Rachael T Richardson

Summary

Affiliation: The Bionic Ear Institute
Country: Australia

Publications

  1. ncbi request reprint Tracing neurotrophin-3 diffusion and uptake in the guinea pig cochlea
    Rachael T Richardson
    The Bionic Ear Institute, 384 388 Albert Street, East Melbourne 3002, Australia
    Hear Res 198:25-35. 2004
  2. pmc Polypyrrole-coated electrodes for the delivery of charge and neurotrophins to cochlear neurons
    Rachael T Richardson
    The Bionic Ear Institute, East Melbourne, Victoria 3002, Australia
    Biomaterials 30:2614-24. 2009
  3. ncbi request reprint A single dose of neurotrophin-3 to the cochlea surrounds spiral ganglion neurons and provides trophic support
    Rachael T Richardson
    The Bionic Ear Institute, 384 388 Albert Street, East Melbourne, VIC 3002, Australia
    Hear Res 204:37-47. 2005
  4. ncbi request reprint Inner ear therapy for neural preservation
    Rachael T Richardson
    The Bionic Ear Institute, East Melbourne, Victoria 3002, Australia
    Audiol Neurootol 11:343-56. 2006
  5. ncbi request reprint The effect of polypyrrole with incorporated neurotrophin-3 on the promotion of neurite outgrowth from auditory neurons
    Rachael T Richardson
    The Bionic Ear Institute, 384 Albert Street, East Melbourne, VIC 3002, Australia
    Biomaterials 28:513-23. 2007
  6. ncbi request reprint Novel drug delivery systems for inner ear protection and regeneration after hearing loss
    Rachael T Richardson
    Bionic Ear Institute, 384 Albert Street, East Melbourne, Victoria 3002, Australia
    Expert Opin Drug Deliv 5:1059-76. 2008
  7. pmc The effect of deafness duration on neurotrophin gene therapy for spiral ganglion neuron protection
    Andrew K Wise
    The Bionic Ear Institute, 384 388 Albert Street, East Melbourne, Victoria 3002, Australia
    Hear Res 278:69-76. 2011
  8. ncbi request reprint Delivery of neurotrophin-3 to the cochlea using alginate beads
    Farnoosh Noushi
    University of Melbourne, Department of Otolaryngology, East Melbourne, Australia
    Otol Neurotol 26:528-33. 2005
  9. pmc Neurotrophin gene therapy for sustained neural preservation after deafness
    Patrick J Atkinson
    Bionics Institute, East Melbourne, Victoria, Australia
    PLoS ONE 7:e52338. 2012
  10. pmc Effects of localized neurotrophin gene expression on spiral ganglion neuron resprouting in the deafened cochlea
    Andrew K Wise
    Bionic Ear Institute, East Melbourne, Victoria, Australia
    Mol Ther 18:1111-22. 2010

