Research Topics
Genomes and Genes
| Jose A VilladangosSummaryAffiliation: The Walter and Eliza Hall Institute of Medical Research Country: Australia Publications
| Collaborators
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Detail Information
Publications
MHC class II expression is regulated in dendritic cells independently of invariant chain degradationJ A Villadangos
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
Immunity 14:739-49. 2001..Late after activation, DC downregulated MHC II synthesis both in vitro and in vivo...- Presentation of antigens by MHC class II molecules: getting the most out of themJ A Villadangos
The Walter and Eliza Hall Institute of Medical Research, P O The Royal Melbourne Hospital, 3050, Victoria, Melbourne, Australia
Mol Immunol 38:329-46. 2001.... 
Found in translation: the human equivalent of mouse CD8+ dendritic cellsJose A Villadangos
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
J Exp Med 207:1131-4. 2010..New data now reveals the likely human equivalent of the mouse DC subset specialized in cross-presentation...- Hold on, the monocytes are coming!Jose A Villadangos
Immunology Division, The Walter and Eliza Hall Institute, 1G Royal Parade Parkville, Victoria 3050, Australia
Immunity 26:390-2. 2007..León et al. (2007) now show that these cells develop "on demand" at a site of Leishmania infection to promote a life-saving T helper 1 immune response... - Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivoJose A Villadangos
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Nat Rev Immunol 7:543-55. 2007..These interactions, which allow the integration of the intrinsic abilities of different DC types, enhance the ability of the DC network to respond to multiple scenarios of infection... - Control of MHC class II antigen presentation in dendritic cells: a balance between creative and destructive forcesJose A Villadangos
Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
Immunol Rev 207:191-205. 2005..We advocate that the mechanisms regulating MHC II-peptide complex turnover should be emphasized as an important theme for future DC research... - Life cycle, migration and antigen presenting functions of spleen and lymph node dendritic cells: limitations of the Langerhans cells paradigmJose A Villadangos
Immunology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3050, Australia
Semin Immunol 17:262-72. 2005..We point out the caveats of assuming that the DC that collect antigens are the ones involved in their presentation, emphasizing the phenomenon of antigen transfer as an important component of the immune response... 
Characterization of an immediate splenic precursor of CD8+ dendritic cells capable of inducing antiviral T cell responsesSammy Bedoui
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
J Immunol 182:4200-7. 2009..The enhanced capacity of CD8(-)CD24(+) DC to induce immune responses upon adoptive transfer makes them an attractive novel tool for DC-based immunotherapies...- Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunityNicholas S Wilson
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
Nat Immunol 7:165-72. 2006..Moreover, inhibition of cross-presentation was overcome by injection of dendritic cells bearing antigen, which provides a new strategy for generating immunity during immunosuppressive blood infections... - Blood-stage Plasmodium berghei infection leads to short-lived parasite-associated antigen presentation by dendritic cellsRachel J Lundie
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Eur J Immunol 40:1674-81. 2010..This provides important evidence that P. berghei not only causes immunosuppression to subsequently encountered third party antigens, but also rapidly limits the capacity to generate effective parasite-specific immunity... - GM-CSF increases cross-presentation and CD103 expression by mouse CD8⁺ spleen dendritic cellsYifan Zhan
Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Eur J Immunol 41:2585-95. 2011..Our findings not only identify GM-CSF as a key molecule regulating CD8(+) DC function, but also as a factor responsible for functional heterogeneity of CD8(+) DCs that is at least substantially demarcated by CD103 expression... - The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capturePetra Schnorrer
Immunology Division and Cooperative Research Centre for Vaccine Technology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
Proc Natl Acad Sci U S A 103:10729-34. 2006..This conclusion has important implications for the design of vaccination strategies based on antigen targeting to DC... - Antibody responses initiated by Clec9A-bearing dendritic cells in normal and Batf3(-/-) miceIrina Caminschi
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
Mol Immunol 50:9-17. 2012..However in normal mice most MHC II presentation of the Clec9A-targeted antigen was by the major CD8(+) DC population, the DC also responsible for presentation on MHC I... - Cutting edge: generation of splenic CD8+ and CD8- dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow culturesShalin H Naik
