G Morahan

Summary

Affiliation: The Walter and Eliza Hall Institute of Medical Research
Country: Australia

Publications

  1. ncbi Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele
    G Morahan
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    Nat Genet 27:218-21. 2001
  2. ncbi A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production
    G Morahan
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Vic, Australia
    Genes Immun 3:414-8. 2002
  3. ncbi Markers on distal chromosome 2q linked to insulin-dependent diabetes mellitus
    G Morahan
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Science 272:1811-3. 1996
  4. ncbi Localization of Idd11 using NOD congenic mouse strains: elimination of Slc9a1 as a candidate gene
    T C Brodnicki
    Genetics and Bioinformatics Group, The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
    Immunogenetics 51:37-41. 2000
  5. pmc Genetic and physiological association of diabetes susceptibility with raised Na+/H+ exchange activity
    G Morahan
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Proc Natl Acad Sci U S A 91:5898-902. 1994
  6. ncbi C57BL/6 and C57BL/10 inbred mouse strains differ at multiple loci on chromosome 4
    P J McClive
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Immunogenetics 39:286-8. 1994
  7. ncbi Genetic polymorphisms of the non-obese diabetic (NOD) mouse
    P J McClive
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Immunol Cell Biol 72:137-42. 1994
  8. ncbi Localization of the mouse Na+/H+ exchanger gene on distal chromosome 4
    G Morahan
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Genomics 15:231-2. 1993
  9. ncbi HLA genes associated with autoimmunity and progression to disease in type 1 diabetes
    B D Tait
    Victorian Transplantation and Immunogenetics Service, Australian Red Cross Blood Service, Melbourne, Victoria, Australia
    Tissue Antigens 61:146-53. 2003
  10. ncbi Polymorphisms in the Il12b gene affect structure and expression of IL-12 in NOD and other autoimmune-prone mouse strains
    S I Ymer
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria 3050, Australia
    Genes Immun 3:151-7. 2002

