Nuzhat Ahmed

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi request reprint Association between alphavbeta6 integrin expression, elevated p42/44 kDa MAPK, and plasminogen-dependent matrix degradation in ovarian cancer
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, University of Melbourne and Royal Women s Hospital, Victoria, Australia
    J Cell Biochem 84:675-86. 2002
  2. ncbi request reprint Epithelial-mesenchymal interconversions in normal ovarian surface epithelium and ovarian carcinomas: an exception to the norm
    Nuzhat Ahmed
    Women s Cancer Research Centre, Royal Women s Hospital, Melbourne, Victoria, Australia
    J Cell Physiol 213:581-8. 2007
  3. pmc Coalition of Oct4A and β1 integrins in facilitating metastasis in ovarian cancer
    Chantel Samardzija
    Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Melbourne, Vic, 3052, Australia
    BMC Cancer 16:432. 2016
  4. pmc Enhanced expression of peroxisome proliferator-activated receptor gamma in epithelial ovarian carcinoma
    G Y Zhang
    Department of Obstetrics and Gynaecology, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan 250012, PR China
    Br J Cancer 92:113-9. 2005
  5. pmc An immunohistochemical perspective of PPAR beta and one of its putative targets PDK1 in normal ovaries, benign and malignant ovarian tumours
    N Ahmed
    Women s Cancer Research Centre, Royal Women s Hospital, Melbourne, Victoria, Australia
    Br J Cancer 98:1415-24. 2008
  6. ncbi request reprint Molecular pathways regulating EGF-induced epithelio-mesenchymal transition in human ovarian surface epithelium
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, Royal Women s Hospital, 132 Grattan St, Carlton, Victoria 3053, Australia
    Am J Physiol Cell Physiol 290:C1532-42. 2006
  7. ncbi request reprint Role of integrin receptors for fibronectin, collagen and laminin in the regulation of ovarian carcinoma functions in response to a matrix microenvironment
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, Department of Obstetrics and Gynaecology, Baker Heart Research Institute, Royal Women s Hospital, The University of Melbourne, Carlton, Victoria, 3053, Australia
    Clin Exp Metastasis 22:391-402. 2005
  8. ncbi request reprint Proteomic tracking of serum protein isoforms as screening biomarkers of ovarian cancer
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, Royal Women s Hospital and The Department of Obstetrics and Gynaecology, The University of Melbourne, Australia
    Proteomics 5:4625-36. 2005
  9. pmc Ascites induces modulation of alpha6beta1 integrin and urokinase plasminogen activator receptor expression and associated functions in ovarian carcinoma
    N Ahmed
    Gynaecological Cancer Research Centre, Royal Women s Hospital, Melbourne, Australia
    Br J Cancer 92:1475-85. 2005
  10. ncbi request reprint Strategies for revealing lower abundance proteins in two-dimensional protein maps
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, Royal Women s Hospital, Department of Obstetrics and Gynaecology, The University of Melbourne, 132 Grattan Street, Carlton, VIC 3053, Australia
    J Chromatogr B Analyt Technol Biomed Life Sci 815:39-50. 2005

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Association between alphavbeta6 integrin expression, elevated p42/44 kDa MAPK, and plasminogen-dependent matrix degradation in ovarian cancer
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, University of Melbourne and Royal Women s Hospital, Victoria, Australia
    J Cell Biochem 84:675-86. 2002
    ..These data suggest that sustained elevation of p42/44 MAPK activity may be required for the co-expression of alphavbeta6 integrin, which in turn may regulate the malignant potential of ovarian cancer cells via proteolytic mechanisms...
  2. ncbi request reprint Epithelial-mesenchymal interconversions in normal ovarian surface epithelium and ovarian carcinomas: an exception to the norm
    Nuzhat Ahmed
    Women s Cancer Research Centre, Royal Women s Hospital, Melbourne, Victoria, Australia
    J Cell Physiol 213:581-8. 2007
    ..Finally, emphasis is placed on the clinical implications of EMT and potential therapeutic opportunities that may arise from these observations have been proposed...
  3. pmc Coalition of Oct4A and β1 integrins in facilitating metastasis in ovarian cancer
    Chantel Samardzija
    Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Melbourne, Vic, 3052, Australia
    BMC Cancer 16:432. 2016
    ..This study investigates the molecular mechanism which associates CSCs and integrins in ovarian cancer metastasis...
  4. pmc Enhanced expression of peroxisome proliferator-activated receptor gamma in epithelial ovarian carcinoma
    G Y Zhang
    Department of Obstetrics and Gynaecology, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan 250012, PR China
    Br J Cancer 92:113-9. 2005
    ..01). These findings suggest an involvement of PPARgamma in the onset and development of ovarian carcinoma and provide an insight into the regulation of this molecule in the progression of the disease...
