Li Wu

Summary

Affiliation: The Walter and Eliza Hall Institute of Medical Research
Country: Australia

Publications

  1. ncbi Interferon-induced protein IFIT4 is associated with systemic lupus erythematosus and promotes differentiation of monocytes into dendritic cell-like cells
    Xiangyang Huang
    Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China
    Arthritis Res Ther 10:R91. 2008
  2. ncbi Development of thymic and splenic dendritic cell populations from different hemopoietic precursors
    L Wu
    Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Victoria, Australia
    Blood 98:3376-82. 2001
  3. ncbi Characterization of thymus-seeding precursor cells from mouse bone marrow
    S Mori
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
    Blood 98:696-704. 2001
  4. ncbi Derivation of dendritic cells from myeloid and lymphoid precursors
    L Wu
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Int Rev Immunol 20:117-35. 2001
  5. ncbi Heterogeneity of thymic dendritic cells
    Li Wu
    The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville, VIC 3050, Australia
    Semin Immunol 17:304-12. 2005
  6. ncbi Development of dendritic-cell lineages
    Li Wu
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Immunity 26:741-50. 2007
  7. ncbi T lineage progenitors: the earliest steps en route to T lymphocytes
    Li Wu
    The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville, Victoria, 3050, Australia
    Curr Opin Immunol 18:121-6. 2006
  8. ncbi RelB is essential for the development of myeloid-related CD8alpha- dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells
    L Wu
    The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia
    Immunity 9:839-47. 1998
  9. ncbi Development of dendritic cell system
    Li Wu
    The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville, Victoria 3050, Australia
    Cell Mol Immunol 1:112-8. 2004
  10. ncbi Cutting edge: generation of splenic CD8+ and CD8- dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures
    Shalin H Naik
    Immunology Division and the Cooperative Research Centre for Vaccine Technology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    J Immunol 174:6592-7. 2005

Detail Information

Publications85

  1. ncbi Interferon-induced protein IFIT4 is associated with systemic lupus erythematosus and promotes differentiation of monocytes into dendritic cell-like cells
    Xiangyang Huang
    Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China
    Arthritis Res Ther 10:R91. 2008
    ..Among these IFN-inducible genes, IFN-induced protein with tetratricopeptide repeats 4 (IFIT4) is a novel gene whose function is unknown...
  2. ncbi Development of thymic and splenic dendritic cell populations from different hemopoietic precursors
    L Wu
    Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Victoria, Australia
    Blood 98:3376-82. 2001
    ..Overall, this study shows that the expression of CD8alpha does not delineate the hemopoietic precursor origin of DCs, and the nature of the early precursors may bias but does not dictate the phenotype of the DC product...
  3. ncbi Characterization of thymus-seeding precursor cells from mouse bone marrow
    S Mori
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
    Blood 98:696-704. 2001
    ..Blood. 2001;98:696-704)..
  4. ncbi Derivation of dendritic cells from myeloid and lymphoid precursors
    L Wu
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Int Rev Immunol 20:117-35. 2001
    ....
  5. ncbi Heterogeneity of thymic dendritic cells
    Li Wu
    The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville, VIC 3050, Australia
    Semin Immunol 17:304-12. 2005
    ..Thymic pDC can produce type-I interferon upon appropriate activation. However, their role in a steady state thymus is currently unclear...
  6. ncbi Development of dendritic-cell lineages
    Li Wu
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Immunity 26:741-50. 2007
    ..The development of different populations of DCs is differentially regulated by various transcription factors and cytokines. This review summarizes the recent advances made in the field of DC development...
  7. ncbi T lineage progenitors: the earliest steps en route to T lymphocytes
    Li Wu
    The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville, Victoria, 3050, Australia
    Curr Opin Immunol 18:121-6. 2006
    ..The essential role of Notch-1 signalling in intrathymic T lineage commitment and subsequent T cell development has been clearly documented...
  8. ncbi RelB is essential for the development of myeloid-related CD8alpha- dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells
    L Wu
    The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia
    Immunity 9:839-47. 1998
    ..However, the deficiency in splenic CD8alpha- DEC-205- DC is a direct, stem cell intrinsic effect of the RelB mutation. Thus, RelB selectively regulates a myeloid-related DC lineage...
