Donald Metcalf

Summary

Affiliation: The Walter and Eliza Hall Institute of Medical Research
Country: Australia

Publications

  1. pmc The colony-stimulating factors and cancer
    Donald Metcalf
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, Victoria, Australia Department of Medical Biology, University of Melbourne, Parkville 3010, Victoria, Australia Telephone 61 3 9345 2555
    Cancer Immunol Res 1:351-6. 2013
  2. pmc Concordant mast cell and basophil production by individual hematopoietic blast colony-forming cells
    Donald Metcalf
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Victoria, Australia
    Proc Natl Acad Sci U S A 110:9031-5. 2013
  3. pmc Crowding-dependent production of colony-stimulating factors by cultured syngeneic or allogeneic hematopoietic cells
    Donald Metcalf
    Division of Cancer and Hematology, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3050 Victoria, Australia
    Proc Natl Acad Sci U S A 100:1244-9. 2003
  4. ncbi Synergistic and inhibitory interactions in the in vitro control of murine megakaryocyte colony formation
    Donald Metcalf
    Division of Cancer and Hematology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Stem Cells 20:552-60. 2002
  5. pmc The lethal effects of transplantation of Socs1-/- bone marrow cells into irradiated adult syngeneic recipients
    Donald Metcalf
    Division of Cancer and Hematology, The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 100:8436-41. 2003
  6. pmc Murine hematopoietic blast colony-forming cells and their progeny have distinctive membrane marker profiles
    Donald Metcalf
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
    Proc Natl Acad Sci U S A 106:19102-7. 2009
  7. ncbi Murine megakaryocyte progenitor cells and their susceptibility to suppression by G-CSF
    Donald Metcalf
    Division of Cancer and Hematology, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Stem Cells 23:55-62. 2005
  8. pmc Multipotential hematopoietic blast colony-forming cells exhibit delays in self-generation and lineage commitment
    Donald Metcalf
    Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia
    Proc Natl Acad Sci U S A 107:16257-61. 2010
  9. pmc Hematopoietic cytokines
    Donald Metcalf
    Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
    Blood 111:485-91. 2008
  10. ncbi The unsolved enigmas of leukemia inhibitory factor
    Donald Metcalf
    Division of Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Stem Cells 21:5-14. 2003

Detail Information

Publications147 found, 100 shown here

  1. pmc The colony-stimulating factors and cancer
    Donald Metcalf
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, Victoria, Australia Department of Medical Biology, University of Melbourne, Parkville 3010, Victoria, Australia Telephone 61 3 9345 2555
    Cancer Immunol Res 1:351-6. 2013
    ....
  2. pmc Concordant mast cell and basophil production by individual hematopoietic blast colony-forming cells
    Donald Metcalf
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Victoria, Australia
    Proc Natl Acad Sci U S A 110:9031-5. 2013
    ....
  3. pmc Crowding-dependent production of colony-stimulating factors by cultured syngeneic or allogeneic hematopoietic cells
    Donald Metcalf
    Division of Cancer and Hematology, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3050 Victoria, Australia
    Proc Natl Acad Sci U S A 100:1244-9. 2003
    ....
  4. ncbi Synergistic and inhibitory interactions in the in vitro control of murine megakaryocyte colony formation
    Donald Metcalf
    Division of Cancer and Hematology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Stem Cells 20:552-60. 2002
    ..The mechanisms involved in this inhibitory action of G-CSF are unknown, but the inhibitory action could be of relevance for the dose-dependent lowering of platelet levels observed in some subjects injected with G-CSF...
  5. pmc The lethal effects of transplantation of Socs1-/- bone marrow cells into irradiated adult syngeneic recipients
    Donald Metcalf
    Division of Cancer and Hematology, The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 100:8436-41. 2003
    ....
  6. pmc Murine hematopoietic blast colony-forming cells and their progeny have distinctive membrane marker profiles
    Donald Metcalf
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
    Proc Natl Acad Sci U S A 106:19102-7. 2009
    ..The commitment events and phenotypic changes during the generation of differing progenitor cells in blast colonies can now be clonally analyzed in a convenient in vitro culture system...
