Leon A Adams

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. doi request reprint Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease
    Leon A Adams
    School of Medicine and Pharmacology, University of Western Australia UWA Perth, Australia
    Hepatology 57:590-600. 2013
  2. ncbi request reprint Cholesteryl ester transfer protein gene polymorphisms increase the risk of fatty liver in females independent of adiposity
    Leon A Adams
    School of Medicine and Pharmacology, The University of Western Australia UWA, Australia
    J Gastroenterol Hepatol 27:1520-7. 2012
  3. doi request reprint Complex non-invasive fibrosis models are more accurate than simple models in non-alcoholic fatty liver disease
    Leon A Adams
    School of Medicine and Pharmacology, The University of Western Australia, Western Australia, Australia
    J Gastroenterol Hepatol 26:1536-43. 2011
  4. doi request reprint Biomarkers of liver fibrosis
    Leon A Adams
    School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA 6009, Australia
    J Gastroenterol Hepatol 26:802-9. 2011
  5. doi request reprint Nonalcoholic fatty liver disease and diabetes mellitus: pathogenesis and treatment
    Briohny W Smith
    School of Medicine and Pharmacology, Sir Charles Gairdner Hospital Unit, University of Western Australia, Nedlands, WA 6009, Australia
    Nat Rev Endocrinol 7:456-65. 2011
  6. doi request reprint NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: an eleven-year follow-up study
    Leon A Adams
    School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA, Australia
    Am J Gastroenterol 104:861-7. 2009
  7. ncbi request reprint Body mass index is a stronger predictor of alanine aminotransaminase levels than alcohol consumption
    Leon A Adams
    School of Medicine and Pharmacology, Fremantle Hospital Campus, The University of Western Australia, Fremantle, Australia
    J Gastroenterol Hepatol 23:1089-93. 2008
  8. ncbi request reprint Ganciclovir and the treatment of Epstein-Barr virus hepatitis
    Leon A Adams
    Department of Gastroenterology and Hepatology, Sir Charles Gardiner Hospital, Nedlands, WA, Australia
    J Gastroenterol Hepatol 21:1758-60. 2006
  9. ncbi request reprint Importance of cardiometabolic risk factors in the association between nonalcoholic fatty liver disease and arterial stiffness in adolescents
    Rae Chi Huang
    School of Medicine and Pharmacology, University of Western Australia UWA, Nedlands, Australia School of Paediatrics and Child Health, UWA, Nedlands, Australia
    Hepatology 58:1306-14. 2013
  10. ncbi request reprint Hepascore: an accurate validated predictor of liver fibrosis in chronic hepatitis C infection
    Leon A Adams
    Department of Gastroenterology and Hepatology, Sir Charles Gairdner Hospital, Perth, Australia
    Clin Chem 51:1867-73. 2005

Collaborators

Detail Information

Publications43

  1. doi request reprint Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease
    Leon A Adams
    School of Medicine and Pharmacology, University of Western Australia UWA Perth, Australia
    Hepatology 57:590-600. 2013
    ..Mean serum levels of GC protein were significantly lower in patients with NAFLD than controls (250 ± 90 versus 298 ± 90, respectively; P = 0.004); GC protein levels decreased with increasing severity of hepatic steatosis (P < 0.01)...
  2. ncbi request reprint Cholesteryl ester transfer protein gene polymorphisms increase the risk of fatty liver in females independent of adiposity
    Leon A Adams
    School of Medicine and Pharmacology, The University of Western Australia UWA, Australia
    J Gastroenterol Hepatol 27:1520-7. 2012
    ..We aimed to use a candidate gene approach to examine the association between FLD and single nucleotide polymorphisms (SNPs) in lipid metabolism genes in the adolescent population-based Western Australian Pregnancy (Raine) Cohort...
  3. doi request reprint Complex non-invasive fibrosis models are more accurate than simple models in non-alcoholic fatty liver disease
    Leon A Adams
    School of Medicine and Pharmacology, The University of Western Australia, Western Australia, Australia
    J Gastroenterol Hepatol 26:1536-43. 2011
    ..We therefore compared the accuracy of simple bedside versus complex fibrosis models across a range of fibrosis in a multi-centre NAFLD cohort...
