A Strasser

Summary

Affiliation: The Walter and Eliza Hall Institute of Medical Research
Country: Australia

Publications

  1. ncbi bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital Post Office, Victoria, Australia
    Cell 67:889-99. 1991
  2. ncbi The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
    A Strasser
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    Biochim Biophys Acta 1333:F151-78. 1997
  3. ncbi Loss of pro-apoptotic BH3-only Bcl-2 family member Bim does not protect mutant Lurcher mice from neurodegeneration
    Philippe Bouillet
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    J Neurosci Res 74:777-81. 2003
  4. ncbi Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
    Simon N Willis
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Science 315:856-9. 2007
  5. ncbi Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity
    Peter D Hughes
    Molecular Genetics of Cancer, The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Immunity 28:197-205. 2008
  6. ncbi The transcriptional regulator Rel is essential for antigen receptor-mediated stimulation of mature T cells but dispensable for positive and negative selection of thymocytes and T cell apoptosis
    A Strasser
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Eur J Immunol 29:928-35. 1999
  7. ncbi Dr. Josef Steiner Cancer Research Prize Lecture: the role of physiological cell death in neoplastic transformation and in anti-cancer therapy
    A Strasser
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Vic, Australia
    Int J Cancer 81:505-11. 1999
  8. ncbi FADD/MORT1, a signal transducer that can promote cell death or cell growth
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Vic, Australia
    Int J Biochem Cell Biol 31:533-7. 1999
  9. ncbi Death in the snow: report on Keystone Conference on 'Apoptosis and Programmed Cell Death' at Breckenridge, CO, April 6-11th 1999
    A Strasser
    Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Melbourne, Australia
    Biochim Biophys Acta 1470:R1-R11. 2000
  10. ncbi Apoptosis signaling
    A Strasser
    1The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Annu Rev Biochem 69:217-45. 2000

Collaborators

Detail Information

Publications150 found, 100 shown here

  1. ncbi bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital Post Office, Victoria, Australia
    Cell 67:889-99. 1991
    ..These observations, together with previous findings on B cells, suggest that modulated bcl-2 expression is a determinant of life and death in normal lymphocytes...
  2. ncbi The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
    A Strasser
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    Biochim Biophys Acta 1333:F151-78. 1997
    ....
  3. ncbi Loss of pro-apoptotic BH3-only Bcl-2 family member Bim does not protect mutant Lurcher mice from neurodegeneration
    Philippe Bouillet
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    J Neurosci Res 74:777-81. 2003
    ..Our studies show that Bim deficiency does not modify the Lurcher phenotype, ruling out an indispensable role for Bim in this neurodegenerative disease...
  4. ncbi Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
    Simon N Willis
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Science 315:856-9. 2007
    ..Our results indicate that BH3-only proteins induce apoptosis at least primarily by engaging the multiple pro-survival relatives guarding Bax and Bak...
  5. ncbi Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity
    Peter D Hughes
    Molecular Genetics of Cancer, The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Immunity 28:197-205. 2008
    ..These results identify critical overlapping roles for Fas and Bim in T cell death in immune response shutdown and prevention of immunopathology and thereby resolve a long-standing controversy...
  6. ncbi The transcriptional regulator Rel is essential for antigen receptor-mediated stimulation of mature T cells but dispensable for positive and negative selection of thymocytes and T cell apoptosis
    A Strasser
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Eur J Immunol 29:928-35. 1999
    ..These results indicate that thymocytes and mature T cells differ in their requirement for Rel in mediating TCR-induced responses...
  7. ncbi Dr. Josef Steiner Cancer Research Prize Lecture: the role of physiological cell death in neoplastic transformation and in anti-cancer therapy
    A Strasser
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Vic, Australia
    Int J Cancer 81:505-11. 1999
    ..Discoveries from cell death research should provide clues for designing therapies for a variety of diseases, including degenerative disorders, auto-immunity and cancer...
