Raymond S Norton

Summary

Affiliation: The Walter and Eliza Hall Institute of Medical Research
Country: Australia

Publications

  1. ncbi Potassium channel blockade by the sea anemone toxin ShK for the treatment of multiple sclerosis and other autoimmune diseases
    Raymond S Norton
    Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Victoria, Australia
    Curr Med Chem 11:3041-52. 2004
  2. doi Structures of sea anemone toxins
    Raymond S Norton
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, Victoria, Australia
    Toxicon 54:1075-88. 2009
  3. doi Mu-conotoxins as leads in the development of new analgesics
    Raymond S Norton
    Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
    Molecules 15:2825-44. 2010
  4. ncbi Conotoxins down under
    Raymond S Norton
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Victoria, Australia
    Toxicon 48:780-98. 2006
  5. ncbi Peptides targeting voltage-gated calcium channels
    Raymond S Norton
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Australia
    Curr Pharm Des 14:2480-91. 2008
  6. pmc Peptide inhibitors of the malaria surface protein, apical membrane antigen 1: identification of key binding residues
    Erinna F Lee
    Structural Biology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
    Biopolymers 95:354-64. 2011
  7. doi Solution conformation, backbone dynamics and lipid interactions of the intrinsically unstructured malaria surface protein MSP2
    Xuecheng Zhang
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Australia
    J Mol Biol 379:105-21. 2008
  8. pmc Mimotopes of apical membrane antigen 1: Structures of phage-derived peptides recognized by the inhibitory monoclonal antibody 4G2dc1 and design of a more active analogue
    Jennifer K Sabo
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Infect Immun 75:61-73. 2007
  9. ncbi Structure of the analgesic mu-conotoxin KIIIA and effects on the structure and function of disulfide deletion
    Keith K Khoo
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
    Biochemistry 48:1210-9. 2009
  10. pmc The SOCS box domain of SOCS3: structure and interaction with the elonginBC-cullin5 ubiquitin ligase
    Jeffrey J Babon
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Mol Biol 381:928-40. 2008

Collaborators

Detail Information

Publications85

  1. ncbi Potassium channel blockade by the sea anemone toxin ShK for the treatment of multiple sclerosis and other autoimmune diseases
    Raymond S Norton
    Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Victoria, Australia
    Curr Med Chem 11:3041-52. 2004
    ..ShK and its analogs are currently undergoing further evaluation as leads in the development of new biopharmaceuticals for the treatment of multiple sclerosis and other T-cell mediated autoimmune disorders...
  2. doi Structures of sea anemone toxins
    Raymond S Norton
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, Victoria, Australia
    Toxicon 54:1075-88. 2009
    ..The prospects for obtaining atomic resolution structures of toxins bound to their receptors are also discussed...
  3. doi Mu-conotoxins as leads in the development of new analgesics
    Raymond S Norton
    Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
    Molecules 15:2825-44. 2010
    ..Such mimetics would constitute lead compounds in the development of new therapeutics for the treatment of pain...
  4. ncbi Conotoxins down under
    Raymond S Norton
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Victoria, Australia
    Toxicon 48:780-98. 2006
    ..With the promise of as many as 50,000 venom components across the entire Conus genus, many more interesting peptides can be anticipated...
  5. ncbi Peptides targeting voltage-gated calcium channels
    Raymond S Norton
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Australia
    Curr Pharm Des 14:2480-91. 2008
    ....
  6. pmc Peptide inhibitors of the malaria surface protein, apical membrane antigen 1: identification of key binding residues
    Erinna F Lee
    Structural Biology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
    Biopolymers 95:354-64. 2011
    ..The identification of a nonpolar region of these peptides containing residues essential for AMA1 binding establishes a basis for the design of anti-malarial drugs based on R1 mimetics...
  7. doi Solution conformation, backbone dynamics and lipid interactions of the intrinsically unstructured malaria surface protein MSP2
    Xuecheng Zhang
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Australia
    J Mol Biol 379:105-21. 2008
    ..MSP2 associates with lipid micelles, but predominantly through the N-terminal region rather than the C terminus, which is GPI-anchored to the membrane in the parasite...
