Jose A Villadangos

Summary

Affiliation: The Walter and Eliza Hall Institute of Medical Research
Country: Australia

Publications

  1. ncbi MHC class II expression is regulated in dendritic cells independently of invariant chain degradation
    J A Villadangos
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Immunity 14:739-49. 2001
  2. ncbi Presentation of antigens by MHC class II molecules: getting the most out of them
    J A Villadangos
    The Walter and Eliza Hall Institute of Medical Research, P O The Royal Melbourne Hospital, 3050, Victoria, Melbourne, Australia
    Mol Immunol 38:329-46. 2001
  3. ncbi Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo
    Jose A Villadangos
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Nat Rev Immunol 7:543-55. 2007
  4. ncbi Hold on, the monocytes are coming!
    Jose A Villadangos
    Immunology Division, The Walter and Eliza Hall Institute, 1G Royal Parade Parkville, Victoria 3050, Australia
    Immunity 26:390-2. 2007
  5. pmc Found in translation: the human equivalent of mouse CD8+ dendritic cells
    Jose A Villadangos
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    J Exp Med 207:1131-4. 2010
  6. ncbi Control of MHC class II antigen presentation in dendritic cells: a balance between creative and destructive forces
    Jose A Villadangos
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Immunol Rev 207:191-205. 2005
  7. ncbi Life cycle, migration and antigen presenting functions of spleen and lymph node dendritic cells: limitations of the Langerhans cells paradigm
    Jose A Villadangos
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3050, Australia
    Semin Immunol 17:262-72. 2005
  8. doi Characterization of an immediate splenic precursor of CD8+ dendritic cells capable of inducing antiviral T cell responses
    Sammy Bedoui
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 182:4200-7. 2009
  9. ncbi Most lymphoid organ dendritic cell types are phenotypically and functionally immature
    Nicholas S Wilson
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, Victoria 3050, Australia
    Blood 102:2187-94. 2003
  10. ncbi Blood-stage Plasmodium berghei infection leads to short-lived parasite-associated antigen presentation by dendritic cells
    Rachel J Lundie
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Eur J Immunol 40:1674-81. 2010

Collaborators

Detail Information

Publications56

  1. ncbi MHC class II expression is regulated in dendritic cells independently of invariant chain degradation
    J A Villadangos
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Immunity 14:739-49. 2001
    ..Late after activation, DC downregulated MHC II synthesis both in vitro and in vivo...
  2. ncbi Presentation of antigens by MHC class II molecules: getting the most out of them
    J A Villadangos
    The Walter and Eliza Hall Institute of Medical Research, P O The Royal Melbourne Hospital, 3050, Victoria, Melbourne, Australia
    Mol Immunol 38:329-46. 2001
    ....
  3. ncbi Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo
    Jose A Villadangos
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Nat Rev Immunol 7:543-55. 2007
    ..These interactions, which allow the integration of the intrinsic abilities of different DC types, enhance the ability of the DC network to respond to multiple scenarios of infection...
  4. ncbi Hold on, the monocytes are coming!
    Jose A Villadangos
    Immunology Division, The Walter and Eliza Hall Institute, 1G Royal Parade Parkville, Victoria 3050, Australia
    Immunity 26:390-2. 2007
    ..The role that monocyte-derived dendritic cells play in vivo remains enigmatic. León et al. (2007) now show that these cells develop "on demand" at a site of Leishmania infection to promote a life-saving T helper 1 immune response...
  5. pmc Found in translation: the human equivalent of mouse CD8+ dendritic cells
    Jose A Villadangos
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    J Exp Med 207:1131-4. 2010
    ..New data now reveals the likely human equivalent of the mouse DC subset specialized in cross-presentation...
  6. ncbi Control of MHC class II antigen presentation in dendritic cells: a balance between creative and destructive forces
    Jose A Villadangos
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Immunol Rev 207:191-205. 2005
    ..We advocate that the mechanisms regulating MHC II-peptide complex turnover should be emphasized as an important theme for future DC research...
  7. ncbi Life cycle, migration and antigen presenting functions of spleen and lymph node dendritic cells: limitations of the Langerhans cells paradigm
    Jose A Villadangos
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3050, Australia
    Semin Immunol 17:262-72. 2005
    ..We point out the caveats of assuming that the DC that collect antigens are the ones involved in their presentation, emphasizing the phenomenon of antigen transfer as an important component of the immune response...