  8. ncbi FADD/MORT1, a signal transducer that can promote cell death or cell growth
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Vic, Australia
    Int J Biochem Cell Biol 31:533-7. 1999
    ..Therapeutic activation of FADD/MORT1 function may be used to kill unwanted cells in cancer or autoimmunity and its suppression may help prevent cell death in certain degenerative disorders...
  9. ncbi Death in the snow: report on Keystone Conference on 'Apoptosis and Programmed Cell Death' at Breckenridge, CO, April 6-11th 1999
    A Strasser
    Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Melbourne, Australia
    Biochim Biophys Acta 1470:R1-R11. 2000
  10. ncbi Apoptosis signaling
    A Strasser
    1The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Annu Rev Biochem 69:217-45. 2000
    ..This article reviews current knowledge of apoptosis signaling, lists several pressing questions, and presents a novel model to explain the biochemical and functional interactions between components of the cell death regulatory machinery...
  11. ncbi The role of bim, a proapoptotic BH3-only member of the Bcl-2 family in cell-death control
    A Strasser
    Walter and Eliza Hall Institute, Post Office Royal Melbourne Hospital, 3050 Vic, Melbourne, Australia
    Ann N Y Acad Sci 917:541-8. 2000
    ..Unleashed BH3-only proteins neutralize the prosurvival function of Bcl-2-like molecules, and this is thought to liberate Apaf-l-like adapters to activate caspase zymogens, which then initiate cell degradation...
  12. ncbi What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain
    Andreas Strasser
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Immunol Cell Biol 86:57-66. 2008
    ..Finally, we speculate on the processes that may lead to the activation of Bim when antigen receptors are activated on autoreactive T or B cells...
  13. ncbi Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases
    Andreas Strasser
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    EMBO J 30:3667-83. 2011
    ....
  14. ncbi The many roles of FAS receptor signaling in the immune system
    Andreas Strasser
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Vic, Australia
    Immunity 30:180-92. 2009
    ..This review describes current understanding of Fas-induced apoptosis signaling and proposes experimental strategies for future advances...
  15. ncbi T-lymphocyte death during shutdown of an immune response
    Andreas Strasser
    Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3050 Victoria, Australia
    Trends Immunol 25:610-5. 2004
    ....
  16. ncbi The role of BH3-only proteins in the immune system
    Andreas Strasser
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Nat Rev Immunol 5:189-200. 2005
    ..This review describes BH3-only proteins, a pro-apoptotic subgroup of the BCL-2 family, and their role in the development and function of the immune system...
  17. ncbi The control of apoptosis in lymphocyte selection
    Andreas Strasser
    Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    Immunol Rev 193:82-92. 2003
    ....
  18. ncbi Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    P Bouillet
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Science 286:1735-8. 1999
    ..Thus, Bim is required for hematopoietic homeostasis and as a barrier to autoimmunity. Moreover, particular death stimuli appear to activate apoptosis through distinct BH3-only proteins...
  19. ncbi Modifications and intracellular trafficking of FADD/MORT1 and caspase-8 after stimulation of T lymphocytes
    L A O'Reilly
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Cell Death Differ 11:724-36. 2004
    ..Interestingly, mitogenic stimulation, but not Fas ligation, induced a unique post-translational modification of FADD. These different modifications may determine whether FADD and caspase-8 induce cell death or proliferation...
  20. ncbi CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease
    K G Smith
    The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    EMBO J 15:5167-76. 1996
    ..These results provide evidence that the phenotype of lpr mice is not simply due to failure of CD95 to trigger T cell apoptosis mediated by ICE...
  21. ncbi Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim
    P Bouillet
    The Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Victoria 3050, Melbourne, Australia
    Dev Cell 1:645-53. 2001
    ..These results demonstrate that Bim levels set the threshold for initiation of apoptosis in several tissues and suggest that degenerative diseases might be alleviated by blocking BH3-only proteins...
  22. ncbi B lymphocytes differentially use the Rel and nuclear factor kappaB1 (NF-kappaB1) transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells
    R J Grumont
    The Walter and Eliza Hall Institute of Medical Research, Post Office The Royal Melbourne Hospital, Victoria 3050, Australia
    J Exp Med 187:663-74. 1998
    ....