  8. pmc Mimotopes of apical membrane antigen 1: Structures of phage-derived peptides recognized by the inhibitory monoclonal antibody 4G2dc1 and design of a more active analogue
    Jennifer K Sabo
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Infect Immun 75:61-73. 2007
    ..With its greater conformational stability and higher affinity for AMA1, J1cc may be a better in vitro correlate of immunity than the peptides identified by phage display...
  9. ncbi Structure of the analgesic mu-conotoxin KIIIA and effects on the structure and function of disulfide deletion
    Keith K Khoo
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
    Biochemistry 48:1210-9. 2009
    ..These findings lay the groundwork for the design of minimized peptides and helical mimetics as novel analgesics...
  10. pmc The SOCS box domain of SOCS3: structure and interaction with the elonginBC-cullin5 ubiquitin ligase
    Jeffrey J Babon
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Mol Biol 381:928-40. 2008
    ..Domains upstream of the SOCS box are not required for elonginBC or cullin5 association, indicating that the SOCS box acts as an independent binding domain capable of recruiting elonginBC and cullin5 to promote E3 ligase formation...
  11. ncbi The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability
    Jeffrey J Babon
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3050, Victoria, Australia
    Mol Cell 22:205-16. 2006
    ..The PEST motif increases SOCS3 turnover and affects its degradation pathway, implying that it has an important regulatory role inside the cell...
  12. ncbi C-terminal domain of insulin-like growth factor (IGF) binding protein 6: conformational exchange and its correlation with IGF-II binding
    Shenggen Yao
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Australia
    Biochemistry 43:11187-95. 2004
    ..Nonetheless, current results strongly suggest possible conformation switching or population shifting between pre-existing conformations in C-BP-6 upon binding to IGF-II...
  13. pmc Dynamics of the SPRY domain-containing SOCS box protein 2: flexibility of key functional loops
    Shenggen Yao
    The Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Victoria, Australia
    Protein Sci 15:2761-72. 2006
    ..The underlying flexibility of certain regions of the B30.2/SPRY domain-containing proteins may also contribute to some apparent structural differences observed between GUSTAVUS or PRYSPRY and SSB-2...
  14. doi SPRY domain-containing SOCS box protein 2: crystal structure and residues critical for protein binding
    Zhihe Kuang
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
    J Mol Biol 386:662-74. 2009
    ....
  15. pmc Identification of key residues involved in fibril formation by the conserved N-terminal region of Plasmodium falciparum merozoite surface protein 2 (MSP2)
    Xiaodong Yang
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, Australia
    Biochimie 92:1287-95. 2010
    ..These mutations had little effect on the aggregation of full-length MSP2, however, suggesting that regions outside the conserved N-terminus have unanticipated importance for fibril formation in the full-length protein...
  16. ncbi Apical membrane antigen 1 as an anti-malarial drug target
    Christopher A MacRaild
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Curr Top Med Chem 11:2039-47. 2011
    ....
  17. doi TLR regulation of SPSB1 controls inducible nitric oxide synthase induction
    Rowena S Lewis
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    J Immunol 187:3798-805. 2011
    ..These results suggest that SPSB1 acts through a negative-feedback loop that, together with SPSB2, controls the extent of iNOS induction and NO production...
  18. ncbi C-terminal domain of insulin-like growth factor (IGF) binding protein-6: structure and interaction with IGF-II
    Stephen J Headey
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Australia
    Mol Endocrinol 18:2740-50. 2004
    ....
  19. pmc The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression
    Jeffrey J Babon
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, Australia
    J Mol Biol 387:162-74. 2009
    ....
  20. ncbi A partially structured region of a largely unstructured protein, Plasmodium falciparum merozoite surface protein 2 (MSP2), forms amyloid-like fibrils
    Xiaodong Yang
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Australia
    J Pept Sci 13:839-48. 2007
    ....
  21. doi Insulin-like growth factor-I (IGF-I): solution properties and NMR chemical shift assignments near physiological pH
    Zhihe Kuang
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Growth Horm IGF Res 19:226-31. 2009
    ..The present study was undertaken to determine a reliable set of assignments under more physiological conditions...
  22. ncbi Inhibition by flavonoids of amyloid-like fibril formation by Plasmodium falciparum merozoite surface protein 2
    Indu R Chandrashekaran
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
    Biochemistry 49:5899-908. 2010
    ..However, these small molecule inhibitors of MSP2 fibril formation will be useful as mechanistic probes in studying oligomerization and fibril assembly of MSP2...
