David L Topping

Summary

Country: Australia

Publications

  1. ncbi request reprint Resistant starch as a prebiotic and synbiotic: state of the art
    David L Topping
    CSIRO Health Sciences and Nutrition, Adelaide, Australia
    Proc Nutr Soc 62:171-6. 2003
  2. pmc Resistant starches protect against colonic DNA damage and alter microbiota and gene expression in rats fed a Western diet
    Michael A Conlon
    CSIRO Preventative Health, Adelaide, South Australia, Australia
    J Nutr 142:832-40. 2012
  3. ncbi request reprint Consumption of foods by young children with diagnosed campylobacter infection - a pilot case-control study
    Scott Cameron
    Department of Human Health Services, South Australian Government, Adelaide, Australia
    Public Health Nutr 7:85-9. 2004
  4. ncbi request reprint Butyrylated starch increases large bowel butyrate levels and lowers colonic smooth muscle contractility in rats
    Balazs H Bajka
    CSIRO Preventative Health National Research Flagship, Food and Nutritional Sciences, Adelaide, South Australia 5000, Australia
    Nutr Res 30:427-34. 2010
  5. ncbi request reprint An arabinoxylan-rich fraction from wheat enhances caecal fermentation and protects colonocyte DNA against diet-induced damage in pigs
    Damien P Belobrajdic
    High Fibre Grains Cluster, CSIRO Food Futures National Research Flagship, Adelaide, SA 5000, Australia
    Br J Nutr 107:1274-82. 2012
  6. ncbi request reprint A novel high-amylose barley cultivar (Hordeum vulgare var. Himalaya 292) lowers plasma cholesterol and alters indices of large-bowel fermentation in pigs
    Anthony R Bird
    CSIRO Health Sciences and Nutrition, Adelaide, Australia
    Br J Nutr 92:607-15. 2004
  7. ncbi request reprint Two high-amylose maize starches with different amounts of resistant starch vary in their effects on fermentation, tissue and digesta mass accretion, and bacterial populations in the large bowel of pigs
    Anthony R Bird
    CSIRO Health Sciences and Nutrition, Adelaide, SA, Australia
    Br J Nutr 97:134-44. 2007
  8. ncbi request reprint Resistant starch prevents colonic DNA damage induced by high dietary cooked red meat or casein in rats
    Shusuke Toden
    CSIRO Human Nutrition, Kintore Avenue, Adelaide, Australia, CSIRO Food Futures National Research, Flagship, Australia
    Cancer Biol Ther 5:267-72. 2006
  9. ncbi request reprint Differential effects of dietary whey, casein and soya on colonic DNA damage and large bowel SCFA in rats fed diets low and high in resistant starch
    Shusuke Toden
    Food Futures National Research Flagship, CSIRO Human Nutrition, Adelaide, Australia
    Br J Nutr 97:535-43. 2007
  10. ncbi request reprint High red meat diets induce greater numbers of colonic DNA double-strand breaks than white meat in rats: attenuation by high-amylose maize starch
    Shusuke Toden
    Food Futures National Research Flagship, CSIRO Human Nutrition, Kintore Ave, Adelaide, South Australia 5000, Australia
    Carcinogenesis 28:2355-62. 2007

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Resistant starch as a prebiotic and synbiotic: state of the art
    David L Topping
    CSIRO Health Sciences and Nutrition, Adelaide, Australia
    Proc Nutr Soc 62:171-6. 2003
    ..More emphasis needs to be given to the investigation of the effects of complex carbohydrates, including RS, on the autochthonous microflora of the human large bowel...
  2. pmc Resistant starches protect against colonic DNA damage and alter microbiota and gene expression in rats fed a Western diet
    Michael A Conlon
    CSIRO Preventative Health, Adelaide, South Australia, Australia
    J Nutr 142:832-40. 2012
    ....
  3. ncbi request reprint Consumption of foods by young children with diagnosed campylobacter infection - a pilot case-control study
    Scott Cameron
    Department of Human Health Services, South Australian Government, Adelaide, Australia
    Public Health Nutr 7:85-9. 2004
    ..To determine whether parentally reported habitual intake of specific foods differed between children with diagnosed Campylobacter jejuni infection and children of a comparison group without diagnosed infection...