Immunology Division and the Cooperative Research Centre for Vaccine Technology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
J Immunol 174:6592-7. 2005..This culture system allows access to bona fide counterparts of the splenic DC subsets... - The inflammatory cytokine, GM-CSF, alters the developmental outcome of murine dendritic cellsYifan Zhan
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
Eur J Immunol 42:2889-900. 2012..Our finding that GM-CSF dominantly changes the regulation of DC development in vitro and in vivo has important implications for inflammatory diseases or GM-CSF therapy... - Selective suicide of cross-presenting CD8+ dendritic cells by cytochrome c injection shows functional heterogeneity within this subsetMing Lee Lin
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville VIC 3050, Australia
Proc Natl Acad Sci U S A 105:3029-34. 2008..Our model opens an avenue to specifically target cross-presenting DCs in vivo for manipulating cytotoxic T lymphocyte responses toward infections, tumors, and transplants... - Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cellsLouise J Young
The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville, Victoria 3050, Australia
Nat Immunol 9:1244-52. 2008..As the antigen-presenting abilities of cDCs and pDCs are fundamentally distinct, these two cell types may activate largely nonoverlapping repertoires of CD4(+) T cells... - Blood-stage Plasmodium infection induces CD8+ T lymphocytes to parasite-expressed antigens, largely regulated by CD8alpha+ dendritic cellsRachel J Lundie
Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
Proc Natl Acad Sci U S A 105:14509-14. 2008..Finally, using three different experimental approaches, we provide evidence that CTL specific for parasite-expressed antigens contribute to ECM... - Resident and monocyte-derived dendritic cells become dominant IL-12 producers under different conditions and signaling pathwaysYifan Zhan
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
J Immunol 185:2125-33. 2010..In contrast, for mDC, IL-12 production was mainly dependent on MyD88 signaling. Thus, conventional DCs and mDCs use different pathways to regulate IL-12 production... - Cognate CD4+ help elicited by resting dendritic cells does not impair the induction of peripheral tolerance in CD8+ T cellsRaymond J Steptoe
Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
J Immunol 178:2094-103. 2007..Thus, effective peripheral tolerance can be induced by resting DC in the presence of CD4(+) and CD8(+) T cells with specificity for the same Ag... - Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL primingRhys S Allan
The Department of Microbiology and Immunology, The University of Melbourne, Parkville 3010, Victoria, Australia
Immunity 25:153-62. 2006.... - Targeting the gut vascular endothelium induces gut effector CD8 T cell responses via cross-presentation by dendritic cellsDorothee Bourges
Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
J Immunol 179:5678-85. 2007..We propose that the augmentation of gut CD8 T cell responses by MAdCAM targeting is due to both accumulation of Ag in the HEV and conversion of a soluble Ag to a cell-associated one, allowing cross-presentation by DCs... - Differential expression of pathogen-recognition molecules between dendritic cell subsets revealed by plasma membrane proteomic analysisElodie Segura
Immunology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Mol Immunol 47:1765-73. 2010..This analysis provides major advantages over genomic approaches as it directly measures protein expression at a particular location. Our study highlights the diversity of surface protein expression amongst components of the DC network... - Dendritic cell preactivation impairs MHC class II presentation of vaccines and endogenous viral antigensLouise J Young
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
Proc Natl Acad Sci U S A 104:17753-8. 2007..These observations have important implications for the design of prophylactic and therapeutic DC vaccines and contribute to the understanding of the mechanisms causing immunosuppression during systemic blood infections... - Different cross-presentation pathways in steady-state and inflammatory dendritic cellsElodie Segura
Immunology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Proc Natl Acad Sci U S A 106:20377-81. 2009..These results demonstrate that the mechanisms responsible for cross-priming by steady-state and inflammatory DC are different, which has important implications for vaccine design... - Cognate CD4(+) T cell licensing of dendritic cells in CD8(+) T cell immunityChristopher M Smith
Division of Immunology, The Co-operative Research Centre for Vaccine Technology at The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