  23. ncbi bcl-2 transgene expression promotes survival and reduces proliferation of CD3-CD4-CD8- T cell progenitors
    L A O'Reilly
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Int Immunol 9:1291-301. 1997
    ....
  24. ncbi A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes
    K Newton
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
    EMBO J 17:706-18. 1998
    ..Thus signalling through FADD/MORT1 does not lead exclusively to cell death, but under certain circumstances can promote cell survival and proliferation...
  25. ncbi Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    EMBO J 14:6136-47. 1995
    ..These data raise the possibility that Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis...
  26. ncbi Expression of a bcl-2 transgene reduces proliferation and slows turnover of developing B lymphocytes in vivo
    L A O'Reilly
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    J Immunol 159:2301-11. 1997
    ..The implications of these results for the normal control of B lymphopoiesis and for lymphomagenesis are discussed...
  27. ncbi Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis
    H Puthalakath
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, P O Royal Melbourne Hospital, 3050 Vic, Australia
    Science 293:1829-32. 2001
    ..Thus, at least two mammalian BH3-only proteins, Bmf and Bim, function to sense intracellular damage by their localization to distinct cytoskeletal structures...
  28. ncbi Tissue expression and subcellular localization of the pro-survival molecule Bcl-w
    L A O'Reilly
    The Walter and Eliza Hall Institute, Melbourne, Australia
    Cell Death Differ 8:486-94. 2001
    ..The implications of these results are discussed in the context of the phenotype of Bcl-w-null mice and recent data that suggest that Bcl-w may play a role in colon carcinogenesis...
  29. ncbi Progenitor tumours from Emu-bcl-2-myc transgenic mice have lymphomyeloid differentiation potential and reveal developmental differences in cell survival
    A Strasser
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Melbourne, Australia 3050
    EMBO J 15:3823-34. 1996
    ..These results provide insight into the process of lineage commitment and suggest new levels of control of cell survival during early steps in haemopoietic development...
  30. ncbi Immunology. Lymphocyte survival--ignorance is BLys
    Y Laabi
    Walter and Eliza Hall Institute of Medical Research, Post Office Royal Victoria, Australia
    Science 289:883-4. 2000
    ..As Laâbi and Strasser explain in their Perspective, the receptors BCMA and TACI and their ligands BAFF/BLys and APRIL, respectively, are important for B lymphocyte survival, proliferation, and differentiation...
  31. ncbi The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex
    H Puthalakath
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Mol Cell 3:287-96. 1999
    ..This freed Bim to translocate together with LC8 to Bcl-2 and to neutralize its antiapoptotic activity. This process did not require caspase activity and therefore constitutes an initiating event in apoptosis signaling...
  32. ncbi Effects of a dominant interfering mutant of FADD on signal transduction in activated T cells
    K Newton
    The Walter and Eliza Hall Institute, Post Office Royal Melbourne Hospital, 3050, Victoria, Australia
    Curr Biol 11:273-6. 2001
    ..Therefore, FADD must act downstream of or in parallel to these signaling pathways...
  33. ncbi Rapid selection against truncation mutants in yeast reverse two-hybrid screens
    H Puthalakath
    Walter and Eliza Hall Institute, Melbourne, Australia
    Biotechniques 30:984-8. 2001
    ..By fusing the green fluorescent protein (GFP) to the C-terminus of a protein of interest, dynein light chain (LC8), we were able to rapidly isolate mutations that did not result in protein truncation...
  34. ncbi bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells
    K G Smith
    The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria 3050, Australia
    J Exp Med 191:475-84. 2000
    ..Continuous competition for antigen does, however, explain formation of the memory compartment...
  35. ncbi Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
    F Kontgen
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Genes Dev 9:1965-77. 1995
    ..The ability of exogenous interleukin-2 to restore T Cell, but not B cell, proliferation indicates that Rel regulates the expression of different genes in B and T cells that are crucial for cell division and immune function...