  23. pmc Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1
    Edmond M Linossi
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia The University of Melbourne, Parkville, Victoria, Australia
    PLoS ONE 8:e70536. 2013
    ..These findings suggest that different domains in SOCS5 contribute to two distinct mechanisms for regulation of cytokine and growth factor signaling...
  24. ncbi Structure and activity of the N-terminal region of the eukaryotic cytolysin equinatoxin II
    Alison Drechsler
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Biochemistry 45:1818-28. 2006
    ....
  25. pmc Binding hot spot for invasion inhibitory molecules on Plasmodium falciparum apical membrane antigen 1
    Karen S Harris
    Department of Biochemistry, La Trobe University, Victoria, Australia
    Infect Immun 73:6981-9. 2005
    ..The interaction between these peptides and AMA1 may further our understanding of the molecular mechanisms of invasion by identifying critical functional regions of AMA1 and aid in the development of novel antimalarial strategies...
  26. ncbi The N-terminal subdomain of insulin-like growth factor (IGF) binding protein 6. Structure and interaction with IGFs
    Indu R Chandrashekaran
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Australia
    Biochemistry 46:3065-74. 2007
    ..The extended structure and flexibility of this subdomain of IGFBP-6 could play a role in enhancing the rate of ligand association and thereby be significant in IGF recognition...
  27. ncbi Structure and inter-domain interactions of domain II from the blood-stage malarial protein, apical membrane antigen 1
    Zhi Ping Feng
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Vic, 3050, Australia
    J Mol Biol 350:641-56. 2005
    ....
  28. ncbi Cooperativity of the N- and C-terminal domains of insulin-like growth factor (IGF) binding protein 2 in IGF binding
    Zhihe Kuang
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Australia
    Biochemistry 46:13720-32. 2007
    ..N-BP-2.C-BP-2 ternary complex, but did not cause it to dissociate...
  29. ncbi Structure, dynamics and heparin binding of the C-terminal domain of insulin-like growth factor-binding protein-2 (IGFBP-2)
    Zhihe Kuang
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Australia
    J Mol Biol 364:690-704. 2006
    ..5, but is largely suppressed at pH 7.4. Possible preferential binding of IGFBP-2 and its C- domain fragments to glycosaminoglycans in the acidic extracellular matrix (ECM) of tumours may be related to their roles in cancer...
  30. ncbi Recombinant protein vaccines against the asexual blood stages of Plasmodium falciparum
    Robin F Anders
    Department of Biochemistry, La Trobe University, Victoria, Australia
    Hum Vaccin 6:39-53. 2010
    ..The very different structural characteristics of MSP2 and AMA1 are discussed, as are some approaches being taken to overcoming the problem of diversity in these antigens...
  31. pmc Interaction between Plasmodium falciparum apical membrane antigen 1 and the rhoptry neck protein complex defines a key step in the erythrocyte invasion process of malaria parasites
    Dave Richard
    Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria 3052, Australia
    J Biol Chem 285:14815-22. 2010
    ..We propose that the formation of the AMA1-RON complex is essential for secretion of the rhoptry contents, which then allows the establishment of parasite infection within the parasitophorous vacuole...
  32. pmc The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation
    Zhihe Kuang
    The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Victoria, Australia
    J Cell Biol 190:129-41. 2010
    ....
  33. pmc Antigenic characterization of an intrinsically unstructured protein, Plasmodium falciparum merozoite surface protein 2
    Christopher G Adda
    Department of Biochemistry, La Trobe University, Victoria, Australia
    Infect Immun 80:4177-85. 2012
    ..Further studies of the structural basis of these antigenic differences are required in order to optimize recombinant MSP2 constructs being evaluated as potential vaccine components...
  34. ncbi Merozoite surface protein 2 of Plasmodium falciparum: expression, structure, dynamics, and fibril formation of the conserved N-terminal domain
    Andrew Low
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3050, Australia
    Biopolymers 87:12-22. 2007
    ....
  35. doi Exchange enhanced sensitivity gain for solvent-exchangeable protons in 2D 1H-15N heteronuclear correlation spectra acquired with band-selective pulses
    Shenggen Yao
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
    J Magn Reson 211:243-7. 2011
    ....
