia, Perth, WA
    Am J Geriatr Psychiatry 19:763-70. 2011
    ..Current practice guidelines suggest that thyroid function tests should be an integral part of the assessment of adults presenting with a depressive episode, although there is a paucity of data available to support such a recommendation...
  34. pmc Depression, antidepressant use and mortality in later life: the Health In Men Study
    Osvaldo P Almeida
    Western Australia Centre for Health and Ageing, University of Western Australia, Perth, Western Australia, Australia
    PLoS ONE 5:e11266. 2010
    ..Depression is associated with increased mortality, but it is unclear if this relationship is dose-dependent and if it can be modified by treatment with antidepressants...
  35. doi request reprint A practical approach to assess depression risk and to guide risk reduction strategies in later life
    Osvaldo P Almeida
    Western Australian Centre for Health and Ageing, Centre for Medical Research of the University of Western Australia, Perth, Australia
    Int Psychogeriatr 23:280-91. 2011
    ..This study gathered information about common modifiable and non-modifiable risk factors for depression with the aim of developing a practical probabilistic model of depression that can be used to guide risk reduction strategies...
  36. doi request reprint Complaints of difficulty to fall asleep increase the risk of depression in later life: the health in men study
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, WA 6009, Australia
    J Affect Disord 134:208-16. 2011
    ..To determine if complaints of poor sleep are associated with incident depression in older men...
  37. doi request reprint 24-month effect of smoking cessation on cognitive function and brain structure in later life
    Osvaldo P Almeida
    Western Australian Centre for Health and Ageing, Centre for Medical Research, University of Western Australia, Crawley, Perth, WA, Australia
    Neuroimage 55:1480-9. 2011
    ..We completed this trial to determine if smoking cessation decreases the progression of cognitive decline in later life...
  38. ncbi request reprint Successful mental health aging: results from a longitudinal study of older Australian men
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Royal Perth Hospital, Perth, WA 6009, Australia
    Am J Geriatr Psychiatry 14:27-35. 2006
    ..The authors investigated the associations of medical and lifestyle factors with the mental health of men in their 80s...
  39. pmc Dementia in residential care: education intervention trial (DIRECT); protocol for a randomised controlled trial
    Christopher D Beer
    WA Centre for Health and Ageing, Centre for Medical Research, Perth, Western Australia, Australia
    Trials 11:63. 2010
    ..The DIRECT study will determine if delivery of education to General Practitioners (GPs) and care staff improves the quality of life of residential care recipients with cognitive impairment...
  40. ncbi request reprint Healthier lifestyle predicts higher circulating testosterone in older men: the Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Australia
    Clin Endocrinol (Oxf) 70:455-63. 2009
    ..We sought to determine whether greater participation in healthy behaviours predicted reduced risk of subsequent lower circulating testosterone in older men...
  41. ncbi request reprint Contribution of the MTHFR gene to the causal pathway for depression, anxiety and cognitive impairment in later life
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, 35 Stirling Highway, Crawley, Perth, WA 6009, Australia
    Neurobiol Aging 26:251-7. 2005
    ..These results indicate that, in isolation, the MTHFR C677T gene variation does not play an important role in the modulation of mood and cognitive performance in later life...
  42. doi request reprint Elevated homocysteine is associated with poorer self-perceived physical health in older men: the Health in Men Study
    Yuen Y E Wong
    Western Australian Centre for Health and Ageing WACHA, Centre for Medical Research, Perth, WA, Australia
    Maturitas 73:158-63. 2012
    ....
  43. doi request reprint Higher free thyroxine levels predict increased incidence of dementia in older men: the Health in Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, Centre for Medical Research, University of Western Australia, Crawley, Western Australia 6009, Australia
    J Clin Endocrinol Metab 97:E2230-7. 2012
    ..Both hypothyroidism and subclinical hyperthyroidism hinder cognitive function...
  44. pmc Factors associated with self and informant ratings of the quality of life of people with dementia living in care facilities: a cross sectional study
    Christopher Beer
    WA Centre for Health and Ageing, Centre for Medical Research, Perth, Western Australia, Australia
    PLoS ONE 5:e15621. 2010
    ..We undertook the present study to describe and determine the factors associated with ratings of the quality of life of a cohort of people with dementia living in a residential care facility...
