D L Vaux

Summary

Affiliation: The Walter and Eliza Hall Institute of Medical Research
Country: Australia

Publications

  1. ncbi request reprint Cell death in development
    D L Vaux
    The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital Victoria, Australia
    Cell 96:245-54. 1999
  2. ncbi request reprint IAPs, RINGs and ubiquitylation
    David L Vaux
    The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Nat Rev Mol Cell Biol 6:287-97. 2005
  3. pmc DIABLO promotes apoptosis by removing MIHA/XIAP from processed caspase 9
    P G Ekert
    The Walter and Eliza Hall Institute, The Royal Melbourne Hospital, Victoria 3050, Australia
    J Cell Biol 152:483-90. 2001
  4. pmc TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1
    D M Moujalled
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, Victoria, Australia
    Cell Death Dis 4:e465. 2013
  5. doi request reprint Necroptosis induced by RIPK3 requires MLKL but not Drp1
    D M Moujalled
    1 Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, Victoria 3052, Australia 2 Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia
    Cell Death Dis 5:e1086. 2014
  6. doi request reprint In defense of the somatic mutation theory of cancer
    David L Vaux
    Walter and Eliza Hall Institute, and LaTrobe Institute for Molecular Science, Melbourne, Australia
    Bioessays 33:341-3. 2011
  7. ncbi request reprint Mammalian mitochondrial IAP binding proteins
    David L Vaux
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Biochem Biophys Res Commun 304:499-504. 2003
  8. ncbi request reprint Apoptosis genes and autoimmunity
    D L Vaux
    The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia
    Curr Opin Immunol 12:719-24. 2000
  9. pmc The buzz about BAFF
    David L Vaux
    The Walter and Eliza Hall Institute, Royal Parade Parkville, Victoria 3050, Australia
    J Clin Invest 109:17-8. 2002
  10. ncbi request reprint Apoptosis and toxicology--what relevance?
    D L Vaux
    The Walter and Eliza Hall Institute of Medical Research, Royal Parade, Parkville, VIC 3050, Australia
    Toxicology 181:3-7. 2002

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Cell death in development
    D L Vaux
    The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital Victoria, Australia
    Cell 96:245-54. 1999
  2. ncbi request reprint IAPs, RINGs and ubiquitylation
    David L Vaux
    The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Nat Rev Mol Cell Biol 6:287-97. 2005
    ..As well as regulating other proteins, the IAPs themselves are controlled by ubiquitin-mediated degradation...
  3. pmc DIABLO promotes apoptosis by removing MIHA/XIAP from processed caspase 9
    P G Ekert
    The Walter and Eliza Hall Institute, The Royal Melbourne Hospital, Victoria 3050, Australia
    J Cell Biol 152:483-90. 2001
    ..Once released into the cytosol, DIABLO bound to MIHA and disrupted its association with processed caspase 9, thereby allowing caspase 9 to activate caspase 3, resulting in apoptosis...
  4. pmc TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1
    D M Moujalled
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, Victoria, Australia
    Cell Death Dis 4:e465. 2013
    ..RIPK1 is therefore not essential for TNF to activate RIPK3 to induce necroptosis nor for the formation of a functional ripoptosome/necrosome...
  5. doi request reprint Necroptosis induced by RIPK3 requires MLKL but not Drp1
    D M Moujalled
    1 Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, Victoria 3052, Australia 2 Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia
    Cell Death Dis 5:e1086. 2014
    ..These results indicate that necroptosis caused by RIPK3 requires MLKL but not Drp1. ..
  6. doi request reprint In defense of the somatic mutation theory of cancer
    David L Vaux
    Walter and Eliza Hall Institute, and LaTrobe Institute for Molecular Science, Melbourne, Australia
    Bioessays 33:341-3. 2011
    ....
  7. ncbi request reprint Mammalian mitochondrial IAP binding proteins
    David L Vaux
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Biochem Biophys Res Commun 304:499-504. 2003
    ....
  8. ncbi request reprint Apoptosis genes and autoimmunity
    D L Vaux
    The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia
    Curr Opin Immunol 12:719-24. 2000
    ..An understanding of the pathophysiology of common autoimmune diseases will require elucidation of many different systems that interact in complex ways, of which the process of apoptosis is just one...
  9. pmc The buzz about BAFF
    David L Vaux
    The Walter and Eliza Hall Institute, Royal Parade Parkville, Victoria 3050, Australia
    J Clin Invest 109:17-8. 2002
  10. ncbi request reprint Apoptosis and toxicology--what relevance?
    D L Vaux
    The Walter and Eliza Hall Institute of Medical Research, Royal Parade, Parkville, VIC 3050, Australia
    Toxicology 181:3-7. 2002
    ....
