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Genomes and GenesSpecies | Leon A AdamsSummaryAffiliation: University of Western Australia Country: Australia Publications
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Publications
Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver diseaseLeon A Adams
School of Medicine and Pharmacology, University of Western Australia UWA Perth, Australia
Hepatology 57:590-600. 2013..01). CONCLUSION: The association between GC and LCP1 SNPs and NAFLD as well as altered biological expression implicate these genes in the pathogenesis of NAFLD...- Cholesteryl ester transfer protein gene polymorphisms increase the risk of fatty liver in females independent of adiposityLeon A Adams
School of Medicine and Pharmacology, The University of Western Australia UWA, Australia
J Gastroenterol Hepatol 27:1520-7. 2012..We aimed to use a candidate gene approach to examine the association between FLD and single nucleotide polymorphisms (SNPs) in lipid metabolism genes in the adolescent population-based Western Australian Pregnancy (Raine) Cohort... 
Ganciclovir and the treatment of Epstein-Barr virus hepatitisLeon A Adams
Department of Gastroenterology and Hepatology, Sir Charles Gardiner Hospital, Nedlands, WA, Australia
J Gastroenterol Hepatol 21:1758-60. 2006..Herein, the successful use of ganciclovir in two immunocompetent patients with severe EBV hepatitis is reported...- NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: an eleven-year follow-up studyLeon A Adams
School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA, Australia
Am J Gastroenterol 104:861-7. 2009..We sought to determine whether NAFLD with elevated aminotransaminase (ALT) levels was a risk factor for incident diabetes or the metabolic syndrome (MS) over an 11-year period... - Biomarkers of liver fibrosisLeon A Adams
School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA 6009, Australia
J Gastroenterol Hepatol 26:802-9. 2011..Novel proteins identified by proteomic technology and genetic polymorphisms from genome association studies offer the possibility for further refinement and individualization of biomarker fibrosis models in the future... - Nonalcoholic fatty liver disease and diabetes mellitus: pathogenesis and treatmentBriohny W Smith
School of Medicine and Pharmacology, Sir Charles Gairdner Hospital Unit, University of Western Australia, Nedlands, WA 6009, Australia
Nat Rev Endocrinol 7:456-65. 2011.... - Complex non-invasive fibrosis models are more accurate than simple models in non-alcoholic fatty liver diseaseLeon A Adams
School of Medicine and Pharmacology, The University of Western Australia, Western Australia, Australia
J Gastroenterol Hepatol 26:1536-43. 2011..We therefore compared the accuracy of simple bedside versus complex fibrosis models across a range of fibrosis in a multi-centre NAFLD cohort... - Body mass index is a stronger predictor of alanine aminotransaminase levels than alcohol consumptionLeon A Adams
School of Medicine and Pharmacology, Fremantle Hospital Campus, The University of Western Australia, Fremantle, Australia
J Gastroenterol Hepatol 23:1089-93. 2008..The relative effects of obesity compared to alcohol on liver injury are uncertain. We examined their effects on alanine aminotransferase (ALT) and gamma glutamyltransferase (GGT) levels in a population-based cohort... - Hepascore: an accurate validated predictor of liver fibrosis in chronic hepatitis C infectionLeon A Adams
Department of Gastroenterology and Hepatology, Sir Charles Gairdner Hospital, Perth, Australia
Clin Chem 51:1867-73. 2005..5 had 74% specificity and 88% sensitivity for advanced fibrosis. CONCLUSIONS: A model of 4 serum markers plus age and sex provides clinically useful information regarding different fibrosis stages among hepatitis C patients... - Gender-specific differences in adipose distribution and adipocytokines influence adolescent nonalcoholic fatty liver diseaseOyekoya T Ayonrinde
School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
Hepatology 53:800-9. 2011..The male phenotype of NAFLD is associated with more adverse metabolic features and greater visceral adiposity than the female phenotype despite the lower prevalence of NAFLD... - Supplementation with n3 fatty acid ethyl esters increases large and small artery elasticity in obese adults on a weight loss dietAnnette T Y Wong
School of Medicine and Pharmacology, Computing and Mathematics, University of Western Australia, Perth, Western Australia, Australia
J Nutr 143:437-41. 2013..Supplementation with n3 FAEEs improves C1 and C2 independently of weight loss in obese adults... - Nonalcoholic steatohepatitis: risk factors and diagnosisLeon A Adams
School of Medicine and Pharmacology, University of Western Australia, Sir Charles Gairdner Hospital Unit, Nedlands, WA 6009, Australia
Expert Rev Gastroenterol Hepatol 4:623-35. 2010..Routine liver aminotransaminase levels are not reliable; however, novel plasma hepatocyte apoptosis markers, either alone or in combination with clinical risk factors, are potential noninvasive diagnostic tools for the future... 