  45. ncbi request reprint A 20-week randomized controlled trial of estradiol replacement therapy for women aged 70 years and older: effect on mood, cognition and quality of life
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, The University of Western Australia M573, 35 Stirling Highway, Crawley, and Department of Psychiatry, Royal Perth Hospital, Perth, WA, Australia
    Neurobiol Aging 27:141-9. 2006
    ..Other more efficacious and safer interventions need to be devised with the aim of improving the mental state and quality of life of older women...
  46. doi request reprint Low free testosterone predicts mortality from cardiovascular disease but not other causes: the Health in Men Study
    Zoe Hyde
    Western Australian Centre for Health and Ageing, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    J Clin Endocrinol Metab 97:179-89. 2012
    ..Low testosterone is associated with all-cause mortality, but the relationship with cause-specific mortality is uncertain...
  47. pmc Cognitive activity for the treatment of older adults with mild Alzheimer's disease (AD)--PACE AD: study protocol for a randomised controlled trial
    Mandy R Vidovich
    Western Australia Centre for Health and Ageing WACHA, School of Psychiatry and Clinical Neurosciences and Centre for Medical Research, University of Western Australia and Royal Perth Hospital, Australia
    Trials 12:47. 2011
    ....
  48. doi request reprint Falls, injuries from falls, health related quality of life and mortality in older adults with vision and hearing impairment--is there a gender difference?
    Derrick Lopez
    Western Australian Centre for Health and Ageing WACHA, Centre for Medical Research, The University of Western Australia, Nedlands, Western Australia, Australia
    Maturitas 69:359-64. 2011
    ..Our objective was to determine if there are gender differences in the associations between visual and hearing impairment and these outcomes...
  49. ncbi request reprint Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial
    Nicola T Lautenschlager
    WA Centre for Health and Ageing, University of Western Australia, Melbourne, Australia
    JAMA 300:1027-37. 2008
    ..Many observational studies have shown that physical activity reduces the risk of cognitive decline; however, evidence from randomized trials is lacking...
  50. doi request reprint Higher luteinizing hormone is associated with poor memory recall: the health in men study
    Zoe Hyde
    Western Australian Institute for Medical Research, Australia
    J Alzheimers Dis 19:943-51. 2010
    ..These findings suggest a role for both androgens and gonadotropins in differing cognitive domains, and that gonadotropins may influence cognition independent of sex steroids...
  51. doi request reprint Higher free thyroxine levels are associated with frailty in older men: the Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Western Australia, Australia
    Clin Endocrinol (Oxf) 76:741-8. 2012
    ..Some symptoms of frailty overlap those of thyroid dysfunction, but it is unclear whether differences in thyroid status influence risk of frailty. We evaluated associations between thyroid status and frailty in older men...
  52. doi request reprint Plasma homocysteine and MTHFRC677T polymorphism as risk factors for incident dementia
    Andrew H Ford
    School of Psychiatry and Clinical Neurosciences M573, University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    J Neurol Neurosurg Psychiatry 83:70-5. 2012
    ..The authors designed this longitudinal study to determine if high tHcy and the MTHFR C677T polymorphism increase the risk of incident dementia among older men...
  53. doi request reprint Low free testosterone predicts frailty in older men: the health in men study
    Zoe Hyde
    Western Australian Centre for Health and Ageing M570, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    J Clin Endocrinol Metab 95:3165-72. 2010
    ..The prevalence of frailty increases, whereas testosterone decreases, as men age. Low testosterone may be a risk factor for development of this syndrome...
  54. pmc A cluster-randomised trial of staff education to improve the quality of life of people with dementia living in residential care: the DIRECT study
    Christopher Beer
    WA Centre for Health and Ageing, Centre for Medical Research, Perth, Western Australia, Australia
    PLoS ONE 6:e28155. 2011
    ....
  55. ncbi request reprint Association between physiological serum concentration of estrogen and the mental health of community-dwelling postmenopausal women age 70 years and over
    Osvaldo P Almeida
    UWA School of Psychiatry and Clinical Neurosciences M573, Level 6, Ainslie House, Royal Perth Hospital, 35 Stirling Highway, Crawley, Perth, WA 6009, Australia
    Am J Geriatr Psychiatry 13:142-9. 2005
    ..The authors investigated the association between physiological levels of estrogen and mood/cognitive functioning among older postmenopausal women...
  56. ncbi request reprint Depression and smoking amongst older general practice patients
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences M573, University of Western Australia, 35 Stirling Highway, Crawley, Perth, WA 6009, Australia
    J Affect Disord 86:317-21. 2005
    ..This study was designed to investigate the association between smoking and depression in people aged 60 years or over...