  36. ncbi The CD2-scl transgene alters the phenotype and frequency of T-lymphomas in N-ras transgenic or p53 deficient mice
    D J Curtis
    The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Oncogene 15:2975-83. 1997
    ..In contrast, CD2-scl transgene expression accelerated lymphomagenesis in p53 heterozygous mice. These data suggest that the collaborative effects of scl with N-ras or p53 vary according to the developmental stage of the T-cell...
  37. ncbi Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis
    E M Michalak
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Cell Death Differ 16:684-96. 2009
    ..They also indicate that additional BH3-only proteins probably also drive Myc-induced apoptosis and that non-apoptotic functions of p53 may contribute substantially to its tumour suppressor role...
  38. ncbi Pharmacological blockade of Bcl-2, Bcl-x(L) and Bcl-w by the BH3 mimetic ABT-737 has only minor impact on tumour development in p53-deficient mice
    S Grabow
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Cell Death Differ 19:623-32. 2012
    ..These data show that, collectively, Bcl-2, Bcl-x(L) and Bcl-w have only minor roles in thymic lymphoma development elicited by defects in p53, and this may indicate that Mcl-1 and/or A1 may feature more prominently in this process...
  39. ncbi Ionizing radiation and chemotherapeutic drugs induce apoptosis in lymphocytes in the absence of Fas or FADD/MORT1 signaling. Implications for cancer therapy
    K Newton
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    J Exp Med 191:195-200. 2000
    ..These results demonstrate that apoptosis induced by ionizing radiation or anticancer drugs requires p53 and is regulated by the Bcl-2 protein family but does not require signals transduced by Fas and FADD/MORT1...
  40. ncbi Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Victoria, Australia
    Proc Natl Acad Sci U S A 91:1376-80. 1994
    ..Thus, although bcl-2 expression hampers the deletion of immature self-reactive cells in the thymus, self-tolerance is maintained...
  41. ncbi Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9
    L A O'Reilly
    The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
    Cell Death Differ 9:832-41. 2002
    ..Caspase-2 processing does not occur in thymocytes lacking Apaf-1 or caspase-9, suggesting that in this cell type, activation of caspase-2 occurs downstream of apoptosome formation...
  42. ncbi Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms
    P Hughes
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Cell Death Differ 13:1123-7. 2006
    ..Loss of one Bcl-2 allele did not influence the PKD1del34 phenotype significantly. We conclude that loss of PKD1 and loss of Bcl-2 elicit PKD through distinct mechanisms...
  43. ncbi Bcl-2 expression promotes B- but not T-lymphoid development in scid mice
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Nature 368:457-60. 1994
    ....
  44. ncbi Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim
    A M Jabbour
    Children s Cancer Centre, Murdoch Children s Research Institute, Royal Children s Hospital, Flemington Road, Parkville, Victoria, Australia
    Cell Death Differ 16:555-63. 2009
    ..These data indicate that Puma functions, in the context of induced overexpression or IL-3 deprivation, primarily by binding and inactivating anti-apoptotic Bcl-2 family members...
  45. ncbi Bim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppression
    D Merino
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Oncogene 31:3392-6. 2012
    ..These results demonstrate that for optimal tumor suppressive activity, Bim must be able to interact with all and not just select pro-survival Bcl-2 family members...
  46. ncbi Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development
    P N Kelly
    The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3050, Australia
    Cell Death Differ 17:1655-64. 2010
    ..Collectively, these results show that Bim and Bad can cooperate in the apoptosis of thymocytes and activated B lymphocytes and in the suppression of thymic lymphoma development...
  47. ncbi Subversion of the Bcl-2 life/death switch in cancer development and therapy
    J M Adams
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Cold Spring Harb Symp Quant Biol 70:469-77. 2005
    ..We find that, like Bad, ABT-737 kills cells efficiently only if Mcl-1 is absent or down-regulated. Thus, manipulation of apoptosis by targeting the Bcl-2 family has exciting potential for cancer treatment...