  8. doi Characterization of an immediate splenic precursor of CD8+ dendritic cells capable of inducing antiviral T cell responses
    Sammy Bedoui
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 182:4200-7. 2009
    ..The enhanced capacity of CD8(-)CD24(+) DC to induce immune responses upon adoptive transfer makes them an attractive novel tool for DC-based immunotherapies...
  9. ncbi Most lymphoid organ dendritic cell types are phenotypically and functionally immature
    Nicholas S Wilson
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, Victoria 3050, Australia
    Blood 102:2187-94. 2003
    ..Therefore, the lymphoid organs contain a large cohort of immature DCs, most likely for the maintenance of peripheral tolerance, which can respond to infections reaching those organs and mature in situ...
  10. ncbi Blood-stage Plasmodium berghei infection leads to short-lived parasite-associated antigen presentation by dendritic cells
    Rachel J Lundie
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Eur J Immunol 40:1674-81. 2010
    ..This provides important evidence that P. berghei not only causes immunosuppression to subsequently encountered third party antigens, but also rapidly limits the capacity to generate effective parasite-specific immunity...
  11. ncbi Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity
    Nicholas S Wilson
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Immunol 7:165-72. 2006
    ..Moreover, inhibition of cross-presentation was overcome by injection of dendritic cells bearing antigen, which provides a new strategy for generating immunity during immunosuppressive blood infections...
  12. doi GM-CSF increases cross-presentation and CD103 expression by mouse CD8⁺ spleen dendritic cells
    Yifan Zhan
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Eur J Immunol 41:2585-95. 2011
    ..Our findings not only identify GM-CSF as a key molecule regulating CD8(+) DC function, but also as a factor responsible for functional heterogeneity of CD8(+) DCs that is at least substantially demarcated by CD103 expression...
  13. doi Antibody responses initiated by Clec9A-bearing dendritic cells in normal and Batf3(-/-) mice
    Irina Caminschi
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
    Mol Immunol 50:9-17. 2012
    ..However in normal mice most MHC II presentation of the Clec9A-targeted antigen was by the major CD8(+) DC population, the DC also responsible for presentation on MHC I...
  14. ncbi Cutting edge: generation of splenic CD8+ and CD8- dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures
    Shalin H Naik
    Immunology Division and the Cooperative Research Centre for Vaccine Technology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    J Immunol 174:6592-7. 2005
    ..This culture system allows access to bona fide counterparts of the splenic DC subsets...
  15. pmc The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture
    Petra Schnorrer
    Immunology Division and Cooperative Research Centre for Vaccine Technology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 103:10729-34. 2006
    ..This conclusion has important implications for the design of vaccination strategies based on antigen targeting to DC...
  16. doi The inflammatory cytokine, GM-CSF, alters the developmental outcome of murine dendritic cells
    Yifan Zhan
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Eur J Immunol 42:2889-900. 2012
    ..Our finding that GM-CSF dominantly changes the regulation of DC development in vitro and in vivo has important implications for inflammatory diseases or GM-CSF therapy...
  17. doi Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells
    Louise J Young
    The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville, Victoria 3050, Australia
    Nat Immunol 9:1244-52. 2008
    ..As the antigen-presenting abilities of cDCs and pDCs are fundamentally distinct, these two cell types may activate largely nonoverlapping repertoires of CD4(+) T cells...
  18. doi Resident and monocyte-derived dendritic cells become dominant IL-12 producers under different conditions and signaling pathways
    Yifan Zhan
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 185:2125-33. 2010
    ..In contrast, for mDC, IL-12 production was mainly dependent on MyD88 signaling. Thus, conventional DCs and mDCs use different pathways to regulate IL-12 production...
  19. pmc Selective suicide of cross-presenting CD8+ dendritic cells by cytochrome c injection shows functional heterogeneity within this subset
    Ming Lee Lin
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville VIC 3050, Australia
    Proc Natl Acad Sci U S A 105:3029-34. 2008
    ..Our model opens an avenue to specifically target cross-presenting DCs in vivo for manipulating cytotoxic T lymphocyte responses toward infections, tumors, and transplants...