  57. ncbi request reprint Vitamins B12, B6, and folic acid for onset of depressive symptoms in older men: results from a 2-year placebo-controlled randomized trial
    Andrew H Ford
    South Metropolitan Health Service, Perth, Australia
    J Clin Psychiatry 69:1203-9. 2008
    ..To examine whether use of vitamins B(12), B(6), and folate was associated with reduced severity of depressive symptoms and 2-year incidence of clinically significant depression...
  58. ncbi request reprint B-vitamins reduce plasma levels of beta amyloid
    Leon Flicker
    School of Medicine and Pharmacology, University of Western Australia, Australia
    Neurobiol Aging 29:303-5. 2008
    ..E.) increase of A beta 40 was 7.0 pg/ml (8.4) in the vitamin group (4.9%), and 26.8 pg/ml (7.7) (18.5%) in the placebo group. We conclude that B vitamins may decrease the plasma level of A beta 40 and have a role in the prevention of AD...
  59. ncbi request reprint In men older than 70 years, total testosterone remains stable while free testosterone declines with age. The Health in Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia
    Eur J Endocrinol 156:585-94. 2007
    ..We sought to determine the distribution and associations of reduced testosterone concentrations in older men...
  60. doi request reprint In older men an optimal plasma testosterone is associated with reduced all-cause mortality and higher dihydrotestosterone with reduced ischemic heart disease mortality, while estradiol levels do not predict mortality
    Bu B Yeap
    School of Medicine and Pharmacology B B Y, S A P C, G J H, L F, University of Western Australia, Perth, Western Australia 6009, Australia Department of Endocrinology and Diabetes B B Y, Fremantle Hospital, Fremantle, Western Australia 6160, Australia Western Australian Centre for Health and Ageing H A, O P A, L F, Centre for Medical Research, University of Western Australia, Perth, Western Australia 6009, Australia PathWest Laboratory Medicine S A P C, Fremantle and Royal Perth Hospitals, Perth, Western Australia 6009, Australia ANZAC Research Institute D J H, University of Sydney, Sydney, New South Wales 2139, Australia School of Psychiatry and Clinical Neurosciences O P A, University of Western Australia, Perth, Western Australia 6009, Australia Vascular Biology Unit J G, Queensland Research Centre for Peripheral Vascular Disease, School of Medicine, James Cook University, Townsville, Queensland 4811, Australia and School of Surgery P E N, University of Western Australia, Perth, Western Australia 6009, Australia
    J Clin Endocrinol Metab 99:E9-18. 2014
    ..Testosterone (T) levels decline with age and lower T has been associated with increased mortality in aging men. However, the associations of its metabolites, dihydrotestosterone (DHT) and estradiol (E2), with mortality are poorly defined...
  61. doi request reprint Homocysteine, frailty, and all-cause mortality in older men: the health in men study
    Yuen Y E Wong
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Perth, Australia
    J Gerontol A Biol Sci Med Sci 68:590-8. 2013
    ..Frailty and hyperhomocysteinemia are common in the older population. The researchers' objectives were to determine whether elevated homocysteine (tHcy) is associated with frailty and mortality...
  62. doi request reprint Elevated LH predicts ischaemic heart disease events in older men: the Health in Men Study
    Zoe Hyde
    Western Australian Centre for Health and Ageing M570, Centre for Medical Research, Western Australian Institute for Medical Research School of Medicine and Pharmacology School of Surgery, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    Eur J Endocrinol 164:569-77. 2011
    ..However, it is uncertain whether the age-related decline in testosterone is associated with ischaemic heart disease (IHD) events...
  63. doi request reprint Lower testosterone levels predict incident stroke and transient ischemic attack in older men
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Crawley, WA 6009, Australia
    J Clin Endocrinol Metab 94:2353-9. 2009
    ..However, it is unclear whether lower testosterone levels predict major cardiovascular events...
  64. ncbi request reprint Subjective memory complaints with and without objective memory impairment: relationship with risk factors for dementia
    Nicola T Lautenschlager
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, 35 Stirling Highway, Crawley, Perth, WA 6009, Australia
    Am J Geriatr Psychiatry 13:731-4. 2005
    ....
  65. doi request reprint Prevalence of sexual activity and associated factors in men aged 75 to 95 years: a cohort study
    Zoe Hyde
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, School of Medicine and Pharmacology, School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Australia
    Ann Intern Med 153:693-702. 2010
    ..Knowledge about sexuality in elderly persons is limited, and normative data are lacking...
