L Schofield

Summary

Affiliation: The Walter and Eliza Hall Institute of Medical Research
Country: Australia

Publications

  1. pmc Opsonising antibodies to P. falciparum merozoites associated with immunity to clinical malaria
    Danika L Hill
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia
    PLoS ONE 8:e74627. 2013
  2. pmc Efficient measurement of opsonising antibodies to Plasmodium falciparum merozoites
    Danika L Hill
    Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia
    PLoS ONE 7:e51692. 2012
  3. ncbi request reprint Rational approaches to developing an anti-disease vaccine against malaria
    Louis Schofield
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3050 Victoria, Australia
    Microbes Infect 9:784-91. 2007
  4. ncbi request reprint Intravascular infiltrates and organ-specific inflammation in malaria pathogenesis
    Louis Schofield
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Immunol Cell Biol 85:130-7. 2007
  5. ncbi request reprint Regulation of host cell function by glycosylphosphatidylinositols of the parasitic protozoa
    L Schofield
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Immunol Cell Biol 74:555-63. 1996
  6. ncbi request reprint Clinical immunity to malaria
    Louis Schofield
    The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville, Victoria 3050, Australia
    Curr Mol Med 6:205-21. 2006
  7. ncbi request reprint Immunological processes in malaria pathogenesis
    Louis Schofield
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Nat Rev Immunol 5:722-35. 2005
  8. ncbi request reprint CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells
    L Schofield
    Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia
    Science 283:225-9. 1999
  9. ncbi request reprint Antidisease vaccines
    L Schofield
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Melbourne, Australia
    Chem Immunol 80:322-42. 2002
  10. ncbi request reprint Synthetic GPI as a candidate anti-toxic vaccine in a model of malaria
    Louis Schofield
    Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia
    Nature 418:785-9. 2002

