Research Topics
Genomes and Genes
| D L VauxSummaryAffiliation: The Walter and Eliza Hall Institute of Medical Research Country: Australia Publications
| Collaborators
|
Detail Information
Publications
Cell death in developmentD L Vaux
The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital Victoria, Australia
Cell 96:245-54. 1999- IAPs, RINGs and ubiquitylationDavid L Vaux
The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3050, Australia
Nat Rev Mol Cell Biol 6:287-97. 2005..As well as regulating other proteins, the IAPs themselves are controlled by ubiquitin-mediated degradation... 
The buzz about BAFFDavid L Vaux
The Walter and Eliza Hall Institute, Royal Parade Parkville, Victoria 3050, Australia
J Clin Invest 109:17-8. 2002- Apoptosis and toxicology--what relevance?D L Vaux
The Walter and Eliza Hall Institute of Medical Research, Royal Parade, Parkville, VIC 3050, Australia
Toxicology 181:3-7. 2002.... 
In defense of the somatic mutation theory of cancerDavid L Vaux
Walter and Eliza Hall Institute, and LaTrobe Institute for Molecular Science, Melbourne, Australia
Bioessays 33:341-3. 2011....- Apoptosis genes and autoimmunityD L Vaux
The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia
Curr Opin Immunol 12:719-24. 2000..An understanding of the pathophysiology of common autoimmune diseases will require elucidation of many different systems that interact in complex ways, of which the process of apoptosis is just one... - Mammalian mitochondrial IAP binding proteinsDavid L Vaux
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Biochem Biophys Res Commun 304:499-504. 2003.... - Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAPJ Silke
The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, VIC 3050
EMBO J 20:3114-23. 2001..Furthermore, these mutants retained full ability to inhibit apoptosis in transfected cells, demonstrating that although XIAP is able to inhibit caspase 3, this activity is dispensable for inhibition of apoptosis by XIAP in vivo... 
DIABLO promotes apoptosis by removing MIHA/XIAP from processed caspase 9P G Ekert
The Walter and Eliza Hall Institute, The Royal Melbourne Hospital, Victoria 3050, Australia
J Cell Biol 152:483-90. 2001..Once released into the cytosol, DIABLO bound to MIHA and disrupted its association with processed caspase 9, thereby allowing caspase 9 to activate caspase 3, resulting in apoptosis...- Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteinsA M Verhagen
The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia
Cell 102:43-53. 2000..As transfection of cells with DIABLO was able to counter the protection afforded by MIHA against UV irradiation, DIABLO may promote apoptosis by binding to IAPs and preventing them from inhibiting caspases... - Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9L A O'Reilly
The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
Cell Death Differ 9:832-41. 2002..Caspase-2 processing does not occur in thymocytes lacking Apaf-1 or caspase-9, suggesting that in this cell type, activation of caspase-2 occurs downstream of apoptosome formation... - Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifsA M Verhagen
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Cell Death Differ 14:348-57. 2007..Through this interaction, many are able to antagonise XIAP inhibition of caspase 3 in vitro... - Tissue distribution of Diablo/Smac revealed by monoclonal antibodiesA Tikoo
The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, VIC 3050, Australia
Cell Death Differ 9:710-6. 2002..In support of previous subcellular localization analysis, Diablo was present within the mitochondria of healthy cells, but released into the cytosol following the induction of apoptosis by UV... - Death in the snow: report on Keystone Conference on 'Apoptosis and Programmed Cell Death' at Breckenridge, CO, April 6-11th 1999A Strasser
Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Melbourne, Australia
Biochim Biophys Acta 1470:R1-R11. 2000 - Cell death regulation by the mammalian IAP antagonist Diablo/SmacA M Verhagen
The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria 3050, Australia
Apoptosis 7:163-6. 2002..Since its discovery, there have been numerous studies investigating how Diablo/Smac interacts with IAPs and promotes cell death. Here we review what is currently known about Diablo/Smac and speculate on other mammalian IAP antagonists... - CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune diseaseK G Smith
The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
EMBO J 15:5167-76. 1996..These results provide evidence that the phenotype of lpr mice is not simply due to failure of CD95 to trigger T cell apoptosis mediated by ICE... - Puma indirectly activates Bax to cause apoptosis in the absence of Bid or BimA M Jabbour
Children s Cancer Centre, Murdoch Children s Research Institute, Royal Children s Hospital, Flemington Road, Parkville, Victoria, Australia
Cell Death Differ 16:555-63. 2009..These data indicate that Puma functions, in the context of induced overexpression or IL-3 deprivation, primarily by binding and inactivating anti-apoptotic Bcl-2 family members... - The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapyA Strasser
The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
Biochim Biophys Acta 1333:F151-78. 1997.... - Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPsA M Verhagen