  7. ncbi Murine megakaryocyte progenitor cells and their susceptibility to suppression by G-CSF
    Donald Metcalf
    Division of Cancer and Hematology, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Stem Cells 23:55-62. 2005
    ....
  8. pmc Multipotential hematopoietic blast colony-forming cells exhibit delays in self-generation and lineage commitment
    Donald Metcalf
    Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia
    Proc Natl Acad Sci U S A 107:16257-61. 2010
    ..Because BL-CFCs can self-generate and are able to generate lymphoid and myeloid populations, BL-CFCs appear to be ideal cells in which to analyze the processes of self-generation and lineage commitment in clonal in vitro cultures...
  9. pmc Hematopoietic cytokines
    Donald Metcalf
    Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
    Blood 111:485-91. 2008
    ....
  10. ncbi The unsolved enigmas of leukemia inhibitory factor
    Donald Metcalf
    Division of Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Stem Cells 21:5-14. 2003
    ....
  11. ncbi Stem cell factor can stimulate the formation of eosinophils by two types of murine eosinophil progenitor cells
    Donald Metcalf
    Division of Cancer and Hematology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Stem Cells 20:460-9. 2002
    ..The observed activity of SCF in marrow cultures was relatively weak, but its action may be stronger in vivo, and SCF needs to be added to GM-CSF, IL-5, and IL-3 in the list of cytokines able to stimulate eosinophil formation...
  12. pmc Clonogenic mast cell progenitors and their excess numbers in chimeric BALB/c mice with inactivated GATA-1
    Donald Metcalf
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Victoria, Australia
    Proc Natl Acad Sci U S A 104:18642-7. 2007
    ..No excess tissue mast cells were observed in GATA-1(Plt13/+) mice, suggesting that the excess mast cell progenitors in these mice might be generating mast cells with a defective in vivo proliferative or tissue homing capacity...
  13. ncbi Lineage commitment and maturation induction in normal and leukemic preprogenitor cells
    D Metcalf
    Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, 3050 Victoria, Australia
    Ann N Y Acad Sci 938:278-91; discussion 291-2. 2001
    ....
  14. ncbi Concise review: hematopoietic stem cells and tissue stem cells: current concepts and unanswered questions
    Donald Metcalf
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Stem Cells 25:2390-5. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  15. ncbi Production of colony-stimulating factors and IL-5 by organs from three types of mice with inflammatory disease due to loss of the suppressor of cytokine signaling-1
    D Metcalf
    Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Royal Melbourne Hospital, Victoria, Australia
    J Immunol 167:4661-7. 2001
    ..The ability of local organs to produce these proinflammatory cytokines could contribute to the development and progression of these inflammatory lesions...
  16. ncbi On hematopoietic stem cell fate
    Donald Metcalf
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Victoria, Australia
    Immunity 26:669-73. 2007
    ..Here, Metcalf considers the origin and heterogeneity of HSCs, their ability to self-generate, and their commitment to the various hematopoietic lineages...
  17. ncbi Loss of PU.1: one of the many roads to myeloid leukemia
    Donald Metcalf
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Cell Cycle 5:673-4. 2006
  18. pmc Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1)
    Donald Metcalf
    The Walter and Eliza Hall Institute of Medical Research, and The Cooperative Research Centre for Cellular Growth Factors, Post Office Royal Melbourne Hospital, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 99:943-8. 2002
    ..The chronic infections and granulomas of SOCS-1(-/-) IFN-gamma(-/-) mice may be based on autoaggression of SOCS-1(-/-) T lymphoid and related cells or a functional deficiency of these cells when lacking SOCS-1...
  19. pmc The colony-stimulating factors and cancer
    Donald Metcalf
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
    Nat Rev Cancer 10:425-34. 2010
    ....
  20. pmc Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia
    Donald Metcalf
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Victoria, Australia
    Proc Natl Acad Sci U S A 103:1486-91. 2006
    ..Acquisition of autocrine growth-factor production and autonomous growth appeared to be major events in the transformation of conditionally deleted PU.1(-/-) cells to fully developed myeloid leukemic populations...