Research Grants

Collaborators

Detail Information

Publications36

  1. pmc Opsonising antibodies to P. falciparum merozoites associated with immunity to clinical malaria
    Danika L Hill
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia
    PLoS ONE 8:e74627. 2013
    ..This study presents the first evidence for merozoite phagocytosis as a correlate of acquired immunity and clinical protection against P. falciparum malaria. ..
  2. pmc Efficient measurement of opsonising antibodies to Plasmodium falciparum merozoites
    Danika L Hill
    Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia
    PLoS ONE 7:e51692. 2012
    ..There is a need for robust functional assays to investigate mechanisms of acquired immunity and vaccine efficacy. To date, the study of merozoite phagocytosis has been confounded by the complexity and variability of in vitro assays...
  3. ncbi request reprint Rational approaches to developing an anti-disease vaccine against malaria
    Louis Schofield
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3050 Victoria, Australia
    Microbes Infect 9:784-91. 2007
    ..This strategy could also reduce the risk posed by 'rebound' infections or immunopathology associated with other interventions...
  4. ncbi request reprint Intravascular infiltrates and organ-specific inflammation in malaria pathogenesis
    Louis Schofield
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Immunol Cell Biol 85:130-7. 2007
    ..Diverse pattern recognition and NK receptors crucially regulate these responding cell populations. Thus, innate immune mechanisms lie at the heart of this massive global public health problem...
  5. ncbi request reprint Regulation of host cell function by glycosylphosphatidylinositols of the parasitic protozoa
    L Schofield
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Immunol Cell Biol 74:555-63. 1996
    ....
  6. ncbi request reprint Clinical immunity to malaria
    Louis Schofield
    The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville, Victoria 3050, Australia
    Curr Mol Med 6:205-21. 2006
    ..This review addresses the targets and determinants of clinical immunity, and considers the implications for vaccine development...
  7. ncbi request reprint Immunological processes in malaria pathogenesis
    Louis Schofield
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Nat Rev Immunol 5:722-35. 2005
    ..This Review article addresses the innate and adaptive immune mechanisms elicited during malaria that either cause or prevent disease and fatalities, and it considers the implications for vaccine design...
  8. ncbi request reprint CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells
    L Schofield
    Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia
    Science 283:225-9. 1999
    ..The CD1-NKT cell pathway regulated immunogobulin G responses to the GPI-anchored surface antigens of Plasmodium and Trypanosoma and may be a general mechanism for rapid, MHC-unrestricted antibody responses to diverse pathogens...
  9. ncbi request reprint Antidisease vaccines
    L Schofield
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Melbourne, Australia
    Chem Immunol 80:322-42. 2002
  10. ncbi request reprint Synthetic GPI as a candidate anti-toxic vaccine in a model of malaria
    Louis Schofield
    Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia
    Nature 418:785-9. 2002
    ..GPI may contribute to pathogenesis and fatalities in humans. Synthetic GPI is therefore a prototype carbohydrate anti-toxic vaccine against malaria...
  11. doi request reprint Robert Koch redux: malaria immunology in Papua New Guinea
    D I Stanisic
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
    Parasite Immunol 32:623-32. 2010
    ..These include age and exposure-related acquisition of immunity, species-specific and cross-species immunity, correlates of protective immunity and determining the prospects for anti-malaria vaccines...
  12. ncbi request reprint Stimulation of innate immune responses by malarial glycosylphosphatidylinositol via pattern recognition receptors
    T Nebl
    The Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
    Parasitology 130:S45-62. 2005
    ..A better understanding of the molecular mechanisms underlying severe malarial pathogenesis may yet lead to substantial new insights with important implications for the development of novel therapeutics for malaria treatment...
  13. ncbi request reprint CD1d-restricted NKT cells contribute to malarial splenomegaly and enhance parasite-specific antibody responses
    Diana S Hansen
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Eur J Immunol 33:2588-98. 2003
    ....
  14. ncbi request reprint NK cells stimulate recruitment of CXCR3+ T cells to the brain during Plasmodium berghei-mediated cerebral malaria
    Diana S Hansen
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Immunol 178:5779-88. 2007
    ....
  15. pmc Inhibition of dendritic cell maturation by malaria is dose dependent and does not require Plasmodium falciparum erythrocyte membrane protein 1
    Salenna R Elliott
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Infect Immun 75:3621-32. 2007
    ..However, our observation that low-dose iRBCs initiate functional DC maturation warrants reevaluation and further investigation of DC interactions with blood-stage P. falciparum...
  16. pmc The risk of malarial infections and disease in Papua New Guinean children
    Pascal Michon
    Papua New Guinea Institute of Medical Research, PO Box 378, Madang, MAD 511, Papua New Guinea
    Am J Trop Med Hyg 76:997-1008. 2007
    ..falciparum malaria remained incomplete. These observations suggest that different mechanisms of immunity may be important for protection from these malaria species...
  17. ncbi request reprint gammadelta-T cells expressing NK receptors predominate over NK cells and conventional T cells in the innate IFN-gamma response to Plasmodium falciparum malaria
    Diana S Hansen
    Infection and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
    Eur J Immunol 37:1864-73. 2007
    ..Applied to longitudinal cohort studies in endemic regions, similar comparative phenotyping should allow assessment of the contribution of diverse cell populations and regulatory receptors to risk of infection and disease...
  18. ncbi request reprint The role of leukocytes bearing Natural Killer Complex receptors and Killer Immunoglobulin-like Receptors in the immunology of malaria
    Diana S Hansen
    The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville 3050, Victoria, Australia
    Curr Opin Immunol 19:416-23. 2007
    ..Population-based immunogenetic analyses should allow the identification of NKC and KIR loci controlling innate and adaptive immune responses to malaria and associated with altered risk of infection and disease...
  19. pmc Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells
    Irina Caminschi
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, 3050, Australia
    J Exp Med 204:2579-90. 2007
    ..Thus, IKDCs resemble NK cells functionally, and neither cell type could be induced to be effective antigen-presenting cells...