  36. ncbi Structural basis for tetrodotoxin-resistant sodium channel binding by mu-conotoxin SmIIIA
    David W Keizer
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Biol Chem 278:46805-13. 2003
    ....
  37. ncbi The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues
    Seth L Masters
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3050, Victoria, Australia
    Nat Struct Mol Biol 13:77-84. 2006
    ..Our findings provide a template for SPRY-domain structure and an insight into the mechanism of SPRY-protein interaction...
  38. pmc Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity
    Jeffrey J Babon
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Pde, Parkville, 3052, Vic, Australia
    Immunity 36:239-50. 2012
    ..Importantly, SOCS3 inhibited JAKs via a noncompetitive mechanism, making it a template for the development of specific and effective inhibitors to treat JAK-based immune and proliferative diseases...
  39. ncbi The N-terminal domains of SOCS proteins: a conserved region in the disordered N-termini of SOCS4 and 5
    Zhi Ping Feng
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
    Proteins 80:946-57. 2012
    ..The recombinant protein will be a valuable tool in identifying these partners and defining the structures of these complexes...
  40. doi 1H, 13C and 15N resonance assignments of a highly-soluble murine interleukin-3 analogue with wild-type bioactivity
    Shenggen Yao
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia
    Biomol NMR Assign 4:73-7. 2010
    ..The new construct vastly improves the solubility of murine IL-3 while maintaining its wild-type biological activity...
  41. doi Structure, dynamics, and selectivity of the sodium channel blocker mu-conotoxin SIIIA
    Shenggen Yao
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Biochemistry 47:10940-9. 2008
    ....
  42. doi Murine interleukin-3: structure, dynamics, and conformational heterogeneity in solution
    Shenggen Yao
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
    Biochemistry 50:2464-77. 2011
    ..Such conformational heterogeneity may facilitate the interaction of mIL-3 with each of two naturally occurring mIL-3Rα isoforms, leading to structurally distinct high-affinity complexes...
  43. doi Dicarba α-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors
    Bianca J Van Lierop
    School of Chemistry, Monash University, Clayton 3800, Victoria, Australia
    ACS Chem Biol 8:1815-21. 2013
    ..1 peptide retains activity at the α9α10 nAChR subtype. These singularly acting analogues will enable the elucidation of the biological target responsible for the peptide's potent analgesic activity. ..
  44. ncbi Predicting disordered regions in proteins based on decision trees of reduced amino acid composition
    Pengfei Han
    School of Computer Science and IT, RMIT University, Melbourne, Victoria, Australia
    J Comput Biol 13:1723-34. 2006
    ..Advantages of our approach are high prediction accuracy for long disordered regions and efficiency for large-scale sequence analysis. Our software is freely available for academic use upon request...
  45. ncbi Design and synthesis of type-III mimetics of ShK toxin
    Jonathan B Baell
    Biomolecular Research Institute, Parkville, Victoria, Australia
    J Comput Aided Mol Des 16:245-62. 2002
    ..We complement our approach with attempted pharmacophore-based database mining...
  46. ncbi De novo design and synthesis of a μ-conotoxin KIIIA peptidomimetic
    Ryan M Brady
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia
    Bioorg Med Chem Lett 23:4892-5. 2013
    ..Herein, we report the de novo design and synthesis of a three-residue (Lys7, Trp8, His12) peptidomimetic based on a novel diketopiperazine (DKP) carboxamide scaffold. ..
  47. ncbi Secondary structure assignment of mouse SOCS3 by NMR defines the domain boundaries and identifies an unstructured insertion in the SH2 domain
    Jeffrey J Babon
    Walter and Eliza Hall Institute, Parkville, Victoria, Australia
    FEBS J 272:6120-30. 2005
    ....
  48. ncbi Structure of a novel P-superfamily spasmodic conotoxin reveals an inhibitory cystine knot motif
    Luke A Miles
    The Walter and Eliza Hall Institute of Medical Research, NMR Laboratory, 381 Royal Parade, Parkville 3052, Australia
    J Biol Chem 277:43033-40. 2002
    ....