  21. pmc The preleukemic state of mice reconstituted with Mixl1-transduced marrow cells
    Donald Metcalf
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 104:20013-8. 2007
    ....
  22. doi Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival
    Marlyse A Debrincat
    Cancer and Hematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Blood 119:5850-8. 2012
    ..Our studies indicate that the combination of Bcl-x(L) and Mcl-1 is essential for the viability of the megakaryocyte lineage...
  23. pmc PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis
    Aleksandar Dakic
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    J Exp Med 201:1487-502. 2005
    ..These findings emphasize the distinct nature of adult hematopoiesis and reveal that PU.1 regulates the specification of the multipotent lymphoid and myeloid compartments and restrains, rather than promotes, granulopoiesis...
  24. ncbi A family of cytokine-inducible inhibitors of signalling
    R Starr
    The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia
    Nature 387:917-21. 1997
    ..Transcription of all four SOCS genes is increased rapidly in response to interleukin-6, in vitro and in vivo, suggesting they may act in a classic negative feedback loop to regulate cytokine signal transduction...
  25. pmc Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation
    Ashley P Ng
    Divisions of Cancer and Haematology, and Molecular Medicine, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia
    Proc Natl Acad Sci U S A 111:5884-9. 2014
    ....
  26. ncbi Suppressor of cytokine signaling-1 has IFN-gamma-independent actions in T cell homeostasis
    Ann L Cornish
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 170:878-86. 2003
    ..Thus, SOCS-1 is a critical regulator of T cell activation and homeostasis, and its influence extends beyond regulating IFN-gamma signaling...
  27. pmc Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation
    Ben A Croker
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Exp Hematol 36:786-98. 2008
    ..The tight regulation by Socs3 of signal transducer and activator of transcription 3 phosphorylation and gene transcription after cytokine receptor ligation significantly influences the fate of myeloid progenitor cells...
  28. doi Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice
    Ashley P Ng
    Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Blood 118:2454-61. 2011
    ..Thus, Erg is a critical regulator of adult HSCs, essential for maintaining self-renewal at times of high HSC cycling...
  29. pmc The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo
    Kristy Boyle
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Blood 110:1466-74. 2007
    ..Overall, the results establish a role for the SOCS box of SOCS3 in the in vivo regulation of G-CSF signaling and the response to inflammatory stimuli...
  30. ncbi SOCS3 negatively regulates IL-6 signaling in vivo
    Ben A Croker
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Nat Immunol 4:540-5. 2003
    ..Our data indicate that SOCS3 and SOCS1 have reciprocal functions in IL-6 and IFN-gamma regulation and imply that SOCS3 has a role in preventing IFN-gamma-like responses in cells stimulated by IL-6...
  31. pmc Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage
    Elizabeth A Kruse
    Divisions of Molecular Medicine and Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, Australia
    Proc Natl Acad Sci U S A 106:13814-9. 2009
    ..These results illustrate an indispensable requirement for both Fli-1 and Erg in normal HSC and megakaryocyte homeostasis, and suggest these transcription factors may coregulate common target genes...
  32. pmc Regulation of hematopoietic stem cells by their mature progeny
    Carolyn A de Graaf
    Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    Proc Natl Acad Sci U S A 107:21689-94. 2010
    ..These studies suggest that disorders of platelet number can have profound effects on the HSC compartment via effects on the feedback regulation of circulating TPO concentration...
  33. pmc Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis
    Toru Okamoto
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia
    Proc Natl Acad Sci U S A 111:261-6. 2014
    ....
  34. ncbi SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis
    Ben A Croker
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Parkville, Victoria 3050, Australia
    Immunity 20:153-65. 2004
    ..We conclude that SOCS3 is a key negative regulator of G-CSF signaling in myeloid cells and that this is of particular significance during G-CSF-driven emergency granulopoiesis...