  4. ncbi request reprint Butyrylated starch increases large bowel butyrate levels and lowers colonic smooth muscle contractility in rats
    Balazs H Bajka
    CSIRO Preventative Health National Research Flagship, Food and Nutritional Sciences, Adelaide, South Australia 5000, Australia
    Nutr Res 30:427-34. 2010
    ..These results demonstrated that elevation of butyrate levels in the large bowel of the rat correlated with reduction of contractile activity of the colonic musculature, which may assist in the reabsorption of water and minerals...
  5. ncbi request reprint An arabinoxylan-rich fraction from wheat enhances caecal fermentation and protects colonocyte DNA against diet-induced damage in pigs
    Damien P Belobrajdic
    High Fibre Grains Cluster, CSIRO Food Futures National Research Flagship, Adelaide, SA 5000, Australia
    Br J Nutr 107:1274-82. 2012
    ..Further studies to determine the relationships between these changes and the lowering of colonocyte DNA damage are warranted...
  6. ncbi request reprint A novel high-amylose barley cultivar (Hordeum vulgare var. Himalaya 292) lowers plasma cholesterol and alters indices of large-bowel fermentation in pigs
    Anthony R Bird
    CSIRO Health Sciences and Nutrition, Adelaide, Australia
    Br J Nutr 92:607-15. 2004
    ..These data support the potential of this novel barley cultivar to improve health through plasma cholesterol reduction and increased large-bowel SCFA production...
  7. ncbi request reprint Two high-amylose maize starches with different amounts of resistant starch vary in their effects on fermentation, tissue and digesta mass accretion, and bacterial populations in the large bowel of pigs
    Anthony R Bird
    CSIRO Health Sciences and Nutrition, Adelaide, SA, Australia
    Br J Nutr 97:134-44. 2007
    ..Although both high-amylose starches promoted fermentation throughout the large bowel, the data suggest that the effects of HTHAMS may be more pronounced in the distal region compared to those of HAMS...
  8. ncbi request reprint Resistant starch prevents colonic DNA damage induced by high dietary cooked red meat or casein in rats
    Shusuke Toden
    CSIRO Human Nutrition, Kintore Avenue, Adelaide, Australia, CSIRO Food Futures National Research, Flagship, Australia
    Cancer Biol Ther 5:267-72. 2006
    ....
  9. ncbi request reprint Differential effects of dietary whey, casein and soya on colonic DNA damage and large bowel SCFA in rats fed diets low and high in resistant starch
    Shusuke Toden
    Food Futures National Research Flagship, CSIRO Human Nutrition, Adelaide, Australia
    Br J Nutr 97:535-43. 2007
    ..The data show also that these changes were reversed by RS...
  10. ncbi request reprint High red meat diets induce greater numbers of colonic DNA double-strand breaks than white meat in rats: attenuation by high-amylose maize starch
    Shusuke Toden
    Food Futures National Research Flagship, CSIRO Human Nutrition, Kintore Ave, Adelaide, South Australia 5000, Australia
    Carcinogenesis 28:2355-62. 2007
    ..Dietary RS protects against this damage and also against loss of the mucus barrier, probably through increased butyrate production...
  11. ncbi request reprint Wholegrain foods made from a novel high-amylose barley variety (Himalaya 292) improve indices of bowel health in human subjects
    Anthony R Bird
    CSIRO Human Nutrition, Adelaide, Australia
    Br J Nutr 99:1032-40. 2008
    ....
  12. doi request reprint Comparative effects of a high-amylose starch and a fructooligosaccharide on fecal bifidobacteria numbers and short-chain fatty acids in pigs fed Bifidobacterium animalis
    Anthony R Bird
    Co operative Research Centre for Food Industry Innovation, CSIRO Human Nutrition, Kintore Avenue, P O Box 10041, Adelaide, SA 5000, Australia
    Dig Dis Sci 54:947-54. 2009
    ..The data confirm that both HAMS and FOS are prebiotics and suggest that they act through different mechanisms and that they are most effective in combination. However only HAMS raises fecal SCFA...
  13. doi request reprint Colonocyte telomere shortening is greater with dietary red meat than white meat and is attenuated by resistant starch
    Nathan J O'Callaghan
    Nutritional Genomics and DNA Damage Research Group, CSIRO Food and Nutritional Sciences, Kintore Avenue, PO Box 10041, Adelaide, SA 5000, Australia
    Clin Nutr 31:60-4. 2012
    ..The current study aimed to determine the effects of cooked red and white meat intake on colonocyte telomere length in rats and whether dietary RS modified their effects...