  20. pmc Blood-stage Plasmodium infection induces CD8+ T lymphocytes to parasite-expressed antigens, largely regulated by CD8alpha+ dendritic cells
    Rachel J Lundie
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 105:14509-14. 2008
    ..Finally, using three different experimental approaches, we provide evidence that CTL specific for parasite-expressed antigens contribute to ECM...
  21. pmc Dendritic cell preactivation impairs MHC class II presentation of vaccines and endogenous viral antigens
    Louise J Young
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 104:17753-8. 2007
    ..These observations have important implications for the design of prophylactic and therapeutic DC vaccines and contribute to the understanding of the mechanisms causing immunosuppression during systemic blood infections...
  22. ncbi Targeting the gut vascular endothelium induces gut effector CD8 T cell responses via cross-presentation by dendritic cells
    Dorothee Bourges
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 179:5678-85. 2007
    ..We propose that the augmentation of gut CD8 T cell responses by MAdCAM targeting is due to both accumulation of Ag in the HEV and conversion of a soluble Ag to a cell-associated one, allowing cross-presentation by DCs...
  23. ncbi Cognate CD4+ help elicited by resting dendritic cells does not impair the induction of peripheral tolerance in CD8+ T cells
    Raymond J Steptoe
    Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 178:2094-103. 2007
    ..Thus, effective peripheral tolerance can be induced by resting DC in the presence of CD4(+) and CD8(+) T cells with specificity for the same Ag...
  24. ncbi Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming
    Rhys S Allan
    The Department of Microbiology and Immunology, The University of Melbourne, Parkville 3010, Victoria, Australia
    Immunity 25:153-62. 2006
    ....
  25. doi Differential expression of pathogen-recognition molecules between dendritic cell subsets revealed by plasma membrane proteomic analysis
    Elodie Segura
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Mol Immunol 47:1765-73. 2010
    ..This analysis provides major advantages over genomic approaches as it directly measures protein expression at a particular location. Our study highlights the diversity of surface protein expression amongst components of the DC network...
  26. ncbi Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling
    Nicholas S Wilson
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Immunol Cell Biol 86:200-5. 2008
    ....
  27. doi Antigen-presentation properties of plasmacytoid dendritic cells
    Jose A Villadangos
    The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville, Victoria 3010, Australia
    Immunity 29:352-61. 2008
    ..In this review, we examine the evidence for a potential role of pDC in antigen capture, processing, and presentation to T cells at sites of infection and in the lymph nodes...
  28. ncbi Dendritic cells constitutively present self antigens in their immature state in vivo and regulate antigen presentation by controlling the rates of MHC class II synthesis and endocytosis
    Nicholas S Wilson
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Blood 103:2187-95. 2004
    ..Our results demonstrate that immature DCs constitutively present self antigens in the lymphoid organs and characterize the molecular basis of the capacity of DCs to provide "antigenic memory" in vivo...
  29. ncbi The protease inhibitor cystatin C is differentially expressed among dendritic cell populations, but does not control antigen presentation
    Dima El-Sukkari
    The Walter and Eliza Hall Institute of Medical Research, Victoria, Melbourne, Australia
    J Immunol 171:5003-11. 2003
    ..Our results also show that CyC expression can differ markedly between closely related cell types, suggesting the existence of hitherto unrecognized mechanisms of control of CyC expression...
  30. pmc Different cross-presentation pathways in steady-state and inflammatory dendritic cells
    Elodie Segura
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 106:20377-81. 2009
    ..These results demonstrate that the mechanisms responsible for cross-priming by steady-state and inflammatory DC are different, which has important implications for vaccine design...
  31. ncbi Cognate CD4(+) T cell licensing of dendritic cells in CD8(+) T cell immunity
    Christopher M Smith
    Division of Immunology, The Co operative Research Centre for Vaccine Technology at The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Nat Immunol 5:1143-8. 2004
    ..In situations in which DCs are poorly licensed by pathogen-derived signals, our findings suggest that CTL immunity may be heavily dependent on cognate DC licensing...
  32. doi Hepatitis B virus-like particles access major histocompatibility class I and II antigen presentation pathways in primary dendritic cells
    Jessica M Moffat
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3010, Australia
    Vaccine 31:2310-6. 2013
    ..Therefore, HBsAgS VLPs can deliver antigen to both MHCI and MHCII antigen presentation pathways in primary DCs and promote cytotoxic and helper T cell priming despite their suppressive effect on pDCs...