  66. doi request reprint Traditional risk factors for incident cardiovascular events have limited importance in later life compared with the health in men study cardiovascular risk score
    Christopher Beer
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, Perth, Australia
    Stroke 42:952-9. 2011
    ..This study aimed to determine, among older men, the risk and independent significant baseline prognostic factors for first-ever stroke and MI...
  67. ncbi request reprint Alcohol use and mortality in older men and women
    Kieran A McCaul
    Western Australian Centre for Health and Ageing, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    Addiction 105:1391-400. 2010
    ..To compare the effect of alcohol intake on 10-year mortality for men and women over the age of 65 years...
  68. ncbi request reprint Efficacy of B vitamins in lowering homocysteine in older men: maximal effects for those with B12 deficiency and hyperhomocysteinemia
    Leon Flicker
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Stroke 37:547-9. 2006
    ..Previous studies, largely in younger individuals, have shown that B vitamins lowered tHcy by substantial amounts and that this effect is greater in people with higher tHcy and lower folate levels...
  69. doi request reprint Perception of worsening health predicts mortality in older men: the Health in Men Study (HIMS)
    Helman Alfonso
    Western Australia Centre for Health and Ageing, Australia
    Arch Gerontol Geriatr 55:363-8. 2012
    ..We concluded that the two measures of SRH are likely to reflect the same domains of health, and the simultaneous use of both measures is the best predictor of short to medium term mortality...
  70. ncbi request reprint Body mass index and survival in men and women aged 70 to 75
    Leon Flicker
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, The University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009
    J Am Geriatr Soc 58:234-41. 2010
    ..To examine in an older population all-cause and cause-specific mortality associated with underweight (body mass index (BMI)<18.5), normal weight (BMI 18.5-24.9), overweight (BMI 25.0-29.9), and obesity (BMI> or =30.0)...
  71. doi request reprint Awareness of cognitive deficits in older adults with cognitive-impairment-no-dementia (CIND): comparison with informant report
    Kathryn R Greenop
    Division of Population Sciences, Telethon Institute for Child Health Research, Center for Child Health Research, University of Western Australia, Subiaco, WA, Australia
    Alzheimer Dis Assoc Disord 25:24-33. 2011
    ..In addition, self-report of cognitive complaints may be at least as useful as informant report when screening community-dwelling older adults at risk of cognitive decline and dementia...
  72. doi request reprint Factors associated with dementia in Aboriginal Australians
    Kate Smith
    Western Australian Centre for Health and Ageing M570, Centre for Health Research, University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009, Australia
    Aust N Z J Psychiatry 44:888-93. 2010
    ..This study was designed to determine the demographic, lifestyle and clinical factors associated with dementia in Aboriginal Australians living in the Kimberley region of Western Australia...
  73. doi request reprint Development and evaluation of an educational intervention for general practitioners and staff caring for people with dementia living in residential facilities
    Christopher Beer
    Western Australian Centre for Health and Ageing M570, Centre for Medical Research, The University of Western Australia, Crawley, Western Australia, Australia
    Int Psychogeriatr 23:221-9. 2011
    ..Small group education, which is flexible, individualized, practical and case-based, is sought. We aimed to develop educational interventions for GPs and RCF staff tailored to meet their perceived educational needs...
  74. pmc Quality use of medicines and health outcomes among a cohort of community dwelling older men: an observational study
    Christopher Beer
    Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research, Perth, WA, Australia
    Br J Clin Pharmacol 71:592-9. 2011
    ..To determine the prevalence of potentially suboptimal medication use and association with adverse outcomes...
  75. ncbi request reprint Latent Semantic Analysis: an improved method to measure cognitive performance in subjects of Non-English-Speaking-Background
    Nicola T Lautenschlager
    School of Psychiatry and Clinical Neurosciences, University of Western Australia
    J Clin Exp Neuropsychol 28:1381-7. 2006
    ..The results suggest that LSA is a more robust measure of cognitive function than traditional scoring methods and may therefore improve the validity of cognitive assessment results on subjects of NESB...
  76. ncbi request reprint Premorbid personality traits are associated with post-stroke behavioral and psychological symptoms: a three-month follow-up study in Perth, Western Australia
    Kathryn R Greenop
    WA Centre for Health and Ageing, University of Western Australia, Perth, Australia
    Int Psychogeriatr 21:1063-71. 2009
    ..This study sought to investigate further the relationship between premorbid personality and a number of common post-stroke behavioral and psychological symptoms in a three-month follow-up study...