  14. doi request reprint Butyrylated starch protects colonocyte DNA against dietary protein-induced damage in rats
    Balazs H Bajka
    Preventative Health National Research Flagship, Adelaide, South Australia
    Carcinogenesis 29:2169-74. 2008
    ..Delivery of butyrate to the large bowel by HAMSB could reduce colorectal cancer risk by preventing diet-induced colonocyte genetic damage...
  15. doi request reprint Effects of dietary beef and chicken with and without high amylose maize starch on blood malondialdehyde, interleukins, IGF-I, insulin, leptin, MMP-2, and TIMP-2 concentrations in rats
    Shusuke Toden
    Food Futures National Research Flagship, Australia, CSIRO Food and Nutritional Sciences, Adelaide, SA 5000 Australia
    Nutr Cancer 62:454-65. 2010
    ..These results suggest diets high in meat or RS could influence cancer initiation or progression by changes in circulating levels of hormones and other factors...
  16. ncbi request reprint Interactive effects of dietary resistant starch and fish oil on short-chain fatty acid production and agonist-induced contractility in ileum of young rats
    Glen S Patten
    CSIRO Health Sciences and Nutrition, Kintore Avenue, Adelaide, South Australia 5000, Australia
    Dig Dis Sci 51:254-61. 2006
    ..Although little interactive effects were demonstrated, these data suggest developmental changes in ileal receptor systems with independent effects of RS and fish oil on some bowel properties in juvenile rats...
  17. ncbi request reprint Dose-dependent reduction of dietary protein-induced colonocyte DNA damage by resistant starch in rats correlates more highly with caecal butyrate than with other short chain fatty acids
    Shusuke Toden
    CSIRO Human Nutrition and CSIRO Food Futures National Research Flagship, Adelaide, SA 5000, Australia
    Cancer Biol Ther 6:253-8. 2007
    ..These data show that HAMS prevents protein-induced colonic DNA damage in a dose-dependent manner. Inclusion of 10% HAMS was found to be sufficient to oppose colonocyte DNA damage, and to increase caecal and fecal SCFA pools...
  18. ncbi request reprint Resistant starch attenuates colonic DNA damage induced by higher dietary protein in rats
    Shusuke Toden
    CSIRO Health Sciences and Nutrition, Kintore Avenue, Adelaide, SA 5000, Australia
    Nutr Cancer 51:45-51. 2005
    ..In humans, this could translate to altered risk of colonic cancer...
  19. doi request reprint Butyrate esterified to starch is released in the human gastrointestinal tract
    Julie M Clarke
    Preventative Health National Research Flagship, Commonwealth Scientific and Industrial Research Organisation, Food and Nutritional Sciences, Adelaide, South Australia, Australia
    Am J Clin Nutr 94:1276-83. 2011
    ..A study with ileostomists showed that starches acylated with specific SCFAs largely survive passage through the small intestine, but the percentage released in the colon has not been established...
  20. doi request reprint Fecal butyrate levels vary widely among individuals but are usually increased by a diet high in resistant starch
    Alexandra L McOrist
    Commonwealth Scientific and Industrial Research Organisation Preventative Health National Research Flagship, Adelaide, SA 5000, Australia
    J Nutr 141:883-9. 2011
    ..76; P < 0.001). In conclusion, fecal butyrate levels vary widely among individuals but consuming a diet high in RS usually increases levels and may help maintain colorectal health...
  21. pmc Butyrate delivered by butyrylated starch increases distal colonic epithelial apoptosis in carcinogen-treated rats
    Julie M Clarke
    Preventative Health National Research Flagship, Commonwealth Scientific and Industrial Research Organisation CSIRO Food and Nutritional Sciences, PO Box 10041, Adelaide BC, Adelaide, South Australia 5000, Australia
    Carcinogenesis 33:197-202. 2012
    ..We propose this pro-apoptotic function of butyrate plays a major role reducing tumour formation in the AOM-treated rat and that these data support a potential protective role of butyrate in CRC...