  33. doi The acquisition of antigen cross-presentation function by newly formed dendritic cells
    Priyanka Sathe
    Walter and Eliza Hall Institute, Parkville, Victoria 3052, Australia
    J Immunol 186:5184-92. 2011
    ..These results explain the considerable variability in CD103 expression by CD8(+) DCs as well as the findings that not all DCs of this lineage are capable of cross-presentation...
  34. ncbi Switching from a restricted to an effective CD4 T cell response by activating CD8+ murine dendritic cells with a Toll-like receptor 9 ligand
    Alexandra Rizzitelli
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Eur J Immunol 35:3209-20. 2005
    ..The difference between a quiescent and an activated state is therefore more extreme for CD8+ than for CD8- DC. The especially tight regulation of the activity of CD8+ DC may be essential for the maintenance of self tolerance...
  35. doi Rapid deletion and inactivation of CTLs upon recognition of a number of target cells over a critical threshold
    Sandro Prato
    Department of Inflammation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    J Immunol 191:3534-44. 2013
    ..Our results advocate the use of adoptive CTL therapy soon after mild chemotherapy. They also suggest a simple mechanism for Ag-specific impairment of anti-self CTLs in the face of an active anti-foreign CTL response. ..
  36. doi Targeting antigen to bone marrow stromal cell-2 expressed by conventional and plasmacytoid dendritic cells elicits efficient antigen presentation
    Jessica M Moffat
    Walter and Eliza Hall Institute, Parkville, Victoria, Australia
    Eur J Immunol 43:595-605. 2013
    ..In summary, BST-2 is a useful receptor to target with antigen, given its broad expression pattern and ability to access both MHCI and MHCII presentation pathways with relative efficiency...
  37. ncbi Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens
    William R Heath
    Department of Immunology and The Cooperative Research Center for Vaccine Technology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Immunol Rev 199:9-26. 2004
    ..In this review, we examine the molecular basis for cross-presentation, discuss the role of DC subsets, and examine the contribution of this process to immunity, with some emphasis on DNA vaccination...
  38. ncbi Regulation of antigen presentation and cross-presentation in the dendritic cell network: facts, hypothesis, and immunological implications
    Nicholas S Wilson
    Immunology Division and The Cooperative Research Center for Vaccine Technology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Adv Immunol 86:241-305. 2005
    ..Throughout, we highlight what we consider to be major knowledge gaps in the field and speculate on possible directions for future research...
  39. doi Differentiation of inflammatory dendritic cells is mediated by NF-κB1-dependent GM-CSF production in CD4 T cells
    Ian K Campbell
    Reid Rheumatology Laboratory, Division of Inflammation, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    J Immunol 186:5468-77. 2011
    ....
  40. doi Induction of antigen-specific effector-phase tolerance following vaccination against a previously ignored B-cell lymphoma
    Sandro Prato
    Department of Immunology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Immunol Cell Biol 89:595-603. 2011
    ..This model can be exploited to further understand the mechanisms of lymphoma immunoevasion and devise effective immunotherapy...
  41. ncbi Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells
    Katherine Baran
    Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrew s Place, East Melbourne 3002, Victoria, Australia
    J Biol Chem 281:30485-91. 2006
    ..We conclude that cathepsin B is not essential for protection of cytotoxic lymphocytes from the toxic effects of their secreted perforin...
  42. pmc Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells
    Irina Caminschi
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, 3050, Australia
    J Exp Med 204:2579-90. 2007
    ..Thus, IKDCs resemble NK cells functionally, and neither cell type could be induced to be effective antigen-presenting cells...
  43. doi The cell biology of cross-presentation and the role of dendritic cell subsets
    Ming Lee Lin
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Immunol Cell Biol 86:353-62. 2008
    ..Further consideration is given to antigen transfer between DC subsets and differential presentation to naive vs memory T cells...
  44. doi Consequences of direct and indirect activation of dendritic cells on antigen presentation: functional implications and clinical considerations
    Javier Vega-Ramos
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    Mol Immunol 55:175-8. 2013
    ..Here, we will summarize recent advances in the field, focusing on how DC regulate antigen presentation during and after maturation, and its functional implications. We will also discuss future perspectives and clinical considerations...