  49. ncbi Mutating a critical lysine in ShK toxin alters its binding configuration in the pore-vestibule region of the voltage-gated potassium channel, Kv1.3
    Mark D Lanigan
    Biomolecular Research Institute, Parkville 3052, Victoria, Australia
    Biochemistry 41:11963-71. 2002
    ....
  50. doi Mammalian neuronal sodium channel blocker μ-conotoxin BuIIIB has a structured N-terminus that influences potency
    Zhihe Kuang
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3052, Australia
    ACS Chem Biol 8:1344-51. 2013
    ..On the basis of previous results for related μ-conotoxins, the dramatic effects of mutations at the N-terminus were unanticipated and suggest that further gains in potency might be achieved by additional modifications of this region. ..
  51. pmc Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity
    Akshay A D'Cruz
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Protein Sci 22:1-10. 2013
    ..Greater understanding of the functional importance of the N-terminal region in "SPRY only" proteins will enhance our ability to interrogate SPRY interactions with their respective binding partners...
  52. ncbi Binding site for the C-domain of insulin-like growth factor (IGF) binding protein-6 on IGF-II; implications for inhibition of IGF actions
    Stephen J Headey
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Australia
    FEBS Lett 568:19-22. 2004
    ..The C-domain is therefore likely to interfere with IGF binding to the IGFIR, providing a structural basis for the potent inhibitory effects of intact IGFBPs on IGF actions...
  53. ncbi Structures of phage-display peptides that bind to the malarial surface protein, apical membrane antigen 1, and block erythrocyte invasion
    David W Keizer
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Biochemistry 42:9915-23. 2003
    ..The structures provide a valuable starting point for the development of peptidomimetics as antimalarial antagonists directed at AMA1...
  54. doi Protein effective rotational correlation times from translational self-diffusion coefficients measured by PFG-NMR
    Shenggen Yao
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3050, Victoria, Australia
    Biophys Chem 136:145-51. 2008
    ....
  55. ncbi Abundance of intrinsically unstructured proteins in P. falciparum and other apicomplexan parasite proteomes
    Zhi Ping Feng
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3050, Australia
    Mol Biochem Parasitol 150:256-67. 2006
    ....
  56. ncbi Solution structure of the eukaryotic pore-forming cytolysin equinatoxin II: implications for pore formation
    Mark G Hinds
    Biomolecular Research Institute, 343 Royal Parade, Parkville 3052, Australia
    J Mol Biol 315:1219-29. 2002
    ..Once the protein is anchored, the N-terminal helix may penetrate the membrane, with up to four helices lining the pore, although other mechanisms of pore formation cannot be ruled out...
  57. pmc Strategies for the development of conotoxins as new therapeutic leads
    Ryan M Brady
    Monash Institute of Pharmaceutical Science, Monash University, 381 Royal Parade, Parkville 3052, Australia
    Mar Drugs 11:2293-313. 2013
    ..This review exemplifies these approaches with peptide toxins from marine organisms, with a particular focus on conotoxins. ..
  58. doi Structure and activity of (2,8)-dicarba-(3,12)-cystino alpha-ImI, an alpha-conotoxin containing a nonreducible cystine analogue
    Christopher A MacRaild
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Victoria, Australia
    J Med Chem 52:755-62. 2009
    ..These findings confirm the potential of the dicarba linkage to improve stability while maintaining alpha-conotoxin function...
  59. ncbi Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling
    W Douglas Fairlie
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Biol Chem 279:2125-34. 2004
    ..Incorporation of two additional mutations (Q29A and G124R), which were found to abrogate cell signaling, led to the generation of highly potent antagonists of both human and murine LIF-induced bioactivity...
  60. ncbi Structure and activity of D-Pro14 melittin
    Dean R Hewish
    CSIRO Health Sciences and Nutrition, Parkville Laboratory, Victoria, Australia
    J Protein Chem 21:243-53. 2002
    ..Electron-paramagnetic resonance studies suggest that there is a positive correlation between hemolytic activity of the peptides and interaction with phospholipid bilayers...
  61. doi Lipid interactions of the malaria antigen merozoite surface protein 2
    Christopher A MacRaild
    Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia
    Biochim Biophys Acta 1818:2572-8. 2012
    ....
  62. ncbi Structure of domain III of the blood-stage malaria vaccine candidate, Plasmodium falciparum apical membrane antigen 1 (AMA1)
    Margie Nair
    Biomolecular Research Institute, 343 Royal Parade, Parkville, VIC 3052, Australia
    J Mol Biol 322:741-53. 2002
    ....