Collaborators

Detail Information

Publications23

  1. ncbi Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele
    G Morahan
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    Nat Genet 27:218-21. 2001
    ..The IL12B 3' UTR alleles showed different levels of expression in cell lines. Variation in IL-12p40 production may influence T-cell responses crucial for either mediating or protecting against this and other autoimmune diseases...
  2. ncbi A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production
    G Morahan
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Vic, Australia
    Genes Immun 3:414-8. 2002
    ..These studies suggest that IL12B polymorphisms, via regulation of IL-12 production, may influence the outcome of malaria infection in at least one African population...
  3. ncbi Markers on distal chromosome 2q linked to insulin-dependent diabetes mellitus
    G Morahan
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Science 272:1811-3. 1996
    ..These results indicate the existence of a gene that acts at an early stage in IDDM development, screening for which may identify a specific subset of at-risk individuals...
  4. ncbi Localization of Idd11 using NOD congenic mouse strains: elimination of Slc9a1 as a candidate gene
    T C Brodnicki
    Genetics and Bioinformatics Group, The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
    Immunogenetics 51:37-41. 2000
    ..These results define a new distal boundary for Idd11 and eliminate the Slc9a1 gene as a candidate. The Idd11 locus has now been definitively mapped to a 13cM interval on mouse Chr 4...
  5. pmc Genetic and physiological association of diabetes susceptibility with raised Na+/H+ exchange activity
    G Morahan
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Proc Natl Acad Sci U S A 91:5898-902. 1994
    ..These results implicate the Na+/H+ exchanger (antiporter) in the development of type 1 diabetes and may provide a screening test for at-risk individuals as well as offering prospects for disease prevention...
  6. ncbi C57BL/6 and C57BL/10 inbred mouse strains differ at multiple loci on chromosome 4
    P J McClive
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Immunogenetics 39:286-8. 1994
  7. ncbi Genetic polymorphisms of the non-obese diabetic (NOD) mouse
    P J McClive
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Immunol Cell Biol 72:137-42. 1994
    ..The expression of uncommon alleles of these antigens suggests candidates whose role in the diabetogenic process can be tested...
  8. ncbi Localization of the mouse Na+/H+ exchanger gene on distal chromosome 4
    G Morahan
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Genomics 15:231-2. 1993
    ..Comparison with previously reported strain distribution patterns shows that the gene encoding the mouse Na+/H+ exchanger maps to distal mouse Chromosome 4, between Lck and Akp-2...
  9. ncbi HLA genes associated with autoimmunity and progression to disease in type 1 diabetes
    B D Tait
    Victorian Transplantation and Immunogenetics Service, Australian Red Cross Blood Service, Melbourne, Victoria, Australia
    Tissue Antigens 61:146-53. 2003
    ....
  10. ncbi Polymorphisms in the Il12b gene affect structure and expression of IL-12 in NOD and other autoimmune-prone mouse strains
    S I Ymer
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria 3050, Australia
    Genes Immun 3:151-7. 2002
    ..These findings have implications for the predisposition to autoimmune responses in NOD and other autoimmune-prone mouse strains...
  11. ncbi Increased nicotinamide nucleotide transhydrogenase levels predispose to insulin hypersecretion in a mouse strain susceptible to diabetes
    K Aston-Mourney
    The University of Melbourne Department of Medicine AH NH, Heidelberg Repatriation Hospital, Heidelberg Heights, Melbourne, Vic, Australia
    Diabetologia 50:2476-85. 2007
    ..We have previously shown that diabetes-susceptible DBA/2 mice congenitally display high insulin secretion. We studied this model to map and identify the gene(s) responsible for this trait...
  12. ncbi Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit
    D Huang
    Complex Genetic Diseases Laboratory, and Cooperative Research Centre for Discovery of Genes for Common Human Diseases, Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria 3050, Australia
    Genes Immun 1:515-20. 2000
    ..This finding places constraints on any preferential involvement of alleles of IL-12p40 in contributing to autoimmune, inflammatory or infectious diseases...
  13. pmc The nu gene acts cell-autonomously and is required for differentiation of thymic epithelial progenitors
    C C Blackburn
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Proc Natl Acad Sci U S A 93:5742-6. 1996
    ..We propose that nu acts to regulate growth and/or differentiation, but not determination, of thymic epithelial progenitors...
  14. ncbi Differential and genetically separable associations of leptin with obesity-related traits
    A W Thorburn
    Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Melbourne, Australia
    Int J Obes Relat Metab Disord 24:742-50. 2000
    ..This has allowed us to determine whether hyperleptinaemia is associated with reduced food intake and increased physical activity in mice spanning a large range in body weight...
  15. ncbi Definition of polymorphisms in the gene encoding the interleukin-12 receptor B1 subunit: testing linkage disequilibrium with Type I diabetes susceptibility
    T Tabone
    The Walter and Eliza Hall Institute of Medical Research, IG Royal Parade, Parville, Victoria, Australia
    Genes Immun 4:222-7. 2003
    ..Although suggestive evidence for linkage to a susceptibility gene was found, none of the IL12RB1 variants we defined demonstrated preferential transmission in these families...
  16. ncbi Effect of localized cytokine dysregulation: accelerated rejection of IL-2-expressing skin grafts
    C Blackburn
    Walter and Eliza Hall Institute of Medical Research and Royal Melbourne Hospital, PO Royal Melbourne Hospital, Victoria, Australia
    Immunol Cell Biol 79:128-31. 2001
    ..We therefore suggest that aberrant expression of IL-2 can accelerate helper-independent CD8+ T cell responses by increasing proliferation and/or differentiation of cytolytic T cells at the effector site...
  17. doi A novel mechanism regulating insulin secretion involving Herpud1 in mice
    N Wong
    Department of Medicine Austin Health, Austin Hospital, University of Melbourne, Heidelberg Heights, Melbourne, Victoria, 3084, Australia
    Diabetologia 56:1569-76. 2013
    ..One distinctive feature of the DBA/2 mouse is that it hypersecretes insulin, independent of changes in insulin sensitivity; we identified Nnt as a gene responsible for this trait...
  18. ncbi Identification of a T1D susceptibility gene
    G Morahan
    Complex Genetic Diseases Laboratoty, The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    ScientificWorldJournal 1:198-9. 2001
    ..But how and why this autoimmune process starts or proceeds unregulated is still not known...
  19. ncbi Assignment of the mouse homologues of 6 loci from HSA1p to chromosomes 3 and 4
    P J McClive
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Genomics 23:243-6. 1994
    ....
  20. ncbi The molecular characterisation of a novel tetraspanin protein, TM4-B(1)
    K L Puls
    The Walter and Eliza Hall Institute of Medical Research, Post Office Box the Royal Melbourne Hospital 3050, Victoria, Australia
    Biochim Biophys Acta 1447:93-9. 1999
    ..This molecule is broadly expressed in most human tissues and cell lines including neural and bone marrow derived tissues. TM4-B was mapped to the q34 region on human chromosome 9...
  21. ncbi A high-resolution map of the chromosomal region surrounding the nude gene
    C C Blackburn
    Walter and Eliza Hall Institute for Medical Research, P O Royal Melbourne Hospital, Victoria, Australia
    Genomics 26:308-17. 1995
    ..We also report the typing of the above microsatellite markers in the AKXD, AKXL, BXD, CXB, and BXH recombinant inbred strains, which confirmed the relative order and separation of loci in this region...
  22. ncbi Deficient IL-12p70 secretion by dendritic cells based on IL12B promoter genotype
    J Muller-Berghaus
    Skin Cancer Unit, German Cancer Research Center Heidelberg and University Hospital Mannheim, Germany
    Genes Immun 5:431-4. 2004
    ..These findings are important for the understanding of the highly complex regulation of IL-12 secretion, and its consequent impact on disease susceptibility, in humans...
  23. ncbi Association of variants in the IL12B gene with leprosy and tuberculosis
    G Morahan
    Diabetes Research Centre, Western Australia Institute for Medical Research, Perth, WA, Australia
    Tissue Antigens 69:234-6. 2007
    ..01) but also more likely to have this in the same haplotype with the high expressing 3'UTR allele (P= 0.0009). These results suggest these infectious diseases may be improved by modulating IL-l2p40 production...