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Tracing neurotrophin-3 diffusion and uptake in the guinea pig cochlea
    Rachael T Richardson
    The Bionic Ear Institute, 384 388 Albert Street, East Melbourne 3002, Australia
    Hear Res 198:25-35. 2004
    ..NT-3 microspheres remained in the cochlea for at least 28 days, suggesting a low clearance rate within cochlear tissues...
  2. pmc Polypyrrole-coated electrodes for the delivery of charge and neurotrophins to cochlear neurons
    Rachael T Richardson
    The Bionic Ear Institute, East Melbourne, Victoria 3002, Australia
    Biomaterials 30:2614-24. 2009
    ..Drug-eluting conducting polymer coatings on cochlear implant electrodes present a clinically viable method to promote preservation of SGNs without adversely affecting the function of the cochlear implant...
  3. ncbi request reprint A single dose of neurotrophin-3 to the cochlea surrounds spiral ganglion neurons and provides trophic support
    Rachael T Richardson
    The Bionic Ear Institute, 384 388 Albert Street, East Melbourne, VIC 3002, Australia
    Hear Res 204:37-47. 2005
    ..The data suggest that only a small proportion of neurotrophins infused into the scala tympani diffuses to the SGNs and their processes and produces trophic effects on SGN cell bodies...
  4. ncbi request reprint Inner ear therapy for neural preservation
    Rachael T Richardson
    The Bionic Ear Institute, East Melbourne, Victoria 3002, Australia
    Audiol Neurootol 11:343-56. 2006
    ..Duration of treatment, drug diffusion, effectiveness and safety are discussed with references to how they may be translated to the implementation of neurotrophic factor treatment for neural preservation...
  5. ncbi request reprint The effect of polypyrrole with incorporated neurotrophin-3 on the promotion of neurite outgrowth from auditory neurons
    Rachael T Richardson
    The Bionic Ear Institute, 384 Albert Street, East Melbourne, VIC 3002, Australia
    Biomaterials 28:513-23. 2007
    ....
  6. ncbi request reprint Novel drug delivery systems for inner ear protection and regeneration after hearing loss
    Rachael T Richardson
    Bionic Ear Institute, 384 Albert Street, East Melbourne, Victoria 3002, Australia
    Expert Opin Drug Deliv 5:1059-76. 2008
    ..However, gradual degeneration of SGNs associated with SNHL can compromise the efficacy of the device...
  7. pmc The effect of deafness duration on neurotrophin gene therapy for spiral ganglion neuron protection
    Andrew K Wise
    The Bionic Ear Institute, 384 388 Albert Street, East Melbourne, Victoria 3002, Australia
    Hear Res 278:69-76. 2011
    ..Clinically, there remains a window of opportunity in which NT gene therapy can provide ongoing trophic support for SGNs...
  8. ncbi request reprint Delivery of neurotrophin-3 to the cochlea using alginate beads
    Farnoosh Noushi
    University of Melbourne, Department of Otolaryngology, East Melbourne, Australia
    Otol Neurotol 26:528-33. 2005
    ..The aim of this study was to design a novel cochlear neurotrophin (NT) delivery system for the rescue of auditory neurons after ototoxicity-induced deafening...
  9. pmc Neurotrophin gene therapy for sustained neural preservation after deafness
    Patrick J Atkinson
    Bionics Institute, East Melbourne, Victoria, Australia
    PLoS ONE 7:e52338. 2012
    ..These data suggest that neurotrophin-gene therapy can provide sustained protection of spiral ganglion neurons and peripheral fibres after hearing loss...
  10. pmc Effects of localized neurotrophin gene expression on spiral ganglion neuron resprouting in the deafened cochlea
    Andrew K Wise
    Bionic Ear Institute, East Melbourne, Victoria, Australia
    Mol Ther 18:1111-22. 2010
    ..05), a first step in promoting organized resprouting of auditory peripheral fibers via gene therapy...
  11. pmc Neurotrophic factors and neural prostheses: potential clinical applications based upon findings in the auditory system
    Lisa N Pettingill
    Bionic Ear Institute, East Melbourne VIC 3002, Australia
    IEEE Trans Biomed Eng 54:1138-48. 2007
    ....
  12. doi request reprint Viability of long-term gene therapy in the cochlea
    Patrick J Atkinson
    1 Bionics Institute, East Melbourne, Victoria, Australia 2 Department of Otolaryngology, University of Melbourne, East Melbourne, Victoria, Australia
    Sci Rep 4:4733. 2014
    ..With further research aimed at transducing stable cochlear cells, gene therapy may be an efficacious way to introduce neurotrophins to promote neuronal survival after hearing loss. ..
  13. ncbi request reprint Effects of round window dexamethasone on residual hearing in a Guinea pig model of cochlear implantation
    David P James
    Department of Otolaryngology, University of Melbourne, Parkville, Australia
    Audiol Neurootol 13:86-96. 2008
    ..Animals that did not receive beads acted as controls. Pure-tone auditory brainstem response thresholds were estimated before and after electrode insertion, and 1 and 4 weeks later. Selected cochlear histology was performed...