Research Topics
Genomes and GenesSpecies | L SchofieldSummaryAffiliation: The Walter and Eliza Hall Institute of Medical Research Country: Australia Publications
Research Grants
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Detail Information
Publications
Regulation of host cell function by glycosylphosphatidylinositols of the parasitic protozoaL Schofield
Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Immunol Cell Biol 74:555-63. 1996....- Rational approaches to developing an anti-disease vaccine against malariaLouis Schofield
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3050 Victoria, Australia
Microbes Infect 9:784-91. 2007..This strategy could also reduce the risk posed by 'rebound' infections or immunopathology associated with other interventions... - Intravascular infiltrates and organ-specific inflammation in malaria pathogenesisLouis Schofield
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Immunol Cell Biol 85:130-7. 2007..Diverse pattern recognition and NK receptors crucially regulate these responding cell populations. Thus, innate immune mechanisms lie at the heart of this massive global public health problem... - Clinical immunity to malariaLouis Schofield
The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville, Victoria 3050, Australia
Curr Mol Med 6:205-21. 2006..This review addresses the targets and determinants of clinical immunity, and considers the implications for vaccine development... - Immunological processes in malaria pathogenesisLouis Schofield
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Nat Rev Immunol 5:722-35. 2005..This Review article addresses the innate and adaptive immune mechanisms elicited during malaria that either cause or prevent disease and fatalities, and it considers the implications for vaccine design... - Antidisease vaccinesL Schofield
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Melbourne, Australia
Chem Immunol 80:322-42. 2002 - CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cellsL Schofield
Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia
Science 283:225-9. 1999..The CD1-NKT cell pathway regulated immunogobulin G responses to the GPI-anchored surface antigens of Plasmodium and Trypanosoma and may be a general mechanism for rapid, MHC-unrestricted antibody responses to diverse pathogens... - Synthetic GPI as a candidate anti-toxic vaccine in a model of malariaLouis Schofield
Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia
Nature 418:785-9. 2002..GPI may contribute to pathogenesis and fatalities in humans. Synthetic GPI is therefore a prototype carbohydrate anti-toxic vaccine against malaria... 
Robert Koch redux: malaria immunology in Papua New GuineaD I Stanisic
The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
Parasite Immunol 32:623-32. 2010..These include age and exposure-related acquisition of immunity, species-specific and cross-species immunity, correlates of protective immunity and determining the prospects for anti-malaria vaccines...- Stimulation of innate immune responses by malarial glycosylphosphatidylinositol via pattern recognition receptorsT Nebl
The Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
Parasitology 130:S45-62. 2005..A better understanding of the molecular mechanisms underlying severe malarial pathogenesis may yet lead to substantial new insights with important implications for the development of novel therapeutics for malaria treatment... 
CD4+ CD25+ regulatory T cells suppress CD4+ T-cell function and inhibit the development of Plasmodium berghei-specific TH1 responses involved in cerebral malaria pathogenesisCatherine Q Nie
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Infect Immun 75:2275-82. 2007....- NK cells stimulate recruitment of CXCR3+ T cells to the brain during Plasmodium berghei-mediated cerebral malariaDiana S Hansen
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
J Immunol 178:5779-88. 2007.... - Inhibition of dendritic cell maturation by malaria is dose dependent and does not require Plasmodium falciparum erythrocyte membrane protein 1Salenna R Elliott
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Infect Immun 75:3621-32. 2007..However, our observation that low-dose iRBCs initiate functional DC maturation warrants reevaluation and further investigation of DC interactions with blood-stage P. falciparum... - The risk of malarial infections and disease in Papua New Guinean childrenPascal Michon
Papua New Guinea Institute of Medical Research, PO Box 378, Madang, MAD 511, Papua New Guinea
Am J Trop Med Hyg 76:997-1008. 2007..falciparum malaria remained incomplete. These observations suggest that different mechanisms of immunity may be important for protection from these malaria species... - gammadelta-T cells expressing NK receptors predominate over NK cells and conventional T cells in the innate IFN-gamma response to Plasmodium falciparum malariaDiana S Hansen
Infection and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
Eur J Immunol 37:1864-73. 2007..Applied to longitudinal cohort studies in endemic regions, similar comparative phenotyping should allow assessment of the contribution of diverse cell populations and regulatory receptors to risk of infection and disease... - The role of leukocytes bearing Natural Killer Complex receptors and Killer Immunoglobulin-like Receptors in the immunology of malariaDiana S Hansen
The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville 3050, Victoria, Australia
Curr Opin Immunol 19:416-23. 2007..Population-based immunogenetic analyses should allow the identification of NKC and KIR loci controlling innate and adaptive immune responses to malaria and associated with altered risk of infection and disease... - Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cellsIrina Caminschi
Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, 3050, Australia
J Exp Med 204:2579-90. 2007..Thus, IKDCs resemble NK cells functionally, and neither cell type could be induced to be effective antigen-presenting cells... - Plasmodium falciparum erythrocyte membrane protein-1 specifically suppresses early production of host interferon-gammaMarthe C D'Ombrain
Infection and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Cell Host Microbe 2:130-8. 2007..These data demonstrate a parasite strategy for downregulating the proinflammatory interferon-gamma response and further establish transgenic parasites lacking PfEMP-1 as powerful tools for elucidating PfEMP-1 functions... - Blood-stage Plasmodium infection induces CD8+ T lymphocytes to parasite-expressed antigens, largely regulated by CD8alpha+ dendritic cellsRachel J Lundie
Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
Proc Natl Acad Sci U S A 105:14509-14. 2008..Finally, using three different experimental approaches, we provide evidence that CTL specific for parasite-expressed antigens contribute to ECM... - Fatty acids from Plasmodium falciparum down-regulate the toxic activity of malaria glycosylphosphatidylinositolsFrançoise Debierre-Grockiego
Institut fur Virologie, AG Parasitologie, Hans Meerwein Str 2, D 35043 Marburg, Germany
Infect Immun 74:5487-96. 2006..This regulatory effect on cytokine production suggests that there is balanced bioactivity for the different categories of malarial lipids... - Preferential invasion of reticulocytes during late-stage Plasmodium berghei infection accounts for reduced circulating reticulocyte levelsDeborah Cromer
Department of Haematology, Prince of Wales Hospital, University of New South Wales, Kensington, NSW 2052, Australia
Int J Parasitol 36:1389-97. 2006.... - The lack of suppressor of cytokine signalling-1 (SOCS1) protects mice from the development of cerebral malaria caused by Plasmodium berghei ANKADenise V R Bullen
The Walter and Eliza Hall Institute of Medical Research and Cooperative Research Centre for Cellular Growth Factors, 1G Royal Parade, Victoria 3050, Australia
Parasite Immunol 25:113-8. 2003..Understanding the mechanism by which SOCS1 deficiency protects mice from cerebral malaria may allow the manipulation of its activity and alleviate pathology... - CD1d-restricted NKT cells contribute to malarial splenomegaly and enhance parasite-specific antibody responsesDiana S Hansen
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Eur J Immunol 33:2588-98. 2003.... - MyD88 is essential for clearance of Leishmania major: possible role for lipophosphoglycan and Toll-like receptor 2 signalingMichael J de Veer
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
Eur J Immunol 33:2822-31. 2003..Thus, the Toll pathway is required for resistance to L. major and LPG is a defined TLR agonist from this important human pathogen... - Transcriptional profiling reveals suppressed erythropoiesis, up-regulated glycolysis, and interferon-associated responses in murine malariaAdrienne C Sexton
The Walter and Eliza Hall Institute of Medical Research, IG Royal Parade, Parkville, Victoria, Australia
J Infect Dis 189:1245-56. 2004.... - The natural killer complex regulates severe malarial pathogenesis and influences acquired immune responses to Plasmodium berghei ANKADiana S Hansen
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Infect Immun 73:2288-97. 2005..To date, NKC-encoded innate system receptors have been shown mainly to regulate viral infections. Our data provide evidence for critical NKC involvement in the broad immunological responses to a protozoan parasite... - Influence of glycosylphosphatidylinositol anchorage on the efficacy of DNA vaccines encoding Plasmodium yoelii merozoite surface protein 4/5Lina Wang
Department of Microbiology and The Victoria Bioinformatics Consortium, Monash University, Clayton, VIC 3800, Australia
Vaccine 23:4120-7. 2005..Despite the induction of specific antibodies, none of these DNA vaccines induced sufficient levels of antibodies to protect mice against a lethal challenge with P. yoelii... - Distinct protein classes including novel merozoite surface antigens in Raft-like membranes of Plasmodium falciparumPaul R Sanders
The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3050 Australia
J Biol Chem 280:40169-76. 2005..This insight into merozoite surfaces provides new opportunities for understanding both erythrocyte invasion and anti-parasite immunity... - Severe malarial anemia of low parasite burden in rodent models results from accelerated clearance of uninfected erythrocytesKrystal J Evans
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Blood 107:1192-9. 2006..Anemia was significantly alleviated by depletion of either phagocytic cells or CD4+ T lymphocytes. This study demonstrates that immunologic mechanisms may contribute to SMA by promoting the accelerated turnover of uninfected RBCs... - Genes for glycosylphosphatidylinositol toxin biosynthesis in Plasmodium falciparumMauro Delorenzi
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
Infect Immun 70:4510-22. 2002..The biosynthetic pathway of the malaria parasite GPI offers potential targets for drug development and may be useful for studying parasite cell biology and the molecular basis for the pathophysiology of parasitic diseases... - Identification and stoichiometry of glycosylphosphatidylinositol-anchored membrane proteins of the human malaria parasite Plasmodium falciparumPaul R Gilson
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
Mol Cell Proteomics 5:1286-99. 2006..Together this work identified 11 and predicted a further 19 GPI-anchored proteins in P. falciparum... - Regulation of murine cerebral malaria pathogenesis by CD1d-restricted NKT cells and the natural killer complexDiana S Hansen
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Immunity 18:391-402. 2003.... - Murine cerebral malaria development is independent of toll-like receptor signalingDieudonnée Togbe
Molecular Immunology and Embryology, Centre National de la Recherche Scientifique, and University of Orleans, Transgenose Institute, Orleans, France
Am J Pathol 170:1640-8. 2007..However, TLR-dependent activation of innate immunity is unlikely to contribute significantly to the proinflammatory response to PbA infection and the development of fatal CM... - Regulation of immunity and pathogenesis in infectious diseases by CD1d-restricted NKT cellsDiana S Hansen
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Int J Parasitol 34:15-25. 2004..Such insights have the potential to add considerably to our understanding of the CD1/NKT cell system and to the immunology and pathogenesis of infectious diseases...
Research Grants
- IMMUNOBIOLOGY OF MALARIA GLYCOSYLPHOSPHATIDYLINOSITOLLouis Schofield; Fiscal Year: 2001..These areas are central to understanding the host/parasite interaction and the development of effective vaccines to several protozoal pathogens. ..
- A CHEMICALLY SYNTHETIC ANTI-TOXIC VACCINE AGAINST MALARILouis Schofield; Fiscal Year: 2002..Clinical immunity to malaria is acquired considerably earlier than anti-parasite immunity, and it is possible that this is mediated by anti-toxin mechanisms. ..