  9. ncbi Development of dendritic cell system
    Li Wu
    The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville, Victoria 3050, Australia
    Cell Mol Immunol 1:112-8. 2004
    ..These findings suggest an early developmental flexibility of precursors for DCs and pDCs. This review summarizes some recent observations on the development of DC system in both human and mouse...
  10. ncbi Cutting edge: generation of splenic CD8+ and CD8- dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures
    Shalin H Naik
    Immunology Division and the Cooperative Research Centre for Vaccine Technology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    J Immunol 174:6592-7. 2005
    ..This culture system allows access to bona fide counterparts of the splenic DC subsets...
  11. ncbi Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance
    Francois Xavier Hubert
    Immunology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Blood 118:2462-72. 2011
    ..It also indicates that mTECs can mediate tolerance by direct presentation of Aire-regulated antigens to both CD4 and CD8 T cells...
  12. ncbi Development of the dendritic cell system during mouse ontogeny
    Aleksandar Dakic
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Immunol 172:1018-27. 2004
    ..These results suggest that the neonatal DC system is not fully developed, and innate immunity is the dominant form of response. The complete DC system required for adaptive immunity in the mouse is not fully developed until 5 wk of age...
  13. ncbi Resident and monocyte-derived dendritic cells become dominant IL-12 producers under different conditions and signaling pathways
    Yifan Zhan
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 185:2125-33. 2010
    ..In contrast, for mDC, IL-12 production was mainly dependent on MyD88 signaling. Thus, conventional DCs and mDCs use different pathways to regulate IL-12 production...
  14. ncbi PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis
    Aleksandar Dakic
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    J Exp Med 201:1487-502. 2005
    ..These findings emphasize the distinct nature of adult hematopoiesis and reveal that PU.1 regulates the specification of the multipotent lymphoid and myeloid compartments and restrains, rather than promotes, granulopoiesis...
  15. ncbi The lymphoid past of mouse plasmacytoid cells and thymic dendritic cells
    Lynn Corcoran
    The Walter and Eliza Hall Institute, Melbourne, Australia
    J Immunol 170:4926-32. 2003
    ..Therefore, many plasmacytoid pre-DC and thymic CD8(+) DC have shared early steps of development with the lymphoid lineages, and differ in origin from conventional peripheral DC...
  16. ncbi Dendritic cells in the thymus contribute to T-regulatory cell induction
    Anna I Proietto
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 105:19869-74. 2008
    ..Finally, using a thymic transplantation system, we demonstrate that the DCs in the periphery can migrate into the thymus, where they efficiently induce T(R) generation and negative selection...
  17. ncbi Convergent differentiation: myeloid and lymphoid pathways to murine plasmacytoid dendritic cells
    Priyanka Sathe
    The Walter and Eliza Hall Institute, Parkville, Australia
    Blood 121:11-9. 2013
    ..However, in these cultures, some pDCs of CMP origin showed evidence of past RAG1 expression and had D-J IgH gene rearrangements; most of these derived from a subset of CMPs already expressing RAG1...
  18. ncbi Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes
    Shalin H Naik
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Vaccine Technology, Parkville, Victoria 3050, Australia
    Nat Immunol 7:663-71. 2006
    ..Thus, the inflammatory status of the host influences the developmental origin and type of DC present in lymphoid tissues...
  19. ncbi Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia
    Donald Metcalf
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Victoria, Australia
    Proc Natl Acad Sci U S A 103:1486-91. 2006
    ..Acquisition of autocrine growth-factor production and autonomous growth appeared to be major events in the transformation of conditionally deleted PU.1(-/-) cells to fully developed myeloid leukemic populations...
  20. ncbi The transcription factor PU.1 controls dendritic cell development and Flt3 cytokine receptor expression in a dose-dependent manner
    Sebastian Carotta
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Immunity 32:628-41. 2010
    ..1 as a critical regulator of both conventional and plasmacytoid DC development and provide one mechanism how altered PU.1 concentration can have profound functional consequences for hematopoietic cell development...
  21. ncbi Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo
    Shalin H Naik
    The Walter and Eliza Hall Institute, Parkville, Victoria 3050, Australia
    Nat Immunol 8:1217-26. 2007
    ..Thus, commitment to particular DC subtypes begins mainly at this pro-DC stage...
  22. ncbi Distinct functional capacities of mouse thymic and splenic dendritic cell populations
    Anna I Proietto
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Immunol Cell Biol 86:700-8. 2008
    ..These results indicate that the microenvironment is an important factor that contributes to the functional specification of DC subsets in different lymphoid tissues...