  35. pmc Hematopoietic overexpression of the transcription factor Erg induces lymphoid and erythro-megakaryocytic leukemia
    Catherine L Carmichael
    Cancer and Hematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Vic, Australia
    Proc Natl Acad Sci U S A 109:15437-42. 2012
    ..Thus, in mice, Erg overexpression induces the development of not only lymphoid leukemia but also erythro-megakaryocytic leukemia...
  36. pmc IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3
    Ben A Croker
    Department of Inflammation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Immunol Cell Biol 90:124-9. 2012
    ..We conclude that SOCS3 is required for survival during inflammatory responses and is a critical regulator of IL-6 in vivo...
  37. pmc Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1
    Ben A Croker
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    Proc Natl Acad Sci U S A 108:13135-40. 2011
    ..These data demonstrate that the intrinsic apoptosis pathway directly controls the kinetics of Fas-triggered apoptosis in neutrophils...
  38. ncbi Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome
    Ashley P Ng
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Blood 115:3966-9. 2010
    ....
  39. pmc Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance
    Kirsteen J Campbell
    Molecular Genetics of CancerDivision, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, Victoria, Australia
    Blood 116:3197-207. 2010
    ..Collectively, these results demonstrate that Mcl-1 overexpression renders hematopoietic cells refractory to many cytotoxic insults, perturbs lymphopoiesis and promotes malignant transformation of hematopoietic stem and progenitor cells...
  40. pmc Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice
    Maria Kauppi
    Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Blood 112:3148-53. 2008
    ....
  41. ncbi Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene
    Donald Metcalf
    Division of Cancer and Hematology, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Blood 105:3480-7. 2005
    ....
  42. doi Reduced lymphocyte longevity and homeostatic proliferation in lamin B receptor-deficient mice results in profound and progressive lymphopenia
    Anne M Verhagen
    Walter and Eliza Hall Institute, Parkville, Victoria 3052, Australia
    J Immunol 188:122-34. 2012
    ..In summary, this study demonstrates that LBR deficiency affects not only nuclear architecture but also proliferation, cell viability, and gene expression of hematopoietic cells...
  43. ncbi The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells
    Stephen J Loughran
    Division of Molecular Medicine, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Immunol 9:810-9. 2008
    ..We show that Erg is required for definitive hematopoiesis, adult hematopoietic stem cell function and the maintenance of normal peripheral blood platelet numbers...
  44. doi Blimp1 is limiting for transformation in a mouse plasmacytoma model
    Kathy D'Costa
    Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Blood 113:5911-9. 2009
    ..These observations suggest that Blimp1 is limiting for plasma cell transformation and thus has potential as a target for new therapies to combat MM...
  45. pmc SOCS2 negatively regulates growth hormone action in vitro and in vivo
    Christopher J Greenhalgh
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research WEHI and the Cooperative Centre for Cellular Growth Factors, Parkville, Victoria, Australia
    J Clin Invest 115:397-406. 2005
    ..Together, the data provide clear evidence that SOCS2 is a negative regulator of GH signaling...
  46. pmc Enforced expression of the homeobox gene Mixl1 impairs hematopoietic differentiation and results in acute myeloid leukemia
    Stefan Glaser
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 103:16460-5. 2006
    ..These observations establish a link between enforced Mixl1 expression and leukemogenesis in the mouse...
  47. ncbi Programmed anuclear cell death delimits platelet life span
    Kylie D Mason
    Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Cell 128:1173-86. 2007
    ....
  48. pmc The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12
    Mark A Hall
    Rotary Bone Marrow Research Laboratory, Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 100:992-7. 2003
    ..These results suggest that SCL is critical for megakaryopoiesis and erythropoiesis, but is dispensable for production of myeloid cells during adult hematopoiesis...
  49. pmc A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia
    Ian J Majewski
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 103:14146-51. 2006
    ..Although the equivalent mutation to Gata-1Plt13 in humans results in production of GATA-1s, a short protein isoform initiated from a start codon downstream of the mutated initiation codon, Gata-1s was not detected in Gata-1Plt13/+ mice...