  22. ncbi request reprint A novel barley cultivar (Himalaya 292) with a specific gene mutation in starch synthase IIa raises large bowel starch and short-chain fatty acids in rats
    Anthony R Bird
    CSIRO Health Sciences and Nutrition, Adelaide 5000, Australia
    J Nutr 134:831-5. 2004
    ....
  23. ncbi request reprint Excretion of starch and esterified short-chain fatty acids by ileostomy subjects after the ingestion of acylated starches
    Julie M Clarke
    Preventative Health Flagship, Commonwealth Scientific and Industrial Research Organisation Human Nutrition a Centre of Food Science Australia, Adelaide, South Australia, Australia
    Am J Clin Nutr 86:1146-51. 2007
    ..The ability of acylated starches to deliver SCFAs to the large bowel has been shown in animal studies but has not been established in humans...
  24. ncbi request reprint Restoration of depressed prostanoid-induced ileal contraction in spontaneously hypertensive rats by dietary fish oil
    Glen S Patten
    CSIRO Health Sciences and Nutrition, Adelaide, South Australia 5000, Australia
    Lipids 40:69-79. 2005
    ....
  25. pmc Effects of high-amylose maize starch and butyrylated high-amylose maize starch on azoxymethane-induced intestinal cancer in rats
    Julie M Clarke
    Preventative Health National Research Flagship, CSIRO Human Nutrition, PO Box 10041, Adelaide BC 5000, South Australia
    Carcinogenesis 29:2190-4. 2008
    ..Interventional strategies designed to maximize luminal butyrate may be of protective benefit in humans...
  26. ncbi request reprint A review of the potential mechanisms for the lowering of colorectal oncogenesis by butyrate
    Kim Y C Fung
    CSIRO Preventative Health National Research Flagship, Adelaide, SA 5000, Australia
    Br J Nutr 108:820-31. 2012
    ..This discussion may help to inform the development of strategies to lower CRC risk at the individual and population levels...
  27. ncbi request reprint Effects of convenience rice congee supplemented diets on guinea pig whole animal and gut growth, caecal digesta SCFA and in vitro ileal contractility
    Glen S Patten
    CSIRO Health Sciences and Nutrition, Kintore Ave, Adelaide, PO Box 10041 Adelaide BC 5000, South Australia, Australia
    Asia Pac J Clin Nutr 13:92-100. 2004
    ....
  28. pmc Colorectal carcinogenesis: a cellular response to sustained risk environment
    Kim Y C Fung
    CSIRO Preventative Health National Research Flagship, P O Box 10041, Adelaide, SA 5001, Australia
    Int J Mol Sci 14:13525-41. 2013
    ..Evidence is drawn from in vivo and in vitro genomic and biochemical studies to frame experiments to test this proposition. ..
  29. ncbi request reprint Processing of novel elevated amylose wheats: functional properties and starch digestibility of extruded products
    Helene Chanvrier
    Commonwealth Scientific and Industrial Research Organization, Food Futures National Research Flagship, P O Box 93, North Ryde, NSW 1670, Australia
    J Agric Food Chem 55:10248-57. 2007
    ..These results are discussed in terms of starch molecular architecture and product microstructure...
  30. ncbi request reprint Acetylated, propionylated or butyrylated starches raise large bowel short-chain fatty acids preferentially when fed to rats
    Geoffrey Annison
    CSIRO Health Sciences and Nutrition, Adelaide 5000 Australia
    J Nutr 133:3523-8. 2003
    ..These data indicate that acylated starches are resistant starch (RS) and raise large bowel SCFA, apparently through bacterial release of the esterified fatty acid and fermentation of the residual starch...
  31. ncbi request reprint Potato pulps lowered the serum cholesterol and triglyceride levels in rats
    Naoto Hashimoto
    Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    J Nutr Sci Vitaminol (Tokyo) 52:445-50. 2006
    ..On the other hand, HK pulp inhibited the synthesis of fatty acids at the mRNA levels of FAS and SREBP-1c, which might lead to a reduction of the serum TG level...
  32. ncbi request reprint Butyrylated starch is less susceptible to enzymic hydrolysis and increases large-bowel butyrate more than high-amylose maize starch in the rat
    Balazs H Bajka
    CSIRO Human Nutrition, Adelaide BC 5000, Australia
    Br J Nutr 96:276-82. 2006
    ..Preparation of carbohydrates to simulate human food in animal experiments may be important to assess nutritional and physiological effects accurately...