  5. pmc An immunohistochemical perspective of PPAR beta and one of its putative targets PDK1 in normal ovaries, benign and malignant ovarian tumours
    N Ahmed
    Women s Cancer Research Centre, Royal Women s Hospital, Melbourne, Victoria, Australia
    Br J Cancer 98:1415-24. 2008
    ..However, overexpression of PDK1 was evident in borderline and low- to high-grade ovarian tumours and is consistent with its known role in tumorigenesis...
  6. ncbi request reprint Molecular pathways regulating EGF-induced epithelio-mesenchymal transition in human ovarian surface epithelium
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, Royal Women s Hospital, 132 Grattan St, Carlton, Victoria 3053, Australia
    Am J Physiol Cell Physiol 290:C1532-42. 2006
    ..Failure to do so may lead to the formation of epithelium-derived inclusion cysts, which are known preferential sites of malignant transformation...
  7. ncbi request reprint Role of integrin receptors for fibronectin, collagen and laminin in the regulation of ovarian carcinoma functions in response to a matrix microenvironment
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, Department of Obstetrics and Gynaecology, Baker Heart Research Institute, Royal Women s Hospital, The University of Melbourne, Carlton, Victoria, 3053, Australia
    Clin Exp Metastasis 22:391-402. 2005
    ....
  8. ncbi request reprint Proteomic tracking of serum protein isoforms as screening biomarkers of ovarian cancer
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, Royal Women s Hospital and The Department of Obstetrics and Gynaecology, The University of Melbourne, Australia
    Proteomics 5:4625-36. 2005
    ....
  9. pmc Ascites induces modulation of alpha6beta1 integrin and urokinase plasminogen activator receptor expression and associated functions in ovarian carcinoma
    N Ahmed
    Gynaecological Cancer Research Centre, Royal Women s Hospital, Melbourne, Australia
    Br J Cancer 92:1475-85. 2005
    ..Based on these findings, we conclude that ascites can induce selective upregulation of integrin and uPA/uPAR in ovarian cancer cells and these changes may modulate the functions of ovarian carcinomas...
  10. ncbi request reprint Strategies for revealing lower abundance proteins in two-dimensional protein maps
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, Royal Women s Hospital, Department of Obstetrics and Gynaecology, The University of Melbourne, 132 Grattan Street, Carlton, VIC 3053, Australia
    J Chromatogr B Analyt Technol Biomed Life Sci 815:39-50. 2005
    ..The potential use of these strategies, as a means of developing diagnostic tools for early screening of diseases and identification of drug targets for therapeutic intervention, will also be discussed...
  11. pmc Proteomic-based identification of haptoglobin-1 precursor as a novel circulating biomarker of ovarian cancer
    N Ahmed
    Gynaecological Cancer Research Centre, Royal Women s Hospital, 132 Grattan Street, Carlton, Victoria 3053, Australia
    Br J Cancer 91:129-40. 2004
    ..These data highlight the need to assess circulating concentration of HAP1 in the serum of ovarian cancer patients and evaluate its potential as a biomarker in the early diagnosis of ovarian cancer...
  12. ncbi request reprint Cell-free 59 kDa immunoreactive integrin-linked kinase: a novel marker for ovarian carcinoma
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, Royal Women s Hospital and The Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia
    Clin Cancer Res 10:2415-20. 2004
    ....
  13. ncbi request reprint Expression and localization of alphavbeta6 integrin in extraplacental fetal membranes: possible role in human parturition
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, Royal Women s Hospital, 132 Grattan Street, Carlton, Victoria 3053, Australia
    Mol Hum Reprod 10:173-9. 2004
    ....
  14. ncbi request reprint An approach to remove albumin for the proteomic analysis of low abundance biomarkers in human serum
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, Royal Women s Hospital and Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Victoria, Australia
    Proteomics 3:1980-7. 2003
    ..In conclusion, treatment of serum samples with Affi-Gel Blue or Aurum kit before 2-DE analysis can be used to remove high abundance proteins in order to increase the detection sensitivity of proteins present in low abundance...
  15. ncbi request reprint Integrin-linked kinase expression increases with ovarian tumour grade and is sustained by peritoneal tumour fluid
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, The Department of Obstetrics and Gynaecology, Royal Women s Hospital, The University of Melbourne, Victoria, Australia
    J Pathol 201:229-37. 2003
    ..Suppression of ILK expression may therefore represent a novel and an efficient mechanism for controlling ovarian tumour growth...
  16. pmc Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells
    N Ahmed
    Department of Obstetrics and Gynaecology, Gynaecological Cancer Research Centre, Royal Women s Hospital, University of Melbourne, Melbourne 3053, Australia
    Br J Cancer 89:374-84. 2003
    ..This novel paradigm of uPAR-integrin signalling may afford opportunities for alternative therapeutic strategies for the treatment of cancer...