  4. doi request reprint Biomarkers of liver fibrosis
    Leon A Adams
    School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA 6009, Australia
    J Gastroenterol Hepatol 26:802-9. 2011
    ..Novel proteins identified by proteomic technology and genetic polymorphisms from genome association studies offer the possibility for further refinement and individualization of biomarker fibrosis models in the future...
  5. doi request reprint Nonalcoholic fatty liver disease and diabetes mellitus: pathogenesis and treatment
    Briohny W Smith
    School of Medicine and Pharmacology, Sir Charles Gairdner Hospital Unit, University of Western Australia, Nedlands, WA 6009, Australia
    Nat Rev Endocrinol 7:456-65. 2011
    ....
  6. doi request reprint NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: an eleven-year follow-up study
    Leon A Adams
    School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA, Australia
    Am J Gastroenterol 104:861-7. 2009
    ..We sought to determine whether NAFLD with elevated aminotransaminase (ALT) levels was a risk factor for incident diabetes or the metabolic syndrome (MS) over an 11-year period...
  7. ncbi request reprint Body mass index is a stronger predictor of alanine aminotransaminase levels than alcohol consumption
    Leon A Adams
    School of Medicine and Pharmacology, Fremantle Hospital Campus, The University of Western Australia, Fremantle, Australia
    J Gastroenterol Hepatol 23:1089-93. 2008
    ..The relative effects of obesity compared to alcohol on liver injury are uncertain. We examined their effects on alanine aminotransferase (ALT) and gamma glutamyltransferase (GGT) levels in a population-based cohort...
  8. ncbi request reprint Ganciclovir and the treatment of Epstein-Barr virus hepatitis
    Leon A Adams
    Department of Gastroenterology and Hepatology, Sir Charles Gardiner Hospital, Nedlands, WA, Australia
    J Gastroenterol Hepatol 21:1758-60. 2006
    ..Herein, the successful use of ganciclovir in two immunocompetent patients with severe EBV hepatitis is reported...
  9. ncbi request reprint Importance of cardiometabolic risk factors in the association between nonalcoholic fatty liver disease and arterial stiffness in adolescents
    Rae Chi Huang
    School of Medicine and Pharmacology, University of Western Australia UWA, Nedlands, Australia School of Paediatrics and Child Health, UWA, Nedlands, Australia
    Hepatology 58:1306-14. 2013
    ..20, 95% confidence interval [CI] 0.01 to 0.38, P = 0.037). Males who had NAFLD in the presence of the metabolic cluster had greater AI@75 (b = 6.3, 95% CI 1.9 to 10.7, P = 0.005)...
  10. ncbi request reprint Hepascore: an accurate validated predictor of liver fibrosis in chronic hepatitis C infection
    Leon A Adams
    Department of Gastroenterology and Hepatology, Sir Charles Gairdner Hospital, Perth, Australia
    Clin Chem 51:1867-73. 2005
    ..We sought to create an algorithm of serum markers that accurately and reliably predict liver fibrosis stage among hepatitis C patients...
  11. doi request reprint Image analysis of liver collagen using sirius red is more accurate and correlates better with serum fibrosis markers than trichrome
    Yi Huang
    School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
    Liver Int 33:1249-56. 2013
    ..Collagen proportional area (CPA) determined by quantitative digital image analysis better quantifies liver fibrosis than histological stage; however, its clinical use has been limited by non-standardized methods...
  12. doi request reprint The Western dietary pattern is prospectively associated with nonalcoholic fatty liver disease in adolescence
    Wendy H Oddy
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    Am J Gastroenterol 108:778-85. 2013
    ..We examined prospective associations between dietary patterns and NAFLD in a population-based cohort of adolescents...
  13. doi request reprint Gender-specific differences in adipose distribution and adipocytokines influence adolescent nonalcoholic fatty liver disease
    Oyekoya T Ayonrinde
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
    Hepatology 53:800-9. 2011
    ..001 for all). Similarly, metabolic syndrome was more common in males than females with NAFLD (24% versus 8%, P = 0.01). Suprailiac skinfold thickness predicted NAFLD independently of the body mass index, insulin resistance, and VAT...