Nonalcoholic fatty liver disease increases risk of death among patients with diabetes: a community-based cohort studyLeon A Adams
School of Medicine and Pharmacology, The University of Western Australia, Perth, Western Australia, Australia
Am J Gastroenterol 105:1567-73. 2010..We sought to determine whether a diagnosis of NAFLD influenced mortality among a community-based cohort of patients with type II diabetes mellitus...- Decreased IP-10 and elevated TGFbeta1 levels are associated with viral clearance following therapy in patients with hepatitis C virusSilvia Lee
Department of Microbiology and Infectious Disease, Royal Perth Hospital, University of Western Australia, Perth, Australia
Dis Markers 28:273-80. 2010..003 relative to Hepascore). Whilst this was only marginally more effective than predictions based on HCV genotype age and sex (p=0.07), it associates high TGFbeta1 and low IP-10 levels with a failure of therapy... - The Western dietary pattern is prospectively associated with nonalcoholic Fatty liver disease in adolescenceWendy H Oddy
Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
Am J Gastroenterol 108:778-85. 2013..We examined prospective associations between dietary patterns and NAFLD in a population-based cohort of adolescents... - Non-invasive diagnosis of nonalcoholic fatty liver and nonalcoholic steatohepatitisLeon A Adams
School of Medicine and Pharmacology, University of Western Australia, Sir Charles Gairdner Hospital Unit, Nedlands, Western Australia, Australia
J Dig Dis 12:10-6. 2011..This review provides a concise overview of the role non-invasive diagnostic tools for the differentiation of fatty liver from NASH as well as for the determination of presence and extent of fibrosis... - DNA methylation of the IGF2/H19 imprinting control region and adiposity distribution in young adultsRae Chi Huang
School of Medicine and Pharmacology, University of Western Australia UWA, Perth, WA, Australia
Clin Epigenetics 4:21. 2012..abstract:.. - Role of liver biopsy and serum markers of liver fibrosis in non-alcoholic fatty liver diseaseLeon A Adams
School of Medicine and Pharmacology, The University of Western Australia, Liver Transplant Unit, Sir Charles Gairdner Hospital, Nedlands, Australia
Clin Liver Dis 11:25-35, viii. 2007.... - Diagnostic performance of a rapid magnetic resonance imaging method of measuring hepatic steatosisMichael J House
School of Physics, The University of Western Australia, Crawley, Australia
PLoS ONE 8:e59287. 2013..The aim of this study was to test the ability of a rapid, routinely available, magnetic resonance imaging (MRI) method to diagnose clinically relevant grades of hepatic steatosis in a cohort of patients with diverse liver diseases... - Genetic determinants of hepatic steatosis in manAmanda J Hooper
Department of Core Clinical Pathology and Biochemistry, Royal Perth Hospital, Perth, Australia
J Lipid Res 52:593-617. 2011..Identifying the genetic determinants of hepatic steatosis will lead to a better understanding of the pathogenesis and progression of NAFLD... - The trials and tribulations of the treatment of nonalcoholic fatty-liver diseaseSeng Khee Gan
Metabolic Research Centre, School of Medicine and Pharmacology, Royal Perth Hospital Unit, Australia, University of Western Australia, Perth, Australia
Curr Opin Lipidol 19:592-9. 2008..To review published clinical trials, with a focus on those of randomized design, of the management of nonalcoholic fatty-liver disease (NAFLD), an increasing complication of the obesity epidemic... - Non-alcoholic fatty liver diseaseBriohny W Smith
School of Medicine and Pharmacology, Sir Charles Gairdner Hospital Unit, University of Western Australia, Nedlands, Australia