  48. ncbi Insights from transgenic mice regarding the role of bcl-2 in normal and neoplastic lymphoid cells
    S Cory
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Philos Trans R Soc Lond B Biol Sci 345:289-95. 1994
    ..Crosses of the bcl-2 transgenic mice with p53-/- mice have addressed whether loss of p53 function and gain of bcl-2 function are synergistic for lymphoid cell survival...
  49. ncbi Bim: a novel member of the Bcl-2 family that promotes apoptosis
    L O'Connor
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    EMBO J 17:384-95. 1998
    ..Hence, Bim appears to act as a 'death ligand' which can only neutralize certain members of the pro-survival Bcl-2 sub-family...
  50. ncbi Neither loss of Bik alone, nor combined loss of Bik and Noxa, accelerate murine lymphoma development or render lymphoma cells resistant to DNA damaging drugs
    L Happo
    Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Cell Death Dis 3:e306. 2012
    ..These results suggest that Bik, even in combination with Noxa, is not a potent suppressor of c-Myc-driven tumourigenesis or critical for chemotherapeutic drug-induced killing of Myc-driven tumours...
  51. ncbi Activation of the mitogen-activated protein kinase pathway induces transcription of the PAC-1 phosphatase gene
    R J Grumont
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Mol Cell Biol 16:2913-21. 1996
    ....
  52. ncbi CD95 (Fas/APO-1) and p53 signal apoptosis independently in diverse cell types
    L O'Connor
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Cancer Res 60:1217-20. 2000
    ..p53 and CD95, therefore, function in independent pathways to cell death in these diverse cell types...
  53. ncbi A novel cellular model (SPGM 1) of switching between the pre-B cell and myelomonocytic lineages
    M Martin
    Lions Laboratory, Royal Melbourne Hospital, Victoria, Australia
    J Immunol 150:4395-406. 1993
    ..This inducible, rapid switch of virtually the entire population provides a unique model for the molecular analysis of mechanisms involved in cell-fate determination...
  54. ncbi Role of "cancer stem cells" and cell survival in tumor development and maintenance
    J M Adams
    Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Cold Spring Harb Symp Quant Biol 73:451-9. 2008
    ..This suggests that these tumors originate in an earlier cell type, such as the pro-B or pre-B cell, and that the nascent neoplastic clones do not require Bcl-2 but may instead be protected by a Bcl-2 relative...
  55. ncbi In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute
    E M Michalak
    Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Cell Death Differ 15:1019-29. 2008
    ..The absence of tumours in the mice suggests that tumour suppression by p53 requires functions in addition to induction of apoptosis...
  56. ncbi Transgenic models of lymphoid neoplasia and development of a pan-hematopoietic vector
    J M Adams
    The Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
    Oncogene 18:5268-77. 1999
    ..This novel vector should aid studies on many aspects of hematopoiesis, including the modeling of leukemogenesis...
  57. ncbi Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Nature 348:331-3. 1990
    ..Suprisingly, the tumours derive from a cell with the hallmarks of a primitive haemopoietic cell, perhaps a lymphoid-committed stem cell...
  58. ncbi Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Proc Natl Acad Sci U S A 88:8661-5. 1991
    ..Thus E mu-bcl-2-22 mice constitute a transgenic model for a systemic autoimmune disease resembling the human disorder systemic lupus erythematosus...
  59. ncbi Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins
    H Puthalakath
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Cell Death Differ 9:505-12. 2002
    ..In this review we describe current knowledge of the functions and transcriptional as well as post-translational control mechanisms of BH3-only proteins...
  60. ncbi Bcl-2 family member Bcl-G is not a proapoptotic protein
    M Giam
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Vic, Australia
    Cell Death Dis 3:e404. 2012
    ..We conclude that Bcl-G most probably does not function in the classical stress-induced apoptosis pathway, but rather has a role in protein trafficking inside the cell...
  61. ncbi Alternative splicing of Bim and Erk-mediated Bim(EL) phosphorylation are dispensable for hematopoietic homeostasis in vivo
    C Clybouw
    The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia
    Cell Death Differ 19:1060-8. 2012
    ..Hence, we conclude that physiological regulation of Bim relies on mechanisms independent of its alternative splicing or the Erk-dependent phosphorylation of Bim(EL)...