  20. ncbi request reprint Plasmodium falciparum erythrocyte membrane protein-1 specifically suppresses early production of host interferon-gamma
    Marthe C D'Ombrain
    Infection and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Cell Host Microbe 2:130-8. 2007
    ..These data demonstrate a parasite strategy for downregulating the proinflammatory interferon-gamma response and further establish transgenic parasites lacking PfEMP-1 as powerful tools for elucidating PfEMP-1 functions...
  21. pmc Blood-stage Plasmodium infection induces CD8+ T lymphocytes to parasite-expressed antigens, largely regulated by CD8alpha+ dendritic cells
    Rachel J Lundie
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 105:14509-14. 2008
    ..Finally, using three different experimental approaches, we provide evidence that CTL specific for parasite-expressed antigens contribute to ECM...
  22. pmc Genes for glycosylphosphatidylinositol toxin biosynthesis in Plasmodium falciparum
    Mauro Delorenzi
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Infect Immun 70:4510-22. 2002
    ..The biosynthetic pathway of the malaria parasite GPI offers potential targets for drug development and may be useful for studying parasite cell biology and the molecular basis for the pathophysiology of parasitic diseases...
  23. pmc CD4+ CD25+ regulatory T cells suppress CD4+ T-cell function and inhibit the development of Plasmodium berghei-specific TH1 responses involved in cerebral malaria pathogenesis
    Catherine Q Nie
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Infect Immun 75:2275-82. 2007
    ....
  24. ncbi request reprint MyD88 is essential for clearance of Leishmania major: possible role for lipophosphoglycan and Toll-like receptor 2 signaling
    Michael J de Veer
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Eur J Immunol 33:2822-31. 2003
    ..Thus, the Toll pathway is required for resistance to L. major and LPG is a defined TLR agonist from this important human pathogen...
  25. ncbi request reprint Transcriptional profiling reveals suppressed erythropoiesis, up-regulated glycolysis, and interferon-associated responses in murine malaria
    Adrienne C Sexton
    The Walter and Eliza Hall Institute of Medical Research, IG Royal Parade, Parkville, Victoria, Australia
    J Infect Dis 189:1245-56. 2004
    ....
  26. pmc The natural killer complex regulates severe malarial pathogenesis and influences acquired immune responses to Plasmodium berghei ANKA
    Diana S Hansen
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Infect Immun 73:2288-97. 2005
    ..To date, NKC-encoded innate system receptors have been shown mainly to regulate viral infections. Our data provide evidence for critical NKC involvement in the broad immunological responses to a protozoan parasite...
  27. ncbi request reprint Influence of glycosylphosphatidylinositol anchorage on the efficacy of DNA vaccines encoding Plasmodium yoelii merozoite surface protein 4/5
    Lina Wang
    Department of Microbiology and The Victoria Bioinformatics Consortium, Monash University, Clayton, VIC 3800, Australia
    Vaccine 23:4120-7. 2005
    ..Despite the induction of specific antibodies, none of these DNA vaccines induced sufficient levels of antibodies to protect mice against a lethal challenge with P. yoelii...
  28. ncbi request reprint The lack of suppressor of cytokine signalling-1 (SOCS1) protects mice from the development of cerebral malaria caused by Plasmodium berghei ANKA
    Denise V R Bullen
    The Walter and Eliza Hall Institute of Medical Research and Cooperative Research Centre for Cellular Growth Factors, 1G Royal Parade, Victoria 3050, Australia
    Parasite Immunol 25:113-8. 2003
    ..Understanding the mechanism by which SOCS1 deficiency protects mice from cerebral malaria may allow the manipulation of its activity and alleviate pathology...
  29. ncbi request reprint Distinct protein classes including novel merozoite surface antigens in Raft-like membranes of Plasmodium falciparum
    Paul R Sanders
    The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3050 Australia
    J Biol Chem 280:40169-76. 2005
    ..This insight into merozoite surfaces provides new opportunities for understanding both erythrocyte invasion and anti-parasite immunity...
  30. pmc Severe malarial anemia of low parasite burden in rodent models results from accelerated clearance of uninfected erythrocytes
    Krystal J Evans
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Blood 107:1192-9. 2006
    ..Anemia was significantly alleviated by depletion of either phagocytic cells or CD4+ T lymphocytes. This study demonstrates that immunologic mechanisms may contribute to SMA by promoting the accelerated turnover of uninfected RBCs...
  31. ncbi request reprint Regulation of murine cerebral malaria pathogenesis by CD1d-restricted NKT cells and the natural killer complex
    Diana S Hansen
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Immunity 18:391-402. 2003
    ....
  32. ncbi request reprint Preferential invasion of reticulocytes during late-stage Plasmodium berghei infection accounts for reduced circulating reticulocyte levels
    Deborah Cromer
    Department of Haematology, Prince of Wales Hospital, University of New South Wales, Kensington, NSW 2052, Australia
    Int J Parasitol 36:1389-97. 2006
    ....
  33. pmc Fatty acids from Plasmodium falciparum down-regulate the toxic activity of malaria glycosylphosphatidylinositols
    Françoise Debierre-Grockiego
    Institut fur Virologie, AG Parasitologie, Hans Meerwein Str 2, D 35043 Marburg, Germany
    Infect Immun 74:5487-96. 2006
    ..This regulatory effect on cytokine production suggests that there is balanced bioactivity for the different categories of malarial lipids...
  34. ncbi request reprint Identification and stoichiometry of glycosylphosphatidylinositol-anchored membrane proteins of the human malaria parasite Plasmodium falciparum
    Paul R Gilson
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Mol Cell Proteomics 5:1286-99. 2006
    ..Together this work identified 11 and predicted a further 19 GPI-anchored proteins in P. falciparum...
  35. pmc Murine cerebral malaria development is independent of toll-like receptor signaling
    Dieudonnée Togbe
    Molecular Immunology and Embryology, Centre National de la Recherche Scientifique, and University of Orleans, Transgenose Institute, Orleans, France
    Am J Pathol 170:1640-8. 2007
    ..However, TLR-dependent activation of innate immunity is unlikely to contribute significantly to the proinflammatory response to PbA infection and the development of fatal CM...
  36. ncbi request reprint Regulation of immunity and pathogenesis in infectious diseases by CD1d-restricted NKT cells
    Diana S Hansen
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Int J Parasitol 34:15-25. 2004
    ..Such insights have the potential to add considerably to our understanding of the CD1/NKT cell system and to the immunology and pathogenesis of infectious diseases...