Nat Immunol 5:1143-8. 2004..In situations in which DCs are poorly licensed by pathogen-derived signals, our findings suggest that CTL immunity may be heavily dependent on cognate DC licensing... - The protease inhibitor cystatin C is differentially expressed among dendritic cell populations, but does not control antigen presentationDima El-Sukkari
The Walter and Eliza Hall Institute of Medical Research, Victoria, Melbourne, Australia
J Immunol 171:5003-11. 2003..Our results also show that CyC expression can differ markedly between closely related cell types, suggesting the existence of hitherto unrecognized mechanisms of control of CyC expression... - The acquisition of antigen cross-presentation function by newly formed dendritic cellsPriyanka Sathe
Walter and Eliza Hall Institute, Parkville, Victoria 3052, Australia
J Immunol 186:5184-92. 2011..These results explain the considerable variability in CD103 expression by CD8(+) DCs as well as the findings that not all DCs of this lineage are capable of cross-presentation... - Antigen-presentation properties of plasmacytoid dendritic cellsJose A Villadangos
The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville, Victoria 3010, Australia
Immunity 29:352-61. 2008..In this review, we examine the evidence for a potential role of pDC in antigen capture, processing, and presentation to T cells at sites of infection and in the lymph nodes... - Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signalingNicholas S Wilson
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Immunol Cell Biol 86:200-5. 2008.... - Switching from a restricted to an effective CD4 T cell response by activating CD8+ murine dendritic cells with a Toll-like receptor 9 ligandAlexandra Rizzitelli
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Eur J Immunol 35:3209-20. 2005..The difference between a quiescent and an activated state is therefore more extreme for CD8+ than for CD8- DC. The especially tight regulation of the activity of CD8+ DC may be essential for the maintenance of self tolerance... - Targeting antigen to bone marrow stromal cell-2 expressed by conventional and plasmacytoid dendritic cells elicits efficient antigen presentationJessica M Moffat
Walter and Eliza Hall Institute, Parkville, Victoria, Australia
Eur J Immunol 43:595-605. 2013..In summary, BST-2 is a useful receptor to target with antigen, given its broad expression pattern and ability to access both MHCI and MHCII presentation pathways with relative efficiency... - Differentiation of inflammatory dendritic cells is mediated by NF-κB1-dependent GM-CSF production in CD4 T cellsIan K Campbell
Reid Rheumatology Laboratory, Division of Inflammation, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
J Immunol 186:5468-77. 2011.... - Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigensWilliam R Heath
Department of Immunology and The Cooperative Research Center for Vaccine Technology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
Immunol Rev 199:9-26. 2004..In this review, we examine the molecular basis for cross-presentation, discuss the role of DC subsets, and examine the contribution of this process to immunity, with some emphasis on DNA vaccination... - Regulation of antigen presentation and cross-presentation in the dendritic cell network: facts, hypothesis, and immunological implicationsNicholas S Wilson
Immunology Division and The Cooperative Research Center for Vaccine Technology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
Adv Immunol 86:241-305. 2005..Throughout, we highlight what we consider to be major knowledge gaps in the field and speculate on possible directions for future research... - Induction of antigen-specific effector-phase tolerance following vaccination against a previously ignored B-cell lymphomaSandro Prato
Department of Immunology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Immunol Cell Biol 89:595-603. 2011..This model can be exploited to further understand the mechanisms of lymphoma immunoevasion and devise effective immunotherapy... - Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cellsKatherine Baran
Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrew s Place, East Melbourne 3002, Victoria, Australia
J Biol Chem 281:30485-91. 2006..We conclude that cathepsin B is not essential for protection of cytotoxic lymphocytes from the toxic effects of their secreted perforin... - Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cellsIrina Caminschi
Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, 3050, Australia
J Exp Med 204:2579-90. 2007..Thus, IKDCs resemble NK cells functionally, and neither cell type could be induced to be effective antigen-presenting cells... - The cell biology of cross-presentation and the role of dendritic cell subsetsMing Lee Lin
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Immunol Cell Biol 86:353-62. 2008..Further consideration is given to antigen transfer between DC subsets and differential presentation to naive vs memory T cells... - DEC-205 is a cell surface receptor for CpG oligonucleotidesMireille H Lahoud