  62. ncbi Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling
    Andreas Villunger
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 101:7052-7. 2004
    ..These results reveal the mechanisms of apoptosis in negative selection of semimature thymocytes and have implications for immunological tolerance and autoimmunity...
  63. ncbi Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells
    Silke F Fischer
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Blood 110:3978-84. 2007
    ..We have identified for the first time the physiologic mechanisms for killing low-affinity antibody-expressing B cells in an immune response and have shown this to be dependent on the BH3-only protein Bim...
  64. ncbi BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
    Philippe Bouillet
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, P O The Royal Melbourne Hospital, Victoria 3050, Australia
    Nature 415:922-6. 2002
    ..TCR ligation upregulated Bim expression and promoted interaction of Bim with Bcl-XL, inhibiting its survival function. These findings identify Bim as an essential initiator of apoptosis in thymocyte-negative selection...
  65. ncbi Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival
    Andreas Villunger
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Blood 101:2393-400. 2003
    ....
  66. ncbi Detection of Bcl-2 family member Bcl-G in mouse tissues using new monoclonal antibodies
    M Giam
    The Walter and Eliza Hall Institute of Medical Research, Molecular Genetics of Cancer Division, Melbourne, Australia
    Cell Death Dis 3:e378. 2012
    ..The Bcl-G monoclonal antibodies represent new tools for studying this protein, using a variety of techniques, including immunoprecipitation and flow cytometry...
  67. ncbi Fas ligand, Bcl-2, granulocyte colony-stimulating factor, and p38 mitogen-activated protein kinase: Regulators of distinct cell death and survival pathways in granulocytes
    A Villunger
    The Walter and Eliza Hall Institute, Melbourne, Victoria 3050, Australia
    J Exp Med 192:647-58. 2000
    ..Moreover, p38 MAPK signaling contributes to granulocyte survival rather than their apoptosis...
  68. ncbi MEK/ERK-mediated phosphorylation of Bim is required to ensure survival of T and B lymphocytes during mitogenic stimulation
    Lorraine A O'Reilly
    Water and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    J Immunol 183:261-9. 2009
    ....
  69. ncbi NF-kappaB1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms
    Ashish Banerjee
    Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Blood 112:5063-73. 2008
    ....
  70. ncbi Role of Bim and other Bcl-2 family members in autoimmune and degenerative diseases
    Peter Hughes
    Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
    Curr Dir Autoimmun 9:74-94. 2006
    ..This chapter focuses on the role of Bim in the development and function of the immune system and its potential role in autoimmunity. Degenerative disorders due to increased apoptosis mediated by Bim are also discussed...
  71. ncbi Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells
    Anselm Enders
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Exp Med 198:1119-26. 2003
    ..Mechanistically, we determined that BCR ligation promoted interaction of Bim with Bcl-2, inhibiting its survival function. These findings demonstrate that Bim is a critical player in BCR-mediated apoptosis and in B lymphocyte deletion...
  72. ncbi p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
    Andreas Villunger
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Science 302:1036-8. 2003
    ..Hence, Puma and Noxa are critical mediators of the apoptotic responses induced by p53 and other agents...
  73. ncbi Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim
    Marc Pellegrini
    Division of Molecular Genetics of Cancer, The Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Australia
    Proc Natl Acad Sci U S A 100:14175-80. 2003
    ..These findings have implications for the therapeutic manipulation of immune responses to infections and immunization...
  74. ncbi BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice
    F Ke
    Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Cell Death Differ 19:915-25. 2012
    ..Collectively, these results indicate that Bok may have a role that largely overlaps with that of other members of the Bcl-2 family, or may have a function restricted to specific stress stimuli and/or tissues...
  75. ncbi The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy
    P N Kelly
    Molecular Genetics of Cancer Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3050, Australia
    Cell Death Differ 18:1414-24. 2011
    ....