  23. ncbi The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement
    Irina Caminschi
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Blood 112:3264-73. 2008
    ..Furthermore, targeting Ags to DCs with antibodies to Clec9A is a promising strategy to enhance the efficiency of vaccines, even in the absence of adjuvants...
  24. ncbi Hemopoietic precursors and development of dendritic cell populations
    Aleksandar Dakic
    The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville, Vic. 3050, Australia
    Leuk Lymphoma 44:1469-75. 2003
    ..The downstream points where the DC sub-lineages branch off from the conventional myeloid and lymphoid precursors, and the cytokines and environmental factors required for inducing their specialised functions are yet to be determined...
  25. ncbi Regeneration of dendritic cells in aged mice
    Serani L H van Dommelen
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
    Cell Mol Immunol 7:108-15. 2010
    ....
  26. ncbi DEC-205 as a marker of dendritic cells with regulatory effects on CD8 T cell responses
    V Kronin
    The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
    Int Immunol 12:731-5. 2000
    ..In conclusion, high expression of DEC-205 appears to be a good marker of the lymphoid-related regulatory type of DC, but DEC-205 itself is not responsible for transmitting negative signals to the T cells...
  27. ncbi The development of functional B lymphocytes in conditional PU.1 knock-out mice
    Matthew Polli
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, Australia 3050
    Blood 106:2083-90. 2005
    ..These findings suggest that PU.1 is not essential for the development of functional B lymphocytes beyond the pre-B stage...
  28. ncbi The acquisition of antigen cross-presentation function by newly formed dendritic cells
    Priyanka Sathe
    Walter and Eliza Hall Institute, Parkville, Victoria 3052, Australia
    J Immunol 186:5184-92. 2011
    ..These results explain the considerable variability in CD103 expression by CD8(+) DCs as well as the findings that not all DCs of this lineage are capable of cross-presentation...
  29. ncbi Enforced expression of the homeobox gene Mixl1 impairs hematopoietic differentiation and results in acute myeloid leukemia
    Stefan Glaser
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 103:16460-5. 2006
    ..These observations establish a link between enforced Mixl1 expression and leukemogenesis in the mouse...
  30. ncbi A specific anti-Aire antibody reveals aire expression is restricted to medullary thymic epithelial cells and not expressed in periphery
    Francois Xavier Hubert
    Division of Molecular and Medicine, Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville, Victoria, Australia
    J Immunol 180:3824-32. 2008
    ..At a cellular level, Aire was expressed in perinuclear speckles within the nucleus. This report provides the first detailed analysis of Aire protein expression, highlighting the precise location at both the tissue and cellular level...
  31. ncbi Cell-autonomous defects in dendritic cell populations of Ikaros mutant mice point to a developmental relationship with the lymphoid lineage
    L Wu
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Immunity 7:483-92. 1997
    ..The complete lack of DCs in the lymphoid organs of Ikaros DN-/- micke points to an essential role for the Ikaros gene family in the development of all DCs...
  32. ncbi Development of dendritic cells in culture from human and murine thymic precursor cells
    K A Kelly
    The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia
    Cell Mol Biol (Noisy-le-grand) 47:43-54. 2001
    ..Thus, although apparently lymphoid-restricted, the human thymic DC precursors responded to the myeloid factor GM-CSF as well as to the cytokines selective for murine lymphoid-related DC...
  33. ncbi Human dendritic cell subsets from spleen and blood are similar in phenotype and function but modified by donor health status
    Diana Mittag
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    J Immunol 186:6207-17. 2011
    ..In particular, the hallmark functions of mouse CD8α(+) DC subsets, that is, IL-12p70 secretion and cross-presentation, are not confined to the equivalent human CD141(+) DC but are shared by CD1b/c(+) and CD16(+) DC subsets...
  34. ncbi Transient Notch signaling induces NK cell potential in Pax5-deficient pro-B cells
    Sebastian Carotta
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Eur J Immunol 36:3294-304. 2006
    ..These data indicate that Notch signaling induces T/NK cell differentiation in Pax5(-/-) pro-B cells that is strikingly similar to early thymopoiesis...
  35. ncbi Signal regulatory protein molecules are differentially expressed by CD8- dendritic cells
    Mireille H Lahoud
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Immunol 177:372-82. 2006
    ..Thus, we postulate that the differential expression of these molecules may confer the ability to regulate the phagocytosis of particular ligands to CD8(-) cDC...