  50. pmc Oct2 enhances antibody-secreting cell differentiation through regulation of IL-5 receptor alpha chain expression on activated B cells
    Dianne Emslie
    Immunology Division, The Walter and Eliza Hall Institute, Parkville, Victoria 3050, Australia
    J Exp Med 205:409-21. 2008
    ..IL-5 augments ASC differentiation in vitro, and we show that IL-5 directly activates the plasma cell differentiation program by enhancing blimp1 expression...
  51. pmc Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells
    Tim Thomas
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Genes Dev 20:1175-86. 2006
    ....
  52. pmc Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity
    Ian J Majewski
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    PLoS Biol 6:e93. 2008
    ..These data suggest that PRC2 is required to maintain a specific gene expression pattern in hematopoiesis that is indispensable to normal stem cell function...
  53. pmc Characterization of thrombopoietin (TPO)-responsive progenitor cells in adult mouse bone marrow with in vivo megakaryocyte and erythroid potential
    Ashley P Ng
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    Proc Natl Acad Sci U S A 109:2364-9. 2012
    ....
  54. pmc Thrombocytopenia and erythrocytosis in mice with a mutation in the gene encoding the hemoglobin β minor chain
    Maria Kauppi
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Australia
    Proc Natl Acad Sci U S A 109:576-81. 2012
    ..The Plt12 mouse is a model of high O(2)-affinity hemoglobinopathy and provides insights into hematopoiesis under conditions of chronic hypoxia...
  55. ncbi Architectural defects in the spleens of Nkx2-3-deficient mice are intrinsic and associated with defects in both B cell maturation and T cell-dependent immune responses
    David Tarlinton
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 170:4002-10. 2003
    ..Collectively, these data indicate a substantial role for Nkx2-3 in the correct association of lymphocytes and splenic stromal elements that is independent of chemokine expression...
  56. ncbi Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance
    Axel Kallies
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Immunol 7:466-74. 2006
    ..These data identify Blimp-1 as an essential regulator of T cell homeostasis and suggest that Blimp-1 regulates both B cell and T cell differentiation...
  57. ncbi A key role for G-CSF-induced neutrophil production and trafficking during inflammatory arthritis
    Jo L Eyles
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Blood 112:5193-201. 2008
    ....
  58. ncbi Hematopoietic defects in the Ts1Cje mouse model of Down syndrome
    Catherine L Carmichael
    Molecular Medicine, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Blood 113:1929-37. 2009
    ..Thus, loss of Gata1 and partial trisomy of chromosome 21 orthologs, when combined, do not appear to be sufficient to induce TMD or AMKL-like phenotypes in mice...
  59. ncbi Genetic influences determining progenitor cell mobilization and leukocytosis induced by granulocyte colony-stimulating factor
    A W Roberts
    The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Blood 89:2736-44. 1997
    ..5), and that this approach may serve as a useful model for the identification of genes involved in the mobilization process...
  60. pmc Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene
    Warren S Alexander
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 103:16442-7. 2006
    ..The disease in plt1/plt1 mice suggests that, in addition to immune-mediated effects, intrinsic C1Gal-T1 deficiency in megakaryocytes and the kidney may contribute to pathology...
  61. pmc The absence of Tssc6, a member of the tetraspanin superfamily, does not affect lymphoid development but enhances in vitro T-cell proliferative responses
    Jacqueline M Tarrant
    The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, 3050 Victoria, Australia
    Mol Cell Biol 22:5006-18. 2002
    ..These results demonstrate that Tssc6 is not required for normal development of the hematopoietic system but may play a role in the negative regulation of peripheral T-lymphocyte proliferation...
  62. pmc Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory disease
    Lorraine Robb
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 102:16333-8. 2005
    ....
  63. doi A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency
    Anne M Verhagen
    Signal Transduction Laboratory, St Vincent s Institute, Fitzroy, Victoria, Australia
    J Immunol 182:2020-9. 2009
    ..Furthermore, our results provide evidence for an additional role for Lyn kinase, distinct from its catalytic activity, in regulating intracellular signaling pathways...
  64. pmc Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development
    Kylie T Greig
    Division of Molecular Medicine, The Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
    Mol Cell Biol 27:5849-59. 2007
    ....