The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia
Genome Biol 2:REVIEWS3009. 2001..These Survivin-like BIRPs regulate cytokinesis and mitotic spindle formation. In this review, we describe the IAPs and other BIRPs, their evolutionary relationships and their subcellular and tissue localizations... - Caspase inhibitorsP G Ekert
The Walter and Eliza Hall Institute of Medical Research, c o Post Office Royal Melbourne Hospital, Victoria 3050, Australia
Cell Death Differ 6:1081-6. 1999.... - Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotypeA G Uren
The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, 3050, Victoria, Australia
Curr Biol 10:1319-28. 2000..To determine the function of Survivin in mammals, we analyzed the pattern of localization of Survivin protein during the cell cycle, and deleted its gene by homologous recombination in mice... - Role for yeast inhibitor of apoptosis (IAP)-like proteins in cell divisionA G Uren
The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria 3050, Australia
Proc Natl Acad Sci U S A 96:10170-5. 1999..Rather than inhibiting caspase-mediated cell death, yeast IAP proteins have roles in cell division and appear to act in a similar way to the IAPs from Caenorhabditis elegans and the mammalian IAP Survivin... - TNF and CD95 promote IL-8 gene transactivation via independent elements in colon carcinoma cellsA M Verhagen
The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria 3050, Australia
Cytokine 15:108-12. 2001..These results suggest that promoter elements/enhancers involved in CD95 mediated IL-8 induction are distinct from those used by TNF and not contained within the 1.6 kb region immediately upstream of the initiation codon... - Cloning of mouse RP-8 cDNA and its expression during apoptosis of lymphoid and myeloid cellsD L Vaux
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
DNA Cell Biol 14:189-93. 1995..Although these data do not prove that RP-8 is not a cell death gene, they show that RP-8 expression is not sufficient for apoptosis, and that transcriptional up regulation of RP-8 is not universally associated with apoptosis... - Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune diseaseA Strasser
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
Proc Natl Acad Sci U S A 88:8661-5. 1991..Thus E mu-bcl-2-22 mice constitute a transgenic model for a systemic autoimmune disease resembling the human disorder systemic lupus erythematosus... - Inhibition of interleukin 1 beta-converting enzyme-mediated apoptosis of mammalian cells by baculovirus IAPC J Hawkins
Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia
Proc Natl Acad Sci U S A 93:13786-90. 1996..These results demonstrate that a baculoviral IAP protein can functionally interact with conserved components of the apoptosis machinery in mammalian cells... - Cell death: shadow baxingJ Silke
Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia
Curr Biol 8:R528-31. 1998..Mammalian Bax, a pro-apoptotic family member, can cause yeast cells to die, and two recent yeast genetic screens shed light on how Bax might function... - Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune privilege upon islet allograftsJ Allison
The Walter and Eliza Hall Institute for Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia
Proc Natl Acad Sci U S A 94:3943-7. 1997..However, transgenic mice developed a granulocytic infiltration in their pancreata. These results demonstrate a pro-inflammatory function of CD95L and suggest that expression of CD95L may not be sufficient to protect organ allografts... - Unlike Diablo/smac, Grim promotes global ubiquitination and specific degradation of X chromosome-linked inhibitor of apoptosis (XIAP) and neither cause apoptosisJohn Silke
Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, VIC 3050, Australia
J Biol Chem 279:4313-21. 2004.... - Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosomeVanessa S Marsden
The Walter and Eliza Hall Institute, Melbourne, 3050, Australia
Nature 419:634-7. 2002..We conclude that Bcl-2 regulates a caspase activation programme independently of the cytochrome c/Apaf-1/caspase-9 'apoptosome', which seems to amplify rather than initiate the caspase cascade... - Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundanceJohn Silke
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Proc Natl Acad Sci U S A 102:16182-7. 2005..Cross control of protein levels by RING domains may therefore enable their levels to be manipulated therapeutically... - The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sitesJohn Silke
The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
J Cell Biol 157:115-24. 2002.... - HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteinsAnne M Verhagen
Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria 3050, Australia
J Biol Chem 277:445-54. 2002.... - Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells diePaul G Ekert
The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
J Cell Biol 165:835-42. 2004..Unlike expression of Bcl-2, loss of Apaf-1, caspase-2, or caspase-9 would therefore be unlikely to enhance the survival of cancer cells... - Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factorsA G Uren
The Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