  11. ncbi request reprint Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
    A M Verhagen
    The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia
    Cell 102:43-53. 2000
    ..As transfection of cells with DIABLO was able to counter the protection afforded by MIHA against UV irradiation, DIABLO may promote apoptosis by binding to IAPs and preventing them from inhibiting caspases...
  12. pmc Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP
    J Silke
    The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, VIC 3050
    EMBO J 20:3114-23. 2001
    ..Furthermore, these mutants retained full ability to inhibit apoptosis in transfected cells, demonstrating that although XIAP is able to inhibit caspase 3, this activity is dispensable for inhibition of apoptosis by XIAP in vivo...
  13. ncbi request reprint Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifs
    A M Verhagen
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Cell Death Differ 14:348-57. 2007
    ..Through this interaction, many are able to antagonise XIAP inhibition of caspase 3 in vitro...
  14. pmc Inhibition of interleukin 1 beta-converting enzyme-mediated apoptosis of mammalian cells by baculovirus IAP
    C J Hawkins
    Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia
    Proc Natl Acad Sci U S A 93:13786-90. 1996
    ..These results demonstrate that a baculoviral IAP protein can functionally interact with conserved components of the apoptosis machinery in mammalian cells...
  15. ncbi request reprint Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9
    L A O'Reilly
    The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
    Cell Death Differ 9:832-41. 2002
    ..Caspase-2 processing does not occur in thymocytes lacking Apaf-1 or caspase-9, suggesting that in this cell type, activation of caspase-2 occurs downstream of apoptosome formation...
  16. ncbi request reprint Anti-apoptotic potential of insect cellular and viral IAPs in mammalian cells
    C J Hawkins
    The Walter and Eliza Hall Institute for Medical Research, Post Office Royal Melbourne Hospital, Victoria, 3050, Australia
    Cell Death Differ 5:569-76. 1998
    ..As OpIAP protected against death induced by ligation of TNF receptor family members, but not by factor nor serum withdrawal from dependent cells, it can inhibit certain apoptotic pathways without affecting others...
  17. ncbi request reprint Death in the snow: report on Keystone Conference on 'Apoptosis and Programmed Cell Death' at Breckenridge, CO, April 6-11th 1999
    A Strasser
    Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Melbourne, Australia
    Biochim Biophys Acta 1470:R1-R11. 2000
  18. ncbi request reprint Tissue distribution of Diablo/Smac revealed by monoclonal antibodies
    A Tikoo
    The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, VIC 3050, Australia
    Cell Death Differ 9:710-6. 2002
    ..In support of previous subcellular localization analysis, Diablo was present within the mitochondria of healthy cells, but released into the cytosol following the induction of apoptosis by UV...
  19. pmc Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs
    A M Verhagen
    The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia
    Genome Biol 2:REVIEWS3009. 2001
    ..These Survivin-like BIRPs regulate cytokinesis and mitotic spindle formation. In this review, we describe the IAPs and other BIRPs, their evolutionary relationships and their subcellular and tissue localizations...
  20. ncbi request reprint Cell death regulation by the mammalian IAP antagonist Diablo/Smac
    A M Verhagen
    The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria 3050, Australia
    Apoptosis 7:163-6. 2002
    ..Since its discovery, there have been numerous studies investigating how Diablo/Smac interacts with IAPs and promotes cell death. Here we review what is currently known about Diablo/Smac and speculate on other mammalian IAP antagonists...
  21. doi request reprint Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim
    A M Jabbour
    Children s Cancer Centre, Murdoch Children s Research Institute, Royal Children s Hospital, Flemington Road, Parkville, Victoria, Australia
    Cell Death Differ 16:555-63. 2009
    ..These data indicate that Puma functions, in the context of induced overexpression or IL-3 deprivation, primarily by binding and inactivating anti-apoptotic Bcl-2 family members...
  22. pmc CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease
    K G Smith
    The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    EMBO J 15:5167-76. 1996
    ..These results provide evidence that the phenotype of lpr mice is not simply due to failure of CD95 to trigger T cell apoptosis mediated by ICE...
  23. pmc Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors
    A G Uren
    The Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
    Proc Natl Acad Sci U S A 93:4974-8. 1996
    ....
  24. ncbi request reprint The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
    A Strasser
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    Biochim Biophys Acta 1333:F151-78. 1997
    ....
  25. ncbi request reprint Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype
    A G Uren
    The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, 3050, Victoria, Australia
    Curr Biol 10:1319-28. 2000
    ..To determine the function of Survivin in mammals, we analyzed the pattern of localization of Survivin protein during the cell cycle, and deleted its gene by homologous recombination in mice...
