Quan Zhao

Summary

Affiliation: The Walter and Eliza Hall Institute of Medical Research
Country: Australia

Publications

  1. doi PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing
    Quan Zhao
    Rotary Bone Marrow Research Laboratories, Melbourne Health Research Directorate, Grattan Street, Parkville, VIC 3050, Australia
    Nat Struct Mol Biol 16:304-11. 2009
  2. pmc Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression
    Gerhard Rank
    Rotary Bone Marrow Research Laboratories, Melbourne Health Research Directorate, Parkville, Australia
    Blood 116:1585-92. 2010
  3. pmc Repression of human gamma-globin gene expression by a short isoform of the NF-E4 protein is associated with loss of NF-E2 and RNA polymerase II recruitment to the promoter
    Quan Zhao
    Rotary Bone Marrow Research Laboratory, Royal Melbourne Hospital Research Foundation, Parkville, Australia
    Blood 107:2138-45. 2006
  4. ncbi Site-specific acetylation of the fetal globin activator NF-E4 prevents its ubiquitination and regulates its interaction with the histone deacetylase, HDAC1
    Quan Zhao
    Rotary Bone Marrow Research Laboratory, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    J Biol Chem 279:41477-86. 2004
  5. pmc Epidermal wound repair is regulated by the planar cell polarity signaling pathway
    Jacinta Caddy
    Rotary Bone Marrow Research Laboratories, Parkville, Victoria 3050, Australia
    Dev Cell 19:138-47. 2010

Collaborators

Detail Information

Publications5

  1. doi PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing
    Quan Zhao
    Rotary Bone Marrow Research Laboratories, Melbourne Health Research Directorate, Grattan Street, Parkville, VIC 3050, Australia
    Nat Struct Mol Biol 16:304-11. 2009
    ..Our findings define DNMT3A as both a reader and a writer of repressive epigenetic marks, thereby directly linking histone and DNA methylation in gene silencing...
  2. pmc Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression
    Gerhard Rank
    Rotary Bone Marrow Research Laboratories, Melbourne Health Research Directorate, Parkville, Australia
    Blood 116:1585-92. 2010
    ..These studies define coordinated epigenetic events linked to fetal globin gene silencing, and provide potential therapeutic targets for the treatment of beta-thalassemia and SCD...
  3. pmc Repression of human gamma-globin gene expression by a short isoform of the NF-E4 protein is associated with loss of NF-E2 and RNA polymerase II recruitment to the promoter
    Quan Zhao
    Rotary Bone Marrow Research Laboratory, Royal Melbourne Hospital Research Foundation, Parkville, Australia
    Blood 107:2138-45. 2006
    ..These findings provide one potential mechanism that could contribute to the autonomous silencing of the human gamma-genes in adult erythroid cells...
  4. ncbi Site-specific acetylation of the fetal globin activator NF-E4 prevents its ubiquitination and regulates its interaction with the histone deacetylase, HDAC1
    Quan Zhao
    Rotary Bone Marrow Research Laboratory, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    J Biol Chem 279:41477-86. 2004
    ..These results provide further demonstration that co-activators, such as PCAF, can influence individual transcription factor properties at multiple levels to alter their effects on gene expression...
  5. pmc Epidermal wound repair is regulated by the planar cell polarity signaling pathway
    Jacinta Caddy
    Rotary Bone Marrow Research Laboratories, Parkville, Victoria 3050, Australia
    Dev Cell 19:138-47. 2010
    ..These results define a role for Grhl3 in PCP signaling and broadly implicate this pathway in epidermal repair...