  36. ncbi Selective suicide of cross-presenting CD8+ dendritic cells by cytochrome c injection shows functional heterogeneity within this subset
    Ming Lee Lin
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville VIC 3050, Australia
    Proc Natl Acad Sci U S A 105:3029-34. 2008
    ..Our model opens an avenue to specifically target cross-presenting DCs in vivo for manipulating cytotoxic T lymphocyte responses toward infections, tumors, and transplants...
  37. ncbi The C-type lectin Clec12A present on mouse and human dendritic cells can serve as a target for antigen delivery and enhancement of antibody responses
    Mireille H Lahoud
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 182:7587-94. 2009
    ..The potent Ab responses induced using microgram amounts of anti-Clec12A and minimal amounts of adjuvant demonstrate that this molecule can be used as an Ag-delivery target to enhance Ab responses to vaccines...
  38. ncbi CD8alpha+ mouse spleen dendritic cells do not originate from the CD8alpha- dendritic cell subset
    Shalin Naik
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Blood 102:601-4. 2003
    ..Most of the immediate precursors of CD8alpha+ DCs are cells that lack the phenotype of a recognizable DC. CD8alpha- DCs and CD8alpha+ DCs are not precursor-product related, though these sublineages may be connected further upstream...
  39. ncbi Nonplasmacytoid, high IFN-α-producing, bone marrow dendritic cells
    Meredith O'Keeffe
    Centre for Immunology, Burnet Institute, Melbourne, Victoria 3004, Australia
    J Immunol 188:3774-83. 2012
    ..We propose that these DC constitute a novel bone marrow inflammatory DC type, ideally geared to linking innate and adaptive immune responses in bone marrow via their potent IFN-α production and high T cell stimulatory capacity...
  40. ncbi The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3
    Angela D'Amico
    The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville, Victoria 3050, Australia
    J Exp Med 198:293-303. 2003
    ..These findings demonstrate that the early precursors for all DC subtypes are within the BM Flt3+ precursor populations, regardless of their lymphoid or myeloid lineage orientation...
  41. ncbi Is PU.1 a dosage-sensitive regulator of haemopoietic lineage commitment and leukaemogenesis?
    Aleksandar Dakic
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Trends Immunol 28:108-14. 2007
    ..1. Here, we will discuss the data that, we believe, argue against the dosage-sensitive model of PU.1-mediated lineage commitment and leukaemogenesis...
  42. ncbi Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors
    Stephen L Nutt
    The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
    J Exp Med 201:221-31. 2005
    ..1(lo) CMPs were the immediate precursors of the MEP. Thus, down-regulation of PU.1 expression in the CMP is the first molecularly identified event associated with the restriction of differentiation to erythroid and megakaryocyte lineages...
  43. ncbi CD4 and CD8 expression and T cell antigen receptor gene rearrangement in early intrathymic precursor cells
    J Ismaili
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Eur J Immunol 26:731-7. 1996
    ..Although they have initiated synthesis of some recombination-associated enzymes, full commitment to the T lineage and TCR gene rearrangement is a later event...
  44. ncbi The impact of circulating dendritic cells on the development and differentiation of thymocytes
    Anna I Proietto
    Immunology Division, Department of Medical Biology, The Walter and Eliza Hall Institute, Parkville, Victoria, Australia
    Immunol Cell Biol 87:39-45. 2009
    ..In this review, the role of DCs in the development and education of T cells in the thymus will be reviewed, with emphasis on the role of circulatory DCs in mediating these processes...
  45. ncbi Isolation of mouse thymic dendritic cell precursors
    Li Wu
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
    Methods Mol Biol 595:265-80. 2010
    ..These experimental systems are crucial for studying the development and functions of thymic DC...
  46. ncbi Differential production of inflammatory chemokines by murine dendritic cell subsets
    Anna I Proietto
    The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville, Vic. 3050, Australia
    Immunobiology 209:163-72. 2004
    ..Thus, we report a new functional difference between the murine splenic cDC subsets, with the CD4+ cDC demonstrating the most efficient production of the inflammatory chemokines Mip-1alpha, Mip-1beta and Rantes...