Research Grants6

  1. IMMUNOBIOLOGY OF MALARIA GLYCOSYLPHOSPHATIDYLINOSITOL
    Louis Schofield; Fiscal Year: 1999
    ..These areas are central to understanding the host/parasite interaction and the development of effective vaccines to several protozoal pathogens. ..
  2. A CHEMICALLY SYNTHETIC ANTI-TOXIC VACCINE AGAINST MALARI
    Louis Schofield; Fiscal Year: 2000
    ..Clinical immunity to malaria is acquired considerably earlier than anti-parasite immunity, and it is possible that this is mediated by anti-toxin mechanisms. ..
  3. IMMUNOBIOLOGY OF MALARIA GLYCOSYLPHOSPHATIDYLINOSITOL
    Louis Schofield; Fiscal Year: 2000
    ..These areas are central to understanding the host/parasite interaction and the development of effective vaccines to several protozoal pathogens. ..
  4. IMMUNOBIOLOGY OF MALARIA GLYCOSYLPHOSPHATIDYLINOSITOL
    Louis Schofield; Fiscal Year: 2001
    ..These areas are central to understanding the host/parasite interaction and the development of effective vaccines to several protozoal pathogens. ..
  5. A CHEMICALLY SYNTHETIC ANTI-TOXIC VACCINE AGAINST MALARI
    Louis Schofield; Fiscal Year: 2001
    ..Clinical immunity to malaria is acquired considerably earlier than anti-parasite immunity, and it is possible that this is mediated by anti-toxin mechanisms. ..
  6. A CHEMICALLY SYNTHETIC ANTI-TOXIC VACCINE AGAINST MALARI
    Louis Schofield; Fiscal Year: 2002
    ..Clinical immunity to malaria is acquired considerably earlier than anti-parasite immunity, and it is possible that this is mediated by anti-toxin mechanisms. ..