  76. ncbi Transgenic overexpression of human Bcl-2 in islet beta cells inhibits apoptosis but does not prevent autoimmune destruction
    J Allison
    The Walter and Eliza Hall Institute for Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia
    Int Immunol 12:9-17. 2000
    ..Although Bcl-2 was able to prevent apoptosis induced by cytotoxic agents against beta cells in vitro, Bcl-2 alone could not prevent or ameliorate cytotoxic or autoimmune beta cell damage in vivo...
  77. ncbi Apoptosis and autoimmune disease
    L A O'Reilly
    Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
    Inflamm Res 48:5-21. 1999
    ..This review describes current understanding of the molecular regulation of apoptosis, and focuses on issues relating to possible roles of defective cell death control in autoimmunity...
  78. ncbi Bfk: a novel weakly proapoptotic member of the Bcl-2 protein family with a BH3 and a BH2 region
    L Coultas
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Cell Death Differ 10:185-92. 2003
    ..Low amounts of Bfk were found in stomach, ovary, bone marrow and spleen, but its level in the mammary gland rose markedly during pregnancy, suggesting that Bfk may play a role in mammary development...
  79. ncbi Mechanisms of beta cell death in diabetes: a minor role for CD95
    J Allison
    The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050 Australia
    Proc Natl Acad Sci U S A 95:13818-22. 1998
    ..An explanation to reconcile these differing results is provided...
  80. ncbi Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
    Vanessa S Marsden
    The Walter and Eliza Hall Institute, Melbourne, 3050, Australia
    Nature 419:634-7. 2002
    ..We conclude that Bcl-2 regulates a caspase activation programme independently of the cytochrome c/Apaf-1/caspase-9 'apoptosome', which seems to amplify rather than initiate the caspase cascade...
  81. ncbi Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1
    Nicholas D Huntington
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Immunol 8:856-63. 2007
    ..Thus, IL-15 regulates the survival of NK cells at multiple steps, with Bim and Noxa being key antagonists of Mcl-1, the critical survivor factor in this process...
  82. ncbi Is tumor growth sustained by rare cancer stem cells or dominant clones?
    Jerry M Adams
    The Walter and Eliza Hall Institute of Medical Research Melbourne, Victoria, Australia
    Cancer Res 68:4018-21. 2008
    ....
  83. ncbi The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins
    Delphine Merino
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia
    J Cell Biol 186:355-62. 2009
    ..Thus, initiation of apoptosis in vivo appears to require features of both models...
  84. ncbi Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax
    Mark D McKenzie
    St Vincent s Institute, Melbourne, Australia
    Diabetes 59:644-52. 2010
    ..We investigated the apoptotic pathway induced in mouse pancreatic islet cells after exposure to high concentrations of the reducing sugars ribose and glucose as a model of beta-cell death due to long-term metabolic stress...
  85. ncbi Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more
    Vanessa S Marsden
    Molecular Genetics of Cancer Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Annu Rev Immunol 21:71-105. 2003
    ..We also consider the pathogenic consequences of failure of apoptosis in the immune system...
  86. ncbi Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma
    Paul G Ekert
    Children s Cancer Centre, Murdoch Children s Research Centre, Royal Children s Hospital, Flemington Rd, Parkville, Victoria 3052, Australia
    Blood 108:1461-8. 2006
    ..Inhibition of the PI3 kinase pathway promoted apoptosis in the presence or absence of IL-3 and did not require Bad, Bim, or Puma, suggesting IL-3 receptor survival signals and PI3 kinase survival signals are independent...
  87. ncbi The role of Rel/NF-kappaB transcription factors in B lymphocyte survival
    Steve Gerondakis
    Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3050 Vic, Melbourne, Australia
    Semin Immunol 15:159-66. 2003
    ....
  88. ncbi Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice
    Marc Pellegrini
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Exp Med 200:1189-95. 2004
    ..This indicates that pharmacological inhibition of Bim function might be useful for boosting immune responses in immunodeficient patients...