  17. ncbi request reprint Proteomic profiling of proteins associated with urokinase plasminogen activator receptor in a colon cancer cell line using an antisense approach
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, Royal Women s Hospital, University of Melbourne, Australia
    Proteomics 3:288-98. 2003
    ....
  18. ncbi request reprint Alpha(v)beta(6) integrin-A marker for the malignant potential of epithelial ovarian cancer
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, The University of Melbourne and Royal Women s Hospital, Carlton, Victoria, Australia
    J Histochem Cytochem 50:1371-80. 2002
    ....
  19. ncbi request reprint Overexpression of alpha(v)beta6 integrin in serous epithelial ovarian cancer regulates extracellular matrix degradation via the plasminogen activation cascade
    N Ahmed
    Gynaecological Cancer Research Centre, Royal Women s Hospital, Melbourne, Australia
    Carcinogenesis 23:237-44. 2002
    ....
  20. pmc Short-term single treatment of chemotherapy results in the enrichment of ovarian cancer stem cell-like cells leading to an increased tumor burden
    Khalid Abubaker
    Women s Cancer Research Centre, Royal Women s Hospital, Victoria 3052, Australia
    Mol Cancer 12:24. 2013
    ..The novel findings in this study are important in understanding the early molecular mechanisms by which chemoresistance and subsequent relapse may be triggered after the first line of chemotherapy treatment...
  21. pmc Isolation and characterization of tumor cells from the ascites of ovarian cancer patients: molecular phenotype of chemoresistant ovarian tumors
    Ardian Latifi
    Women s Cancer Research Centre, Royal Women s Hospital, Victoria, Australia
    PLoS ONE 7:e46858. 2012
    ....
  22. ncbi request reprint Neutrophil gelatinase-associated lipocalin (NGAL) an early-screening biomarker for ovarian cancer: NGAL is associated with epidermal growth factor-induced epithelio-mesenchymal transition
    Ratana Lim
    Gynaecological Cancer Research Centre, Royal Women s Hospital, Carlton, Victoria, Australia
    Int J Cancer 120:2426-34. 2007
    ..These data indicate that NGAL may be a good marker to monitor changes of benign to premalignant and malignant ovarian tumors and that the molecule may be involved in the progression of epithelial ovarian malignancies...
  23. ncbi request reprint Epithelial mesenchymal transition and cancer stem cell-like phenotypes facilitate chemoresistance in recurrent ovarian cancer
    Nuzhat Ahmed
    Women s Cancer Research Centre, Royal Women s Hospital, Melbourne, Australia
    Curr Cancer Drug Targets 10:268-78. 2010
    ..We propose the molecular targeting of distinct 'EMT transformed cancer stem-like cells' and suggest ways that may improve the efficacy of current chemotherapeutic regimens much needed for the management of this disease...
  24. doi request reprint Cisplatin treatment of primary and metastatic epithelial ovarian carcinomas generates residual cells with mesenchymal stem cell-like profile
    Ardian Latifi
    Women s Cancer Research Centre, Royal Women s Hospital, Victoria 3052, Australia
    J Cell Biochem 112:2850-64. 2011
    ....
  25. ncbi request reprint Direct integrin alphavbeta6-ERK binding: implications for tumour growth
    Nuzhat Ahmed
    Gynaecological Cancer Research Centre, The Royal Women s Hospital, Melbourne and University of Melbourne, Melbourne, Australia
    Oncogene 21:1370-80. 2002
    ..The physical interaction between integrin alphavbeta6 and ERK2 defines a novel paradigm of integrin-mediated signalling and provides a therapeutic target for cancer treatment...
  26. pmc Targeted Disruption of the JAK2/STAT3 Pathway in Combination with Systemic Administration of Paclitaxel Inhibits the Priming of Ovarian Cancer Stem Cells Leading to a Reduced Tumor Burden
    Khalid Abubaker
    Women s Cancer Research Centre, Royal Women s Hospital, Parkville, Vic, Australia Department of Surgery, St Vincent Hospital, University of Melbourne, Melbourne, Vic, Australia
    Front Oncol 4:75. 2014
    ..These novel findings have the potential for the development of CSC-targeted therapy to improve the treatment outcomes of ovarian cancer patients...
  27. pmc Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden
    Khalid Abubaker
    Women s Cancer Research Centre, Royal Women s Hospital, 20 Flemington Road, Parkville, Melbourne, Victoria 3052, Australia
    BMC Cancer 14:317. 2014
    ..In this report we looked at the mechanisms of the enrichment of CSC-like residual cells in response to paclitaxel treatment...