  26. ncbi request reprint Cloning of mouse RP-8 cDNA and its expression during apoptosis of lymphoid and myeloid cells
    D L Vaux
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    DNA Cell Biol 14:189-93. 1995
    ..Although these data do not prove that RP-8 is not a cell death gene, they show that RP-8 expression is not sufficient for apoptosis, and that transcriptional up regulation of RP-8 is not universally associated with apoptosis...
  27. ncbi request reprint Caspase inhibitors
    P G Ekert
    The Walter and Eliza Hall Institute of Medical Research, c o Post Office Royal Melbourne Hospital, Victoria 3050, Australia
    Cell Death Differ 6:1081-6. 1999
    ....
  28. pmc Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Proc Natl Acad Sci U S A 88:8661-5. 1991
    ..Thus E mu-bcl-2-22 mice constitute a transgenic model for a systemic autoimmune disease resembling the human disorder systemic lupus erythematosus...
  29. ncbi request reprint TNF and CD95 promote IL-8 gene transactivation via independent elements in colon carcinoma cells
    A M Verhagen
    The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria 3050, Australia
    Cytokine 15:108-12. 2001
    ..These results suggest that promoter elements/enhancers involved in CD95 mediated IL-8 induction are distinct from those used by TNF and not contained within the 1.6 kb region immediately upstream of the initiation codon...
  30. pmc Role for yeast inhibitor of apoptosis (IAP)-like proteins in cell division
    A G Uren
    The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 96:10170-5. 1999
    ..Rather than inhibiting caspase-mediated cell death, yeast IAP proteins have roles in cell division and appear to act in a similar way to the IAPs from Caenorhabditis elegans and the mammalian IAP Survivin...
  31. ncbi request reprint Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat
    M G Hinds
    Biomolecular Research Institute, Parkville, Australia
    Nat Struct Biol 6:648-51. 1999
    ..The structure consists of a series of short alpha-helices and turns with the zinc packed in an unusually hydrophobic environment created by residues that are highly conserved among all BIRs...
  32. pmc Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die
    Paul G Ekert
    The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Cell Biol 165:835-42. 2004
    ..Unlike expression of Bcl-2, loss of Apaf-1, caspase-2, or caspase-9 would therefore be unlikely to enhance the survival of cancer cells...
  33. pmc Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance
    John Silke
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 102:16182-7. 2005
    ..Cross control of protein levels by RING domains may therefore enable their levels to be manipulated therapeutically...
  34. ncbi request reprint Unlike Diablo/smac, Grim promotes global ubiquitination and specific degradation of X chromosome-linked inhibitor of apoptosis (XIAP) and neither cause apoptosis
    John Silke
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, VIC 3050, Australia
    J Biol Chem 279:4313-21. 2004
    ....
  35. pmc The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites
    John Silke
    The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
    J Cell Biol 157:115-24. 2002
    ....
  36. ncbi request reprint Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
    Vanessa S Marsden
    The Walter and Eliza Hall Institute, Melbourne, 3050, Australia
    Nature 419:634-7. 2002
    ..We conclude that Bcl-2 regulates a caspase activation programme independently of the cytochrome c/Apaf-1/caspase-9 'apoptosome', which seems to amplify rather than initiate the caspase cascade...
  37. ncbi request reprint HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins
    Anne M Verhagen
    Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria 3050, Australia
    J Biol Chem 277:445-54. 2002
    ....
  38. ncbi request reprint Cell death: shadow baxing
    J Silke
    Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia
    Curr Biol 8:R528-31. 1998
    ..Mammalian Bax, a pro-apoptotic family member, can cause yeast cells to die, and two recent yeast genetic screens shed light on how Bax might function...
  39. pmc Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts
    J Allison
    The Walter and Eliza Hall Institute for Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia
    Proc Natl Acad Sci U S A 94:3943-7. 1997
    ..However, transgenic mice developed a granulocytic infiltration in their pancreata. These results demonstrate a pro-inflammatory function of CD95L and suggest that expression of CD95L may not be sufficient to protect organ allografts...
  40. doi request reprint RIPK1 is not essential for TNFR1-induced activation of NF-kappaB
    W W L Wong
    Department of Biochemistry, La Trobe University, Kingsbury Drive, Melbourne, Victoria 3086, Australia
    Cell Death Differ 17:482-7. 2010
    ..Furthermore, several cell types from E18 RIPK1(-/-) embryos seem to activate NF-kappaB in response to TNF. These data indicate that models proposing that RIPK1 is essential for TNFR1 to activate canonical NF-kappaB are incorrect...
  41. ncbi request reprint Two kinds of BIR-containing protein - inhibitors of apoptosis, or required for mitosis
    J Silke
    The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Parkville, Australia
    J Cell Sci 114:1821-7. 2001
    ....
  42. pmc Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9
    Vanessa S Marsden
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Cell Biol 165:775-80. 2004
    ..These findings suggest that caspases other than caspases 2 and 9 can promote cytochrome c release and initiate Bcl-2-regulated apoptosis...
