Research Topics
Genomes and Genes
Species | Andrew W RobertsSummaryAffiliation: The Walter and Eliza Hall Institute of Medical Research Country: Australia Publications
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Detail Information
Publications
In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomasKylie D Mason
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
Proc Natl Acad Sci U S A 105:17961-6. 2008..Our data suggest that antagonism of Bcl-2 with small organic compounds is an attractive approach to enhance the efficacy of conventional therapy for the treatment of Myc-driven lymphomas that over-express this prosurvival molecule...
Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory diseaseAndrew W Roberts
MBBS, Department of Clinical Haematology and BMT, The Royal Melbourne Hospital, 2 Centre, Grattan St, Parkville 3050, Victoria, Australia
J Clin Oncol 30:488-96. 2012..A phase I trial in patients with CLL was conducted to evaluate the safety, pharmacokinetics, and biologic activity of oral navitoclax...
G-CSF: a key regulator of neutrophil production, but that's not all!Andrew W Roberts
Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
Growth Factors 23:33-41. 2005..An attempt is made to link the current issues about the biology of G-CSF with its clinical uses, both present and future...- Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survivalMarlyse A Debrincat
Cancer and Hematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
Blood 119:5850-8. 2012..Our studies indicate that the combination of Bcl-x(L) and Mcl-1 is essential for the viability of the megakaryocyte lineage... - Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiationBen A Croker
Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Exp Hematol 36:786-98. 2008..The tight regulation by Socs3 of signal transducer and activator of transcription 3 phosphorylation and gene transcription after cytokine receptor ligation significantly influences the fate of myeloid progenitor cells... - The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivoKristy Boyle
The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
Blood 110:1466-74. 2007..Overall, the results establish a role for the SOCS box of SOCS3 in the in vivo regulation of G-CSF signaling and the response to inflammatory stimuli... - IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3Ben A Croker
Department of Inflammation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Immunol Cell Biol 90:124-9. 2012..We conclude that SOCS3 is required for survival during inflammatory responses and is a critical regulator of IL-6 in vivo... - Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2Hiu Kiu
Division of Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, 3050, Australia
Growth Factors 27:384-93. 2009..Our results suggest that SOCS2 is not a physiological regulator of SOCS3 expression and action in primary haemopoietic cells... - SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritisPeter K K Wong
Reid Rheumatology Laboratory, Division of Autoimmunity and Transplantation, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
J Clin Invest 116:1571-81. 2006..These findings provide direct in vivo evidence that endogenous SOCS-3 is a critical negative regulator of multiple cell types orchestrating inflammatory joint disease... - Mechanism of crosstalk inhibition of IL-6 signaling in response to LPS and TNFalphaHiu Kiu
Division of Cancer and Hematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
Growth Factors 25:319-28. 2007..Finally, we have identified an additional, novel mechanism of crosstalk inhibition: a reduction in total cellular levels of gp130 following stimulation with LPS and TNFalpha... - SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesisBen A Croker
Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Parkville, Victoria 3050, Australia
Immunity 20:153-65. 2004..We conclude that SOCS3 is a key negative regulator of G-CSF signaling in myeloid cells and that this is of particular significance during G-CSF-driven emergency granulopoiesis... - Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesisBrendan J Jenkins
Ludwig Institute for Cancer Research, Victoria, Australia
Blood 109:2380-8. 2007..Collectively, these data genetically define distinct roles of IL-6 and IL-11 in driving pathologic hematopoietic and lymphoid responses mediated by STAT3 hyperactivation... - A key role for G-CSF-induced neutrophil production and trafficking during inflammatory arthritisJo L Eyles
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Blood 112:5193-201. 2008.... - Programmed anuclear cell death delimits platelet life spanKylie D Mason
Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
Cell 128:1173-86. 2007.... - Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory diseaseLorraine Robb
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Proc Natl Acad Sci U S A 102:16333-8. 2005.... - Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1Ben A Croker
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Proc Natl Acad Sci U S A 108:13135-40. 2011..These data demonstrate that the intrinsic apoptosis pathway directly controls the kinetics of Fas-triggered apoptosis in neutrophils... - Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cellsDelphine Merino
The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
Blood 119:5807-16. 2012..These results have profound implications for how BH3-mimetics induce apoptosis and how the use of these compounds can be optimized for treating lymphoid malignancies... - The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralizedMark F van Delft
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Cancer Cell 10:389-99. 2006..Hence, ABT-737 should prove efficacious in tumors with low Mcl-1 levels, or when combined with agents that inactivate Mcl-1, even to treat those tumors that overexpress Bcl-2... - Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 geneWarren S Alexander
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Proc Natl Acad Sci U S A 103:16442-7. 2006..The disease in plt1/plt1 mice suggests that, in addition to immune-mediated effects, intrinsic C1Gal-T1 deficiency in megakaryocytes and the kidney may contribute to pathology... - Overcoming blocks in apoptosis with BH3-mimetic therapy in haematological malignanciesSeong Lin Khaw
Divisions of Cancer and Haematology and Chemical Biology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Pathology 43:525-35. 2011..These drugs also offer promise as adjuncts to existing or emerging therapies in a broader range of cancers... - Towards a four-dimensional view of neutrophilsBen A Croker
The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Australia