  45. pmc DEC-205 is a cell surface receptor for CpG oligonucleotides
    Mireille H Lahoud
    Centre for Immunology, Burnet Institute, Melbourne, VIC 3004, Australia
    Proc Natl Acad Sci U S A 109:16270-5. 2012
    ..Our findings identify an important receptor for class B CpG ODN and reveal a unique function for DEC-205...
  46. doi A modular and combinatorial view of the antigen cross-presentation pathway in dendritic cells
    Elodie Segura
    INSERM U932, 26 Rue d Ulm, 75005 Paris, France
    Traffic 12:1677-85. 2011
    ..Cross-presentation of each MHC I-peptide complex may result from combining one or more options for each of these modules...
  47. ncbi Outside looking in: the inner workings of the cross-presentation pathway within dendritic cells
    Jose A Villadangos
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Australia
    Trends Immunol 28:45-7. 2007
    ..Two recent papers describe intracellular components tailored to the dendritic cell cross-presentation pathway...
  48. doi IL-10 controls cystatin C synthesis and blood concentration in response to inflammation through regulation of IFN regulatory factor 8 expression
    Yuekang Xu
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    J Immunol 186:3666-73. 2011
    ..Our results also indicate that caution should be exerted when using the concentration of serum CstC as an indicator of kidney function in conditions in which inflammation may alter CstC production...
  49. doi Cutting edge: B220+CCR9- dendritic cells are not plasmacytoid dendritic cells but are precursors of conventional dendritic cells
    Elodie Segura
    Immunology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 183:1514-7. 2009
    ..After in vivo transfer, these cells down-regulate B220 expression and convert into the two major cDC subsets, showing that they are a developmental stage of cDC differentiation...
  50. ncbi Selecting cells with different Alzheimer's disease gamma-secretase activity using FACS. Differential effect on presenilin exon 9 gamma- and epsilon-cleavage
    M Fleur Sernee
    Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia
    Eur J Biochem 270:495-506. 2003
    ..The single aspartate mutations showed a concomitant reduction in Abeta secretion, whereas the D257A/D385A and DeltaE9 mutations had no effect on Abeta secretion...
  51. doi Control of MHC II antigen presentation by ubiquitination
    Jessica M Moffat
    Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3052, Australia
    Curr Opin Immunol 25:109-14. 2013
    ..Understanding how ubiquitin E2 and E3 ligases contribute to controlling MHC II antigen presentation will shed light on the critical regulatory controls of this important pathway of immunity...
  52. ncbi Enhanced survival of lung tissue-resident memory CD8⁺ T cells during infection with influenza virus due to selective expression of IFITM3
    Linda M Wakim
    Division of Inflammation, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Nat Immunol 14:238-45. 2013
    ..Thus, lung T(RM) cells were programmed to retain IFITM3 expression, which facilitated their survival and protection from viral infection during subsequent exposures...
  53. ncbi Cutting edge: conventional CD8 alpha+ dendritic cells are preferentially involved in CTL priming after footpad infection with herpes simplex virus-1
    Christopher M Smith
    Cooperative Research Center for Vaccine Technology, University of Melbourne, Victoria, Australia
    J Immunol 170:4437-40. 2003
    ..Given that such class I-restricted presentation is essential for CTL priming, this implies that these conventional CD8alpha(+) dendritic cells are the key subset involved in CTL immunity to this virus...
  54. ncbi Lymphoid organ dendritic cells: beyond the Langerhans cells paradigm
    Nicholas S Wilson
    Immunology Division and Cooperative Research Centre for Vaccine Technology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Immunol Cell Biol 82:91-8. 2004
    ..We also discuss the implications of the maturational status of the DC subsets contained in the lymphoid organs for their putative roles in the induction of immune responses and the maintenance of peripheral tolerance...
  55. doi Antigen presentation by dendritic cells in vivo
    Elodie Segura
    INSERM U, Paris, France
    Curr Opin Immunol 21:105-10. 2009
    ..Understanding the contribution of each DC subset to a physiological immune response is particularly relevant for rational vaccine design...
  56. doi A critical role for granzymes in antigen cross-presentation through regulating phagocytosis of killed tumor cells
    Sabine Hoves
    Cancer Cell Death Laboratory, Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne 3002, Victoria, Australia
    J Immunol 187:1166-75. 2011
    ....