  43. ncbi request reprint HtrA2/Omi, a sheep in wolf's clothing
    David L Vaux
    The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, 3050, Victoria, Australia
    Cell 115:251-3. 2003
    ..This suggests that instead of promoting cell death by antagonizing inhibitor of apoptosis (IAP) proteins, the primary function of HtrA2/Omi is to handle misfolded proteins in the mitochondria...
  44. ncbi request reprint Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma
    Paul G Ekert
    Children s Cancer Centre, Murdoch Children s Research Centre, Royal Children s Hospital, Flemington Rd, Parkville, Victoria 3052, Australia
    Blood 108:1461-8. 2006
    ..Inhibition of the PI3 kinase pathway promoted apoptosis in the presence or absence of IL-3 and did not require Bad, Bim, or Puma, suggesting IL-3 receptor survival signals and PI3 kinase survival signals are independent...
  45. ncbi request reprint Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation
    Bernard A Callus
    The Walter and Eliza Hall Institute, Parkville, VC, Australia
    FEBS J 273:4264-76. 2006
    ..Together these results show that hSav can bind to, and be phosphorylated by, Mst, and that the stabilizing effect of Mst on hSav requires its interaction with hSav but is probably not due to phosphorylation of hSav by Mst...
  46. ncbi request reprint IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis
    James E Vince
    Department of Biochemistry, La Trobe University, Kingsbury Drive, Melbourne, VIC 3086, Australia
    Cell 131:682-93. 2007
    ..Cells treated with an IAC, or those in which cIAP1 was deleted, became sensitive to apoptosis induced by exogenous TNFalpha, suggesting novel uses of these compounds in treating cancer...
  47. ncbi request reprint The mitochondrial death squad: hardened killers or innocent bystanders?
    Paul G Ekert
    The Walter and Eliza Hall Institute, 1G Royal Parade Parkville, Victoria 3050, Australia
    Curr Opin Cell Biol 17:626-30. 2005
    ..Gene knockout experiments suggest that many were wrongly convicted on circumstantial evidence, and just happened to be in the wrong place at the wrong time...
  48. ncbi request reprint Expression of candidate cell death genes in cell lines during apoptosis
    G Hacker
    Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia
    Biochem Cell Biol 72:451-4. 1994
    ..These results suggest that expression of RP-2 and nedd2 is not sufficient for apoptosis, and if the products of these genes are involved in apoptosis of FDC-P1 cells, they are regulated by posttranslational mechanisms...
  49. pmc TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis
    James E Vince
    Department of Biochemistry, La Trobe University, Kingsbury Drive, Melbourne, Victoria 3086, Australia
    J Biol Chem 284:35906-15. 2009
    ..These results show that TRAF2 has anti-apoptotic signaling roles in addition to promoting NF-kappaB signaling and that efficient activation of NF-kappaB by TNFR1 requires the recruitment of cIAP1/2 by TRAF2...
  50. pmc TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha
    James E Vince
    Department of Biochemistry, La Trobe University, Kingsbury Drive, Melbourne, VIC 3086, Australia
    J Cell Biol 182:171-84. 2008
    ..Lysosomal degradation of cIAP1-TRAF2 by TWEAK/FN14 therefore critically alters the balance of life/death signals emanating from TNF-R1 in immortalized cells...
  51. ncbi request reprint Apoptosis in the development and treatment of cancer
    Robert Gerl
    The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Carcinogenesis 26:263-70. 2005
    ..Novel treatments designed to exploit our knowledge of apoptotic mechanisms are under development to promote apoptosis of cancer cells and limit concurrent death of normal cells...
  52. pmc A novel Apaf-1-independent putative caspase-2 activation complex
    Stuart H Read
    Hanson Institute, Adelaide, Australia 5000
    J Cell Biol 159:739-45. 2002
    ..Our data are consistent with a model where caspase-2 activation occurs by oligomerization, independent of the Apaf-1 apoptosome...
  53. ncbi request reprint Apoptosis. A cinderella caspase takes center stage
    Sharad Kumar
    Hanson Institute, Frome Road, Adelaide 5000, Australia
    Science 297:1290-1. 2002
  54. ncbi request reprint Early work on the function of Bcl-2, an interview with David Vaux
    David L Vaux
    Cell Death Differ 11:S28-32. 2004
  55. ncbi request reprint Alterations in the apoptotic machinery and their potential role in anticancer drug resistance
    Scott H Kaufmann
    Division of Oncology Research, Guggenheim 1342C, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Oncogene 22:7414-30. 2003
    ..A key issue is whether the direct toxic activity of these treatments is of benefit when neoplastic cells contain changes that diminish their ability to undergo apoptosis...