  28. doi request reprint Cancerous ovarian stem cells: obscure targets for therapy but relevant to chemoresistance
    Nuzhat Ahmed
    Women s Cancer Research Centre, Royal Women s Hospital, Melbourne, Australia
    J Cell Biochem 114:21-34. 2013
    ..We also propose the molecular targeting of CSCs and suggest ways that may improve the efficacy of current chemotherapeutic regimens needed for the management of this disease...
  29. doi request reprint 2D-PAGE of ovarian cancer: analysis of soluble and insoluble fractions using medium-range immobilized pH gradients
    Ratana Lim
    Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia
    Biochem Biophys Res Commun 406:408-13. 2011
    ..These proteins are associated with cytoskeleton rearrangement, cell metabolism, tumour suppression function, apoptosis and induction of host response...
  30. pmc Investigation of human cationic antimicrobial protein-18 (hCAP-18), lactoferrin and CD163 as potential biomarkers for ovarian cancer
    Ratana Lim
    Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Vic, Australia
    J Ovarian Res 6:5. 2013
    ....
  31. doi request reprint Epidermal growth factor-induced ovarian carcinoma cell migration is associated with JAK2/STAT3 signals and changes in the abundance and localization of alpha6beta1 integrin
    Michelle Colomiere
    Women s Cancer Research Centre, Royal Women s Hospital, Melbourne, Australia
    Int J Biochem Cell Biol 41:1034-45. 2009
    ....
  32. pmc Alpha2beta1 integrin affects metastatic potential of ovarian carcinoma spheroids by supporting disaggregation and proteolysis
    Kristy Shield
    Gynaecological Cancer Research Centre, Royal Women s Hospital, Melbourne Australia
    J Carcinog 6:11. 2007
    ..This study was designed to elucidate early inherent mechanism(s) of spheroid survival, growth and disaggregation required for peritoneal metastases..
  33. pmc A critical role of Oct4A in mediating metastasis and disease-free survival in a mouse model of ovarian cancer
    Chantel Samardzija
    Women s Cancer Research Centre, Royal Women s Hospital, Victoria, 3052, Australia
    Mol Cancer 14:152. 2015
    ..This study aimed to investigate the role of Oct4A, an embryonic stem cell factor and known master regulator of pluripotency in EOC progression, metastasis and chemoresistance...
  34. pmc Attributes of Oct4 in stem cell biology: perspectives on cancer stem cells of the ovary
    Chantel Samardzija
    Women s Cancer Research Centre, Royal Women s Hospital, 20 Flemington Road, Parkville, Vic, 3052, Australia
    J Ovarian Res 5:37. 2012
    ..Overall, we highlight why ovarian cancer patients, who initially respond to conventional chemotherapy subsequently relapse with recurrent chemoresistant disease that is essentially incurable...
  35. doi request reprint Multicellular spheroids in ovarian cancer metastases: Biology and pathology
    Kristy Shield
    Center for Cellular and Molecular Biology, Deakin University, Melbourne, Australia
    Gynecol Oncol 113:143-8. 2009
    ..This review article outlines the key biological features of spheroids, specifically discussing their role in EOC dissemination and chemo-response as well as providing insights into spheroid functionality...
  36. pmc Neuronal transcription factor Brn-3a(l) is over expressed in high-grade ovarian carcinomas and tumor cells from ascites of patients with advanced-stage ovarian cancer
    Nuzhat Ahmed
    Women s Cancer Research Centre, Royal Women s Hospital, 20 Flemington Road, Parkville, Victoria 3052, Australia
    J Ovarian Res 3:17. 2010
    ..The expression of Brn-3a(l) was also evaluated in normal ovarian and cancer cell lines and tumor cells isolated from the ascites of advanced-stage ovarian cancer patients...
  37. doi request reprint Ovarian cancer stem cells: Molecular concepts and relevance as therapeutic targets
    Nuzhat Ahmed
    Women s Cancer Research Centre, Royal Women s Hospital, Melbourne, Australia Department of Obstetrics and Gynaecology, University of Melbourne, Australia Department of Surgery, University of Melbourne, Australia Australia and Prince Henry s Institute of Medical Research, Melbourne, Australia Electronic address
    Mol Aspects Med 39:110-25. 2014
    ..Understanding the distinct mechanisms that facilitate cancer stem cell survival and propagation are likely to reveal opportunities for improving the treatment outcomes for ovarian cancer patients. ..
  38. ncbi request reprint Integrin expression in colon cancer cells is regulated by the cytoplasmic domain of the beta6 integrin subunit
    Jun Niu
    Newcastle Bowel Cancer Research Collaborative, Hunter Medical Research Institute, John Hunter Hospital, The University of Newcastle, Callaghan, New South Wales 2310, Australia
    Int J Cancer 99:529-37. 2002
    ..Given the dominance of the beta6-ERK2 interaction over PKC-mediated expression of both beta5 and beta6 integrin subunits, targeting the beta6-ERK2 interaction may prove useful as an anticancer strategy in colon cancer...