Centre for Immunology, Burnet Institute, Melbourne, VIC 3004, Australia
Proc Natl Acad Sci U S A 109:16270-5. 2012..Our findings identify an important receptor for class B CpG ODN and reveal a unique function for DEC-205... - A modular and combinatorial view of the antigen cross-presentation pathway in dendritic cellsElodie Segura
INSERM U932, 26 Rue d Ulm, 75005 Paris, France
Traffic 12:1677-85. 2011..Cross-presentation of each MHC I-peptide complex may result from combining one or more options for each of these modules... - Outside looking in: the inner workings of the cross-presentation pathway within dendritic cellsJose A Villadangos
Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Australia
Trends Immunol 28:45-7. 2007..Two recent papers describe intracellular components tailored to the dendritic cell cross-presentation pathway... - IL-10 controls cystatin C synthesis and blood concentration in response to inflammation through regulation of IFN regulatory factor 8 expressionYuekang Xu
Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
J Immunol 186:3666-73. 2011..Our results also indicate that caution should be exerted when using the concentration of serum CstC as an indicator of kidney function in conditions in which inflammation may alter CstC production... - Cutting edge: B220+CCR9- dendritic cells are not plasmacytoid dendritic cells but are precursors of conventional dendritic cellsElodie Segura
Immunology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
J Immunol 183:1514-7. 2009..After in vivo transfer, these cells down-regulate B220 expression and convert into the two major cDC subsets, showing that they are a developmental stage of cDC differentiation... - Enhanced survival of lung tissue-resident memory CD8⁺ T cells during infection with influenza virus due to selective expression of IFITM3Linda M Wakim
Division of Inflammation, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
Nat Immunol 14:238-45. 2013..Thus, lung T(RM) cells were programmed to retain IFITM3 expression, which facilitated their survival and protection from viral infection during subsequent exposures... - Cutting edge: conventional CD8 alpha+ dendritic cells are preferentially involved in CTL priming after footpad infection with herpes simplex virus-1Christopher M Smith
Cooperative Research Center for Vaccine Technology, University of Melbourne, Victoria, Australia
J Immunol 170:4437-40. 2003..Given that such class I-restricted presentation is essential for CTL priming, this implies that these conventional CD8alpha(+) dendritic cells are the key subset involved in CTL immunity to this virus... - Lymphoid organ dendritic cells: beyond the Langerhans cells paradigmNicholas S Wilson
Immunology Division and Cooperative Research Centre for Vaccine Technology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Immunol Cell Biol 82:91-8. 2004..We also discuss the implications of the maturational status of the DC subsets contained in the lymphoid organs for their putative roles in the induction of immune responses and the maintenance of peripheral tolerance... - Antigen presentation by dendritic cells in vivoElodie Segura
INSERM U, Paris, France
Curr Opin Immunol 21:105-10. 2009..Understanding the contribution of each DC subset to a physiological immune response is particularly relevant for rational vaccine design... - Hepatitis B virus-like particles access major histocompatibility class I and II antigen presentation pathways in primary dendritic cellsJessica M Moffat
Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3010, Australia Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria 3010, Australia
Vaccine 31:2310-6. 2013..Therefore, HBsAgS VLPs can deliver antigen to both MHCI and MHCII antigen presentation pathways in primary DCs and promote cytotoxic and helper T cell priming despite their suppressive effect on pDCs... - A critical role for granzymes in antigen cross-presentation through regulating phagocytosis of killed tumor cellsSabine Hoves
Cancer Cell Death Laboratory, Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne 3002, Victoria, Australia
J Immunol 187:1166-75. 2011.... - Consequences of direct and indirect activation of dendritic cells on antigen presentation: Functional implications and clinical considerationsJavier Vega-Ramos
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
Mol Immunol 55:175-8. 2013..Here, we will summarize recent advances in the field, focusing on how DC regulate antigen presentation during and after maturation, and its functional implications. We will also discuss future perspectives and clinical considerations... - Control of MHC II antigen presentation by ubiquitinationJessica M Moffat
Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3052, Australia
Curr Opin Immunol 25:109-14. 2013..Understanding how ubiquitin E2 and E3 ligases contribute to controlling MHC II antigen presentation will shed light on the critical regulatory controls of this important pathway of immunity...