  47. ncbi Id2 expression delineates differential checkpoints in the genetic program of CD8α+ and CD103+ dendritic cell lineages
    Jacob T Jackson
    Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    EMBO J 30:2690-704. 2011
    ..Genetic mapping DC subset differentiation using Id2-GFP may have broad implications in understanding the interplay of DC subsets during protective and pathological immune responses...
  48. ncbi Suppressor of cytokine signaling-1 has IFN-gamma-independent actions in T cell homeostasis
    Ann L Cornish
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 170:878-86. 2003
    ..Thus, SOCS-1 is a critical regulator of T cell activation and homeostasis, and its influence extends beyond regulating IFN-gamma signaling...
  49. ncbi Functional analysis of Mel-14+ and Mel-14- early precursor cells in the adult mouse thymus
    L Wu
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Immunol Lett 40:89-92. 1994
    ..This strengthens the hypothesis that one precursor cell has the potential to form all three lineages...
  50. ncbi Molecular and cellular mediators of interleukin-1-dependent acute inflammatory arthritis
    K E Lawlor
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Arthritis Rheum 44:442-50. 2001
    ..This model of acute monarticular arthritis is particularly suitable for further investigations into cell-mediated immunity in arthritis and the role of IL-1...
  51. ncbi Functional regulation of monocyte-derived dendritic cells by microRNAs
    Yifan Zhan
    The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia
    Protein Cell 3:497-507. 2012
    ..Emerging evidence indicates that microRNAs (miRNAs), as a new class of gene regulators, potently regulate the function of moDCs. Here we summarize recent progress in this area...
  52. ncbi Surprising new roles for PU.1 in the adaptive immune response
    Sebastian Carotta
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Immunol Rev 238:63-75. 2010
    ..1 in peripheral T-cell differentiation. Here, we review insights derived from these mouse models of PU.1 deficiency, with particular emphasis on these functions of PU.1 in the lymphocyte and dendritic cell lineages...
  53. ncbi Generation of a functional mammary gland from a single stem cell
    Mark Shackleton
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Nature 439:84-8. 2006
    ..Our data establish that single cells within the Lin-CD29hiCD24+ population are multipotent and self-renewing, properties that define them as MaSCs...
  54. ncbi Mouse plasmacytoid cells: long-lived cells, heterogeneous in surface phenotype and function, that differentiate into CD8(+) dendritic cells only after microbial stimulus
    Meredith O'Keeffe
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    J Exp Med 196:1307-19. 2002
    ..Hence as well as activating preexistant DCs, microbial infection induces a wave of production of a new DC subtype. The functional implications of this shift in the DC network remain to be determined...
  55. ncbi Development of murine plasmacytoid dendritic cell subsets
    Shalin H Naik
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Vaccine Technology, Melbourne, Victoria, Australia
    Immunol Cell Biol 83:563-70. 2005
    ....
  56. ncbi The network of cytokines, receptors and transcription factors governing the development of dendritic cell subsets
    Priyanka Sathe
    Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Protein Cell 2:620-30. 2011
    ..Here, we review recent findings on the factors important in DC development in the context of the developmental pathways that have been described...
  57. ncbi c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells
    Iwao Isomura
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    J Exp Med 206:3001-14. 2009
    ..Collectively, our results indicate that c-Rel is important for both the thymic development and peripheral homeostatic proliferation of T reg cells...
  58. ncbi Dendritic cell origins: puzzles and paradoxes
    S Vandenabeele
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Immunol Cell Biol 77:411-9. 1999
    ..It is concluded that three or four different pathways lead to the development of different subtypes of dendritic cells...
  59. ncbi Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death
    Ewa M Michalak
    The Walter and Eliza Hall Institute of Medical Research, Parkville VIC 3050, Australia
    Genes Dev 24:1608-13. 2010
    ..Our demonstration that cycles of cell attrition and repopulation by stem/progenitor cells can drive tumorigenesis has parallels in human cancers, such as therapy-induced malignancies...
  60. ncbi Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN
    Li Wu
    HIV Drug Resistance Program, Laboratory of Genomic Diversity, and Basic Research Program, Science Applications International Corporation Frederick, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 99:1568-73. 2002
    ....
  61. ncbi Recruitment of HIV and its receptors to dendritic cell-T cell junctions
    David McDonald
    Department of Microbiology and Immunology, University of Illinois, Chicago, IL 60612, USA
    Science 300:1295-7. 2003
    ..We propose that contact between dendritic cells and T cells facilitates transmission of HIV by locally concentrating virus, receptor, and coreceptor during the formation of an infectious synapse...