Proc Natl Acad Sci U S A 93:4974-8. 1996.... - Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeatM G Hinds
Biomolecular Research Institute, Parkville, Australia
Nat Struct Biol 6:648-51. 1999..The structure consists of a series of short alpha-helices and turns with the zinc packed in an unusually hydrophobic environment created by residues that are highly conserved among all BIRs... - Two kinds of BIR-containing protein - inhibitors of apoptosis, or required for mitosisJ Silke
The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Parkville, Australia
J Cell Sci 114:1821-7. 2001.... - IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosisJames E Vince
Department of Biochemistry, La Trobe University, Kingsbury Drive, Melbourne, VIC 3086, Australia
Cell 131:682-93. 2007..Cells treated with an IAC, or those in which cIAP1 was deleted, became sensitive to apoptosis induced by exogenous TNFalpha, suggesting novel uses of these compounds in treating cancer... - Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylationBernard A Callus
The Walter and Eliza Hall Institute, Parkville, VC, Australia
FEBS J 273:4264-76. 2006..Together these results show that hSav can bind to, and be phosphorylated by, Mst, and that the stabilizing effect of Mst on hSav requires its interaction with hSav but is probably not due to phosphorylation of hSav by Mst... - Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on PumaPaul G Ekert
Children s Cancer Centre, Murdoch Children s Research Centre, Royal Children s Hospital, Flemington Rd, Parkville, Victoria 3052, Australia
Blood 108:1461-8. 2006..Inhibition of the PI3 kinase pathway promoted apoptosis in the presence or absence of IL-3 and did not require Bad, Bim, or Puma, suggesting IL-3 receptor survival signals and PI3 kinase survival signals are independent... - The mitochondrial death squad: hardened killers or innocent bystanders?Paul G Ekert
The Walter and Eliza Hall Institute, 1G Royal Parade Parkville, Victoria 3050, Australia
Curr Opin Cell Biol 17:626-30. 2005..Gene knockout experiments suggest that many were wrongly convicted on circumstantial evidence, and just happened to be in the wrong place at the wrong time... - HtrA2/Omi, a sheep in wolf's clothingDavid L Vaux
The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, 3050, Victoria, Australia
Cell 115:251-3. 2003..This suggests that instead of promoting cell death by antagonizing inhibitor of apoptosis (IAP) proteins, the primary function of HtrA2/Omi is to handle misfolded proteins in the mitochondria... - Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9Vanessa S Marsden
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
J Cell Biol 165:775-80. 2004..These findings suggest that caspases other than caspases 2 and 9 can promote cytochrome c release and initiate Bcl-2-regulated apoptosis... - RIPK1 is not essential for TNFR1-induced activation of NF-kappaBW W L Wong
Department of Biochemistry, La Trobe University, Kingsbury Drive, Melbourne, Victoria 3086, Australia
Cell Death Differ 17:482-7. 2010..Furthermore, several cell types from E18 RIPK1(-/-) embryos seem to activate NF-kappaB in response to TNF. These data indicate that models proposing that RIPK1 is essential for TNFR1 to activate canonical NF-kappaB are incorrect... - TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosisJames E Vince
Department of Biochemistry, La Trobe University, Kingsbury Drive, Melbourne, Victoria 3086, Australia
J Biol Chem 284:35906-15. 2009..These results show that TRAF2 has anti-apoptotic signaling roles in addition to promoting NF-kappaB signaling and that efficient activation of NF-kappaB by TNFR1 requires the recruitment of cIAP1/2 by TRAF2... - TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalphaJames E Vince
Department of Biochemistry, La Trobe University, Kingsbury Drive, Melbourne, VIC 3086, Australia
J Cell Biol 182:171-84. 2008..Lysosomal degradation of cIAP1-TRAF2 by TWEAK/FN14 therefore critically alters the balance of life/death signals emanating from TNF-R1 in immortalized cells... - Apoptosis in the development and treatment of cancerRobert Gerl
The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3050, Australia
Carcinogenesis 26:263-70. 2005..Novel treatments designed to exploit our knowledge of apoptotic mechanisms are under development to promote apoptosis of cancer cells and limit concurrent death of normal cells... - A novel Apaf-1-independent putative caspase-2 activation complexStuart H Read
Hanson Institute, Adelaide, Australia 5000
J Cell Biol 159:739-45. 2002..Our data are consistent with a model where caspase-2 activation occurs by oligomerization, independent of the Apaf-1 apoptosome... - Apoptosis. A cinderella caspase takes center stageSharad Kumar
Hanson Institute, Frome Road, Adelaide 5000, Australia
Science 297:1290-1. 2002 - Alterations in the apoptotic machinery and their potential role in anticancer drug resistanceScott H Kaufmann
Division of Oncology Research, Guggenheim 1342C, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Oncogene 22:7414-30. 2003..A key issue is whether the direct toxic activity of these treatments is of benefit when neoplastic cells contain changes that diminish their ability to undergo apoptosis... - Early work on the function of Bcl-2, an interview with David VauxDavid L Vaux
Cell Death Differ 11:S28-32. 2004