  65. pmc Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling
    Marina R Carpinelli
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville VIC 3052, Australia
    Proc Natl Acad Sci U S A 101:6553-8. 2004
    ....
  66. doi NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells
    Seth L Masters
    The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia
    Immunity 37:1009-23. 2012
    ..Conversely, NLRP1-deficient mice showed enhanced recovery from chemotherapy and LCMV infection, demonstrating that NLRP1 acts as a cellular sentinel to alert Caspase-1 to hematopoietic and infectious stress...
  67. pmc FADD and caspase-8 are required for cytokine-induced proliferation of hemopoietic progenitor cells
    Marc Pellegrini
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville VIC 3050, Australia
    Blood 106:1581-9. 2005
    ..These data demonstrate that the enzymatic activity of caspase-8 and its adaptor FADD are required for cytokine-induced proliferation of hemopoietic progenitor cells...
  68. pmc SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function
    Christine Brender
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Mol Cell Biol 24:6094-103. 2004
    ..Therefore, although SOCS5 is expressed in primary B and T cells, it appears to be dispensable for the regulation of lymphocyte function...
  69. pmc Development of hydrocephalus in mice lacking SOCS7
    Danielle L Krebs
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 101:15446-51. 2004
    ..In situ hybridization studies revealed prominent expression of Socs7 in the brain, suggestive of an important functional role of SOCS7 in this organ...
  70. ncbi Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo
    Shalin H Naik
    The Walter and Eliza Hall Institute, Parkville, Victoria 3050, Australia
    Nat Immunol 8:1217-26. 2007
    ..Thus, commitment to particular DC subtypes begins mainly at this pro-DC stage...
  71. pmc Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets
    Emma C Josefsson
    Molecular Medicine Division, Cancer and Hematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia
    J Exp Med 208:2017-31. 2011
    ..Thus, megakaryocytes do not activate the intrinsic pathway to generate platelets; rather, the opposite is true: they must restrain it to survive and progress safely through proplatelet formation and platelet shedding...
  72. pmc The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
    J G Zhang
    Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, P O Royal Melbourne Hospital, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 96:2071-6. 1999
    ..Analogous to the family of F-box-containing proteins, it appears that the SOCS proteins may act as adaptor molecules that target activated cell signaling proteins to the protein degradation pathway...
  73. pmc Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors
    Stephen L Nutt
    The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
    J Exp Med 201:221-31. 2005
    ..1(lo) CMPs were the immediate precursors of the MEP. Thus, down-regulation of PU.1 expression in the CMP is the first molecularly identified event associated with the restriction of differentiation to erythroid and megakaryocyte lineages...
  74. ncbi Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes
    Shalin H Naik
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Vaccine Technology, Parkville, Victoria 3050, Australia
    Nat Immunol 7:663-71. 2006
    ..Thus, the inflammatory status of the host influences the developmental origin and type of DC present in lymphoid tissues...
  75. ncbi Murine flt3 ligand protects M1 leukemic cells from LIF-induced differentiation and suppression of self-renewal
    C G Begley
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Exp Hematol 24:1247-57. 1996
    ....
  76. pmc Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1
    R Starr
    Walter and Eliza Hall Institute of Medical Research and Cooperative Research Centre for Cellular Growth Factors, Post Office Royal Melbourne Hospital, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 95:14395-9. 1998
    ..Thus, SOCS-1 is required for in vivo regulation of multiple cell types and is indispensable for normal postnatal growth and survival...
  77. pmc Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling
    Sandra E Nicholson
    The Walter and Eliza Hall Institute of Medical Research, Cooperative Research Centre for Cellular Growth Factors, Parkville, Victoria 3052, Australia
    Proc Natl Acad Sci U S A 102:2328-33. 2005
    ..This result suggests that the inhibition of signaling occurs through enhanced proteasomal degradation of the EGF-R through SOCS box recruitment of E3 ubiquitin ligase activity...