  77. pmc Homocysteine, grey matter and cognitive function in adults with cardiovascular disease
    Andrew H Ford
    Western Australian Centre for Health and Ageing, University of Western Australia, Perth, Western Australia, Australia
    PLoS ONE 7:e33345. 2012
    ..Elevated total plasma homocysteine (tHcy) has been associated with cognitive impairment, vascular disease and brain atrophy...
  78. ncbi request reprint Preventing depression after stroke: Results from a randomized placebo-controlled trial
    Osvaldo P Almeida
    Unit of Geriatric Psychiatry, Royal Perth Hospital and University of Western Australia, Perth, Australia
    J Clin Psychiatry 67:1104-9. 2006
    ..We designed this study to determine whether the daily treatment of nondepressed acute stroke patients with sertraline reduced the incidence of depression at follow-up...
  79. ncbi request reprint Higher serum free testosterone is associated with better cognitive function in older men, while total testosterone is not. The Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Australia
    Clin Endocrinol (Oxf) 68:404-12. 2008
    ..To determine the relationship of total and free serum testosterone to cognitive performance in older men...
  80. ncbi request reprint Effectiveness of a smoking cessation intervention in older adults
    Robert J Tait
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Australia
    Addiction 102:148-55. 2007
    ....
  81. ncbi request reprint Memory loss
    Leon A Flicker
    Western Australian Centre for Health and Ageing, University of Western Australia and Royal Perth Hospital, Perth, WA
    Med J Aust 196:114-7. 2012
    ..The role of antidepressants in managing depressive symptoms in patients with mild cognitive impairment is uncertain and may increase the risk of delirium and falls...
  82. pmc The PACE study: a randomised clinical trial of cognitive activity (CA) for older adults with mild cognitive impairment (MCI)
    Mandy R Vidovich
    Western Australia Centre for Health and Ageing, School of Psychiatry and Clinical Neurosciences, Perth, Western Australia, Australia
    Trials 10:114. 2009
    ..The Promoting Healthy Ageing with Cognitive Exercise (PACE) study has been designed to determine whether a cognitive activity intervention decreases the rate of cognitive decline amongst older adults with mild cognitive impairment (MCI)...
  83. ncbi request reprint Healthy mental ageing
    Leon Flicker
    Department of Geriatric Medicine, School of Medicine and Pharmacology, University of Western Australia, Australia
    J Br Menopause Soc 12:92-6. 2006
    ....
  84. ncbi request reprint Association between lifestyle factors and mental health measures among community-dwelling older women
    Kellie Cassidy
    School of Psychiatry, and Clinical Neurosciences, University of Western Australia, Perth, Australia
    Aust N Z J Psychiatry 38:940-7. 2004
    ..To investigate the association between potentially modifiable lifestyle factors and cognitive abilities/depressive symptoms in community-dwelling women aged 70 years and over...
  85. pmc Predictors of cognitive decline in older individuals with diabetes
    David G Bruce
    1School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
    Diabetes Care 31:2103-7. 2008
    ..The purpose of this study was to determine longitudinal predictors of cognitive decline in older individuals with diabetes who did not have dementia...
  86. ncbi request reprint Relationship between quantity and frequency of alcohol use and indices of suicidal behavior in an elderly Australian sample
    Jon J Pfaff
    Western Australian Center for Health and Ageing, School of Psychiatry and Clinical Neurosciences, University of Western Australia in Perth, Australia
    Suicide Life Threat Behav 37:616-26. 2007
    ..The interaction between quantity and frequency of alcohol use was significant, suggesting that those who use alcohol less frequently but in greater quantities (i.e., binge drinking) are more likely to have a history of suicide attempts...
  87. ncbi request reprint A randomized trial of early psychiatric intervention in residential care: impact on health outcomes
    Ria Kotynia-English
    School of Psychiatry and Clinical Neurosciences, University of Western Australia and Royal Perth Hospital, Perth, Western Australia
    Int Psychogeriatr 17:475-85. 2005
    ..We hypothesized that subjects in the intervention group would have better mental and physical health outcomes than controls...
  88. ncbi request reprint Medical morbidity and severity of depression in a large primary care sample of older Australians: the DEPS-GP project
    Jon J Pfaff
    Western Australian Centre for Health and Ageing, Perth, WA, Australia
    Med J Aust 190:S75-80. 2009
    ..To estimate the prevalence of depression among older Australians with common medical morbidities, and to determine the association between poor physical health and depression in this age group...
