Andrew W Roberts

Summary

Affiliation: The Walter and Eliza Hall Institute of Medical Research
Country: Australia

Publications

  1. pmc In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas
    Kylie D Mason
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 105:17961-6. 2008
  2. doi Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease
    Andrew W Roberts
    MBBS, Department of Clinical Haematology and BMT, The Royal Melbourne Hospital, 2 Centre, Grattan St, Parkville 3050, Victoria, Australia
    J Clin Oncol 30:488-96. 2012
  3. ncbi G-CSF: a key regulator of neutrophil production, but that's not all!
    Andrew W Roberts
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
    Growth Factors 23:33-41. 2005
  4. doi Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival
    Marlyse A Debrincat
    Cancer and Hematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Blood 119:5850-8. 2012
  5. pmc Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation
    Ben A Croker
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Exp Hematol 36:786-98. 2008
  6. pmc The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo
    Kristy Boyle
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Blood 110:1466-74. 2007
  7. pmc IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3
    Ben A Croker
    Department of Inflammation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Immunol Cell Biol 90:124-9. 2012
  8. pmc Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2
    Hiu Kiu
    Division of Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, 3050, Australia
    Growth Factors 27:384-93. 2009
  9. pmc SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis
    Peter K K Wong
    Reid Rheumatology Laboratory, Division of Autoimmunity and Transplantation, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Clin Invest 116:1571-81. 2006
  10. ncbi Programmed anuclear cell death delimits platelet life span
    Kylie D Mason
    Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Cell 128:1173-86. 2007