  78. ncbi A novel mutation in the Nfkb2 gene generates an NF-kappa B2 "super repressor"
    Elena Tucker
    St Vincent s Institute, Fitzroy, Victoria, Australia
    J Immunol 179:7514-22. 2007
    ..These findings demonstrate a key role for NF-kappaB2 in the regulation of RelA activation and suggest overlap in the function of NF-kappaB members in canonical and noncanonical pathway signaling...
  79. ncbi Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl
    W S Alexander
    The Walter and Eliza Hall Institute for Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Blood 87:2162-70. 1996
    ..Moreover, our results also imply an important role for TPO and c-Mpl in the production of primitive pluripotent progenitor cells as well as progenitor cells committed to nonmegakaryocytic lineages...
  80. ncbi The residual megakaryocyte and platelet production in c-mpl-deficient mice is not dependent on the actions of interleukin-6, interleukin-11, or leukemia inhibitory factor
    T Gainsford
    The Walter and Eliza Hall Institute for Medical Research, the Cooperative Research Centre for Cellular Growth Factors and the Rotary Bone Marrow Research Laboratories, Royal Melbourne Hospital, Victoria, Australia
    Blood 95:528-34. 2000
    ..Blood. 2000;95:528-534)..
  81. pmc Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival
    S Ogilvy
    The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 96:14943-8. 1999
    ..Thus, Bcl-2 has multiple effects on the hematopoietic system. These mice should help to further clarify the role of apoptosis in the development and homeostasis of this compartment...
  82. pmc Hematopoietic and lung abnormalities in mice with a null mutation of the common beta subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5
    L Robb
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Proc Natl Acad Sci U S A 92:9565-9. 1995
    ..The data establish that beta C is normally limiting for high-affinity binding of GM-CSF and demonstrate that systemic clearance of GM-CSF is not mediated via such high-affinity receptor complexes...
  83. ncbi Development of dendritic cells in culture from human and murine thymic precursor cells
    K A Kelly
    The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia
    Cell Mol Biol (Noisy-le-grand) 47:43-54. 2001
    ..Thus, although apparently lymphoid-restricted, the human thymic DC precursors responded to the myeloid factor GM-CSF as well as to the cytokines selective for murine lymphoid-related DC...
  84. ncbi Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    P Bouillet
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Science 286:1735-8. 1999
    ..Thus, Bim is required for hematopoietic homeostasis and as a barrier to autoimmunity. Moreover, particular death stimuli appear to activate apoptosis through distinct BH3-only proteins...
  85. ncbi Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
    F Kontgen
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Genes Dev 9:1965-77. 1995
    ..The ability of exogenous interleukin-2 to restore T Cell, but not B cell, proliferation indicates that Rel regulates the expression of different genes in B and T cells that are crucial for cell division and immune function...
  86. ncbi Aberrant hematopoiesis in mice with inactivation of the gene encoding SOCS-1
    D Metcalf
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    Leukemia 13:926-34. 1999
    ..The suppressive effects of IFN-gamma therefore appear to involve interactions with particular growth factor-initiated signals in -/- cells--interactions that are strongly modulated by the action of the SOCS-1 protein...
  87. ncbi SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine
    W S Alexander
    The Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
    Cell 98:597-608. 1999
    ..Our data indicate that SOCS1 is a key modulator of IFNgamma action, allowing the protective effects of this cytokine to occur without the risk of associated pathological responses...
  88. pmc Two distinct types of murine blast colony-forming cells are multipotential hematopoietic precursors
    D Metcalf
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 105:18501-6. 2008
    ..Both types of blast colonies offer remarkable opportunities to analyze multilineage commitment at a clonal level in vitro...
  89. pmc Critical role for granulocyte colony-stimulating factor in inflammatory arthritis
    Kate E Lawlor
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 101:11398-403. 2004
    ..Our results reveal a critical role for G-CSF in driving joint inflammation and highlight G-CSF as a potential therapeutic target in inflammatory joint diseases, such as rheumatoid arthritis...