  14. doi request reprint High biological variation of serum hyaluronic acid and Hepascore, a biochemical marker model for the prediction of liver fibrosis
    Enrico Rossi
    Biochemistry, PathWest, QE II Medical Centre, Nedlands, Western Australia, Australia
    Clin Chem Lab Med 51:1107-14. 2013
    ....
  15. pmc Diagnostic performance of a rapid magnetic resonance imaging method of measuring hepatic steatosis
    Michael J House
    School of Physics, The University of Western Australia, Crawley, Australia
    PLoS ONE 8:e59287. 2013
    ..The aim of this study was to test the ability of a rapid, routinely available, magnetic resonance imaging (MRI) method to diagnose clinically relevant grades of hepatic steatosis in a cohort of patients with diverse liver diseases...
  16. ncbi request reprint Low serum 25-hydroxyvitamin D concentrations associate with non-alcoholic fatty liver disease in adolescents independent of adiposity
    Lucinda J Black
    Telethon Institute for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia
    J Gastroenterol Hepatol 29:1215-22. 2014
    ..We aimed to determine the prevalence of vitamin D deficiency in adolescents with NAFLD and to investigate the prospective and cross-sectional associations between s25[OH]D concentrations and NAFLD...
  17. ncbi request reprint Lower fructose intake may help protect against development of nonalcoholic Fatty liver in adolescents with obesity
    Therese A Oʼsullivan
    School of Exercise and Health Science, Edith Cowan University, Joondalup Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, West Perth School of Population Health, University of Western Australia, Crawley School of Public Health School of Medicine and Pharmacology, University of Western Australia, Fremantle Department of Gastroenterology, Fremantle Hospital, Fremantle, Australia
    J Pediatr Gastroenterol Nutr 58:624-31. 2014
    ..We evaluated associations between fructose and total sugar intake and subsequent diagnosis of NAFL in adolescents with obesity and without obesity in a population-based cohort...
  18. doi request reprint Supplementation with n3 fatty acid ethyl esters increases large and small artery elasticity in obese adults on a weight loss diet
    Annette T Y Wong
    School of Medicine and Pharmacology, Computing and Mathematics, University of Western Australia, Perth, Western Australia, Australia
    J Nutr 143:437-41. 2013
    ..Supplementation with n3 FAEEs improves C1 and C2 independently of weight loss in obese adults...
  19. doi request reprint Nonalcoholic steatohepatitis: risk factors and diagnosis
    Leon A Adams
    School of Medicine and Pharmacology, University of Western Australia, Sir Charles Gairdner Hospital Unit, Nedlands, WA 6009, Australia
    Expert Rev Gastroenterol Hepatol 4:623-35. 2010
    ..Routine liver aminotransaminase levels are not reliable; however, novel plasma hepatocyte apoptosis markers, either alone or in combination with clinical risk factors, are potential noninvasive diagnostic tools for the future...
  20. pmc Decreased IP-10 and elevated TGFbeta1 levels are associated with viral clearance following therapy in patients with hepatitis C virus
    Silvia Lee
    Department of Microbiology and Infectious Disease, Royal Perth Hospital, University of Western Australia, Perth, Australia
    Dis Markers 28:273-80. 2010
    ..003 relative to Hepascore). Whilst this was only marginally more effective than predictions based on HCV genotype age and sex (p=0.07), it associates high TGFbeta1 and low IP-10 levels with a failure of therapy...
  21. pmc Nonalcoholic fatty liver disease increases risk of death among patients with diabetes: a community-based cohort study
    Leon A Adams
    School of Medicine and Pharmacology, The University of Western Australia, Perth, Western Australia, Australia
    Am J Gastroenterol 105:1567-73. 2010
    ..We sought to determine whether a diagnosis of NAFLD influenced mortality among a community-based cohort of patients with type II diabetes mellitus...
