Research Topics
| Jacques F A MillerSummaryAffiliation: The Walter and Eliza Hall Institute of Medical Research Country: Australia Publications
| Collaborators
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Detail Information
Publications
Mechanisms of tolerance to selfJ F Miller
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
Curr Opin Immunol 8:815-21. 1996..Once there, their ultimate fate is determined by the availability of T cell help...
Antigen-specific clone selection in vivoJacques F A P Miller
Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Victoria 3050, Australia
Immunol Cell Biol 86:24-5. 2008
Vestigial no moreJacques F A P Miller
Department of Immunology, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Nat Immunol 7:3-5. 2006
A scientific odyssey: unravelling the secrets of the thymusJacques F A Miller
Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3050, Australia
Med J Aust 183:582-4. 2005
Self-nonself discrimination by T lymphocytesJacques Miller
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
C R Biol 327:399-408. 2004..Whether self-reactive lymphocytes ignore their target autoantigen, or are tolerized by the various mechanisms discussed, depends on the circumstances...
Events that led to the discovery of T-cell development and function--a personal recollectionJ F A P Miller
The Walter and Eliza Hall Institute of Medical Research, IG Royal Parade, Parkville, Victoria 3050, Australia
Tissue Antigens 63:509-17. 2004..This led to a re-investigation of numerous immunological phenomena to determine the contribution of each subset to the particular immune response under scrutiny...
Discovering the origins of immunological competenceJ F Miller
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
Annu Rev Immunol 17:1-17. 1999....
Induction of peripheral CD8+ T-cell tolerance by cross-presentation of self antigensJ F Miller
Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Victoria, Australia
Immunol Rev 165:267-77. 1998....
The golden anniversary of the thymusJacques F A P Miller
Department of Immunology, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Nat Rev Immunol 11:489-95. 2011..In this article, I summarize the key advances that have led to our current knowledge of the functions of the thymus and its T cells in immunity...
The CD8alpha(+) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigensGabrielle T Belz
Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
J Exp Med 196:1099-104. 2002....
Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by BimGayle M Davey
The Walter and Eliza Hall Institute of Medical Research, P.O. Royal Melbourne Hospital, Parkville 3050, Victoria, Australia
J Exp Med 196:947-55. 2002..Bim-deficient T cells were not deleted in response to cross-presented self-antigen, strongly implicating Bim as the pro-apoptotic mediator of cross-tolerance...
Beta cells cannot directly prime diabetogenic CD8 T cells in nonobese diabetic miceJames de Jersey
Department of Immunology, Faculty of Medicine, Nursing and Health Sciences, Monash University, The Alfred Hospital, Commercial Road, Melbourne, Victoria 3004, Australia
Proc Natl Acad Sci U S A 104:1295-300. 2007..Importantly, our findings demonstrate unequivocally that CD8 T cells cannot be primed to become diabetogenic by islet beta cells alone...
Thymic regeneration: teaching an old immune system new tricksStuart P Berzins
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Brigham and Women s Hospital, Dept of Medicine, Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
Trends Mol Med 8:469-76. 2002..In the future, thymic regeneration might become a feasible and potentially powerful approach to rejuvenating a depleted peripheral T-cell pool...