  62. ncbi Protective effect of extract from Paeonia lactiflora and Astragalus membranaceus against liver injury induced by bacillus Calmette-Guérin and lipopolysaccharide in mice
    Wu yi Sun
    Institute of Clinical Pharmacology, Anhui Medical University, Anhui Key Laboratory of Anti inflammatory and Immunopharmacology, Anhui, China
    Basic Clin Pharmacol Toxicol 103:143-9. 2008
    ....
  63. ncbi Functional evaluation of DC-SIGN monoclonal antibodies reveals DC-SIGN interactions with ICAM-3 do not promote human immunodeficiency virus type 1 transmission
    Li Wu
    HIV Drug Resistance Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Virol 76:5905-14. 2002
    ..While these findings do not discount the role of intercellular contact in facilitating HIV-1 transmission, our in vitro data indicate that DC-SIGN interactions with ICAM-3 do not promote DC-SIGN-mediated virus transmission...
  64. ncbi Human embryonic stem cell lines derived from the Chinese population
    Zhen Fu Fang
    Center for Developmental Biology, Xinhua Hospital, Shanghai Second Medical University, Shanghai, China
    Cell Res 15:394-400. 2005
    ..Human embryonic stem cell lines from the Chinese population should facilitate stem cell research and may be valuable in studies of population genetics and ecology...
  65. ncbi Role of DC-SIGN in the activation of dendritic cells by HPV-16 L1 virus-like particle vaccine
    Alfonso J Garcia-Pineres
    SAIC Frederick NCI Frederick, Frederick, MD, USA
    Eur J Immunol 36:437-45. 2006
    ..These results suggest that DC-SIGN has a functional role in DC activation induced by HPV-16 L1-VLP, and thus highlight new aspects of DC interactions with HPV VLP...
  66. ncbi CD4 coexpression regulates DC-SIGN-mediated transmission of human immunodeficiency virus type 1
    Jian Hua Wang
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, BSB 203, Milwaukee, WI 53226, USA
    J Virol 81:2497-507. 2007
    ..These results suggest that CD4, which is present at various levels in DC-SIGN-positive primary cells, is a key regulator of HIV-1 transmission...
  67. ncbi Raji B cells, misidentified as THP-1 cells, stimulate DC-SIGN-mediated HIV transmission
    Li Wu
    Model Development Section, HIV Drug Resistance Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA
    Virology 318:17-23. 2004
    ..These data indicate that there are features common to B cells and DCs that facilitate transmission of HIV-1 and provide new insights toward the mechanism of DC-SIGN-mediated HIV-1 transmission...
  68. ncbi The thymic stromal cell line MTSC4 induced thymocyte apoptosis in a non-MHC-restricted manner
    Xue Ying He
    Department of Immunology, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100083, China
    Cell Res 14:125-33. 2004
    ..Our study has also shown that the interaction of MTSC4 stromal cells and thymocytes is required for the induction of thymocyte apoptosis...
  69. ncbi Developmental pathway of CD4+CD8- medullary thymocytes during mouse ontogeny and its defect in Aire-/- mice
    Juan Li
    Department of Immunology, Peking University Health Science Center, 38 Xue Yuan Road, Beijing 100083, China
    Proc Natl Acad Sci U S A 104:18175-80. 2007
    ..Precise dissection of this program should facilitate further inquiry into the molecular mechanisms governing normal thymocyte development and its disturbance in pathological conditions...
  70. ncbi Dendritic-cell interactions with HIV: infection and viral dissemination
    Li Wu
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Nat Rev Immunol 6:859-68. 2006
    ..This Review highlights the latest advances in our understanding of the interactions between DCs and HIV, focusing on the mechanisms of DC-mediated viral dissemination...
  71. ncbi Are dendritic cells end cells?
    Ken Shortman
    Nat Immunol 5:1105-6. 2004
  72. ncbi Conformationally-flexible benzamide analogues as dopamine D3 and sigma 2 receptor ligands
    Robert H Mach
    Department of Radiology, PET Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Bioorg Med Chem Lett 14:195-202. 2004
    ..Consequently, these novel compounds may be useful for characterizing the functional role of sigma2 receptors and for imaging the sigma2 receptor status of tumors in vivo with PET...