  22. ncbi request reprint Effect of ω-3 Fatty Acid Ethyl Esters on Apolipoprotein B-48 Kinetics in Obese Subjects on a Weight-Loss Diet: A New Tracer Kinetic Study in the Postprandial State
    Annette T Y Wong
    School of Medicine and Pharmacology A T Y W, D C C, P H R B, G F W and Faculty of Engineering, Computing, and Mathematics P H R B, University of Western Australia, Perth, Western Australia, WA 6847 Australia and Department of Gastroenterology and Hepatology L A A, Sir Charles Gairdner Hospital, Perth, Western Australia, WA 6009 Australia
    J Clin Endocrinol Metab 99:E1427-35. 2014
    ..Supplementation with ω-3 fatty acid ethyl ester (FAEE) decreases plasma triglyceride. However, its effect on postprandial chylomicron metabolism in obese subjects on a weight-loss diet has not yet been investigated...
  23. ncbi request reprint Image analysis of liver biopsy samples measures fibrosis and predicts clinical outcome
    Yi Huang
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia Department of Gastroenterology and Hepatology, Sir Charles Gairdner Hospital, Perth, Australia
    J Hepatol 61:22-7. 2014
    ..Liver collagen quantification may allow use of small size biopsies and improve the prediction of clinical outcomes. This study evaluated the ability of the collagen proportional area (CPA) measurement to predict clinical outcomes...
  24. doi request reprint Non-invasive diagnosis of nonalcoholic fatty liver and nonalcoholic steatohepatitis
    Leon A Adams
    School of Medicine and Pharmacology, University of Western Australia, Sir Charles Gairdner Hospital Unit, Nedlands, Western Australia, Australia
    J Dig Dis 12:10-6. 2011
    ..This review provides a concise overview of the role non-invasive diagnostic tools for the differentiation of fatty liver from NASH as well as for the determination of presence and extent of fibrosis...
  25. ncbi request reprint Prediction of morbidity and mortality in patients with chronic hepatitis C by non-invasive liver fibrosis models
    Mohamed A Chinnaratha
    Department of Gastroenterology Hepatology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia
    Liver Int 34:720-7. 2014
    ..Liver fibrosis is prognostic of outcomes among patients with chronic hepatitis C (CHC). We evaluated the accuracy of non-invasive markers and liver biopsy in predicting morbidity and mortality in CHC patients...
  26. pmc DNA methylation of the IGF2/H19 imprinting control region and adiposity distribution in young adults
    Rae Chi Huang
    School of Medicine and Pharmacology, University of Western Australia UWA, Perth, WA, Australia
    Clin Epigenetics 4:21. 2012
    ..abstract:..
  27. ncbi request reprint Role of liver biopsy and serum markers of liver fibrosis in non-alcoholic fatty liver disease
    Leon A Adams
    School of Medicine and Pharmacology, The University of Western Australia, Liver Transplant Unit, Sir Charles Gairdner Hospital, Nedlands, Australia
    Clin Liver Dis 11:25-35, viii. 2007
    ....
  28. pmc Genetic determinants of hepatic steatosis in man
    Amanda J Hooper
    Department of Core Clinical Pathology and Biochemistry, Royal Perth Hospital, Perth, Australia
    J Lipid Res 52:593-617. 2011
    ..Identifying the genetic determinants of hepatic steatosis will lead to a better understanding of the pathogenesis and progression of NAFLD...
  29. ncbi request reprint The trials and tribulations of the treatment of nonalcoholic fatty-liver disease
    Seng Khee Gan
    Metabolic Research Centre, School of Medicine and Pharmacology, Royal Perth Hospital Unit, Australia, University of Western Australia, Perth, Australia
    Curr Opin Lipidol 19:592-9. 2008
    ..To review published clinical trials, with a focus on those of randomized design, of the management of nonalcoholic fatty-liver disease (NAFLD), an increasing complication of the obesity epidemic...
  30. ncbi request reprint Screening for HFE and iron overload
    John Ombiga
    Department of Gastroenterology, Fremantle Hospital, Fremantle, Western Australia, Australia
    Semin Liver Dis 25:402-10. 2005
    ..Potential ethical, legal, and psychosocial issues arising through application of genetic screening programs also must be resolved prior to implementation of general population screening programs...