  90. ncbi The unusual species cross-reactivity of the leukemia inhibitory factor receptor alpha-chain is determined primarily by the immunoglobulin-like domain
    C M Owczarek
    Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, P O Royal Melbourne Hospital, Victoria 3050, Australia
    J Biol Chem 272:23976-85. 1997
    ..These findings should enable the development of a "humanized" mouse LIFR that could act as a potent antagonist of hLIF biological activities in vivo...
  91. ncbi The SOCS-1 story
    D Metcalf
    The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Exp Hematol 27:1715-23. 1999
    ..SOCS-1-/- mice allowed to survive the neonatal period by cross-mating with IFN-gamma-/- mice may well ultimately develop other disease states, because loss of SOCS-1 potentially renders them hyperresponsive to other cytokine signaling...
  92. ncbi Gigantism in mice lacking suppressor of cytokine signalling-2
    D Metcalf
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Royal Melbourne Hospital, Victoria, Australia
    Nature 405:1069-73. 2000
    ....
  93. pmc The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo
    J G Zhang
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, P O Royal Melbourne Hospital, Parkville, VIC 3050, Australia
    Proc Natl Acad Sci U S A 98:13261-5. 2001
    ..These results demonstrate that deletion of the SOCS box leads to a partial loss of function of SOCS-1...
  94. ncbi Cellular processing of murine colony-stimulating factor (Multi-CSF, GM-CSF, G-CSF) receptors by normal hemopoietic cells and cell lines
    N A Nicola
    Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Victoria, Australia
    Growth Factors 1:41-9. 1988
    ..This resulted in a flexibility of the kinetic parameters that matched the variety of biological responses elicited by CSFs in different cell types...
  95. pmc The combined absence of NF-kappa B1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells
    Thomas Pohl
    The Walter and Eliza Hall Institute of Medical Research, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 99:4514-9. 2002
    ..These findings demonstrate that in the B lineage overlapping roles for NF-kappaB1 and c-Rel appear to be restricted to regulating the activation and function of mature cells...
  96. ncbi Role of granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor in the development of an acute neutrophil inflammatory response in mice
    D Metcalf
    Walter and Eliza Hall Institute of Medical Research, Ludwig, Victoria, Australia
    Blood 88:3755-64. 1996
    ..Typical eosinophil inflammatory responses to the injection of casein or thioglycollate occurred in GM-CSF -/ -mice but not in beta c -/- mice, suggesting that interleukin-5 was necessary for this response...
  97. pmc Molecular cloning and expression of the human homologue of the murine gene encoding myeloid leukemia-inhibitory factor
    N M Gough
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Proc Natl Acad Sci U S A 85:2623-7. 1988
    ..This factor competed with 125I-labeled native murine LIF for binding to specific cellular receptors on murine cells, compatible with a high degree of structural similarity between the murine and human factors...
  98. pmc The development of fatal myocarditis and polymyositis in mice heterozygous for IFN-gamma and lacking the SOCS-1 gene
    D Metcalf
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Post Office, Royal Melbourne Hospital, 3050 Victoria, Australia
    Proc Natl Acad Sci U S A 97:9174-9. 2000
    ....
  99. pmc Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin
    S Kimura
    The Walter and Eliza Hall Institute for Medical Research and The Cooperative Research Centre for Cellular Growth Factors PO Royal Melbourne Hospital, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 95:1195-200. 1998
    ..These data imply that TPO, signaling through c-Mpl, plays a vital physiological role in the regulation of hematopoietic stem cell production and function...
  100. ncbi Clearance and fate of leukemia-inhibitory factor (LIF) after injection into mice
    D J Hilton
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    J Cell Physiol 148:430-9. 1991
    ..The appearance of a large amount of nonprecipitable 125I in the urine suggested that the kidneys were the major route of LIF clearance from the body...
  101. pmc Synergistic suppression: anomalous inhibition of the proliferation of factor-dependent hemopoietic cells by combination of two colony-stimulating factors
    D Metcalf
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Proc Natl Acad Sci U S A 89:2819-23. 1992
    ..This phenomenon of synergistic suppression may have relevance for the future clinical use of combinations of CSFs, because a potentially similar suppression is also observable with some normal macrophage progenitor cells...