  89. ncbi request reprint Association between hormone replacement therapy and dementia: is it time to forget?
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia and Royal Perth Hospital, Perth, Western Australia
    Int Psychogeriatr 17:155-64. 2005
    ....
  90. ncbi request reprint Cognitive impairment, physical disability and depressive symptoms in older diabetic patients: the Fremantle Cognition in Diabetes Study
    David G Bruce
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Diabetes Res Clin Pract 61:59-67. 2003
    ..To determine whether the prevalence of dementia, depression and/or disability in older diabetic subjects warrants an active screening approach by diabetes health care workers...
  91. ncbi request reprint One year follow-up study of the association between chemical castration, sex hormones, beta-amyloid, memory and depression in men
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Mail Point M573 Level 6, Ainslie House, Royal Perth Hospital, 35 Stirling Highway, Perth, WA 6009, Australia
    Psychoneuroendocrinology 29:1071-81. 2004
    ..The performance of subjects on the WL test was negatively correlated with plasma levels of Abeta, but the clinical significance of this finding remains to be determined...
  92. ncbi request reprint A cross-sectional analysis of factors that influence the detection of depression in older primary care patients
    Jon J Pfaff
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Unit Of Geriatric Psychiatry M573, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    Aust N Z J Psychiatry 39:262-5. 2005
    ..To determine the characteristics of depressed older patients whose mental health status is detected by their general practitioner (GP)...
  93. pmc Detecting suicidal ideation in older patients: identifying risk factors within the general practice setting
    Jon J Pfaff
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Western Australia
    Br J Gen Pract 55:269-73. 2005
    ..GPs are the most frequently accessed health professional among suicidal individuals in the community...
  94. ncbi request reprint Testosterone and dementia: too much ado about too little data
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Royal Perth Hospital, Perth, Australia
    J Br Menopause Soc 9:107-10. 2003
    ..In conclusion, currently available evidence does not support the existence of a strong association between testosterone and cognitive function/AD...
  95. pmc Current experiences and educational preferences of general practitioners and staff caring for people with dementia living in residential facilities
    Christopher Beer
    Western Australian Centre for Health and Ageing, Western Australian Institute for Medical Research, Perth, Australia
    BMC Geriatr 9:36. 2009
    ..We sought to determine participation in dementia education, perceived levels of current knowledge regarding dementia, perceived unmet educational needs, current barriers, facilitators and preferences for dementia education...
  96. ncbi request reprint Dementia associated with alcohol and other drug use
    Gary K Hulse
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Australia
    Int Psychogeriatr 17:S109-27. 2005
    ..Health promotion programs designed to decrease tobacco smoking and "harmful" alcohol use (and possibly other drug use) may decrease the burden of cognitive impairment and perhaps dementia in later life...
  97. ncbi request reprint Smoking as a risk factor for Alzheimer's disease: contrasting evidence from a systematic review of case-control and cohort studies
    Osvaldo P Almeida
    Department of Psychiatry and Behavioural Science, University of Western Australia, Perth, Australia
    Addiction 97:15-28. 2002
    ..To investigate the risk of Alzheimer's disease (AD) associated with smoking...
  98. ncbi request reprint [Bipolar disorder with late onset: an organic variety of mood disorder?]
    Osvaldo P Almeida
    Escola de Psiquiatria e Neurociências Clínicas, Universidade da Austrália Ocidental, Australia
    Rev Bras Psiquiatr 26:27-30. 2004
    ..It concludes that the split of bipolar disorder according to age at onset is artificial, and lacks clinical significance and epidemiological support...
  99. pmc Sleep complaints among older general practice patients: association with depression
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth
    Br J Gen Pract 55:864-6. 2005
    ..GPs should consider screening for the presence of depressive symptoms whenever older adults complain of sleep difficulties...
  100. ncbi request reprint Latent semantic analysis: a new method to measure prose recall
    John C Dunn
    Department of Psychiatry and Behavioural Science, University of Western Australia, Nedlands, WA, Australia
    J Clin Exp Neuropsychol 24:26-35. 2002
    ..This suggests that LSA may serve as an improved measure of prose recall...
  101. ncbi request reprint Identifying suicidal ideation among older adults in a general practice setting
    Jon J Pfaff
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, RPH Ainslie House M573, Nedlands, WA 6009, Australia
    J Affect Disord 83:73-7. 2004
    ..The purpose of this study was to identify the clinical and demographic characteristics of older adults who are contemplating suicide and are in contact with a GP...