  31. ncbi request reprint Nonalcoholic fatty liver disease
    Leon A Adams
    School of Medicine and Pharmacology, The University of Western Australia, Fremantle Hospital Campus, Australia
    Ann Epidemiol 17:863-9. 2007
    ..Management is further complicated by the inability to predict which patients will develop liver-related morbidity and thus benefit from treatment...
  32. doi request reprint Bevacizumab reverses need for liver transplantation in hereditary hemorrhagic telangiectasia
    Andrew Mitchell
    Western Australian Liver Transplant Service, Sir Charles Gairdner Hospital, Nedlands, Australia
    Liver Transpl 14:210-3. 2008
    ..Bevacizumab may potentially alleviate the need for liver transplantation in this group of patients...
  33. doi request reprint Non-alcoholic fatty liver disease
    Briohny W Smith
    School of Medicine and Pharmacology, Sir Charles Gairdner Hospital Unit, University of Western Australia, Nedlands, Australia
    Crit Rev Clin Lab Sci 48:97-113. 2011
    ....
  34. ncbi request reprint Nonalcoholic fatty liver disease and diabetes mellitus
    Leon A Adams
    School of Medicine, The University of Western Australia, Sir Charles Gairdner Hospital, Perth, Australia
    Endocr Res 32:59-69. 2007
  35. ncbi request reprint Vitamins E and C for the treatment of NASH: duplication of results but lack of demonstration of efficacy
    Leon A Adams
    Am J Gastroenterol 98:2348-50. 2003
  36. ncbi request reprint Treatment of nonalcoholic steatohepatitis: antioxidants or insulin sensitizers?
    Leon A Adams
    Clin Gastroenterol Hepatol 2:1059-60. 2004
  37. ncbi request reprint A pilot trial of pentoxifylline in nonalcoholic steatohepatitis
    Leon A Adams
    Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 99:2365-8. 2004
    ..Pentoxifylline inhibits TNF alpha production. We therefore conducted a 12-month pilot trial to assess the efficacy and safety of pentoxifylline (1,600 mg/day) among 20 patients with NASH...
  38. ncbi request reprint Diagnostic evaluation of nonalcoholic fatty liver disease
    Leon A Adams
    Division of Gastroenterology and Hepatology, Mayo Clinic and College of Medicine, Rochester, MN 55905, USA
    J Clin Gastroenterol 40:S34-8. 2006
    ..Clinical features, particularly diabetes, obesity, and older age, can aid in stratifying patients at risk for advanced fibrosis but are not sufficiently accurate to replace liver biopsy...
  39. pmc Nonalcoholic fatty liver disease
    Leon A Adams
    Division of Gastroenterology and Hepatology, Mayo Clinic and College of Medicine, Rochester, Minn 55905, USA
    CMAJ 172:899-905. 2005
    ..In this article we discuss the etiology, pathogenesis and diagnosis of nonalcoholic fatty liver disease as well as approaches to its management...
  40. ncbi request reprint The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies
    Leon A Adams
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    J Hepatol 42:132-8. 2005
    ..The histological course of nonalcoholic fatty liver disease (NAFLD) remains undescribed. Therefore, we examined the liver histology of NAFLD patients who had undergone sequential liver biopsies...
  41. ncbi request reprint Treatment of hyperlipidemia in nonalcoholic fatty liver disease: fat for thought
    Leon A Adams
    Indian J Gastroenterol 23:127-8. 2004
  42. ncbi request reprint Nonalcoholic fatty liver disease among patients with hypothalamic and pituitary dysfunction
    Leon A Adams
    Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Hepatology 39:909-14. 2004
    ..The novel evidence that hypothalamic/pituitary dysfunction may be accompanied by progressive NAFLD has important implications for the work-up and management of patients with hypothalamic/pituitary disease...
  43. ncbi request reprint The bulge, booze, and the liver
    Leon A Adams
    Clin Gastroenterol Hepatol 3:1195-7. 2005