Crit Rev Clin Lab Sci 48:97-113. 2011.... - Screening for HFE and iron overloadJohn Ombiga
Department of Gastroenterology, Fremantle Hospital, Fremantle, Western Australia, Australia
Semin Liver Dis 25:402-10. 2005..Potential ethical, legal, and psychosocial issues arising through application of genetic screening programs also must be resolved prior to implementation of general population screening programs... - Nonalcoholic fatty liver diseaseLeon A Adams
School of Medicine and Pharmacology, The University of Western Australia, Fremantle Hospital Campus, Australia
Ann Epidemiol 17:863-9. 2007..Management is further complicated by the inability to predict which patients will develop liver-related morbidity and thus benefit from treatment... - Bevacizumab reverses need for liver transplantation in hereditary hemorrhagic telangiectasiaAndrew Mitchell
Western Australian Liver Transplant Service, Sir Charles Gairdner Hospital, Nedlands, Australia
Liver Transpl 14:210-3. 2008..Bevacizumab may potentially alleviate the need for liver transplantation in this group of patients... - Nonalcoholic fatty liver disease and diabetes mellitusLeon A Adams
School of Medicine, The University of Western Australia, Sir Charles Gairdner Hospital, Perth, Australia
Endocr Res 32:59-69. 2007 - Diagnostic evaluation of nonalcoholic fatty liver diseaseLeon A Adams
Division of Gastroenterology and Hepatology, Mayo Clinic and College of Medicine, Rochester, MN 55905, USA
J Clin Gastroenterol 40:S34-8. 2006..Clinical features, particularly diabetes, obesity, and older age, can aid in stratifying patients at risk for advanced fibrosis but are not sufficiently accurate to replace liver biopsy... - Nonalcoholic fatty liver disease among patients with hypothalamic and pituitary dysfunctionLeon A Adams
Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, Minnesota, USA
Hepatology 39:909-14. 2004..The novel evidence that hypothalamic/pituitary dysfunction may be accompanied by progressive NAFLD has important implications for the work-up and management of patients with hypothalamic/pituitary disease... - Treatment of hyperlipidemia in nonalcoholic fatty liver disease: fat for thoughtLeon A Adams
Indian J Gastroenterol 23:127-8. 2004 - A pilot trial of pentoxifylline in nonalcoholic steatohepatitisLeon A Adams
Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
Am J Gastroenterol 99:2365-8. 2004..62) or albumin (4.0 +/- 0.2 vs 4.2 +/- 0.3, p= 0.41). CONCLUSIONS: Aminotransferase levels among patients with NASH improve with administration of pentoxifylline. Strategies to overcome side effects will be needed for future trials... - Treatment of nonalcoholic steatohepatitis: antioxidants or insulin sensitizers?Leon A Adams
Clin Gastroenterol Hepatol 2:1059-60. 2004 - The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsiesLeon A Adams
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
J Hepatol 42:132-8. 2005..Changes of aminotransferases do not parallel changes in fibrosis stage. Diabetic patients with elevated BMI and low fibrosis stage are at risk for higher rates of fibrosis progression... - Nonalcoholic fatty liver diseaseLeon A Adams
Division of Gastroenterology and Hepatology, Mayo Clinic and College of Medicine, Rochester, Minn 55905, USA
CMAJ 172:899-905. 2005..In this article we discuss the etiology, pathogenesis and diagnosis of nonalcoholic fatty liver disease as well as approaches to its management... - The bulge, booze, and the liverLeon A Adams
Clin Gastroenterol Hepatol 3:1195-7. 2005 - Vitamins E and C for the treatment of NASH: duplication of results but lack of demonstration of efficacyLeon A Adams
Am J Gastroenterol 98:2348-50. 2003