  89. ncbi Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis
    Leigh Coultas
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    EMBO J 24:3963-73. 2005
    ..Thus, Bik and Bim share, upstream of Bax, the role of eliminating supernumerary germ cells during the first wave of spermatogenesis, a process vital for normal testicular development...
  90. ncbi NKT cell stimulation with glycolipid antigen in vivo: costimulation-dependent expansion, Bim-dependent contraction, and hyporesponsiveness to further antigenic challenge
    Adam P Uldrich
    Department Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    J Immunol 175:3092-101. 2005
    ..In summary, this study significantly enhances our understanding of how NKT cells respond to primary and secondary antigenic challenge in vivo...
  91. ncbi TNF cytokine family: more BAFF-ling complexities
    Y Laabi
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, 3050, Victoria, Australia
    Curr Biol 11:R1013-6. 2001
    ....
  92. ncbi Novel murine homeo box gene on chromosome 1 expressed in specific hematopoietic lineages and during embryogenesis
    J D Allen
    Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Australia
    Genes Dev 5:509-20. 1991
    ..It probably also functions outside the hematopoietic system, however, because Hlx mRNA could be detected in diverse adult tissues and in embryos from as early as day 8 of development...
  93. ncbi Fold up or perish: unfolded protein response and chemotherapy
    A Strasser
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Australia
    Cell Death Differ 15:223-5. 2008
  94. ncbi Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts
    J Allison
    The Walter and Eliza Hall Institute for Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia
    Proc Natl Acad Sci U S A 94:3943-7. 1997
    ..However, transgenic mice developed a granulocytic infiltration in their pancreata. These results demonstrate a pro-inflammatory function of CD95L and suggest that expression of CD95L may not be sufficient to protect organ allografts...
  95. ncbi Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis
    Leigh Coultas
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Cell Sci 120:2044-52. 2007
    ..These results demonstrate that HRK contributes to apoptosis signalling elicited by trophic factor withdrawal in certain neuronal populations but is dispensable for apoptosis of haematopoietic cells...
  96. ncbi Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim
    Thomas Kaufmann
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia
    Immunity 30:56-66. 2009
    ..These observations identify caspase-8 and the BH3-only proteins Bid and Bim as potential therapeutic targets for treatment of inflammatory liver diseases...
  97. ncbi BH3-only proteins - evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death
    Philippe Bouillet
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    J Cell Sci 115:1567-74. 2002
    ..In response, they unleash the apoptotic cascade by inactivating the protective function of the pro-survival members of the Bcl-2 family and by activating the Bax/Bax-like pro-apoptotic family members...
  98. ncbi Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim
    Gayle M Davey
    The Walter and Eliza Hall Institute of Medical Research, P.O. Royal Melbourne Hospital, Parkville 3050, Victoria, Australia
    J Exp Med 196:947-55. 2002
    ..Bim-deficient T cells were not deleted in response to cross-presented self-antigen, strongly implicating Bim as the pro-apoptotic mediator of cross-tolerance...
  99. ncbi B cell growth is controlled by phosphatidylinosotol 3-kinase-dependent induction of Rel/NF-kappaB regulated c-myc transcription
    Raelene J Grumont
    The Walter and Eliza Hall Institute of Medical Research, P O Box The Royal Melbourne Hospital, 3050, Victoria, Australia
    Mol Cell 10:1283-94. 2002
    ..Collectively, these findings establish a role for Rel/NF-kappaB signaling in the mitogen-induced growth of mammalian cells, which in B lymphocytes requires a PI3K/c-myc-dependent pathway...
  100. ncbi Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic
    Mark S Cragg
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    J Clin Invest 118:3651-9. 2008
    ..Thus, the therapeutic efficacy of MEK inhibition requires concurrent unleashing of apoptosis by a BH3 mimetic and represents a potent combination treatment for tumors harboring B-RAF mutations...
  101. ncbi Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9
    Vanessa S Marsden
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Cell Biol 165:775-80. 2004
    ..These findings suggest that caspases other than caspases 2 and 9 can promote cytochrome c release and initiate Bcl-2-regulated apoptosis...