Collaborators

Detail Information

Publications42

  1. pmc In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas
    Kylie D Mason
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 105:17961-6. 2008
    ..Our data suggest that antagonism of Bcl-2 with small organic compounds is an attractive approach to enhance the efficacy of conventional therapy for the treatment of Myc-driven lymphomas that over-express this prosurvival molecule...
  2. doi Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease
    Andrew W Roberts
    MBBS, Department of Clinical Haematology and BMT, The Royal Melbourne Hospital, 2 Centre, Grattan St, Parkville 3050, Victoria, Australia
    J Clin Oncol 30:488-96. 2012
    ..A phase I trial in patients with CLL was conducted to evaluate the safety, pharmacokinetics, and biologic activity of oral navitoclax...
  3. ncbi G-CSF: a key regulator of neutrophil production, but that's not all!
    Andrew W Roberts
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
    Growth Factors 23:33-41. 2005
    ..An attempt is made to link the current issues about the biology of G-CSF with its clinical uses, both present and future...
  4. doi Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival
    Marlyse A Debrincat
    Cancer and Hematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Blood 119:5850-8. 2012
    ..Our studies indicate that the combination of Bcl-x(L) and Mcl-1 is essential for the viability of the megakaryocyte lineage...
  5. pmc Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation
    Ben A Croker
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Exp Hematol 36:786-98. 2008
    ..The tight regulation by Socs3 of signal transducer and activator of transcription 3 phosphorylation and gene transcription after cytokine receptor ligation significantly influences the fate of myeloid progenitor cells...
  6. pmc The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo
    Kristy Boyle
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Blood 110:1466-74. 2007
    ..Overall, the results establish a role for the SOCS box of SOCS3 in the in vivo regulation of G-CSF signaling and the response to inflammatory stimuli...
  7. pmc IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3
    Ben A Croker
    Department of Inflammation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Immunol Cell Biol 90:124-9. 2012
    ..We conclude that SOCS3 is required for survival during inflammatory responses and is a critical regulator of IL-6 in vivo...
  8. pmc Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2
    Hiu Kiu
    Division of Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, 3050, Australia
    Growth Factors 27:384-93. 2009
    ..Our results suggest that SOCS2 is not a physiological regulator of SOCS3 expression and action in primary haemopoietic cells...
  9. pmc SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis
    Peter K K Wong
    Reid Rheumatology Laboratory, Division of Autoimmunity and Transplantation, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Clin Invest 116:1571-81. 2006
    ..These findings provide direct in vivo evidence that endogenous SOCS-3 is a critical negative regulator of multiple cell types orchestrating inflammatory joint disease...
  10. ncbi Programmed anuclear cell death delimits platelet life span
    Kylie D Mason
    Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Cell 128:1173-86. 2007
    ....
  11. doi Mechanism of crosstalk inhibition of IL-6 signaling in response to LPS and TNFalpha
    Hiu Kiu
    Division of Cancer and Hematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
    Growth Factors 25:319-28. 2007
    ..Finally, we have identified an additional, novel mechanism of crosstalk inhibition: a reduction in total cellular levels of gp130 following stimulation with LPS and TNFalpha...
  12. ncbi Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis
    Brendan J Jenkins
    Ludwig Institute for Cancer Research, Victoria, Australia
    Blood 109:2380-8. 2007
    ..Collectively, these data genetically define distinct roles of IL-6 and IL-11 in driving pathologic hematopoietic and lymphoid responses mediated by STAT3 hyperactivation...
  13. ncbi A key role for G-CSF-induced neutrophil production and trafficking during inflammatory arthritis
    Jo L Eyles
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Blood 112:5193-201. 2008
    ....
  14. ncbi SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis
    Ben A Croker
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Parkville, Victoria 3050, Australia
    Immunity 20:153-65. 2004
    ..We conclude that SOCS3 is a key negative regulator of G-CSF signaling in myeloid cells and that this is of particular significance during G-CSF-driven emergency granulopoiesis...
  15. pmc Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory disease
    Lorraine Robb
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 102:16333-8. 2005
    ....
  16. pmc Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1
    Ben A Croker
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    Proc Natl Acad Sci U S A 108:13135-40. 2011
    ..These data demonstrate that the intrinsic apoptosis pathway directly controls the kinetics of Fas-triggered apoptosis in neutrophils...
  17. pmc Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease
    Kylie D Mason
    The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia
    Proc Natl Acad Sci U S A 110:2599-604. 2013
    ..This suggests that direct activators of the intrinsic apoptotic pathway, such as BH3 mimetics, may be useful for treatment of diverse autoimmune diseases...
  18. pmc Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells
    Delphine Merino
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Blood 119:5807-16. 2012
    ..These results have profound implications for how BH3-mimetics induce apoptosis and how the use of these compounds can be optimized for treating lymphoid malignancies...
  19. pmc Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene
    Warren S Alexander
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 103:16442-7. 2006
    ..The disease in plt1/plt1 mice suggests that, in addition to immune-mediated effects, intrinsic C1Gal-T1 deficiency in megakaryocytes and the kidney may contribute to pathology...
  20. pmc The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
    Mark F van Delft
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Cancer Cell 10:389-99. 2006
    ..Hence, ABT-737 should prove efficacious in tumors with low Mcl-1 levels, or when combined with agents that inactivate Mcl-1, even to treat those tumors that overexpress Bcl-2...
  21. doi Overcoming blocks in apoptosis with BH3-mimetic therapy in haematological malignancies
    Seong Lin Khaw
    Divisions of Cancer and Haematology and Chemical Biology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Pathology 43:525-35. 2011
    ..These drugs also offer promise as adjuncts to existing or emerging therapies in a broader range of cancers...
  22. doi Towards a four-dimensional view of neutrophils
    Ben A Croker
    The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Australia
    Methods Mol Biol 844:87-99. 2012
    ..Here, we review recent advances that provide insight into the genetic and biochemical regulators of neutrophil production, function, and survival...
  23. pmc Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets
    Emma C Josefsson
    Molecular Medicine Division, Cancer and Hematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia
    J Exp Med 208:2017-31. 2011
    ..Thus, megakaryocytes do not activate the intrinsic pathway to generate platelets; rather, the opposite is true: they must restrain it to survive and progress safely through proplatelet formation and platelet shedding...
  24. ncbi Absence of suppressor of cytokine signalling 3 reduces self-renewal and promotes differentiation in murine embryonic stem cells
    Ariel Forrai
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Stem Cells 24:604-14. 2006
    ..Its absence perturbs the balance between activation of the JAK-STAT and SHP-2-ERK-1/2-MAPK pathways, resulting in less self-renewal and a greater potential for differentiation into the primitive endoderm lineage...
  25. pmc Structural basis for apoptosis inhibition by Epstein-Barr virus BHRF1
    Marc Kvansakul
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    PLoS Pathog 6:e1001236. 2010
    ....
  26. doi Neutrophils require SHP1 to regulate IL-1β production and prevent inflammatory skin disease
    Ben A Croker
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    J Immunol 186:1131-9. 2011
    ..These data indicate that the neutrophil- and IL-1-dependent disease in SHP1(Y208N/Y208N) mice is a consequence of loss of negative regulation of TLR and IL-1R signaling...
  27. ncbi Granulocyte colony-stimulating factor and neutrophils--forgotten mediators of inflammatory disease
    Jo L Eyles
    Reid Rheumatology Laboratory, Division of Autoimmunity and Transplantation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Nat Clin Pract Rheumatol 2:500-10. 2006
    ..These findings implicate G-CSF as an important proinflammatory cytokine. This article discusses the roles of neutrophils and G-CSF during chronic inflammatory diseases...
  28. pmc Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic
    Junya Kuroda
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 103:14907-12. 2006
    ..These results demonstrate that Bim and Bad account for most, perhaps all, imatinib-induced killing of Bcr/Abl+ leukemic cells and suggest previously undescribed drug combination strategies for cancer therapy...
  29. pmc Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling
    Marina R Carpinelli
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville VIC 3052, Australia
    Proc Natl Acad Sci U S A 101:6553-8. 2004
    ....
  30. ncbi Improved survival for relapsed diffuse large B cell lymphoma is predicted by a negative pre-transplant FDG-PET scan following salvage chemotherapy
    Michael Dickinson
    Division of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, East Melbourne, Vic, Australia
    Br J Haematol 150:39-45. 2010
    ..Although those with positive scans can still be salvaged with current treatments, PET may useful for selecting patients eligible for novel consolidation strategies after salvage therapies...
  31. pmc Critical role for granulocyte colony-stimulating factor in inflammatory arthritis
    Kate E Lawlor
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 101:11398-403. 2004
    ..Our results reveal a critical role for G-CSF in driving joint inflammation and highlight G-CSF as a potential therapeutic target in inflammatory joint diseases, such as rheumatoid arthritis...
  32. ncbi SOCS3 negatively regulates IL-6 signaling in vivo
    Ben A Croker
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Nat Immunol 4:540-5. 2003
    ..Our data indicate that SOCS3 and SOCS1 have reciprocal functions in IL-6 and IFN-gamma regulation and imply that SOCS3 has a role in preventing IFN-gamma-like responses in cells stimulated by IL-6...
  33. ncbi Genetic heterogeneity of granulocytes for the JAK2 V617F mutation in essential thrombocythaemia: implications for mutation detection in peripheral blood
    William S Stevenson
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Pathology 38:336-42. 2006
    ....
  34. ncbi Hematopoietic abnormalities in mice deficient in gp130-mediated STAT signaling
    Brendan J Jenkins
    Ludwig Institute for Cancer Research, Molecular Biology Laboratory, Victoria, Australia
    Exp Hematol 30:1248-56. 2002
    ..This study examined the specific contribution of gp130-mediated STAT1/3 signaling to the regulation of hematopoiesis...
  35. doi Consolidation therapy with low-dose thalidomide and prednisolone prolongs the survival of multiple myeloma patients undergoing a single autologous stem-cell transplantation procedure
    Andrew Spencer
    Malignant Haematology and Stem Cell Transplantation Service, Alfred Hospital, Melbourne, Victoria, Australia
    J Clin Oncol 27:1788-93. 2009
    ..This study assessed whether the addition of thalidomide consolidation following ASCT would improve the durability of responses achieved and overall survival...
  36. ncbi RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis
    James A Rickard
    The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia Department of Medical Biology, University of Melbourne, Parkville, VIC 3050, Australia
    Cell 157:1175-88. 2014
    ..These results reveal a key function for RIPK1 in inhibiting necroptosis and, thereby, a role in limiting, not only promoting, inflammation. ..
  37. doi Bortezomib: putting mantle cell lymphoma on death row
    Andrew H Wei
    Department of Malignant Haematology and Stem Cell Transplantion, The Alfred Hospital, Melbourne, Victoria, Australia
    Leuk Lymphoma 49:657-8. 2008
  38. ncbi Mobilization of dendritic cells in cancer patients treated with granulocyte colony-stimulating factor and chemotherapy
    Fiona J Radcliff
    Department of Haematology and Oncology, The Royal Children s Hospital, Parkville, Victoria, Australia
    Br J Haematol 119:204-11. 2002
    ..This strategy may be a feasible, low-risk means of acquiring cells for DC-based vaccine studies...
  39. ncbi The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes
    Ben A Croker
    Division of Cancer and Hematology and Immunology, Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    J Immunol 168:3376-86. 2002
    ..Rac2 is therefore an essential element in regulating B lymphocyte functions and maintaining B lymphocyte populations in vivo...
  40. ncbi The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis
    Brendan J Jenkins
    Ludwig Institute for Cancer Research, Colon Molecular and Cell Biology Laboratory, PO Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia
    Blood 105:3512-20. 2005
    ....
  41. doi Perturbed thymopoiesis in vitro in the absence of suppressor of cytokine signalling 1 and 3
    Hayley A Croom
    Signal Transduction Laboratory, St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia
    Mol Immunol 45:2888-96. 2008
    ..This is the first demonstration of functional redundancy within the SOCS family, and has uncovered a vital role for SOCS1 and SOCS3 during two important checkpoints in early T cell development...
  42. ncbi Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in T(H)1 responses
    Ben A Croker
    Divisions of Cancer, Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, South Australia
    Immunol Cell Biol 80:231-40. 2002
    ..Cytotoxic T-lymphocyte responses to cytomegalovirus and ovalbumin were also normal. Although Rac2 is required for normal T-lymphocyte migration, its role in the generation of T(H)1 responses to infection in vivo is largely redundant...