  73. ncbi Rabbit embryonic stem cell lines derived from fertilized, parthenogenetic or somatic cell nuclear transfer embryos
    Zhen F Fang
    Center for Developmental Biology, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, 1665 Kong Jiang Road, Shanghai 200092, P.R. China
    Exp Cell Res 312:3669-82. 2006
    ..In combination with genetic engineering, the ES cell technology should facilitate the creation of new rabbit lines...
  74. ncbi [Study on the active protein fractions from scorpii tegument]
    Li Wu
    Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China
    Zhongguo Zhong Yao Za Zhi 30:1083-6. 2005
    ..CONCLUSION: Protein from scorpii tegument could modulate the immune system, which may offer a new way for people to find protein drugs...
  75. ncbi Potential mechanisms for astrocyte-TIMP-1 downregulation in chronic inflammatory diseases
    Jessica Gardner
    Laboratory of Cellular Neuroimmunology, Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5215, USA
    J Neurosci Res 83:1281-92. 2006
    ..These data are important for unraveling the mechanisms underlying astrocyte responses during chronic neuroinflammation and have broader implications in other inflammatory diseases that involve MMP/TIMP imbalance...
  76. ncbi Protective effect of fufanghuangqiduogan against acute liver injury in mice
    Shuang-Ying Gui
    Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, Anhui Province, China
    World J Gastroenterol 11:2984-9. 2005
    ....
  77. ncbi Impact of carrier stiffness and microtopology on two-dimensional kinetics of P-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) interactions
    Li Wu
    National Microgravity Laboratory, Center for Biomechanics and Bioengineering, Institute of Mechanics, Chinese Academy of Sciences, Beijing 100080, China
    J Biol Chem 282:9846-54. 2007
    ..This provides new insights into understanding the rolling and tethering mechanism of leukocytes onto endothelium in both physiological and pathological processes...
  78. ncbi Loop dynamics and ligand binding kinetics in the reaction catalyzed by the Yersinia protein tyrosine phosphatase
    Mazdak Khajehpour
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 46:4370-8. 2007
    ..The significance of these dynamic results is interpreted in terms of the catalytic cycle of the enzyme...
  79. ncbi Novel member of the CD209 (DC-SIGN) gene family in primates
    Arman A Bashirova
    Science Application International Corporation at Frederick, Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Maryland 21702, USA
    J Virol 77:217-27. 2003
    ....
  80. ncbi Functionally distinct transmission of human immunodeficiency virus type 1 mediated by immature and mature dendritic cells
    Jian Hua Wang
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Virol 81:8933-43. 2007
    ..Our results provide new insights into the mechanisms underlying DC-mediated HIV-1 transmission, suggesting that HIV-1 exploits mDCs to facilitate its dissemination within lymphoid tissues...
  81. ncbi Characterization of human immunodeficiency virus type 1 replication in immature and mature dendritic cells reveals dissociable cis- and trans-infection
    Chunsheng Dong
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Virol 81:11352-62. 2007
    ..Our results suggest that various DC subsets in vivo may differentially contribute to HIV-1 dissemination via dissociable cis- and trans-infections...
  82. ncbi Trans-dominant cellular inhibition of DC-SIGN-mediated HIV-1 transmission
    Li Wu
    Model Development Section, HIV Drug Resistance Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    Retrovirology 1:14. 2004
    ..We thus examined whether K562 erythroleukemic cells could recapitulate efficient DC-SIGN-mediated HIV-1 transmission (DMHT)...
  83. ncbi p53 mutations and survival in stage I non-small-cell lung cancer: results of a prospective study
    Steven A Ahrendt
    Department of Surgery, University of Rochester, Rochester, NY 14642, USA
    J Natl Cancer Inst 95:961-70. 2003
    ..Therefore, we initiated a prospective study to determine the association of p53 gene mutations with survival in patients with stage I NSCLC...
  84. ncbi Productive infection of human immunodeficiency virus type 1 in dendritic cells requires fusion-mediated viral entry
    Alicia M Janas
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Virology 375:442-51. 2008
    ..Together, these results provide functional evidence in understanding HIV-1 cis-infection of DCs, suggesting that different pathways of HIV-1 entry into DCs determine the outcome of viral infection...
  85. ncbi Regulation of tissue inhibitor of metalloproteinase-1 by astrocytes: links to HIV-1 dementia
    Radhika Suryadevara
    Laboratory of Cellular Neuroimmunology, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Glia 44:47-56. 2003
    ..Our studies reveal new opportunities for repair-based therapeutic strategies in HAD...