  63. ncbi Ferric ions are essential for the biological activity of the hormone glycine-extended gastrin
    Julie Pannequin
    University of Melbourne Department of Surgery, Austin Campus, ARMC, Heidelberg, Victoria 3084, Australia
    J Biol Chem 277:48602-9. 2002
    ..This is the first report of an essential role for a metal ion in the action of a hormone...
  64. pmc Effects of the eukaryotic pore-forming cytolysin Equinatoxin II on lipid membranes and the role of sphingomyelin
    Boyan B Bonev
    Biomembrane Structure Unit, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK
    Biophys J 84:2382-92. 2003
    ..This effect was greatly enhanced in sphingomyelin-containing mixed lipid membranes compared with pure phosphatidylcholine bilayers, suggesting a preferential interaction between the toxin and bilayer sphingomyelin...
  65. ncbi Stabilization of the helical structure of Y2-selective analogues of neuropeptide Y by lactam bridges
    Shenggen Yao
    Biomolecular Research Institute, 343 Royal Parade, Parkville, Victoria 3052, Australia
    J Med Chem 45:2310-8. 2002
    ..These findings support the proposal that these Y2-selective analogues adopt a helical structure when bound to the Y2 receptor...
  66. ncbi Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis
    Kevin J Barnham
    Department of Pathology, The University of Melbourne, Victoria 3010, Australia
    J Biol Chem 278:17401-7. 2003
    ..The surface location of this site, structural homology of CuBD to copper chaperones, and the role of APP in neuronal copper homeostasis are consistent with the CuBD acting as a neuronal metallotransporter...
  67. ncbi Backbone 1H, 13C and 15N assignments of the 25 kDa SPRY domain-containing SOCS box protein 2 (SSB-2)
    Shenggen Yao
    J Biomol NMR 31:69-70. 2005
  68. ncbi Interaction of the eukaryotic pore-forming cytolysin equinatoxin II with model membranes: 19F NMR studies
    Gregor Anderluh
    Department of Biology, Biotechnical Faculty, University of Ljubljana, Vecna pot 111, 1000 Ljubljana, Slovenia
    J Mol Biol 347:27-39. 2005
    ....
  69. pmc Structure and sodium channel activity of an excitatory I1-superfamily conotoxin
    Olga Buczek
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    Biochemistry 46:9929-40. 2007
    ..Thus, there is a convergence of structure and function in iota-RXIA, as its disulfide pairing and structure resemble those of funnel web spider toxins that also target sodium channels...
  70. ncbi Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels
    Grzegorz Bulaj
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    Biochemistry 44:7259-65. 2005
    ..Taken together, structural and functional differences among mu-conotoxins SmIIIA, SIIIA, and KIIIA offer a unique insight into the "evolutionary engineering" of conotoxin activity...
  71. pmc Alpha-RgIA, a novel conotoxin that blocks the alpha9alpha10 nAChR: structure and identification of key receptor-binding residues
    Michael Ellison
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    J Mol Biol 377:1216-27. 2008
    ..Our findings contribute to a better understanding of the molecular basis for antagonism of the alpha9alpha10 nAChR subtype, which is a target for the development of analgesics for the treatment of chronic neuropathic pain...
  72. ncbi Structural and functional characteristics of the Val44Met insulin-like growth factor I missense mutation: correlation with effects on growth and development
    Adam Denley
    School of Molecular and Biomedical Science, University of Adelaide, Adelaide, 5005 South Australia
    Mol Endocrinol 19:711-21. 2005
    ....
  73. pmc Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7
    Brian Fiedler
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    Biochem Pharmacol 75:2334-44. 2008
    ..6 at nodes of Ranvier as well as in unmyelinated axons. Sixteen peptides homologous to iota-RXIA have been identified from a single species of Conus, so these peptides represent a rich family of novel sodium channel-targeting ligands...
  74. ncbi Solution structure and alanine scan of a spider toxin that affects the activation of mammalian voltage-gated sodium channels
    Gerardo Corzo
    Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Apartado Postal 510 3, Cuernavaca, Morelos 61500, Mexico
    J Biol Chem 282:4643-52. 2007
    ..These two distinct classes of toxin, with different amino acid sequences and different structures, may utilize similar groups of residues on their surface to achieve the common end of modifying voltage-gated sodium channel function...