Methods Mol Biol 844:87-99. 2012..Here, we review recent advances that provide insight into the genetic and biochemical regulators of neutrophil production, function, and survival... - Absence of suppressor of cytokine signalling 3 reduces self-renewal and promotes differentiation in murine embryonic stem cellsAriel Forrai
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Stem Cells 24:604-14. 2006..Its absence perturbs the balance between activation of the JAK-STAT and SHP-2-ERK-1/2-MAPK pathways, resulting in less self-renewal and a greater potential for differentiation into the primitive endoderm lineage... - Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce plateletsEmma C Josefsson
Molecular Medicine Division, Cancer and Hematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia
J Exp Med 208:2017-31. 2011..Thus, megakaryocytes do not activate the intrinsic pathway to generate platelets; rather, the opposite is true: they must restrain it to survive and progress safely through proplatelet formation and platelet shedding... - Structural basis for apoptosis inhibition by Epstein-Barr virus BHRF1Marc Kvansakul
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
PLoS Pathog 6:e1001236. 2010.... - Granulocyte colony-stimulating factor and neutrophils--forgotten mediators of inflammatory diseaseJo L Eyles
Reid Rheumatology Laboratory, Division of Autoimmunity and Transplantation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Nat Clin Pract Rheumatol 2:500-10. 2006..These findings implicate G-CSF as an important proinflammatory cytokine. This article discusses the roles of neutrophils and G-CSF during chronic inflammatory diseases... - Neutrophils require SHP1 to regulate IL-1β production and prevent inflammatory skin diseaseBen A Croker
Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
J Immunol 186:1131-9. 2011..These data indicate that the neutrophil- and IL-1-dependent disease in SHP1(Y208N/Y208N) mice is a consequence of loss of negative regulation of TLR and IL-1R signaling... - Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimeticJunya Kuroda
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
Proc Natl Acad Sci U S A 103:14907-12. 2006..These results demonstrate that Bim and Bad account for most, perhaps all, imatinib-induced killing of Bcr/Abl+ leukemic cells and suggest previously undescribed drug combination strategies for cancer therapy... - Improved survival for relapsed diffuse large B cell lymphoma is predicted by a negative pre-transplant FDG-PET scan following salvage chemotherapyMichael Dickinson
Division of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, East Melbourne, Vic, Australia
Br J Haematol 150:39-45. 2010..Although those with positive scans can still be salvaged with current treatments, PET may useful for selecting patients eligible for novel consolidation strategies after salvage therapies... - Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signalingMarina R Carpinelli
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville VIC 3052, Australia
Proc Natl Acad Sci U S A 101:6553-8. 2004.... - Critical role for granulocyte colony-stimulating factor in inflammatory arthritisKate E Lawlor
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
Proc Natl Acad Sci U S A 101:11398-403. 2004..Our results reveal a critical role for G-CSF in driving joint inflammation and highlight G-CSF as a potential therapeutic target in inflammatory joint diseases, such as rheumatoid arthritis... - SOCS3 negatively regulates IL-6 signaling in vivoBen A Croker
Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, 1G Royal Parade, Parkville, Victoria 3050, Australia
Nat Immunol 4:540-5. 2003..Our data indicate that SOCS3 and SOCS1 have reciprocal functions in IL-6 and IFN-gamma regulation and imply that SOCS3 has a role in preventing IFN-gamma-like responses in cells stimulated by IL-6... - Genetic heterogeneity of granulocytes for the JAK2 V617F mutation in essential thrombocythaemia: implications for mutation detection in peripheral bloodWilliam S Stevenson
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Pathology 38:336-42. 2006.... - Hematopoietic abnormalities in mice deficient in gp130-mediated STAT signalingBrendan J Jenkins
Ludwig Institute for Cancer Research, Molecular Biology Laboratory, Victoria, Australia
Exp Hematol 30:1248-56. 2002..This study examined the specific contribution of gp130-mediated STAT1/3 signaling to the regulation of hematopoiesis... - Consolidation therapy with low-dose thalidomide and prednisolone prolongs the survival of multiple myeloma patients undergoing a single autologous stem-cell transplantation procedureAndrew Spencer
Malignant Haematology and Stem Cell Transplantation Service, Alfred Hospital, Melbourne, Victoria, Australia
J Clin Oncol 27:1788-93. 2009..This study assessed whether the addition of thalidomide consolidation following ASCT would improve the durability of responses achieved and overall survival... - Mobilization of dendritic cells in cancer patients treated with granulocyte colony-stimulating factor and chemotherapyFiona J Radcliff
Department of Haematology and Oncology, The Royal Children's Hospital, Parkville, Victoria, Australia
Br J Haematol 119:204-11. 2002..This strategy may be a feasible, low-risk means of acquiring cells for DC-based vaccine studies... - The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytesBen A Croker
Division of Cancer and Hematology and Immunology, Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
J Immunol 168:3376-86. 2002..Rac2 is therefore an essential element in regulating B lymphocyte functions and maintaining B lymphocyte populations in vivo... - Perturbed thymopoiesis in vitro in the absence of suppressor of cytokine signalling 1 and 3Hayley A Croom
Signal Transduction Laboratory, St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia
Mol Immunol 45:2888-96. 2008..This is the first demonstration of functional redundancy within the SOCS family, and has uncovered a vital role for SOCS1 and SOCS3 during two important checkpoints in early T cell development... - Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in T(H)1 responsesBen A Croker
Divisions of Cancer, Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, South Australia
Immunol Cell Biol 80:231-40. 2002..Cytotoxic T-lymphocyte responses to cytomegalovirus and ovalbumin were also normal. Although Rac2 is required for normal T-lymphocyte migration, its role in the generation of T(H)1 responses to infection in vivo is largely redundant... - The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesisBrendan J Jenkins
Ludwig Institute for Cancer Research, Colon Molecular and Cell Biology Laboratory, PO Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia
Blood 105:3512-20. 2005....