  75. ncbi Contributions of the N- and C-terminal domains of IGF binding protein-6 to IGF binding
    Stephen J Headey
    University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg 3084, Australia
    J Mol Endocrinol 33:377-86. 2004
    ..In conclusion, both the N- and C-domains of IGFBP-6 are involved in IGF binding, the C-domain is responsible for the IGF-II binding preference of IGFBP-6 and intact IGFBP-6 is necessary for high affinity IGF binding...
  76. ncbi Biological activity and ferric ion binding of fragments of glycine-extended gastrin
    Hong He
    The University of Melbourne Department of Surgery, Austin Health, Heidelberg, Victoria 3084, Australia
    Biochemistry 43:11853-61. 2004
    ..These observations indicate that extensive proteolytic processing may not completely inactivate Ggly and that bioactive forms that are not detected by current radioimmunoassays may be present in tissues and/or plasma...
  77. ncbi Conotoxins containing nonnatural backbone spacers: cladistic-based design, chemical synthesis, and improved analgesic activity
    Brad R Green
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Chem Biol 14:399-407. 2007
    ..The resulting polytides provide a promising strategy for transforming disulfide-rich peptides into therapeutics...
  78. ncbi 1H, 13C and 15N resonance assignments of the C-terminal domain of insulin-like growth factor binding protein-6 (IGFBP-6)
    Stephen J Headey
    J Biomol NMR 25:251-2. 2003
  79. ncbi Structural insights into the interaction of insulin-like growth factor 2 with IGF2R domain 11
    Christopher Williams
    Department of Organic and Biological Chemistry, School of Chemistry, Cantock s Close, University of Bristol, Bristol, United Kingdom
    Structure 15:1065-78. 2007
    ..The models reveal that the molecular interaction is driven by critical hydrophobic residues on IGF2 and IGF2R, while a ring of flexible, charged residues on IGF2R may modulate binding...
  80. ncbi Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels
    Min Min Zhang
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 282:30699-706. 2007
    ..2 and that further engineering of micro-conopeptides belonging to the KIIIA group may provide subtype-selective pharmacological compounds for mammalian neuronal sodium channels and potential therapeutics for the treatment of pain...
  81. ncbi Synthesis and characterization of delta-atracotoxin-Ar1a, the lethal neurotoxin from venom of the Sydney funnel-web spider (Atrax robustus)
    Dianne Alewood
    Institute for Molecular Bioscience, University of Queensland, Queensland 4072 Australia
    Biochemistry 42:12933-40. 2003
    ..This successful oxidative refolding of synthetic delta-ACTX-Ar1a paves the way for future structure-activity studies to determine the toxin pharmacophore...
  82. ncbi The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation
    Christine Beeton
    Department of Physiology and Biophysics, University of California, California, Irvine, 92697 4560, USA
    J Biol Chem 283:988-97. 2008
    ..Being resistant to proteolysis and nonantigenic, this analogue should be useful in K(+) channel studies; all-d analogues with improved Kv1.3 potency and specificity may have therapeutic advantages...
  83. pmc Tyrosine modification enhances metal-ion binding
    Graham S Baldwin
    The University of Melbourne Department of Surgery, Austin Health, Heidelberg, Victoria 3084, Australia
    Biochem J 416:77-84. 2008
    ..The results of the present study demonstrate that tyrosine modification may increase the affinity of metal-ion binding to peptides, and imply that metal ions may directly regulate many signalling pathways...
  84. ncbi Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections
    Xavier Lauth
    Department of Pediatrics, University of California San Diego, School of Medicine, San Diego, California 92093, USA
    J Biol Chem 280:9272-82. 2005
    ..Our results suggest that hepcidin plays a key role in the antimicrobial defenses of bass and that its functions are potentially conserved between fish and human...
  85. ncbi Predicting disordered regions in proteins based on decision trees of reduced amino acid composition
    Pengfei Han
    J Comput Biol 13:1579-90. 2006
    ..Advantages of our approach are high prediction accuracy for long disordered regions and efficiency for large-scale sequence analysis. Our software is freely available for academic use upon request...